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| 1 | Heart-type fatty acid binding protein (H-FABP) as a biomarker for acute myocardial injury and long-term post-ischemic prognosis显示文摘尖锐心肌的梗塞(AMI ) 是一个威胁生活的事件。甚至与及时处理,尖锐 ischemic 心肌的损害和随后的局部缺血灌注损害(IRI ) 能仍然是困难的问题处理。除了放射学并且另外的辅助考试,适用的心脏的 biomarkers 的实验室测试为这混乱监视的早诊断和结束也是必要的。心类型丰满的酸绑定蛋白质(H-FABP ) 主要在 cardiomyocytes 内存在,最近为心肌的损害作为潜在地有希望的 biomarker 出现了。在这评论,我们在对心肌的损害和 IRI 的评价讨论 H-FABP 的敏感和特性,特别在早阶段,和它与另外的通常使用的心脏的 biomarkers 比较的长期的预示的价值,包括肌球素( Mb ),心脏的 troponin 我( cTnI ),肌酸 kinase MB ( CK-MB ),C反应的蛋白质( CRP ),肝糖 phosphorylase isoenzyme BB ( GPBB ),和高敏感的心脏的 troponin T ( hs-cTnT )。有另外的 biomarkers 的 H-FABP 的联合申请的潜力和值也被讨论。最后, H-FABP 的前景被总结;几个技术问题被讨论在临床的实践便于 H-FABP 的更宽的申请。 | Xiao-dong YE Yi HE Sheng WANG Gordon T WONG Michael G IRWIN Zhengyuan XIA | 2018 | Acta Pharmacologica Sinica2018，39，7： | 72 |
| 2 | Out of southern East Asia: the natural history of domestic dogs across the world显示文摘 | Guo-Dong Wang Weiwei Zhai He-Chuan Yang Lu Wang LioZhong Yan-Hu Liu Ruo-Xi Fan Ting-Ting Yin Chun-Ling Zhu Andrei D Poyarkov David M Irwin Marjo K Hytonen Hannes Lohi Chung-I Wu Peter Savolainen Ya-Ping Zhang | 2016 | Cell Research2016，26，1： | 16 |
| 3 | 功能的限制的积极选择而非松驰在鸡驯服期间驾驶视觉的进化显示文摘是由达尔文,注意了鸡有所有鸟,而是国内鸡和他们的野祖先之间的有趣的进化差别的最大的 phenotypic 差异,红 Junglefowl,是他们的比较地更弱的视觉。存在理论建议在国内鸡之中的减少的视觉英勇反映功能的限制的松驰在识别负责的内在的基因机制的视觉,而是证据上驾驶的变化因为这个变化决定性地没被描绘。这里,国内鸡的染色体宽的分析和红 Junglefowl 染色体为涉及视觉的发展的断然选择的基因显示出重要丰富。关于为在视网膜的这些基因的 mRNA 表示的水平国内鸡和他们的野祖先之间有重要差别。涉及视觉的发展的众多的另外的基因也在在国内鸡和他们的野祖先之间的 mRNA 表示显示出重要差别,特别地为与 phototransduction 和光敏电阻器开发联系的基因,例如 RHO (视紫红质) , GUCA1A, PDE6B 和 NR2E3。最后,我们在视觉描绘了 VIT 基因的潜在的角色,它在村庄鸡的视网膜经历了积极选择和 downregulated 表示。总的来说,我们的结果建议净化选择的那种积极选择,而非松驰,在国内鸡贡献了视觉的进化。怀有更弱的视觉的国内鸡的祖先可能显示出减少的害怕回答和警戒,使他们更安逸无意识地被选择或驯养。 | Ming-Shan Wang Rong-wei Zhang Ling-Yan Su Yah Li Min-Sheng Peng He-Qun Liu Lin Zeng David M Irwin Jiu-Lin Du Yong-Gang Yao Dong-Dong Wu Ya-Ping Zhang | 2016 | Cell Research2016，26，5： | 15 |
| 4 | Proliferation and phenotypic changes of stromal cells in response to varying estrogen/androgen levels in castrated rats显示文摘人的良性的 prostatic 增生可能从雌激素 / 雄激素(E/T ) 产生,这被知道不平衡。我们学习了阉割的老鼠前列腺的反应到传播 E/T 的不同比率。阉割的男 Wistar 老鼠随机在不同比率与 E/T 被注射 4 个星期。染色的 prostatic 索引, hematoxylin 和曙红给不同 prostatic 增生回答看的 E/T (1:100 ) 组的前列腺,和光滑的肌肉肌动朊(SMA ) 的量的 immunohistochemical 分析。在这个组,为 Vimentin 积极的房间,非肌肉肌浆球蛋白重链(NMMHC ) 和原子抗原(PCNA ) 在基质和上皮增加了的增殖的房间。而且, mRNA 光滑的肌肉肌浆球蛋白铺平重链(SMMHC ) 和增加的 NMMHC。在 1:100 的比率的 E/T 能因此导致 stromal 在阉割的老鼠的前列腺的增生的反应。观察的主要变化是光滑的肌肉房间的增加,而一些上皮的变化也在老鼠前列腺被看见。 | Ying Zhou Xiang-Qian Xiao Lin-Feng Chen Rui Yang Jian-Dang Shi Xiao-Ling Du Helmut Klocker Irwin Park Chung Lee Ju Zhang | 2009 | Asian Journal of Andrology2009，11，4： | 10 |
| 5 | Mechanisms of action of leptin in preventing gastric ulcer显示文摘AIM: To investigate the effects of leptin (1-20 μg/kg) on acidified ethanol (AE)- and indomethacin (Indo)-induced gastric lesions in rats and compare it with ranitidine, lansoprazole, and omeprazole and to determine its mechanisms of actions.METHODS: Gastric ulcers, which were approximately 1 mm in width, formed in the glandular portion of the gastric mucosa produced by oral administration of either AE or Indo were taken as ulcer index. The inhibitory effect of subcutaneous administration of leptin, two proton pump inhibitors (PPIs) lansoprazole and omeprazole, or H2-receptor antagonist ranitidine 30 min before AE or Indo was evaluated.A radioimmunoassay was used to determine the PGE2concentration in the homogenate of the glandular portion of the stomach. We performed histological study of the glandular stomach for the evaluation of total, acidic, and sulfated mucus content.RESULTS: Subcutaneous administration of leptin, two PPIs lansoprazole and omeprazole or H2-receptor antagonist ranitidine 30 min before AE or Indo produced a dosedependent and reproducible inhibition of gastric ulcers (GUs). This inhibition was found to be more