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| 1 | Role of CARD15,DLG5 and OCTN genes polymorphisms in children with inflammatory bowel diseases显示文摘AIM: To investigate the contribution of variants of CARD15, OCTN1/2 and DLG5 genes in disease predispo- sition and phenotypes in a large Italian cohort of pediatric patients with inflammatory bowel diseases (IBD). METHODS: Two hundred patients with Crohn’s disease (CD), 186 ulcerative colitis (UC) patients, 434 par- ents (217 trios), and 347 healthy controls (HC) were studied. Polymorphisms of the three major variants of CARD15, 1672C/T and -207G/C SNPs for OCTN genes, IGR2096a_1 and IGR2198a_1 SNPs for the IBD5 locus, and 113G/A variant of the DLG5 gene were evaluated. Potential correlations with clinical sub-phenotypes were investigated. RESULTS: Polymorphisms of CARD15 were significantly associated with CD, and at least one variant was found in 38% of patients (15% in HC, OR = 2.7, P < 0.001). Homozygosis for both OCTN1/2 variants was more com- mon in CD patients (1672TT 24%, -207CC 29%) than in HC (16% and 21%, respectively; P = 0.03), with an in- creased frequency of the TC haplotype (44.8% vs 38.3% in HC, P = 0.04). No association with the DLG5 variant was found. CD carriers of OCTN1/2 and DLG5 variants more frequently had penetrating disease (P = 0.04 and P = 0.01), while carriers of CARD15 more frequently had ileal localization (P = 0.03). No gene-gene interaction was found. In UC patients, the TC haplotype was morefrequent (45.4%, P = 0.03), but no genotype/phenotype correlation was observed. CONCLUSION: Polymorphisms of CARD15 and OCTN genes, but not DLG5 are associated with pediatric on- set of CD. Polymorphisms of CARD15, OCTN, and DLG5 genes exert a weak influence on CD phenotype. | S Cucchiara A Latiano O Palmieri AM Staiano R D'Incà G Guariso G Vieni V Rutigliano O Borrelli MR Valvano V Annese | 2007 | World Journal of Gastroenterology2007，13，8： | 9 |
| 2 | Development of antibiotic resistance genes in microbial communities during long-term operation of anaerobic reactors in the treatment of pharmaceutical wastewater显示文摘 | AYDIN S INCE B INCE O | 2015 | Water Res2015，83，： | 1 |
| 3 | Pro- tective effect of polydatin, a natural precursor of resvera- trol, against cisplatin-induced toxicity in rats 显示文摘 | INCE S ARSLAN ACAROZ D NEUWIRTH O | 2014 | Food Chem Toxicol2014，72，： | 1 |
| 4 | Crosslinked PS-DVB microspheres with sulfonated polystyrene brushes as new generation of ion exchange resins显示文摘 | Ozer O Ince A Karagoz B | 2013 | Desalination2013，309，： | 1 |
| 5 | Inhibition of volatile fatty acid production in granular sludge from a UASB reactor显示文摘 | Dogan T Ince O Oz N A | 2005 | EnvironTechnol2005，40，3： | 1 |
| 6 | Respirometric kinetic parameter calculations of a batch jet loop bioreactor treating leachate and oxygen uptake rate estimation by DTM显示文摘 | Ince M Yildiz F Engin G O | 2008 | Journal of Hazardous Materials2008，153，3： | 1 |
| 7 | An investigation into the pretreatment of dairy wastewater prior to aerobic biological treatment显示文摘 | KASAPGIL B ANDERSON G K INCE O | 1994 | Water Sci Technol1994，29，： | 1 |
| 8 | Experimental investigation of pipeline stability in very soft clay 显示文摘 | GHAZZALY O I MCClelland Engineers Inc | 1975 | Offshore Technology Conference1975，，： | 1 |
| 9 | Single-stage revision of peri-prosthetic infection following total elbow replacement显示文摘 | Gille J Ince A González O | 2006 | J Bone Joint Surg Br2006，88，10： | 1 |
| 10 | Anaerobic treatment of a chemical synthesis-based pharmaceutical wastewater in a hybrid upfiow anaerobic sludge blanket reactor 显示文摘 | Oktem Y A Ince O Sallis P | 2008 | Bioresour Technol2008，99，5： | 1 |
| 11 | Effect of wastewater composition on methanogenic activity in an anaerobic reactor 显示文摘 | Oz N A Ince O Ince B K | 2004 | Journal of Environmental Science and Health-Part A Toxic/Hazardous Substances and Environmental Engineering2004，39，1112： | 1 |
| 12 | Ultrasonographic visceral fatthickness in the first trimester can predict metabolic syndrome andgestational diabetes mellitus显示文摘 | Gur EB Ince O Turan GA | 2014 | Endocrine2014，47，2： | 1 |
| 13 | Anaerobic treatment of a chemical synthesis-based pharmaceutical wastewater in a hybrid upflow anaerobic sludge blanket reactor 显示文摘 | Oktem Y A Ince O Sallis P | 2008 | Bioresource Technology2008，99，5： | 1 |
| 14 | Diagnostic value of diuretic-enhanced excretory MR urography in patients with obstructive uropathy 显示文摘 | KARABACAKOGLU A KARAKOSE S INCE O | 2004 | EurJ Radiol2004，52，3： | 1 |
| 15 | Ultrasonographic visceral fat thickness in the first trimester can predict metabolic syndrome and gestational diabetes mellitus显示文摘 | GUR EB INCE O TURAN GA | 2014 | Endocrine2014，47，2： | 1 |
| 16 | Restoration of the eutrophicLake Eymir,Turkey,by biomanipulation after a major externalnutrient controlΙ显示文摘 | BEKLIOGLU M INCE O TUZUN I | 2003 | Hydrobiologia2003，490，123： | 1 |
| 17 | Determination of optimum operating conditions of an acidification reactor treating a chemical synthesis-based pharmaceutical wastewater显示文摘 | Oktem Y A Ince O Donnelly T | 2006 | Process Biochem2006，41，11： | 1 |
| 18 | Treatment efficiency and VFA composition of a thermophilic anaerobic contact reactor treat ing food industry wastewater 显示文摘 | Entftrk E S Ince M Engin G O | 2010 | Journal of Hazardous Materials2010，176，： | 1 |
| 19 | Effect of wastewater composition on archaeal population diversity显示文摘 | Akarsubasi A T Ince O Kirdar B | 2005 | Water Res2005，39，： | 1 |
| 20 | Composition of the microbial population in a membrane anaerobic reactor system during start-up 显示文摘 | Ince O Anderson G K Kasapgil B | 1997 | Water Research1997，31，1： | 1 |
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