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| 1 | CSF total and oligomeric α-Synuclein along with TNF-α as risk biomarkers for Parkinson’s disease: a study in LRRK2 mutation carriers显示文摘Background Asymptomatic carriers of leucine-rich repeat kinase 2(LRRK2)gene mutations constitute an ideal population for discovering prodromal biomarkers of Parkinson’s disease(PD).In this study,we aim to identify CSF candidate risk biomarkers of PD in individuals with LRRK2 mutation carriers.Methods We measured the levels of CSF total-(t-),oligomeric(o-)and phosphorylated S129(pS129-)α-syn,total-tau(tTau),phosphorylated threonine 181 tau(pTau),amyloid-beta 40(Aβ-40),amyloid-beta-42(Aβ-42)and 40 inflammatory chemokines in symptomatic(n=23)and asymptomatic(n=51)LRRK2 mutation carriers,subjects with a clinical diagnosis of PD(n=60)and age-matched healthy controls(n=34).General linear models corrected for age and gender were performed to assess differences in CSF biomarkers between the groups.Markers that varied significantly between the groups were then analyzed using backward-elimination logistic regression analysis to identify an ideal biomarkers panel of prodromal PD.Results Discriminant function analysis revealed low levels of CSF t-α-syn,high levels of CSF o-α-syn and TNF-αbest discriminated asymptomatic LRRK2 mutation carriers from both symptomatic PD and healthy controls.Assessing the discriminative power using receiver operating curve analysis,an area under the curve>0.80 was generated.Conclusions The current study suggests that CSF t-,o-α-syn and TNF-αare candidate risk biomarkers for the detection of PD at the prodromal stage.Our findings also highlight the dynamic interrelationships between CSF proteins and the importance of using a biomarkers’panel approach for an accurate and timely diagnosis of PD. | Nour K.Majbour Jan O.Aasly Eldbjørg Hustad Mercy A.Thomas Nishant N.Vaikath Naser Elkum Wilma D.Jvan de Berg Takahiko Tokuda Brit Mollenhauer Henk W.Berendse Omar M.A.El-Agnaf | 2020 | Translational Neurodegeneration2020，9，2： | 2 |
| 2 | Products distribution and gas release in pyrolysis of thermally thick biomass residues samples显示文摘 | Becidan M Skreiberg O Hustad J E | 2007 | Journal of Analytical and Applied Pyrolysis2007，78，1： | 1 |
| 3 | Pyrolysis characteristics and kinetics of municipal solid wastes显示文摘 | Sφrum L Grφnli M G Hustad J E | 2001 | Fuel2001，80，9： | 1 |
| 4 | Catalytic production of olefin block copolymers via chain shuttlingpolymerization显示文摘 | Arriola D J Carnahan E M Hustad P D | 2006 | Science2006，312，5774： | 1 |
| 5 | Continuous production of ethylene-based diblock copolymers using coordinative chain transfer polymerization显示文摘 | Hustad P D Kuhlman R L Arriola D J Carnahan E M Wenzel T T | | 0，，： | 1 |
| 6 | Py- rolysis characteristics and kinetics of municipal solid wastes显示文摘 | S RUM L G R NLI M G HUSTAD J E | 2001 | Fuel2001，80，9： | 1 |
| 7 | Catalytic productionof olefin block copolymers via chain shuttling polymerization显示文摘 | Arriola D J Carnahan E M Hustad P D | 2006 | Science2006，312，71： | 1 |
| 8 | A- nalysis of behavior-related adverse experiences in clini- cal trials of montelukast显示文摘 | PHILIP G HUSTAD C M MALICE M P | 2009 | J Allergy Clin Immunol2009，124，： | 1 |
| 9 | Ethylene-based olefin block copolymers by chain shuttling显示文摘 | Arriola D J Carnahan E M Hustad P D | 2006 | Polym Prepr2006，47，2： | 1 |
| 10 | Grapefruit juice and licorice increase eortisol availability in patients with Addison's disease 显示文摘 | Methlie P Husebye EE Hustad S | 2011 | Eur J Endocrinol2011，165，5： | 1 |
| 11 | Modeling andsimulation of catalytic partial oxidation of methane tosynthesis gas by using a plasma-assisted gliding arcreactor显示文摘 | Rafiq M H Jakobsen H A Hustad J E | 2012 | Fuel Processing Technology2012，，101： | 1 |
| 12 | Vitamins B2and B6 and genetic polymorphisms related to one-carbonmetabolism as risk factors for gastric adenocarcinoma inthe European prospective investigation into cancer and nu-trition 显示文摘 | Eussen SJ Vollset SE Hustad S | 2010 | Cancer Epidemiol Biomarkers Prev2010，19，1： | 1 |
| 13 | An exploration of the effects of reversibility in chain transfer to metal in olefin polymerization显示文摘 | Hustad P D Kuhlman R L Carnahan E M | 2008 | Maeromolecules2008，41，12： | 1 |
| 14 | Catalytic production of olefin block copolymers via chain shuttling polymerization显示文摘 | Arriola D J Carnahan E M Hustad P D | | 0，，5774： | 1 |
| 15 | Pyrolysis characteristics and kinetics of municipal solid wastes显示文摘 | Sφrum L Grφnli M G Hustad J E | 2001 | Fuel2001，80，9： | 1 |
| 16 | Riboflavin as a determinant of plasma total homocysteine: effect modification by the metbylenetetrahydrofolate reductase C677T polymorphism 显示文摘 | Hustad S Ueland PM Vollset SE | 2000 | Clin Chem2000，46，81： | 1 |
| 17 | Photonic polyethylene from self-assembled mesophases of polydisperse olefin block copolymers显示文摘 | Hustad P D Marchand G R Eddy I | | 0，，： | 1 |
| 18 | The itchy locus encodes a novel ubiquitin protein ligase that is disrupted in al8H mice显示文摘 | Perry WL Hustad CM Swing DA | 1998 | Nat Genet1998，18，2： | 1 |
| 19 | Sintering characteristics of sewage sludge ashes at elevated temperatures显示文摘 | Wang L Skjevrak G Hustad J E | 2012 | Fuel Processing Technology2012，96，： | 1 |
| 20 | Pyrolysis characteristics and kinetics of municipal solid wastes 显示文摘 | Sorum L Gronli M G Hustad J E | 2001 | Fuel2001，80，10： | 1 |
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