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| 1 | 早发急性心肌梗死的长期结局和风险评估:10年随访研究显示文摘早发急性心肌梗死(acute myocardial infarction,AMI)是一种罕见的疾病,发病率和死亡率很高。该文在再灌注治疗广泛应用的大环境下,纳入前瞻性研究人群进行早发AMI的预后研究。方法:这项前瞻性多中心研究中连续纳入102例AMI存活者(≤40岁),临床预后通过奥地利死亡登记处和维也纳集中患者管理系统进行查询。 | 刘莉 叶鹏 Winter MP Blessberger H Alimohammadi A Pavo N Huber K Wojta J Lang IM Wiesbauer F Goliasch G | 2017 | 中华高血压杂志2017，25，4： | 5 |
| 2 | Significance of postoperative follow-up of patients with metastatic colorectal cancer using circulating tumor DNA显示文摘BACKGROUND One of the most notable applications for circulating tumor DNA(ctDNA)detection in peripheral blood of patients with metastatic colorectal cancer(mCRC)is a long-term postoperative follow-up.Sometimes referred to as a“liquid(re)biopsy”it is a minimally invasive procedure and can be performed repeatedly at relatively short intervals(months or even weeks).The presence of the disease and the actual extent of the tumor burden(tumor mass)within the patient’s body can be monitored.This is of particular importance,especially when evaluating radicality of surgical treatment as well as for early detection of disease progression or recurrence.AIM To confirm the radicality of surgery using ctDNA and compare available methods for detection of recurrence in metastatic colorectal cancer.METHODSA total of 47 patients with detected ctDNA and indications for resection of mCRC were enrolled in the multicenter study involving three surgical centers.Standard postoperative follow-ups using imaging techniques and the determination of tumor markers were supplemented by ctDNA sampling.In addition to the baseline ctDNA testing prior to surgery,a postoperative observation was conducted by evaluating ctDNA presence up to a week after surgery and subsequently at approximately three-month intervals.The presence of ctDNA was correlated with radicality of surgical treatment and the actual clinical status of the patient.RESULTS Among the monitored patients,the R0(curative)resection correlated with postoperative ctDNA negativity in 26 out of 28 cases of surgical procedures(26/28,93%).In the remaining cases of R0 surgeries that displayed ctDNA,both patients were diagnosed with a recurrence of the disease after 6 months.In 7 patients who underwent an R1 resection,4 ctDNA positivities(4/7,57%)were detected after surgery and associated with the confirmation of early disease recurrence(after 3 to 7 months).All 15 patients(15/15,100%)undergoing R2 resection remained constantly ctDNA positive during the entire follow-up period.In 22 cases of recurrence,ctDNA positivity was detected 22 times(22/22,100%)compared to 16 positives(16/22,73%)by imaging methods and 15 cases(15/22,68%)of elevated tumor markers.CONCLUSION ctDNA detection in patients with mCRC is a viable tool for early detection of disease recurrence as well as for confirmation of the radicality of surgical treatment. | Lucie Benešová Tereza Hálková Renata Ptáčková Anastasiya Semyakina Kateřina Menclová JiříPudil Miroslav Ryska Miroslav Levý JaromírŠimša Filip Pazdírek JiříHoch Milan Blaha Marek Minárik | 2019 | World Journal of Gastroenterology2019，25，48： | 3 |
