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| 1 | Tumor necrosis factor-α inhibitor therapy and fetal risk:A systematic literature review显示文摘Tumor necrosis factor-α inhibitors (anti-TNFs) are effective in the treatment of inflammatory bowel disease (IBD) recalcitrant to conventional medical therapy. As the peak incidence of IBD overlaps with the prime reproductive years, it is crucial to establish pharmacologic regimens for women of childbearing age that achieve effective disease control without posing significant fetal harm. A systematic literature review was performed to identify all human studies with birth outcomes data after maternal exposure to infliximab, adalimumab, or certolizumab pegol within 3 mo of conception or during any trimester of pregnancy. Live births, spontaneous abortions or stillbirths, preterm or premature births, low birth weight or small for gestational age infants, and congenital abnormalities were recorded. Fifty selected references identified 472 pregnancy exposures. The subsequent review includes general information regarding anti-TNF therapy in pregnancy followed by a summary of our findings. The benefits of biologic modalities in optimizing disease control during pregnancy must be weighed against the potential toxicity of drug exposure on the developing fetus. Although promising overall, there is insufficient evidence to prove absolute safety for use of anti-TNFs during pregnancy given the limitations of available data and lack of controlled trials. | Renée M Marchioni Gary R Lichtenstein | 2013 | World Journal of Gastroenterology2013，19，17： | 11 |
| 2 | Impact of pediatric inflammatory bowel disease diagnosis on exercise and sports participation: Patient and parent perspectives显示文摘BACKGROUND Inflammatory bowel disease(IBD)may limit physical activity due to intestinal or extraintestinal manifestations,fatigue,or exercise perception.We sought to evaluate the influence of IBD diagnosis on exercise and sports participation in a pediatric population.We compared patient-reported and parent-reported perspectives.AIM To evaluate the influence of IBD diagnosis on exercise and sports participation in a pediatric population.METHODS Consecutive IBD outpatients(aged 10-18 years)and their parents completed parallel voluntary surveys.A validated,patient-reported functional activity scale,the Hospital for Special Surgery Pediatric Functional Activity Brief Scale(HSS Pedi-FABS)was used to assess children’s activity levels.RESULTS There were 149 completed surveys(75%response rate)with mean participant age of 16.5 years[standard deviation(SD)=4.0]and mean age at IBD diagnosis of 11.8 years(SD=3.4).Most patients(77%)were diagnosed within 12 mo of symptom onset.Current athletic participation was reported in 65%across 65 sports.Participation was greatest before(40%)rather than after(32%)IBD diagnosis,with no reported change in 28%.IBD negatively impacted play/performance in 45%but did not change play/performance in 44%.IBD treatment improved patients’desire to exercise(70%)and subjective capacity for aerobic exercise(72%).Patients and parents agreed that IBD subjects demonstrate normal capacity for aerobic exercise(0.40,95%CI:0.22-0.58)and that treatment improved both participatory desire(0.33,95%CI:0.12-0.54)and capacity for aerobic exercise(0.52,95%CI:0.31-0.71).Almost all(99%)viewed exercise as healthy,and most encouraged its practice.IBD patients demonstrated normal mean HSS Pedi-FABS scores.CONCLUSION After pediatric IBD diagnosis,most patients continue exercise and sports,with mean activity levels comparable to American youth.Treatment positively impacts participatory desire and aerobic capacity.Patients favor the role of exercise in IBD. | Renée M Marchioni Beery Enju Li Laurie N Fishman | 2019 | World Journal of Gastroenterology2019，25，31： | 2 |
