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| 1 | Live cell screening platform identifies PPAR6 as a regulator of cardiomyocyte proliferation and cardiac repair显示文摘Zebrafish 能高效地通过 cardiomyocyte 增长改革他们的心。相反,哺乳动物的 cardiomyocytes 站立即在出生以后增殖,限制出生后的哺乳动物的心的再生能力。因此,如果出生后的 cardiomyocyte 增长的内长的潜力能被提高,它能为心失败病人提供有希望的未来治疗。这里,我们开始系统地识别触发出生后的 cardiomyocyte 增长的小分子。由屏蔽为估计房间周期阶段利用一个基于 Fucci 的系统的化学复合图书馆,我们作为出生后的 cardiomyocyte 增长的 inducer 识别了 carbacyclin。在 vitro, carbacyclin 经由 peroxisome 导致了新生、成年的 mononuclear 老鼠 cardiomyocytes 的增长激活 proliferator 的受体(PPAR )/PDK1/p308Akt/GSK3/-catenin 小径。PPAR 的抑制在 zebrafish 心新生期间减少了 cardiomyocyte 增长。尤其是,象有在在老鼠的心肌的梗塞以后的 PPAR 收缩筋的治疗一样的组成地活跃的 PPAR 的可诱导的 cardiomyocyte 特定的 overexpression 在 cardiomyocytes 导致了房间周期前进,减少了结疤,并且改进了心脏的功能。一起,我们建立了屏蔽系统和礼品的 cardiomyocyte 增长有为心脏的病理的治疗的诺言的一个新 drugable 目标由 cardiomyocyte 损失引起了。 | Ajit Magadum Yishu Ding Lan He Teayoun Kim Mohankrishna Dalvoy Vasudevarao Qinqiang Long Kevin Yang Nadeera Wickramasinghe Harsha V Renikunta Nicole Dubois Gilbert Weidinger Qinglin Yang Felix B Engel | 2017 | Cell Research2017，27，8： | 6 |
| 2 | Aetin up in the nucleus显示文摘 | Blaine T B Gilbert D Amberg D C | 2004 | Nature2004，5，： | 1 |
| 3 | Associated factors in 1611 cases of brachial plexus injury显示文摘 | Nesbitt TS Panielsen B | 1999 | Obstet Gynecol1999，93，： | 1 |
| 4 | yon Willebrand factor in cardiovascular disease :focus on acute coronary syndromes 显示文摘 | Spiel AO Gilbert JC Jilma B | 2008 | Circulation2008，117，11： | 1 |
| 5 | Mast cell growth factor maps near the steel locus on mouse chromosome 10 and is deleted in a mumber of steel alleses显示文摘 | Copeland N C Gilbert D J Cho B C | 1990 | Cell1990，63，： | 1 |
| 6 | A study of biologically active peptide sequences (P-15) on the surface of an ABM scaffold (PepGen P-15TM) using AFM and FTIR显示文摘 | HOLE B B SCHWARZ J A GILBERT J L | 2005 | J Biomed Mater Res A2005，74，4： | 1 |
| 7 | Pyrosequencing of Mytilus galloprovincialis cDNAs= tissue-specific ex pression patterns显示文摘 | Craft J A Gilbert J A Temperton B | 2010 | PLoS ONE2010，5，1： | 1 |
| 8 | Carbo- hydrate-binding modules: fine-tuning polysaccharide recognition 显示文摘 | Boraston A B Bolam D N Gilbert H J | 2004 | Biochemistry Journal2004，382，： | 1 |
| 9 | Gold and trace element zonation in pyrite using a laser imaging technique: Implications for the timing of gold in orogenic and Carlin- style sediment- hosted deposits 显示文摘 | R R Large L Danyushevsky C Hollit V Maslennikov S Meffer S Gilbert S Bull R Scott P Emsbo H Thomas B Singh J Foster | 2009 | Economic Geology2009，104，5： | 1 |
| 10 | Determinants of portfolio performance Ⅱ: An update 显示文摘 | BRINSON G P SINGER B D GILBERT L BEE- BOWER G L | 1991 | Financial Analysis Journal1991，47，3： | 1 |
| 11 | Stacked stigma: on- cology social workersperceptions of the lung cancer ex- perience显示文摘 | Conlon A Gilbert D Jones B | 2010 | J Psychosoc Oncol2010，28，1： | 1 |
| 12 | Methane yield from switchgrass harvested at different stages of development in Eastern Canada显示文摘 | Daniel Massé Yan Gilbert Philippe Savoie Gilles Bélanger Gaétan Parent Daniel Babineau | 2010 | Bioresource Technology2010，，24： | 1 |
| 13 | 5-Lipoxygenase is a direct p53 target gene in humans显示文摘 | Gilbert B Ahmad K Roos J er a! | 2015 | Biochim Biophys Acta2015，1849，8： | 1 |
| 14 | Sensing of lead ions by a carboxylate-substituted PPE: Multivalency effects显示文摘 | Kim I B Dunkhorst A Gilbert J | 2005 | Macromolecules2005，38，11： | 1 |
| 15 | Childbearing beyond age 40 pregnancy outcome in 24,032 cases 显示文摘 | Gilbert W M Nesbitt T S Danielaen B | 1999 | Obstet Gynecol1999，93，1： | 1 |
| 16 | Toughening tetrafunctional epoxy resins using polyetherimide显示文摘 | Clive B Bucknall Adrian H Gilbert | 1989 | Polymer1989，30，2： | 1 |
| 17 | Toughening tetrafunctional epoxy resins using polyetherimide 显示文摘 | BUCKNALL C B GILBERT A H | 1989 | Polymer1989，30，2： | 1 |
| 18 | Comparative analysis of the exopolysaccharide biosynthesis gene clusters from four strains of Lactobacillua rhamnosus显示文摘 | PEANT B LAPOINTE G GILBERT C | 2005 | Microbiology2005，151，6： | 1 |
| 19 | Influence of shellfish farming activities on nitrification,nitrate reduction to ammonium and denitrification at the water-sediment interface of the Thau lagoon,France显示文摘 | Gilbert F Souchu P Bianchi M B | 1997 | Marine Ecology Progress Series1997，151，： | 1 |
| 20 | Childbearing beyond age 40:pregnancy outcome in 24,032 cases显示文摘 | Gilbert WM Nesbitt TS Danielsen B | 1999 | Obstet Gynecol1999，93，1： | 1 |
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