| 3 | Bevacizumab plus oxaliplatin-based chemotherapy as adjuvant treatment for colon cancer (AVANT): a phase 3 randomised controlled trial显示文摘 | Aimery de Gramont Eric Van Cutsem Hans-Joachim Schmoll Josep Tabernero Stephen Clarke Malcolm J Moore David Cunningham Thomas H Cartwright J Randolph Hecht Fernando Rivera Seock-Ah Im Gy?rgy Bodoky Ramon Salazar Frédérique Maindrault-Goebel Einat Shacham- | 2012 | Lancet Oncology2012，，12： | 3 |
| 4 | Immunohistochemical study of central neurocytoma, subependymoma,and subependymal giant cell astrocytoma显示文摘 | You H Kim YI Im SY | 2005 | J Neurooncol2005，74，1： | 1 |
| 5 | Large-scale synthesisof silver nanocubes:the role of HCl in promoting cube per-fection and monodisperty显示文摘 | Im S H Lee Y T Wiley B | 2005 | Angew Chem2005，117，14： | 1 |
| 6 | Rapid fabrication of aluminum shoe mold using vacuum sealed casting process 显示文摘 | Chung S Im Y Jeong H | 2003 | Journal of Materials Processing Technology2003，142，： | 1 |
| 7 | Scintillators for alpha and neutron radiations synthesized by room temperature sol-gel processing 显示文摘 | IM H J WILLIS C SAENGKERDSUB S | 2004 | Journal of Sol-Gel Science and Technology2004，32，13： | 1 |
| 8 | Selective serotonin reuptake inhibitors and intraoperative blood pressure显示文摘 | van Haelst IM van Klei WA Doodeman H J | | 0，，02： | 1 |
| 9 | 查看详情显示文摘 | Maeng Y J Yoon B S Suh M H Im W B Lee S H | | 0，，： | 1 |
| 10 | Enhancement of red spectral emission intensity of Y3Al5O12:Ce3+phosphor via Pr Co-doping and Tb substitution for the application to white LEDs显示文摘 | JANG H S IM W B LEE D C | 2007 | J Lumin2007，126，2： | 1 |
| 11 | Binge drinking and its relation to metabolic syndrome in korean adult men 显示文摘 | Im H J Park S M Choi J H | 2014 | Korean J Fam Med2014，35，4： | 1 |
| 12 | Retinal detachment after phacoemulsification in high myopia: analysis of 2356 cases 显示文摘 | Neuhann IM Neuhann TF Heimann H | 2008 | J Cataract Refract Surg2008，34，10： | 1 |
| 13 | Cyclic loading test for reinforced concrete emulated beam column connection of precast concrete moment frame 显示文摘 | IM H J PARK H G EOM T S | 2013 | ACI Structural Journal2013，110，1： | 1 |
| 14 | Growth of CH3NH3PbI3 cuboids with controlled size for high-efficiency per- ovskite solar cells显示文摘 | Im J H Jang 1 H Pellet N | 2014 | Nature Nanoteclmology2014，9，11： | 1 |
| 15 | Apoptosis and modulation of cell cycle control by synthetic derivatives of ursodeoxycholic acid and chenodeoxycholic acid in human prostate cancer cells显示文摘 | Choi Y H Im E O Suh H | 2003 | Cancer Lett2003，199，2： | 1 |
| 16 | Therapeutic drug concentrations of teicoplanin in clinical settings显示文摘 | Nah S Y Im J H Yeo J Y | 2014 | Infect Chemother2014，46，1： | 1 |
| 17 | Prognostic impact of clinicopathologic parameters in stage Ⅱ / Ⅲ breast cancer treated with neoadjuvant docetaxel and doxorubicin chemotherapy: paradoxical features of the triple negative breast cancer显示文摘 | Keam B Im S A Kim H J | 2007 | BMC Cancer2007，1，： | 1 |
| 18 | Magnetic field analysis of 2-D permanent magnet array for planar motor 显示文摘 | Cho H S Im C H Jung H K | 2001 | IEEE Transactions on Magnetics2001，37，5： | 1 |
| 19 | Finite element investigation of friction condition in a backward extrusion of aluminum alloy 显示文摘 | IM Y T KANG S H CHEON J S | 2003 | Journal of Manufacturing Science and Engineering2003，125，2： | 1 |
| 20 | Nonconservative amino acid substitution variants exist at polymorphic frequency in DNA repair genes in healthy humans显示文摘 | Shen MR Jones IM Mohrenweiser H | 1998 | Cancer Res1998，58，4： | 1 |
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