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| 1 | Nanoplasmonic mid-infrared biosensor for in vitro protein secondary structure detection显示文摘Plasmonic nanoantennas offer new applications in mid-infrared(mid-IR)absorption spectroscopy with ultrasensitive detection of structural signatures of biomolecules,such as proteins,due to their strong resonant near-fields.The amide I fingerprint of a protein contains conformational information that is greatly important for understanding its function in health and disease.Here,we introduce a non-invasive,label-free mid-IR nanoantenna-array sensor for secondary structure identification of nanometer-thin protein layers in aqueous solution by resolving the content of plasmonically enhanced amide I signatures.We successfully detect random coil to crossβ-sheet conformational changes associated withα-synuclein protein aggregation,a detrimental process in many neurodegenerative disorders.Notably,our experimental results demonstrate high conformational sensitivity by differentiating subtle secondary-structural variations in a nativeβ-sheet protein monolayer from those of crossβ-sheets,which are characteristic of pathological aggregates.Our nanoplasmonic biosensor is a highly promising and versatile tool for in vitro structural analysis of thin protein layers. | Dordaneh Etezadi John B Warner IV Francesco S Ruggeri Giovanni Dietler Hilal A Lashuel Hatice Altug | 2017 | Light(Science & Applications)2017，6，1： | 2 |
| 2 | Bidding games for valuation of aesthetic environmental improvements显示文摘 | RANDALL A IVES B EASTMAN C | 1974 | Journal of Environmental Economics and Management1974，，1： | 1 |
| 3 | In vitro anti-Helicobacter pylori activity of the probiotic strain Bacillus显示文摘 | Pinchuk IV Bressollier P Verneuil B | 2001 | Antimicrob Agents Chemother2001，45，11： | 1 |
| 4 | Axillary lymph node status of operable breast cancers by combined steroid receptor and HER-2status:triple positive tumours are more likely lymph node positive显示文摘 | van Calster B Bempt IV Drijkoningen M | 2009 | Breast Cancer Res Treatment2009，113，1： | 1 |
| 5 | User involvement and MIS success:areview of research显示文摘 | IVES B OLSON M H | 1984 | Management Science1984，30，5： | 1 |
| 6 | An Empirical Comparison of Social,Collaborative Filtering,and Hybrid Recommenders显示文摘 | Alejandro B Iván C Fernando D | 2013 | ACM Transactions on Intelligent Systems and Technology2013，4，1： | 1 |
| 7 | In search of sustainability显示文摘 | FEENY D IVES B | 1990 | Journal of Management Information Systems1990，7，1： | 1 |
| 8 | Genome, transcriptome, and secretome analysis of wood decay fungus Postia placenta supports unique mechanisms of lignocellulose conversion 显示文摘 | Martinez D Challacombe J Morgenstern 1 Hibbett D Schmoll M Kubicek CP Ferreira P Ruiz-Duenas FJ Martinez AT Kersten P Hammel KE Wymelenberg AV Gaskell J Lindquist E Sabat G BonDurant SS Larrondo LF Canessa P Vicuna R Yadav J Doddapaneni H Subramanian V Pisabarro AG Lavin JL Oguiza JA Master E Henrissat B Coutinho PM Harris P Magnuson JK Baker SE Bruno K Kenealy W Hoegger PJ Kties U Ramaiya P kucas S Salamov A Shapiro H Tu H Chee CL Misra M Xie G Teter S Yaver D James T Mokrejs M Pospisek M Grigoriev IV Brettin T Rokhsar D Berka R Cullen D | 2009 | PNAS2009，106，6： | 1 |
| 9 | Bidding games for valuation of aesthetic environmental improvements显示文摘 | Randall A Ives B Eastman C | 1974 | Journal of Environ- mental Economics and Management1974，1，2： | 1 |
| 10 | The chal enge for gene therapy:innate immune response to adenoviruses显示文摘 | Thaci B Ulasov IV Wainwright DA | | 0，，03： | 1 |
| 11 | Epoxidation of Thermally Degraded Poly (vinyl chloride) 显示文摘 | Tibor Szakács Béla Iván | 2004 | Polymer Degradation and Stability2004，85，3： | 1 |
| 12 | Executive involvement and partici- pation in the management of information technology显示文摘 | Jarvenpaa S Ives B | 1991 | MIS Quarterly1991，15，2： | 1 |
| 13 | User involvement and MIS success: a review of research显示文摘 | Ives B Olson M H | 1984 | Management science1984，30，5： | 1 |
| 14 | Bidding games for valuation of aesthetic environmental improvements显示文摘 | RANDALL A IVES B EASTMAN C | 1974 | Journal of Environmental Eco-nomics and Management1974，1，2： | 1 |
| 15 | The immune system in space and other extreme conditions显示文摘 | Konstantinova IV Fushs B | 1991 | Immunology1991，，： | 1 |
| 16 | Executive Involvement and Participation in the Management of Information Technology 显示文摘 | Jarvenpaa S L Ives B | 1991 | MIS Quarterly1991，15，2： | 1 |
| 17 | Food-web Interactions Govern the Resistance of Communities after Non-random Extinctions 显示文摘 | Ives A R Cardinale B J | 2004 | Nature2004，429，： | 1 |
| 18 | Web-based Virtual Learning Environments:A Research Framework and A Preliminary Assessment of Effectiveness in Basic IT Skills Training显示文摘 | Piccoli G.R Ives B | | 0，，04： | 1 |
| 19 | User Involvement and MIS Success: A Review of Research显示文摘 | Ives B Olson M H | 1984 | Management Science1984，30，5： | 1 |
| 20 | Computerbased cotton pest management in Australia 显示文摘 | HEAM A B Ives P M Room P M | 1981 | Field Crops Research1981，4，： | 1 |
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