potent than other antagonists used. In NG-nitro L-arginine methyl ester (L-NAME)-pretreated animals, the ulcer prevention ability of leptin in AE-induced ulcer was significantly reduced,compared to rats without L-NAME pretreatment. However,the ulcer prevention ability of leptin was not altered by L-NAME treatment in Indo-induced ulcers. Leptin produced a dose-dependent increase in PGE2 level in the gastric glandular tissues. Leptin also increased mucus secretion.CONCLUSION: The results of the present study show that leptin inhibits GU formation by AE or Indo in a dosedependent and reproducible manner in rats. The results also suggest that leptin prevents ulcer formation by increasing the activities of the cyclo-oxygenase and/or nitric oxide pathways and by increasing mucus secretion. | Edward O.Adeyemi Salim A.Bastaki Irwin S.Chandranath Mohammed Y.Hasan Mohammed Fahim Abdu Adem | 2005 | World Journal of Gastroenterology2005，11，27： | 9 |
| 6 | 超氧化物歧化酶显示文摘呼吸细胞中普遍存在一种奇特的酶活性,底物是一种能在任何瞬间微量存在的不稳定自由基,即使在此酶缺失的情况下,这种催化反应也能快速进行。然而这种酶对于需氧细胞的存活是至关重要的,它可以催化清除超氧自由基,因而可以抵御氧中毒,因为超氧自由基是产生氧中毒的重要物质。超氧自由基清除反应是歧化反应,这种酶可提高反应速率,反应式如下。 | Irwin Fridovich 黄思玲 | 2010 | 食品与药品2010，12，7： | 8 |
| 7 | 肌苷调节视网膜节细胞轴突再生显示文摘目的 探讨肌苷对中枢神经再生的影响。方法 分离并制作均匀的视网膜神经节细胞 (RGC)悬液 ,采用 2 4孔培养皿培养 ,观察嘌呤类物质对RGC轴突生长及细胞存活的影响。结果 ( 1)肌苷促使RGC轴突生长 ;腺苷只有水解脱氨生成肌苷才能促使轴突生长。 ( 2 )肌苷与 6 硫鸟嘌呤 ( 6 TG)可能竞争性作用于蛋白激酶N(PKN)调节轴突生长。( 3 )肌苷刺激RGC致GAP 43表达增强。 ( 4 )肌苷的细胞内信息传递通路可能通过有丝分裂原激活蛋白激酶 (MAPK)、磷脂酰肌醇激酶 (PI3K)两条途径起作用。结论 肌苷在RGC神经再生中起积极的调节作用。 | 景筠 Nina Irwin Larry I.Benowitz | 2000 | 眼科研究2000，18，3： | 7 |
| 8 | Convergent genomic signatures of high-altitude adaptation among domestic mammals显示文摘Abundant and diverse domestic mammals living on the Tibetan Plateau provide useful materials for investigating adaptive evolution and genetic convergence.Here,we used 327 genomes from horses,sheep,goats,cattle,pigs and dogs living at both high and low altitudes,including 73 genomes generated for this study,to disentangle the genetic mechanisms underlying local adaptation of domestic mammals.Although molecular convergence is comparatively rare at the DNA sequence level,we found convergent signature of positive selection at the gene level,particularly the EPAS1 gene in these Tibetan domestic mammals.We also reported a potential function in response to hypoxia for the gene C10 orf67,which underwent positive selection in three of the domestic mammals.Our data provide an insight into adaptive evolution of high-altitude domestic mammals,and should facilitate the search for additional novel genes involved in the hypoxia response pathway. | Dong-Dong Wu Cui-Ping Yang Ming-Shan Wang Kun-Zhe Dong Da-Wei Yan Zi-Qian Hao Song-Qing Fan Shu-Zhou Chu Qiu-Shuo Shen Li-Ping Jiang Yan Li Lin Zeng He-Qun Liu Hai-Bing Xie Yun-Fei Ma Xiao-Yan Kong Shu-Li Yang Xin-Xing Dong Ali Esmailizadeh David M Irwin Xiao Xiao Ming Li Yang Dong Wen Wang Peng Shi Hai-Peng Li Yue-Hui Ma Xiao Gou Yong-Bin Chen Ya-Ping Zhang | 2020 | National Science Review2020，7，6： | 7 |
| 9 | 美国反倾销诉讼案上升的历史透视显示文摘 | Douglas Irwin 卢欣 宫恒刚 | 2005 | 经济资料译丛2005，，4： | 7 |
| 10 | Genetic and phenological variation of tocochromanol(vitamin E)content in wild(Daucus carota L.var.carota)and domesticated carrot(D.carota L.var.sativa)显示文摘Carrot roots(Daucus carota L.var.sativa)produce tocochromanol compounds,collectively known as vitamin E.However,little is known about their types and amounts.Here we determined the range and variation in types and amounts of tocochromanols in a variety of cultivated carrot accessions throughout carrot postharvest storage and reproductive stages and in wild-type roots(Daucus carota L.var.carota).Of eight possible tocochromanol compounds,we detected and quantified α-,and the combined peak for β-and γ-forms of tocopherols and tocotrienols.Significant variation in amounts of tocochromanol compounds was observed across accessions and over time.Large increases in a-tocopherol were noted during both reproductive growth and the postharvest stages.The variation of tocochromanols in carrot root tissue provides useful information for future research seeking to understand the role of these compounds in carrot root tissue or to breed varieties with increased levels of these compounds. | Claire H Luby Hiroshi A Maeda Irwin L Goldman | 2014 | Horticulture Research2014，1，1： | 6 |