| 3 | Functional anatomy of the Eustachian tube显示文摘 | Cunsolo E Marchioni D Leo G | 2010 | Int J Immunopathol Pharmacol2010，23，1： | 1 |
| 4 | Postinfectious inflammato-ry disorders:subgroups based on prospective follow-up显示文摘 | Marchioni E Ravaglia S Piccolo G | 2005 | Neurolo-gy2005，65，7： | 1 |
| 5 | Primary lung cancer presenting with gastrointestinal tract involvement:dinicopathologic and immunohistochemical features in a series of 18 consecutive cases显示文摘 | Rossi G Marchioni A Romagnani E | 2007 | J Thorac Oncol2007，2，2： | 1 |
| 6 | Postinfectious inflammatory disorders: subgroups based on pro spective follow-up 显示文摘 | Marchioni E Ravaglia S Piccolo G | 2005 | Neurology2005，65，： | 1 |
| 7 | Smearing of soft cheese with Enterococcus faecium WHE 81,a multi-bacteriocin producer,against Listeria monocytogenes显示文摘 | Izquierdo E Marchioni E Aoude-Wemer D | 2009 | Food Microbiology2009，26，1： | 1 |
| 8 | Acute disseminated encephalomyelitis 显示文摘 | Marchioni E Tavazzi E Minoli L | 2008 | Neurol Sci2008，29，： | 1 |
| 9 | Expression of Fas and Fas ligand in human testicular germ cell tumours显示文摘 | Baldini E Ulisse S Marchioni E | 2009 | Int J Androl2009，32，2： | 1 |
| 10 | ICHD-II diagnostic criteria for Tolosa-hunt syndrome in idiopathic inflammatory syndromes of the orbit and/or the cavernous sinus显示文摘 | Colnaghi S Versino M Marchioni E | 2008 | Cephalalgia2008，28，6： | 1 |
| 11 | ICHD- II diagnostic criteria for Tolosa - Hunt syndrome in idiopathic inflammatory syndrome of the orbit and/or the cavernous sinus 显示文摘 | COLNAGHI S VERSINO M MARCHIONI E | 2008 | Cephalalgia2008，28，6： | 1 |
| 12 | Smearing of soft cheese with Enterococcus faecium WHE 81 ,a multi-bacteriocin producer, against Listeria monocytogenes显示文摘 | Izquierdo E Marchioni E Aoude-Wemer D | 2009 | Food Microbiology2009，26，1： | 1 |
| 13 | Smearing of soft cheese with Enterococcus faecium WHE 81, a multi-bacteriocin producer, against Listeria monocytogenes显示文摘 | IZQUIERDO E MARCHIONI E AOUDE-WERNER D | 2009 | Food Microbiology2009，26，1： | 1 |
| 14 | T-norm-basedlogics with an independent involutive negation显示文摘 | Flaminio T Marchioni E | 2006 | Fuzzy Sets and Systems2006，157，24： | 1 |
| 15 | A ran domized phase Ⅲ study: comparison between intravenous and intraarterial ACNU administration in newly diagnosed primary glioblastomas显示文摘 | IMBESI F MARCHIONI E BENERICETTI E | 2006 | Anticancer Res2006，26，1： | 1 |
| 16 | ICHD-II diagnostic criteria for Tolosa-Hunt syndrome in idiopathic inflammatory syndromes of the orbit and/or thecavernous sinus显示文摘 | Colnaghi S Versino M Marchioni E | 2008 | Cephalalgia2008，28，6： | 1 |
| 17 | Severe recurrent myelitis in patients with hepatitis C virus infection显示文摘 | K Marinou Aktipi S Ravaglia M Ceroni R Nemni M Debiaggi S Bastianello E Alfonsi E Zardini L Minoli E Tavazzi E Marchioni | 2007 | Neurology2007，，6： | 1 |
| 18 | Congenital postauricular swelling in a child显示文摘 | Marchioni D Cuzzola E Massone F | 2002 | Pediatr Dermatology2002，19，3： | 1 |
| 19 | t-Norm-Based Logics with an Independent Involutive Negation 显示文摘 | Flaminio T Marchioni E | 2006 | Fuzzy Sets and Systems2006，157，24： | 1 |
| 20 | Postinfectious inflammatory disorders:subgroups based on prospective follow-up显示文摘 | Marchioni E Ravaglia S Piccolo G | 2005 | Neurology2005，65，7： | 1 |
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