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| 1 | Propensity score analysis demonstrated the prognostic advantage of anatomical liver resection in hepatocellular carcinoma显示文摘AIM:To compare the prognoses of hepatocellular carcinoma(HCC)patients that underwent anatomic liver resection(AR)or non-anatomic liver resection(NAR)using propensity score-matched populations.METHODS:Between January 2002 and December2010,268 consecutive HCC patients,including 110 and158 patients that underwent AR and NAR,respectively,were retrospectively enrolled in this study.Forty-four patients from each group were selected and matched using logistic multivariate analysis followed by propensity score analysis.RESULTS:In the whole analysis set,the histological background of the liver,liver function,and tumor marker levels differed significantly among the groups.Although the overall survival(OS)and recurrence-free survival rates of the two groups did not differ significantly in the whole analysis set,the OS of the AR group was significantly longer than that of the NAR group after propensity matching(76.2±6.3 mo vs 58.9±6.3mo;P=0.0039).Although AR(HR=0.456,P=0.039)was found to be a prognostic factor in the univariate analysis,only vascular invasion(HR=0.228,P=0.002)and the hepatocyte growth factor level(HR=52.366,P=0.035)were subsequently found to be independent prognostic factors.CONCLUSION:AR conveys a survival advantage over NAR in specific subpopulations of HCC patients with tumors of less than 5 cm in diameter,single tumor,and good liver function. | Masayuki Ishii Toru Mizuguchi Masaki Kawamoto Makoto Meguro Shigenori Ota Toshihiko Nishidate Kenji Okita Yasutohsi Kimura Thomas T Hui Koichi Hirata | 2014 | World Journal of Gastroenterology2014，20，12： | 12 |
| 2 | 脑缺血后N-myc下游调控基因2保护血脑屏障完整性显示文摘脑缺血后血脑屏障(BBB)的破坏与外周细胞向脑内浸润、病孔损形成与进展、以及临床病程恶化密切相关。目前BBB完整性的调控机制,尤其是在永久性缺血后的调控机制尚未明确。本研究使用小鼠永久性脑缺血模型进行相关研究,结果显示,星形胶质细胞N-myc下游调控基因2(NDRG2)可能是缺血性脑卒中后BBB通透性的调控分子,该分子与分化和应激相关。免疫组化显示,在永久性大脑中动脉闭塞(MCAO)后,NDRG2在星形胶质细胞中的表达显著增加。敲除NDRG2基因,脑梗死体积增加,免疫细胞在缺血同侧大脑半球积聚增加。MCAO后,NDRG2基因敲除小鼠缺血侧皮质的缺血灶内及灶周血管周围区域内的血清蛋白(包括纤维蛋白原和免疫球蛋白)的外渗增强此之,MCAO后NDRG2基因敲除小鼠体内基质金属蛋白酶(MMPs)的表达也显著增加。在细胞培养中,NDRG2-/-星形胶质细胞中MMP-3的表达和分泌增加,这种增加可被腺病毒介导的NDRG2再表达所逆转。综上所述,脑缺血后,星形胶质细胞内的NDRG2可能通过调节MMP的表达,而在BBB通透性的调节和免疫细胞浸润中起到重要作用。 | Takarada-Iemata M Yoshikawa A Ta HM Okitani N Nishiuchi T Aida Y Kamide T Hattori T Ishii H Tamatani T Le TM Roboon J Kitao Y Matsuyama T Nakada M Hori O 聂昊 | 2018 | 神经损伤与功能重建2018，13，4： | 4 |
| 3 | Callus induction and somatic embryogenesis of Phalaenopsis显示文摘 | Ishii Y Takamura T Goi M | 1998 | Plant Cell Reports1998，17，67： | 2 |
| 4 | 卒中介入治疗培训指南:国际多学会共识文件显示文摘1背景
缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞(emergent large vesselocclusion,ELVO)患者都会遗留长期残疾。事实上,这些颅内大动脉闭塞经常会导致大面积脑损伤,进而造成患者死亡或严重致残。 | Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka T Iihara K Ishii A Higashi T Hirohata M Hyodo A Ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart RA Meyers PM Mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩 孙瑞 郭芮兵 | 2017 | 国际脑血管病杂志2017，25，5： | 2 |
