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| 1 | Hypofractionated stereotactic rad iotherapy alone without whole-brain irradiation for patien ts with solitary and oligo brain metastasis using noninvasive fixation of the skull显示文摘To evaluate the efficacy and toxicity of hypofractionated stereotactic radiotherapy(HSRT)using noninvasive fixation of the sk ull on solitary or oligo brain metastatic p atients as an alternative to stereotactic radiosurgery(SRS)using invasive fixation.The subjects were 87patients who had 4or fewer brain meta stases(50solitary,37oligometastases).Treatment was conducted on 159meta stases by using a linac-based stereotactic system.T he median isocentric dose was 35Gy in4fractions.Whole-brain irradiati on was not applied as an initial treatment.For the salvage treatmen t of metachronous brain metastases,repeat HSRT or whole-brain irradiation was applied.The actuarial1-year local tumor control rate was 81%.Treatment-related complicatio ns were observed in 4patients in the e arly period(<3months)and in 2patients in the late period.T he median survival period was 8.7mon ths.Metachronous brain metastases occurred in 30patients,and none of the 18patients who were eligible for salvage HSRT refused to re ceive it again.Hypofractionated stereotactic radiotherapy achieved tumor control and survival equivalent to those of SRS reported i n the literature.The results suggested that HSRT could be an alternative for solitary or oligo br ain metastatic patients with less to xicity and less invasiveness compared to | Aoyama H Shirato H Onimaru R Kagei K Ikeda J Ishii N Sawamura Y Miyasaka K | 2003 | 癌症2003，22，7： | 12 |
| 2 | 脑缺血后N-myc下游调控基因2保护血脑屏障完整性显示文摘脑缺血后血脑屏障(BBB)的破坏与外周细胞向脑内浸润、病孔损形成与进展、以及临床病程恶化密切相关。目前BBB完整性的调控机制,尤其是在永久性缺血后的调控机制尚未明确。本研究使用小鼠永久性脑缺血模型进行相关研究,结果显示,星形胶质细胞N-myc下游调控基因2(NDRG2)可能是缺血性脑卒中后BBB通透性的调控分子,该分子与分化和应激相关。免疫组化显示,在永久性大脑中动脉闭塞(MCAO)后,NDRG2在星形胶质细胞中的表达显著增加。敲除NDRG2基因,脑梗死体积增加,免疫细胞在缺血同侧大脑半球积聚增加。MCAO后,NDRG2基因敲除小鼠缺血侧皮质的缺血灶内及灶周血管周围区域内的血清蛋白(包括纤维蛋白原和免疫球蛋白)的外渗增强此之,MCAO后NDRG2基因敲除小鼠体内基质金属蛋白酶(MMPs)的表达也显著增加。在细胞培养中,NDRG2-/-星形胶质细胞中MMP-3的表达和分泌增加,这种增加可被腺病毒介导的NDRG2再表达所逆转。综上所述,脑缺血后,星形胶质细胞内的NDRG2可能通过调节MMP的表达,而在BBB通透性的调节和免疫细胞浸润中起到重要作用。 | Takarada-Iemata M Yoshikawa A Ta HM Okitani N Nishiuchi T Aida Y Kamide T Hattori T Ishii H Tamatani T Le TM Roboon J Kitao Y Matsuyama T Nakada M Hori O 聂昊 | 2018 | 神经损伤与功能重建2018，13，4： | 4 |
| 3 | 卒中介入治疗培训指南:国际多学会共识文件显示文摘1背景
缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞(emergent large vesselocclusion,ELVO)患者都会遗留长期残疾。事实上,这些颅内大动脉闭塞经常会导致大面积脑损伤,进而造成患者死亡或严重致残。 | Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka T Iihara K Ishii A Higashi T Hirohata M Hyodo A Ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart RA Meyers PM Mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩 孙瑞 郭芮兵 | 2017 | 国际脑血管病杂志2017，25，5： | 2 |
| 4 | Role of ghrelin in streptozotocininduced diabetic hyperphagia 显示文摘 | Ishii S Kamegai J Tamura H | 2002 | Endocrinology2002，143，49： | 1 |