| 11 | 煽动性的肠疾病苛评的内视镜的管理显示文摘 Stricture formation is a common complication of Crohn’s disease, occurring in approximately one third of all patients with this condition. While the traditional management of such strictures has been largely surgical, there have been case series going back three decades high-lighting the potential role of endoscopic balloon dilation in this clinical setting. This review article summarizes the stricture pathogenesis, focusing on known clinical and genetic risk factors. It then highlights the endo-scopic balloon dilation research to date, with particular emphasis on three large recent case series. It concludes by describing the literature consensus regarding specific methodology and presenting avenues for future investigations. | Raluca Vrabie Gerald L Irwin David Friedel | 2012 | World Journal of Gastrointestinal Endoscopy2012，4，11： | 5 |
| 12 | Exporting National Champions:China's Outward Foreign Direct Investment Finance in Comparative Perspective显示文摘We examine the extent to which Chinese development banks have financed the globalization of China's 'national champion'firms:specifically,through outward foreign direct investment(OFDI).We create a database of Chinese finance for OFDI and compare our results to the existing literature and available data on Japan,Korea and other Asian nations.We estimate the total value of China 's OFDI finance from 2002 to 2012 at US$140bn.As a percentage of total OFDI,China's lending is roughly three times higher than Japan 's,the previous global leader in OFDI finance.We identify two major reasons for China 's high(31 percent)ratio of OFDI lending to total OFDI.First,China has a greater incentive to give OFDI loans than Japan or Korea ever did because its borrowers are state-owned so it can more easily channel funds to targeted areas.Second,China has a greater capacity to give OFDI loans because it has significantly higher savings and foreign exchange reserves than Japan and Korea. | Kevin P.Gallagher Amos Irwin | 2014 | China & World Economy2014，22，6： | 5 |
| 13 | The influence of chlorinated aromatics' structure on their adsorption characteristics on activated carbon to tackle chemical spills in drinking water source显示文摘 | Pengfei LIN Yuan ZHANG Xiaojian ZHANG Chao CHEN Yuefeng XIE Irwin H SUFFET | 2015 | Frontiers of Environmental Science & Engineering2015，9，1： | 4 |
| 14 | Impact of social isolation on behavioral health in elderly: Systematic review显示文摘AIM: To examine and compare the effects of subjective and objective social isolation on behavioral health in elderly adults.METHODS: A systematic search of Pub Med was performed for original research articles from peerreviewed journals examining one of the following topics: 'Social isolation and sleep disturbance', 'social isolation and depression', or 'social isolation and fatigue in older adults'. Studies were selected following the criteria established based on the aim of this review. Data were extracted from the articles by two independent reviewers. Due to the heterogeneity in study designs and outcome measures of the included studies, qualitative and narrative analyses were conducted.RESULTS: The set criteria were used to select a total of 16 studies for the review. Of the 16, 13 were crosssectional studies. The characteristics of study populations were identified as follows. A total of 12 studies randomly selected subjects irrespective of pre-existing health conditions. Consequently, an unspecified