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| 1 | Relationship between vitamin D and IL-23,IL-17 and macrophage chemoattractant protein-1 as markers of fibrosis in hepatitis C virus Egyptians显示文摘AIM:To assess vitamin D in hepatitis C patients and its relationship to interleukin (IL)-23, IL-17, and macrophage chemoattractant protein-1 (MCP-1). METHODS:The study was conducted on 50 Egyptian hepatitis C virus (HCV) genotype number IV-infected patients and 25 ageand gender-matched healthy subjects. Venous blood samples were obtained. Samples were allowed to clot and sera were separated by centrifugation and stored at -20 ℃. A 25 hydroxy vitamin D assay was carried out using solid phase RIA. A 1,25 dihydroxy vitamin D assay was carried out using a commercial kit purchased from Incstar Corporation. IL-17 and -23 and MCP-1 were assayed by an enzyme immunoassay. Quantitative and qualitative polymerase chain reaction for HCV virus were done by TaqMan technology. Only HCV genotype IV-infected subjectswere included in the study. The mean ± SD were determined, a t-test for comparison of means of different parameters was used. Correlation analysis was done using Pearson's correlation. Differences among different groups were determined using the Kruskal-Wallis test. RESULTS:The mean vitamin D level in HCV patients (groupⅠ) was 15 ± 5.2 ng/mL while in control (group Ⅱ) was 39.7 ± 10.8. For active vitamin D in groupⅠas 16.6 ± 4.8 ng/mL while in group Ⅱ was 41.9 ± 7.9. IL-23 was 154 ± 97.8 in group Ⅰ and 6.7 ± 2.17 in group Ⅱ. IL-17 was 70.7 ± 72.5 in cases and 1.2 ± 0.4 in control. MCP-1 was 1582 ± 794.4 in group Ⅰand 216.1 ± 5.38 in group Ⅱ. Vitamin D deficiency affected 72% of HCV-infected patients and 0% of the control group. Vitamin D insufficiency existed in 28% of HCV-in-fected patients and 12% of the control group. One hundred percent of the cirrhotic patients and 40% of non cirrhotic HCV-infected patients had vitamin D deficiency. IL-23, IL-17, and MCP-1 were markedly increased in HCV-infected patients in comparison to controls.A significant negative correlation between vitamin D and IL-17 and-23 and MCP-1 was detected. HCV-infected males and females showed no differences with respect to viral load, vitamin D levels, IL-17, IL-23 and MCP-1. The viral load was negatively correlated with vitamin D and active vitamin D (P = 0.0001 and P = 0.001, respectively), while positively correlated with IL-23, IL-17, and MCP-1. We classified the patients according to sonar findings into four groups. Group Ⅰa with bright hepatomegaly and included 14 patients. Group Ⅰb with perihepatic fibrosis and included 11 patients. Group Ⅰc with liver cirrhosis and included 11 patients. Group Ⅰd with he patocellular carcinoma (HCC) and included 14 patients. Vitamin D and active vitamin D were shown to be lower in cirrhotic patients and much lower in patients with HCC, and this difference was highly significant (P = 0.0001). IL-17 and-23 and MCP-1 were higher in advanced liver disease) and the differences were highly significant (P = 0.0001).CONCLUSION:Whether the deficiency of vitamin D is related to HCV-induced chronic liver disease or predisposing factor for higher viral load is a matter of debate. | Noha M El Husseiny Hala M Fahmy Waleed A Mohamed Hisham H Amin | 2012 | World Journal of Hepatology2012，4，8： | 12 |
| 2 | Pregnancy Outcome at Maternal Age 40 and Older显示文摘 | Bahia Namavar Jahromi Zahra Husseini | 2008 | Taiwanese Journal of Obstetrics & Gynecology2008，，： | 2 |