| 5 | Some bounds on approximation algorithms for n|m|I|Lmax and n|2 |F|Lmax scheduling problems 显示文摘 | Masuda T Ishii H Nishzda I | 1983 | Opns Res Soc Japan1983，26，： | 2 |
| 6 | Effect of vesicular-arbuscular mycorrhizal fungi on the growth, photosynthsis, transpiration and the distribution of photosynathates of bearing satsumam and arintrees显示文摘 | Shrestha Y H Ishii T | 1995 | Jounlal of Japanese Society of Horticultural Science1995，65，： | 1 |
| 7 | Rhamnogalacturonan II: structure and function of a borate cross-linked cell wall pectic pelysaccharide显示文摘 | O'Neill M A Ishii T Albersheim P | 2004 | Armu Rev Plant Biol2004，55，： | 1 |
| 8 | Room-temperature single-electron memory 显示文摘 | Yano K Ishii T Hasimoto T Kobayashi F | 1994 | IEEE Transactions on Electron Devices1994，41，9： | 1 |
| 9 | Casein kinase 2 is the major enzyme in brain that phosphorylates Ser129 of human alpha synuelein: Implication for alpha-synueleinopathies显示文摘 | ISHII A NONAKA T TANIGUCHI S SAOTO T ARAI T MANN D IWATSUBO T HISANAQA S GOEDERT M HASEQAWA M | 2007 | FEBS Lett2007，581，24： | 1 |
| 10 | Association between alpha - 1 - antichymotrypsin polymorphism and susceptibility to chronic obstructive pulmonary disease 显示文摘 | Ishii T Matsuse T | 2000 | Eur J Clin Invest2000，30，6： | 1 |
| 11 | Structure of neutral branched xylooligosaccharides produced by xylanase from in situ reduced hardwood xylan显示文摘 | NISHIMURA T ISHIHARA M ISHII T | 1998 | Carbohydrate Research1998，308，12： | 1 |
| 12 | Transcription factor Nrf2 coordinately regulates a group of oxidative stress inducible genes inmacrophages显示文摘 | Ishii T Itoh K Takahashi S | 2000 | J Biol Chem2000，275，16： | 1 |
| 13 | Encapsulation efficiency of water - soluble and insoluble drug in liposomes prepared by the microencapsulation vesicle method 显示文摘 | NII T ISHII F | 2005 | International Journal of Phannaceutics2005，298，： | 1 |
| 14 | Structures and proper-ties of seven isoforms of the NMDA receptor generated by al-ternative splicing显示文摘 | Sugihara H Moriyoshi K Ishii T | 1992 | Biochem Biophys Res Commun1992，185，： | 1 |
| 15 | The RRASK motif in xenopus cyclin B2 is required for the substrate recognition of Cdc25C by the cyclin B-Cdc2 complex 显示文摘 | Goda T Ishii T Nakajo N | 2003 | J Biol Chem2003，278，19： | 1 |
| 16 | Elevated SCF levels in theserum of patients with chronic renal failure显示文摘 | Kitoh T Ishikawa H Ishii T | 1998 | Br J Haemesatol1998，102，5： | 1 |
| 17 | Affinity of placental decorin for collagen显示文摘 | Batbayar T Nomura Y Ishii Y | 2000 | Biosci Biotechnol Biochem2000，64，11： | 1 |
| 18 | Physiological role of peroxisomal beta-oxidation in liver of fasted rats显示文摘 | Ishii H Horie S Suga T | 1980 | J Biochem1980，87，： | 1 |
| 19 | Elevated SCF levels in the serum of patients with chronic renal failure 显示文摘 | Kitoh T Ishikawa H Ishii T | 1998 | Br J Haematol1998，102，5： | 1 |
| 20 | Sequential follow-up results of catheter intervention for coronary artery lesions after Kawasaki disease:quantitative comary artery angiography and intravascular ultrasound imaging study 显示文摘 | Ishii M Ueno T Ikeda H | 2002 | Circulation2002，105，25： | 1 |
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