number of the study subjects had chronic diseases in the studies compared. In addition, cultural and ethnic backgrounds of studies in this review were diverse, and included subjects living in North America, South America, Asia, Europe, and Oceania. Both subjective and objective types of social isolation increased behavioral symptoms, such as sleep disturbance, depressive symptoms, and fatigue in older adults. Furthermore, a few recent studies reported stronger effects of subjective social isolation than objective social isolation on sleep disturbance and depressive symptoms.CONCLUSION: Social isolation affects behavioral health in older adults. Compared to the objective social isolation, subjective social isolation contributes more significantly to sleep disturbance and depression. | Hanbyul Choi Michael R Irwin Hyong Jin Cho | 2015 | World Journal of Psychiatry2015，5，4： | 4 |
| 15 | Penile revascularization--contemporary update显示文摘为可勃起的机能障碍的当代的治疗通常向老人被指向并且普遍雇佣药理学或设备相关治疗选择。阴茎 revascularization,用 microvascular 动脉绕过外科的技术,是非药理学, non-device-related,和为有被瓦克拉夫·米查尔博士首先在 1973 描述的可勃起的机能障碍的人的改造外科的策略。当代的阴茎 revascularization 尝试到 ‘ cure' 纯 arteriogenic 在有在远侧的内部 pudendal 的动脉的闭塞的病理的年轻人的可勃起的机能障碍,对从钝骨盆、会阴或阴茎的损伤的焦点的 endothelial 损害第二等的普通阴茎或近似的 cavernosal 动脉。microvascular 吻合在腹上部的施主晚辈和接受者之间被塑造背面的阴茎动脉。增加的灌注压力理论上经由穿孔被传达到 cavernosal 动脉从背面的动脉的分支。这篇文章将与可勃起的机能障碍,利用的当前的外科的技术和外科的结果在年轻人考察钝导致损伤的焦点的动脉的闭塞的疾病的历史,指示和 pathophysiology。阴茎 revascularization 的当代的使用是一种逻辑、想要的治疗学的选择试图在支撑了钝骨盆、会阴或阴茎的损伤的年轻人颠倒可勃起的机能障碍。 | Brian Dicks Martin Bastuba Irwin Goldstein | 2013 | Asian Journal of Andrology2013，15，1： | 4 |
| 16 | New perspectives on exploitation of incretin peptides for the treatment of diabetes and related disorders显示文摘The applicability of stable gut hormones for the treatment of obesity-related diabetes is now undisputable. This is based predominantly on prominent and sustained glucoselowering actions, plus evidence that these peptides can augment insulin secretion and pancreatic islet function over time. This review highlights the therapeutic potential of glucagon-like peptide-1(GLP-1), glucose-dependent insulinotropic polypeptide(GIP), oxyntomodulin(OXM) and cholecystokinin(CCK) for obesity-related diabetes.Stable GLP-1 mimetics have already been successfully adopted into the diabetic clinic, whereas GIP, CCK and OXM molecules offer promise as potential new classes of antidiabetic drugs. Moreover, recent studies have shown improved therapeutic effects following simultaneous modulation of multiple receptor signalling pathways by combination therapy or use of dual/triple agonist peptides. However, timing and composition of injections may be important to permit interludes of beta-cell rest. The review also addresses the possible perils of incretin based drugs for treatment of prediabetes. Finally, the unanticipated utility of stable gut peptides as effective treatments for complications of diabetes, bone disorders, cognitive impairment and cardiovascular dysfunction is considered. | Nigel Irwin Peter R Flatt | 2015 | World Journal of Diabetes2015，6，15： | 4 |
| 17 | Alzheimer's disease: the silver tsunami of the 21^(st) century显示文摘Alzheimer's disease(AD), a fatal progressive neurodegenerative disorder, has no cure to date. One of the causes of AD is the accumulation of amyloid-beta 42(Aβ42) plaques, which result in the onset of neurodegeneration. It is not known how these plaques trigger the onset of neurodegeneration. There are several animal models developed to(i) study etiology of disease,(ii) look for genetic modifiers, and(iii) identify chemical inhibitors that can block neurodegeneration and help to find cure for this disease. An insect model of Drosophila melanogaster has also provided new insights into the disease. Here we will discuss the utility of the Drosophila eye model to study Alzheimer's disease. | Ankita Sarkar Madison Irwin Aditi Singh Matthew Riccetti Amit Singh | 2016 | Neural Regeneration Research2016，11，5： | 4 |
