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7篇 您的检索式：作者名="I.LEE"

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		题名	作者	年代	出处	被引量
	1	Crosslinked hydrogels--a promising class of insoluble solid molecular dispersion carriers for enhancing the delivery of poorly soluble drugs显示文摘Water-insoluble materials containing amorphous solid dispersions(ASD)are an emerging category of drug carriers which can effectively improve dissolution kinetics and kinetic solubility of poorly soluble drugs.ASDs based on water-insoluble crosslinked hydrogels have unique features in contrast to those based on conventional water-soluble and water-insoluble carriers.For example,solid molecular dispersions of poorly soluble drugs in poly(2-hydroxyethyl methacrylate)(PHEMA)can maintain a high level of supersaturation over a prolonged period of time via a feedback-controlled diffusion mechanism thus avoiding the initial surge of supersaturation followed by a sharp decline in drug concentration typically encountered with ASDs based on water-soluble polymers.The creation of both immediate-and controlled-release ASD dosage forms is also achievable with the PHEMA based hydrogels.So far,ASD systems based on glassy PHEMA have been shown to be very effective in retarding precipitation of amorphous drugs in the solid state to achieve a robust physical stability.This review summarizes recent research efforts in investigating the potential of developing crosslinked PHEMA hydrogels as a promising alternative to conventional water-soluble ASD carriers,and a related finding that the rate of supersaturation generation does affect the kinetic solubility profiles implications to hydrogel based ASDs.	Dajun D.Sun Ping I.Lee	2014	Acta Pharmaceutica Sinica B2014，4，1：	2
	2	High-dielectricconstant silver-epoxy composites as embedded dielectrics显示文摘	LAI QI BURTRANG I.LEE SIHAI CHEN		0，，17：	1
	3	Iterative detection and decoding with an improved V-BLAST for MIMOOFDM systems显示文摘	H.Lee B.Lee I.Lee		0，，03：	1
	4	A New Approach for Health Monitoring of Structures: Terrestrial Laser Scanning显示文摘	H. S.Park H. M.Lee HojjatAdeli I.Lee	2006	Computer‐Aided Civil and Infrastructure Engineering2006，，1：	1
	5	Java-MaC:a runtime assurance approach for Java programs显示文摘	M.Kim S.Kannan I.Lee O.Sokolsky M.Viswanathan		0，，02：	1
	6	Heme oxygenase‐1 protects human periodontal ligament cells against substance?P‐induced RANKL expression显示文摘	H.‐J.Lee G.‐S.Jeong S.‐H.Pi S.‐I.Lee W.‐J.Bae S.‐J.Kim S.‐K.Lee E.‐C.Kim	2010	Journal of Periodontal Research2010，，3：	1
	7	Editorial显示文摘The research process for new drug is complicated,time-consum-ing,and costly.Thousands of chemical compounds must be made and tested in an effort to find one that can achieve a desirable result.It may take approximately ten years to study and test a new drug before it can be approved for the general public.However,in today's pharmaceutical industry drug delivery has become keys in drug product development.New innovative pharmaceutical technologies allow for increased performance of new and existing pharmaceutical compounds.	Dajun D.Sun Ping I.Lee	2014	Acta Pharmaceutica Sinica B2014，4，1：	0

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