| 5 | Prognostic value of serum concentration of heart-type fatty acid-binding protein relative to cardiac troponin T on admission in the early hours of acute coronary syndrome 显示文摘 | Ishii J Ozaki Y Lu J | 2005 | Clin Chem2005，51，8： | 1 |
| 6 | Token+constraint systems for tangible interaction with digital information 显示文摘 | Ullmer B Ishii H Jacob R J K | 2005 | A CM Transactions on Computer Human Interaction2005，12，1： | 1 |
| 7 | Pre-treatment of cucumber plants with acibenzolar-S-methyl systemically primes a phenylalanine ammonia lyase gene (PAL1) for enhanced expression upon attack with a pathogenic fungus显示文摘 | Cools H J Ishii H | 2002 | Physiological and Molecular Plant Pathology2002，61，5： | 1 |
| 8 | The fine structure in the field change produced by positive ground stroke 显示文摘 | Hojo J Ishii M Kawamura T | 1985 | J Geo- physRes1985，90，： | 1 |
| 9 | Inte immune recognition of, and regulation by, DNA 显示文摘 | ISHII K J AKIRA S | 2006 | Trend Immunol2006，27，11： | 1 |
| 10 | Short-term complications and long-term results of expansive open-door laminoplasty for cervical stenotie myelopathy 显示文摘 | Satomi K Ogawa J Ishii Y | 2001 | Spine J2001，1，1： | 1 |
| 11 | The nature and growth of vertical specialization in world trade显示文摘 | Hummels D Ishii J Yi K M | | 0，，01： | 1 |
| 12 | Particulate adjuvant and innate immunity: Past achievements, present findings, and future prospects显示文摘 | Kuroda E Coban C Ishii K J | 2013 | International Reviews of Immunology2013，32，2： | 1 |
| 13 | Gas embolism in laparoscopic hepatec-tomy: what is the optimal pneumoperitoneal pressure for laparoscopicmajor hepatectomy显示文摘 | Otsuka Y Katagiri T Ishii J | 2013 | Journal of Hepato-Biliary-Pancreatic Sciences2013，20，2： | 1 |
| 14 | Short-term complications and long-term results of expansive open-door laminoplasty for cervical stenotic myelopathy 显示文摘 | Satomi K Ogawa J Ishii Y | 2001 | Spine J2001，1，1： | 1 |
| 15 | Suppressive oligonucleotides protect against collagen-induced arthritis in mice 显示文摘 | Dong L ho S Ishii K J | 2004 | Arthritis Rheum2004，50，5： | 1 |
| 16 | Three-dimensional helical computed tomagraphic angiography in neonates and infants with complex congenital heart disease显示文摘 | Kawano T Ishii M Takagi J | | 39(5):654-6550，39，5： | 1 |
| 17 | Contrast enhancement patterns of hepatic tumours during the vascular phase using coded harmonic imaging and Levovist to differentiate hepatocellular carcinoma from other focal lesions显示文摘 | FURUSE J NAGASE M ISHII H | 2003 | Br J Radiol2003，76，906： | 1 |
| 18 | Potential role of phosphatidylinositol 3 kinase, rather than DNA dependent protein kinase, in CpG ODN induced immune activation 显示文摘 | Ishii K J Takeshita F Gursel I et al | 2002 | J Exp Med2002，196，： | 1 |
| 19 | Dielectric properties of two-phase mixture ceramics composed of rutile and its compounds显示文摘 | Haga K Ishii T Mashiyama J | 1992 | Jpn J Appl Phys1992，31，： | 1 |
| 20 | Lysophosphatidic acid receptors 显示文摘 | Contos JJ Ishii L Chun J | 2000 | Mol Pharmacol2000，58，6： | 1 |
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