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| 1 | Fecal stream diversion and mucosal cytokine levels in collagenous colitis:A case report显示文摘In this case report, we examined the levels of cytokines expressed before and during fecal stream diversion and after intestinal continuity was restored in a patient with collagenous colitis. We report the case of a46-year-old woman with chronic, active collagenous colitis who either failed to achieve clinical remission or experienced adverse effects with the following drugs:loperamide, cholestyramine, budesonide, methotrexate and adalimumab. Due to the intractable nature of the disease and because the patient was having up to 15 watery bowel movements per day, she underwent a temporary ileostomy. Colonic biopsies were analyzed for mucosal cytokine protein levels before and during fecal stream diversion and after intestinal continuity was restored. Mucosal protein levels of interleukin(IL)-1β,IL-2, IL-6, IL-12, IL-17 A, IL-23, TNF, IFN-γ, IL-4, IL-5,IL-10 and IL-13 were all higher during active disease and decreased to non-detectable or considerably lower levels during fecal stream diversion. One month after the restoration of bowel continuity, when the patient experienced a relapse of symptoms, IL-2, IL-23 and IL-21 levels were again increased. Our results indicate that fecal stream diversion in this patient suppressed the levels of all cytokines analyzed in colonic biopsies. With the recurrence of clinical symptoms and histological changes after bowel reconstruction,the levels of primarily proinflammatory cytokines increased. Our findings support the hypothesis that a luminal factor triggers the inflammation observed in collagenous colitis. | Niki Daferera Ashok Kumar Kumawat Elisabeth Hultgren-Honquist Simone Ignatova Magnus Strom Andreas Münch | 2015 | World Journal of Gastroenterology2015，21，19： | 2 |
| 2 | Development of a strategy and process parameters for a green process in counter-current chromatography; purification of tanshinone Ⅱ A and cryptotanshinone from Salvialx miltiorrhiza Bunge as a case study 显示文摘 | ZHANG M IGNATOVA S HU P | 2011 | J Chromatogr A2011，1218，36： | 1 |
| 3 | Drug-loaded electrospun materials in wound-dressing applications and in local cancer treatment显示文摘 | Ignatova M Rashkov I Manolova N | 2013 | Expert Opin Drug Deliv2013，10，4： | 1 |
| 4 | Check list of mosses of East Europe and North Asia显示文摘 | IGNATOV M S AFONINA O M IGNATOVA E A | 2006 | Arctoa2006，15，130： | 1 |
| 5 | Design of an tibacterial surfaces by a combination of electrochemis try and controlled radical polymerization 显示文摘 | Voccia S Ignatova M Jerome R | 2006 | Lang muir2006，22，： | 1 |
| 6 | Combination of electrografting and atom-transfer radical polymerization for making the stainless steel surface antibacterialand protein antiadhesive显示文摘 | Ignatova M Voccia S Gilbert B | 2006 | Langmuir2006，22，1： | 1 |
| 7 | Electrospun non-woven nanofibrous hybrid mats based on chitosan and PLA for wound-dressing applications显示文摘 | Ignatova M Manolova N Markova N | | 0，，01： | 1 |
| 8 | Novel antibacterial fibers of quaternized chitosan and poly (vinyl pyrroli- done) prepared by eleetrospinning 显示文摘 | IGNATOVA M MANOLOVA N RASHKOV I | 2007 | European Polymer Journal2007，43，4： | 1 |
| 9 | Cost-efficient and process- efficient separation of geniposide from Gardenia jasminoides Ellis by high-performance counter-current chromatography 显示文摘 | Zhang M Ignatova S Hu P | 2012 | Separation and Purification Technology2012，89，： | 1 |
| 10 | Novel antibacterial fibers of quatemized chitosan and poly(vinyl pyrrolidone)prepared by elect-rospinning显示文摘 | IGNATOVA M MANOLOVA N RASHKOV I | 2007 | European Polymer Journal2007，43，4： | 1 |
| 11 | 显示文摘 | Ignatova M Stoilova O Manolova N | 2009 | EuropeanPolymer Journal2009，45，9： | 1 |
| 12 | Adalimumab in budesonide and methotrexate refractory collagenous colitis 显示文摘 | MUnch A Ignatova S Str6m M | 2012 | Scand J Gastroenterol2012，47，1： | 1 |
| 13 | Quatemized chitosan-coated nanofibrous materials containing gossypol:Preparation by electrospinning,characterization and antiproliferative activity towards HeLa cells显示文摘 | Ignatova M Manolova N Toshkova R | | 0，，1： | 1 |
| 14 | Adalimumab in budesonide and methotrexate refractory collagenous colitis 显示文摘 | MUnch A Ignatova S Strum M | 2012 | Scand J Gastroen- terol2012，47，1： | 1 |
| 15 | Novel antibacterial fibers of quaternized chitosan and poly(vinyl pyrrolidone)prepared by electrospinning显示文摘 | IGNATOVA M MANOLOVA N RASHKOV I | 2007 | Eur Polym J2007，43，3： | 1 |
| 16 | 显示文摘 | Ignatova M Manolova N Markova N | 2009 | Macromolecu- lar Bioscience2009，9，1： | 1 |
| 17 | Electro spun non-woven nanofibrous hybrid mats based on chitosan and PLA for wound-dressing applications 显示文摘 | Ignatova M Manolova N Markova N | 2009 | Macromol Biosci2009，9，1： | 1 |
| 18 | Preparation and Metal Ion Complexing Ability of Polyethers with 8-Hydroxy-5-quinolinyl End Groups显示文摘 | Manolova N Ignatova M Rashkov I | 1998 | Eur Polym J1998，34，8： | 1 |
| 19 | Checklist of mosses of East Europe and North Asia显示文摘 | IGNATOV M S AFONINA O M IGNATOVA E A | 2006 | Arctoa2006，15，： | 1 |
| 20 | Bryophyte flora of the projected Utrish Nature Reserve(North-West Caucasus,Russia)显示文摘 | IGNATOVA E A IGNATOV M S SEREGIN A P etal | 2005 | Arctoa2005，14，： | 1 |
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