| 3 | Rapid and sensitive assay of dobutamine in plasma by high-performance liquid chroma-tography and electrochemical detection显示文摘 | H. Husseini V. Mitrovie M. Schlepper | | 0，，： | 1 |
| 4 | Ultrasonic-activated micellar drug delivery for cancer treatment 显示文摘 | Husseini G Pitt W | 2009 | J Pharm Sci2009，98，3： | 1 |
| 5 | Increased Expression of LP-PLA2 in Aortic Stenosis Is Associated With Mineralization and Tissue Remodelling显示文摘 | M. Abulajiang M. Boulanger D.E. Husseini D. Fournier R. Bouchareb J. Després P. Pibarot Y. Bossé P. Mathieu | 2013 | Canadian Journal of Cardiology2013，，10： | 1 |
| 6 | Posttransplantation production of donor HLA-specific antibodies as a predictor of renal transplant outcome显示文摘 | WORTHINGTON J E MARTIN S AI HUSSEINI D M | 2003 | Transplantation2003，75，7： | 1 |
| 7 | Biodegradable antibiotic delivery systems 显示文摘 | E1 - Husseiny M Patel S MacFarlane RJ | 2011 | J Bone Joint Surg Br2011，93，2： | 1 |
| 8 | Proinflammatory cyto- kines (TNF- alpha and IL -6 ) in Egyptian patients with SLE:its correlation with disease activity显示文摘 | Sabry A Sheashaa H EI - Husseini A | 2006 | Cytokine2006，35，： | 1 |
| 9 | On bubbles and liposomes (June 11, 2007) 显示文摘 | Pitt WG Husseini GA | 2008 | Control Release2008，125，2： | 1 |
| 10 | The Lower Silurian Qalibah Formation of Saudi Arabia: an important hydrocarbon source rock显示文摘 | Mahmoud M D Vaslet D Husseini M I | 1992 | AAPG Bulletin1992，76，： | 1 |
| 11 | Kinetics of ultrasonic release of doxorubicin from pluronic P-105 micelles Colloids and Surfaces B显示文摘 | Husseini GA Rapoport NY Christensen DA | 2002 | Biointerfaces2002，24，4： | 1 |
| 12 | Mapping single-crystal dendritic microstructure and defects in nickel-base superalloys with synchrotron radiation 显示文摘 | Husseini N S Kumah D P Yi J Z | 2008 | Acta Materialia2008，56，17： | 1 |
| 13 | The Lower Silurian Qualibab Formation of Saudi Arabia: An important hydrocarbon source rock 显示文摘 | MAHMOND M D VASLET D HUSSEINI M I | 1992 | AAPG Bulletin1992，76，： | 1 |
| 14 | Use of evidence to support healthy public policy: a policy effectiveness-feasibility loop显示文摘 | Bowman Sarah Unwin Nigel Critchley Julia Capewell Simon Husseini Abdullatif Maziak Wasim Zaman Shahaduz Romdhane Habiba Ben Fouad Fouad Phillimore Peter Unal Belgin Khatib Rana Shoaibi Azza Ahmad Balsam | 2012 | Bulletin of the World Health Organization2012，，11： | 1 |
| 15 | Biosynthesis of gold nanoparticles using Pseudomonas aeruginosa 显示文摘 | HUSSEINY M I EL-AZIZ M A BADR Y | 2007 | Spectrochimiea Aeta Part A: Molecular and Biomoleeular Spectroscopy2007，67，3： | 1 |
| 16 | The role of cavitation in acoustically activated drug delivery 显示文摘 | Husseini GA Mario AD Eric SR | 2005 | Journal of Controlled Release2005，107，2： | 1 |
| 17 | Preliminary re- sults of combining low frequency low intensity ultrasound and liposomal drug delivery to treat tumors in rats显示文摘 | Pitt WG Husseini GA Roeder BL | 2011 | J Nanosci Nanotechnol2011，11，3： | 1 |
| 18 | Pregnancy outcome at maternal age 40 and older 显示文摘 | Jahromi BN Husseini Z | 2008 | Taiwan J Obstet Gynecol2008，47，3： | 1 |
| 19 | Release of doxorubicin from unstabilized and stabilized micelles under the action of ultrasound 显示文摘 | Husseini GA de la Rosa MAD Gabuji T | 2007 | J Nanosci Nanotechnol2007，7，3： | 1 |
| 20 | Drug delivery in pluronic micelles : effect of high-frequency ultrasound on drug release from micelles and intracellular uptake 显示文摘 | Matin A Sun H Husseini GA | 2002 | J Control Release2002，84，12： | 1 |
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