| 18 | Shellfish allergy and relation to iodinated contrast media: United Kingdom survey显示文摘AIM: To assess current practice of United Kingdom cardiologists with respect to patients with reported shellfish/iodine allergy, and in particular the use of iodinated contrast for elective coronary angiography.Moreover we have reviewed the current evidence-base and guidelines available in this area.METHODS: A questionnaire survey was send to 500senior United Kingdom cardiologists(almost 50% cardiologists registered with British Cardiovascular Society)using email and first 100 responses used to analyze practise. We involved cardiologists performing coronary angiograms routinely both at secondary and tertiary centres. Three specific questions relating to allergy were asked:(1) History of shellfish/iodine allergy in pre-angiography assessment;(2) Treatments offeredfor shellfish/iodine allergy individuals; and(3) Any specific treatment protocol for shellfish/iodine allergy cases. We aimed to establish routine practice in United Kingdom for patients undergoing elective coronary angiography. We also performed comprehensive PubMed search for the available evidence of relationship between shellfish/iodine allergy and contrast media.RESULTS: A total of 100 responses were received, representing 20% of all United Kingdom cardiologists. Ninety-three replies were received from consultant cardiologists, 4 from non-consultant grades and 3 from cardiology specialist nurses. Amongst the respondents, 66% routinely asked about a previous history of shellfish/iodine allergy. Fifty-six percent would pre-treat these patients with steroids and anti-histamines. The other 44% do nothing, or do nonspecific testing based on their personal experience as following:(1) Skin test with 1 mL of subcutaneous contrast before intravenous contrast;(2) Test dose 2 mL contrast before coronary injection;(3) Close observation for shellfish allergy patients; and(4) Minimal evidence that the steroid and anti-histamine regime is effective but it makes us feel better.CONCLUSION: There is no evidence that allergy to shellfish alters the risk of reaction to intravenous contrast more than any other allergy and asking about such allergies in pre-angiogram assessment will not provide any additional information except propagating the myth. | Mudassar Baig Ahmad Farag Jamal Sajid Rahul Potluri R Bruce Irwin Hafiz Mohammed Idrees Khalid | 2014 | World Journal of Cardiology2014，6，3： | 3 |
| 19 | All Frames Are Not Created Equal: A Typology and Critical Analysis of Framing Effects显示文摘 | Irwin P. Levin Sandra L. Schneider Gary J. Gaeth | 1998 | Organizational Behavior and Human Decision Processes1998，，2： | 3 |
| 20 | Motilin and ghrelin gene experienced episodic evolution during primitive placental mammal evolution显示文摘Motilin and ghrelin,members of a structure-function-related hormone family,play important roles in gastrointestinal function,regulation of energy homeostasis and growth hormone secretion.We observed episodic evolution in both of their prehormone gene sequences during primitive placental mammal evolution,during which most of the nonsynonymous changes result in radical substitution.Of note,a functional obestatin hormone might have only originated after this episodic evolution event.Early in placental mammal evolution,a series of biology complexities evolved.At the same time the motilin and ghrelin prehormone genes,which play important roles in several of these processes,experienced episodic evolution with dramatic changes in their coding sequences.These observations suggest that some of the lineage-specific physiological adaptations are due to episodic evolution of the motilin and ghrelin genes. | IRWIN M. David | 2010 | Science China(Life Sciences)2010，53，6： | 3 |
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