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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Generation of planar and helical elliptical gears by application of rack-cutter, hob, and shaper 显示文摘 | Litvin F L Ignacio G P Kenji Y | 2007 | Comput Methods Appl Mech Engrg2007，196，： | 1 |
| 3 | Negative heat capacity of sodium clusters 显示文摘 | Reyes-nava J A Ignacio L G | 2003 | Phys Rev2003，67，16： | 1 |
| 4 | De- sign, generation and stress analysis of face-gear drive with helical pinion 显示文摘 | LITIVIN F L IGNACIO G P ALFONSO F | 2005 | Computer Methods in Applied Mechanics and Engineering2005，194，9： | 1 |
| 5 | Trends in the Structure and Bonding of Noble Metal Clusters 显示文摘 | Eva M F Jose M S M Ignacio L G | 2004 | Phys Rev B2004，70，16： | 1 |
| 6 | Determination of tin and titanium in soils,sediments and sludges using electrothermal atomic absorption spectrometry with slurry sample introduction显示文摘 | Ignacio L G Isabel A J Natalia C | 2004 | Talanta2004，62，： | 1 |
| 7 | Measuring efficiency of sun & beach tourism destination 显示文摘 | Medina L F Ignacio G G Sandra M M | 2012 | Annals of Tourism Re- search2012，，39： | 1 |
| 8 | Generalized comcept of meshing and comtact of involute crossed helical gear and its application显示文摘 | FAYDOR L L IGNACIO G P ALFONSO F | 2005 | Computer Methods in Applied Mechanics and Engineering2005，194，3435： | 1 |
| 9 | Effects of thinning intensity on radial growth patterns and temperature sensitivity in Pinus canariensis afforestations on Tenerife Island, Spain显示文摘 | Gonzalo P L Ignacio G VicenteR | 2011 | Annals of Forest Science2011，68，： | 1 |
| 10 | Hepatitis C virus core protein regulates p300/CBP co-activation function. Possible role in the regulation of NF-AT1 transcriptional activity显示文摘 | Marta Gómez-Gonzalo Ignacio Benedicto Marta Carretero Enrique Lara-Pezzi Alejandra Maldonado-Rodríguez Ricardo Moreno-Otero Michael M.C. Lai Manuel López-Cabrera | 2004 | Virology2004，，1： | 1 |
| 11 | Generation of Planar and Helical Elliptical Gears by Application of Rackcutter, Hob, and Shaper显示文摘 | FAYDOR L L IGNACIO G P KENJI Y | 2007 | Computer Methods in Applied Mechanics and Engineering2007，196，4144： | 1 |
| 12 | The fractal nature of river networks 显示文摘 | David G T Rafael L B Ignacio R | 1988 | Water Resources Research1988，24，8： | 1 |
| 13 | Comprehensive Functional Assessment of MLH1 Variants of Unknown Significance显示文摘 | Ester Borràs Marta Pineda Angela Brieger Inga Hinrichsen Carolina Gómez Matilde Navarro Judit Balma?a Teresa Ramón y Cajal Asunción Torres Joan Brunet Ignacio Blanco Guido Plotz Conxi Lázaro Gabriel Capellá | 2012 | Human Mutation2012，，1： | 1 |
| 14 | Analysis of lead content in automotive shredder residue (ASR) 显示文摘 | Oscar G F Sofia P Ignacio Q Maria L C | 2009 | Waste Management2009，29，： | 1 |
| 15 | Generation and Stress Analysis of Face-gear Drive with Helical Pinion显示文摘 | Faydor L L Ignacio G P Alfonso F | 2005 | Computer Methods in Applied Mechaics Andengineering2005，194，： | 1 |
| 16 | Enzymatic synthesis of capsaicin analogs and their effect on the T-type Ca2 channels显示文摘 | EDMUNDO C IGNACIO L G RUBEN D R | 2007 | Alberto Darszon Biochemical and Biophysical Research Communications2007，356，： | 1 |
| 17 | Design,simulation of meshing,and contact stresses for an improved worm gear drive显示文摘 | LITVIN F L IGNACIO G P KENJI Y | | 0，，： | 1 |
| 18 | A model predictive control strategy for supply chain optimization 显示文摘 | Edgar P L Ydstie B E Ignacio E G | 2003 | Computers and Chemical Engineering2003，27，： | 1 |
| 19 | Differences between carbon nanofibers produced using Fe and Ni catalysts in a floating catalyst reactor 显示文摘 | IGNACIO M G JOSE V JUAN A C JOSE L G | 2006 | Carbon2006，44，8： | 1 |
| 20 | Informational net- works and innovation in mature industrial clusters显示文摘 | Cristobal C Ignacio C Jose L G | 2013 | Journal of Business Research2013，66，5： | 1 |
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