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| 1 | Outcome of non-variceal acute upper gastrointestinal bleeding in relation to the time of endoscopy and the experience of the endoscopist: A two-year survey显示文摘AIM: To prospectively assess the impact of time of endoscopy and endoscopist's experience on the outcome of non-variceal acute upper gastrointestinal (GI) bleeding patients in a large teaching hospital.METHODS: All patients admitted for non-variceal acute upper GI bleeding for over a 2-year period were potentially eligible for this study. They were managed by a team of seven endoscopists on 24-h call whose experience was categorized into two levels (high and low) according to the number of endoscopic hemostatic procedures undertaken before the study. Endoscopic treatment was standardized according to Forrest classification of lesions as well as the subsequent medical therapy. Time of endoscopy was subdivided into two time periods: routine (8 a.m.-5 p.m.) and on-call (5 p.m.-8 a.m.). For each category of experience and time periods rebleeding rate, transfusion requirement, need for surgery, length of hospital stay and mortality we compared. Multivariate analysis was used to discriminate the impact of different variables on the outcomes that were considered.RESULTS: Study population consisted of 272 patients (mean age 67.3 years) with endoscopic stigmata of hemorrhage. The patients were equally distributed among the endoscopists, whereas only 19% of procedures were done out of working hours. Rockall score and Forrest classification at admission did not differ between time periods and degree of experience.Univariate analysis showed that higher endoscopist's experience was associated with significant reduction in rebleeding rate (14% vs 37%), transfusion requirements (1.8±0.6 vs 3.0±1.7 units) as well as surgery (4% vs 10%), but not associated with the length of hospital stay nor mortality. By contrast, outcomes did not significantly differ between the two time periods of endoscopy.On multivariate analysis, endoscopist's experience was independently associated with rebleeding rate and transfusion requirements. Odds ratios for low experienced endoscopist were 4.47 for rebleeding and 6.90 for need of transfusion after the endoscopy.CONCLUSION: Endoscopist's experience is an important independent prognostic factor for non-variceal acute upper GI bleeding. Urgent endoscopy should be undertaken preferentially by a skilled endoscopist as less expert staff tends to underestimate some risk lesions with a negative influence on hemostasis. | Fabrizio Parente Andrea Anderloni Stefano Bargiggia Venerina Imbesi Emilio Trabucchi Cinzia Baratti Silvano Gallus Gabriele Bianchi Porro | 2005 | World Journal of Gastroenterology2005，11，45： | 4 |
| 2 | Role of the advanced glycation end products receptor in Crohn's disease inflammation显示文摘AIM:To investigate the level of mucosal expression and the involvement of the receptor for the advanced glycation end products(RAGE)in delayed apoptosis and tumor necrosis factor(TNF)-αproduction in Crohn’s disease(CD).METHODS:Surgical and endoscopic specimens from both inflamed and non-inflamed areas of the ileum and/or colon were collected from 20 and 14 adult CD patients,respectively,and used for the assessment of RAGE expression by means of immunohistochemistry and western blotting analysis.Normal tissues from 21 control subjects were used for comparison.The same polyclonal anti-human RAGE antibody(R and D System)was used in all experimental conditions.RAGE staining was quantized by a score including both the amount of positive cells and intensity of immunoreactivity;cellular pattern was also described.The effects of RAGE blocking on apoptotic rate and TNF-αproduction were investigated on immune cells freshly isolated from CD mucosa and incubated both with and without the muramyl dipeptide used as antigenic stimulus.Statistical analysis was performed via the test for trend,with regression models to account for intra-patient correlations.A 2-sided P<0.05 was considered significant.RESULTS:In inflamed areas,RAGE expression in both the epithelial and lamina propria compartments was higher than control tissues(P=0.001 and 0.021,respectively),and a cluster of positive cells were usually found in proximity of ulcerative lesions.Similar results were obtained in the lamina propria compartment of non-inflamed areas(P=0.025).The pattern of staining was membranous and granular cytosolic at the epithelial level,while in the lamina propria it was diffuse cytosolic.When evaluating the amount of protein expression by immunoblotting,a significant increase of both surface area and band intensity(P<0.0001 for both)was observed in CD inflamed areas compared to control tissue,while in non-inflamed areas a significant increase was found only for band intensity(P<0.005).Moreover,a significantly lower expression in