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| 1 | Inhibition of hypoxia-inducible factor 1 with acriflavine sensitizes hypoxic tumor cells to photodynamic therapy with zinc phthalocyanine-encapsulating cationic liposomes显示文摘光力学的治疗(太平洋夏季时间) 是 tumorlocalized photosensitizer 与光是激动的一种肿瘤治疗在形式,它导致反应的氧种类,肿瘤 vasculature 的破坏,肿瘤组织缺氧,肿瘤房间死亡,和反肿瘤免疫者回答的正式就职的本地生产。然而,先存在肿瘤组织缺氧可以减少肿瘤到由激活组织缺氧可诱导的因素的太平洋夏季时间 1 (HIF-1 ) 幸存小径。因此,我们与吖啶黄(ACF ) 假设了 HIF-1 的那抑制将在人的表皮状的癌(A431 ) 加重房间死亡房间。A431 肿瘤房间的太平洋夏季时间用包含 photosensitizer 锌酞毒(ZnPC ) 的最新发达并且优化的 PEGylated cationic liposomes 被执行。分子的停靠表明 ACF 绑在 HIF-1 的 dimerization 领域,并且共焦的显微镜学在组织缺氧下面从 cytosol 证实了 ACF 的 translocation 到原子核。HIF-1 在 hypoxic,然而并非 normoxic 被稳定, A431 房间列在后面太平洋夏季时间。有 ACF 的 HIF-1 的抑制在 hypoxic 条件下面增加了导致太平洋夏季时间的房间死亡的程度并且减少了 HIF-1 目标基因 VEGF, PTGS2,和 EDN1 的表示。而且,在包含 ZnPC liposomes 的水的核心的 ACF 的合作封装在比得上非包含的 ACF 的太平洋夏季时间功效上产出辅助效果。在结论, HIF-1 与 liposomal ZnPC 贡献 A431 肿瘤房间幸存追随者太平洋夏季时间。HIF-1 与的抑制免费或 liposomal ACF 改进太平洋夏季时间功效。 | Mans Broekgaarden Ruud Weijer Massis Krekorian Bas van den IJssel Milan Kos Lindy K. Alles Albert C. van Wijk1 Zsolt Bikadi Eszter Hazai Thomas M. van Gulik Michal Heger | 2016 | Nano Research2016，9，6： | 4 |
| 2 | BAC to the future or oligonucleotides:a perspective for microarray comparative genomic hybridization (array CGH)显示文摘 | Ylstra B van den Ijssel P Carvalho B | 2006 | Nucl Acid Res2006，34，： | 1 |
| 3 | Human and mouse oligonucleotide-based array CGH显示文摘 | van den Ijssel P Tijssen M Chin S F | 2005 | Nucleic Acids Res2005，33，22： | 1 |
| 4 | The influence of alloy composition and microstructure on the corrosion behavior of copper-nickel alloys in seawater 显示文摘 | Drolenga L J P IJsseling F P Kolster B H | 1983 | Mater Corros1983，34，： | 1 |
| 5 | Validation of Fast Pre-mission Error Analysis of the GOCE Gradiometry Mission by a Full Gravity Field Recovery Simulation显示文摘 | SNEEUW N VAN DEN IJSSEL J KOOP R | 2002 | Journal of Geodynamics2002，33，12： | 1 |
| 6 | Verification of CHAMP Accelerometer Observations显示文摘 | Visser P N A M Ijssel J | 2003 | Advances in Space Research2003，31，： | 1 |
| 7 | Molecular analysis of glyceraldehyde-Svphosphate dehydrogenase in Trypanoplasma borelli : an evolutionary scenario of subcellular com partmentation in kinetoplastida显示文摘 | Wiemer E Av Hannaert V Van den Ijssel P Rv | 1995 | J Mol Evol1995，40，4： | 1 |
| 8 | Translocation of small heat shock proteins to the actin cytoskeleton upon proteasomal inhibition显示文摘 | Croes Y IJssel PRLA | 2002 | J Mol Cell Cardiol2002，34，： | 1 |
| 9 | Exploring gravity field determination from orbit perturbations of the European Gravity Mission GOCE显示文摘 | Visscr P N A M Van den Ijssel J Koop R and Klees R | 2001 | Journal of Geodesy2001，75，： | 1 |
| 10 | BAC to the future or oligonucleotides: a persp- ective for microarmy comparative ge- nomic hybridization ( array CGH) 显示文摘 | Ylstra B van den Ijssel P Carvalho B | 2006 | Nucleic Acids Research2006，34，： | 1 |
| 11 | Human and mouse oligonucleotide-based array CGH显示文摘 | van den Ijssel P Tijssen M Chin S F | 2005 | Nucleic Acids Res2005，33，22： | 1 |
| 12 | General Guideline for Corrosion Testing of Materials for Marine Applications显示文摘 | IJSSELING F P | 1989 | British Corrosion Journal1989，24，1： | 1 |
| 13 | The Influence of Alloy Composition and Microstructure on the Corrosion Behavior of Copper-nickel Alloys in Seawater显示文摘 | PROLENGA L J P IJSSELING F P KOSTER B H | 1983 | Werk Korro1983，34，： | 1 |
| 14 | BAC to the futureor oligonueleotides:a pempeelive for micro array comparative genomic hybridization(army CGH)显示文摘 | van den Ijssel P Carvalho B | 2006 | Nudcic Acids Res2006，34，2： | 1 |
| 15 | The influence of alloy composition and microstructure on the corrosion behavior of copper-nickel alloys in seawater 显示文摘 | Prolenga L J P Ijsseling F P Koster B H | 1983 | WerkKorro1983，34，： | 1 |
| 16 | Verification of CHAMP Accelerometer Observations 显示文摘 | VAN DEN IJSSEL J | 2003 | Advances in Space Research2003，31，8： | 1 |
| 17 | Exploring Gravity Field Determination from Orbit Perturbations of the European Gravity Mission GOCE显示文摘 | Visser P N A M van den Ijssel J Koop R | 2001 | Journal of Geodesy2001，75，： | 1 |
| 18 | Efficient gravity field recovery from GOCE gravity gradient observations显示文摘 | Klees R Koop R Visser P Ijssel J V D | | 0，，7： | 1 |
| 19 | Exploring gravity field determination from orbit perturbations of the European Gravity Mission GOCE显示文摘 | Visser P N A M IJssel J V D Koop R Klees R | | 0，，2： | 1 |
| 20 | Intermediate filament interactions can be altered by HSP27 and αB-crystallin显示文摘 | Perng MD Cairns L van den IJssel P | | 0，，13： | 1 |
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