noninflamed areas in comparison with inflamed areas was found for both surface area and band intensity(P<0.0006 for both).Finally,RAGE blocking largely affects both the apoptotic rate of mucosal cells(towards an increase in both non-inflamed and inflamed areas of P<0.001 and<0.0001,respectively)and TNF-αsecretion(towards a decrease in both non-inflamed and inflamed areas of P<0.05 and<0.01,respectively),mainly in the presence of antigenic stimulation.CONCLUSION:RAGE is up-regulated in CD,especially in inflamed areas,and it appears to play a role in the mechanisms involved in chronic inflammation. | Rachele Ciccocioppo Alessandro Vanoli Catherine Klersy Venerina Imbesi Vincenzo Boccaccio Rachele Manca Elena Betti Giuseppina Cristina Cangemi Elena Strada Roberta Besio Antonio Rossi Colomba Falcone Sandro Ardizzone Paolo Fociani Piergiorgio Danelli Gino Roberto Corazza | 2013 | World Journal of Gastroenterology2013，19，45： | 2 |
| 3 | Effects of MK-886, a 5-lipoxygenase activating protein (FLAP) inhibitor, and 5-lipoxygenase deficiency on the forced swimming behavior of mice显示文摘 | Tolga Uz Nikola Dimitrijevic Marta Imbesi Hari Manev Radmila Manev | 2008 | Neuroscience Letters2008，，2： | 1 |
| 4 | Proton magnetic resonance spectroscopy of mesial temporal sclerosis: Analysis of voxel shape and position to improve diagnostic accuracy显示文摘 | Imbesi SG | 2006 | J Comput Assist Tomogr2006，30，： | 1 |
| 5 | Temozoiomide and thalidomide in the treatment of glioblastoma multiforme显示文摘 | Riva M Imbesi F Beghi E | 2007 | Anticancer Res2007，27，2： | 1 |
| 6 | The pattern of melatonin recaptor expression in the brain may influence antidepressant treatment 显示文摘 | Hirsch-Rodriguez E Imbesi M Manev R | 2007 | Med Hypotheses2007，69，1： | 1 |
| 7 | Role of pro-ton magnetic resonance spectroscopy in the diagnosis of gliomatosis cerebri:a unique pattern of normal choline but elevated Myoinositol metabolite levels显示文摘 | Imbesi SG Diet rich R | 2004 | J Comput Assist Tomogr2004，28，1： | 1 |
| 8 | Role of melatonin receptorsin the effects of melatonin on BDNF and neuroprotectionin mouse cerebellar neurons显示文摘 | Imbesi M Uz T Manev H | 2008 | Journal of Neural Trans-mission2008，115，11： | 1 |
| 9 | Use of double-balloon enteroscopy in the management of patients with Crohn’s disease: feasibility and diagnostic yield in a high-volume centre for inflammatory bowel disease显示文摘 | Gianpiero Manes Venerina Imbesi Sandro Ardizzone Andrea Cassinotti Stefano Pallotta Gabriele Bianchi Porro | 2009 | Surgical Endoscopy2009，，12： | 1 |
| 10 | Metabolite fi ndings in tumefactive demyelinating lesions utilizing short echo time proton magnetic resonance spectroscopy显示文摘 | Cianfoni A Niku S Imbesi SG | 2007 | AJNR2007，28，： | 1 |
| 11 | Metabolite findings in tume- factive demyelinating lesions utilizing short echo time pro- ton magnctic resonance spectroscopy 显示文摘 | Cianfoni A Niku S Imbesi SG | 2007 | Am J Neuroradiol2007，28，2： | 1 |
| 12 | Immtnosenescence:a review显示文摘 | Malaguarnera L Ferlito L Imbesi RM | 2001 | Arch Gerontol Geriatr2001，32，1： | 1 |
| 13 | The pattern of melatonin receptor expression in the brain may influence antidepressant treatment显示文摘 | Hirsch-Rodriguez E Imbesi M Manev R | 2007 | Med Hypotheses2007，69，1： | 1 |
| 14 | Effects of dietary extra - virgin olive oil on oxidative stress resulting resulting from exhaustive exercise in rat skeletal muscle: a morphological study 显示文摘 | MUSUMECI G MARIA TROCATO F IMBESI R | 2014 | Ac- ta Histochemica2014，116，1： | 1 |
| 15 | Metabolite findings in tumefac-tive demyelinating lesions utilizing short echo time proton mag- netic resonance spectroscopy 显示文摘 | Cianfoni A Niku S Imbesi SG | 2007 | AJNR Am J Neuroradiol2007，28，2： | 1 |
| 16 | Oxidative stress and skeletalmuscle in exercise显示文摘 | Gastrogiovanni P Imbesi R | 2012 | Ital J Anat Embryol2012，117，2： | 1 |
| 17 | A ran domized phase Ⅲ study: comparison between intravenous and intraarterial ACNU administration in newly diagnosed primary glioblastomas显示文摘 | IMBESI F MARCHIONI E BENERICETTI E | 2006 | Anticancer Res2006，26，1： | 1 |
| 18 | The pave pace integrated core processor显示文摘 | Imbesi D J Kaplow W K | 1992 | Digital Object Identifier1992，5，： | 1 |
| 19 | Treatment with rapamycin ameliorates clinical and histological signs of protracted relapsing experimental allergic encephalomyelitis in Dark Agouti rats and induces expansion of peripheral CD4+CD25+Foxp3+ regulatory T cells显示文摘 | Marco Donia Katia Mangano Alfredo Amoroso Maria Clorinda Mazzarino Rosa Imbesi Paola Castrogiovanni Marinella Coco PierLuigi Meroni Ferdinando Nicoletti | 2009 | Journal of Autoimmunity2009，，2： | 1 |
| 20 | Development of a posterior cerebral artery aneurysm subsequent to occlusion of the contralater- al internal carotid artery for giant cavernous aneurysm 显示文摘 | Wolf RL Imbesi SG Galetta SL | 2002 | Neurora- diology2002，44，： | 1 |
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