|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 藏毛窦发病率和远期复发率现况及其影响因素分析显示文摘目的调查德国部队中藏毛窦的发病率和术后远期复发率的现状及其发展变化趋势,分析不同手术治疗方法、体格状况和吸烟量等因素对藏毛窦的发病率和术后远期复发率的影响。方法对德国三家部队医院1980至1996年收治的所有藏毛窦患者的资料进行统计,随机抽取其中500例患者进行随访。结果德国部队中藏毛窦的发病率由1985年的0.3/1000上升到2007年的2.4/1000。随机抽取的500例患者中2例死亡,498例接受了随访。其术后复发率从1981年的33%,到1986年的23%,再到1996年的12%,呈明显下降趋势(P=0.01)。藏毛窦切除后行开放愈合的复发率为16.8%,显著低于行一期缝合的复发率31.0%(P〈0.01)。部队中人均体质量每十年增加1kg,德国国民人均体质量每十年增加1.9kg,但是体质量的增加与藏毛窦复发率之间无显著相关性(P=0.72)。每天吸烟20支以上者藏毛窦的复发率比吸烟≤20支者显著升高(P=0.015)。结论在藏毛窦的术后复发率下降,特别是切除后开放愈合的术后复发率下降的同时,藏毛窦的发病率上升了近十倍。 | Theo Evers Dietrich Doll Edouard Matevossian Sebastian Noe Konrad Neumann 李挥力 Norbert Huser Rainer Ludde Sebastian Hoffmann Bjorn Dirk Krapohl | 2011 | 中华外科杂志2011，49，9： | 14 |
| 2 | Deep-learning based denoising and reconstruction of super-resolution structured illumination microscopy images显示文摘Super-resolution structured illumination microscopy(SR-SIM) provides an up to twofold enhanced spatial resolution of fluorescently labeled samples. The reconstruction of high-quality SR-SIM images critically depends on patterned illumination with high modulation contrast. Noisy raw image data(e.g., as a result of low excitation power or low exposure time), result in reconstruction artifacts. Here, we demonstrate deep-learning based SR-SIM image denoising that results in high-quality reconstructed images. A residual encoding–decoding convolutional neural network(RED-Net) was used to successfully denoise computationally reconstructed noisy SR-SIM images.We also demonstrate the end-to-end deep-learning based denoising and reconstruction of raw SIM images into high-resolution SR-SIM images. Both image reconstruction methods prove to be very robust against image reconstruction artifacts and generalize very well across various noise levels. The combination of computational image reconstruction and subsequent denoising via RED-Net shows very robust performance during inference after training even if the microscope settings change. | ZAFRAN HUSSAIN SHAH MARCEL MÜLLER TUNG-CHENG WANG PHILIP MAURICE SCHEIDIG AXEL SCHNEIDER MARK SCHÜTTPELZ THOMAS HUSER WOLFRAM SCHENCK | 2021 | Photonics Research2021，9，5： | 11 |
| 3 | High-contrast,fast chemical imaging by coherent Raman scattering using a self-synchronized two-colour fibre laser显示文摘Coherent Raman scattering(CRS)microscopy is widely recognized as a powerful tool for tackling biomedical problems based on its chemically specific label-free contrast,high spatial and spectral resolution,and high sensitivity.However,the clinical translation of CRS imaging technologies has long been hindered by traditional solid-state lasers with environmentally sensitive operations and large footprints.Ultrafast fibre lasers can potentially overcome these shortcomings but have not yet been fully exploited for CRS imaging,as previous implementations have suffered from high intensity noise,a narrow tuning range and low power,resulting in low image qualities and slow imaging speeds.Here,we present a novel high-power self-synchronized two-colour pulsed fibre laser that achieves excellent performance in terms of intensity stability(improved by 50 dB),timing jitter(24.3 fs),average power fluctuation(<0.5%),modulation depth(>20 dB)and pulse width variation(<1.8%)over an extended wavenumber range(2700-3550 cm^(−1)).The versatility of the laser source enables,for the first time,high-contrast,fast CRS imaging without complicated noise reduction via balanced detection schemes.These capabilities are demonstrated in this work by imaging a wide range of species such as living human cells and mouse arterial tissues and performing multimodal nonlinear imaging of mouse tail,kidney and brain tissue sections by utilizing second-harmonic generation and twophoton excited fluorescence,which provides multiple optical contrast mechanisms simultaneously and maximizes the gathered information content for biological visualization and medical diagnosis.This work also establishes a general scenario for remodelling existing lasers into synchronized two-colour lasers and thus promotes a wider popularization and application of CRS imaging technologies. | Cihang Kong Christian Pilger Henning Hachmeister Xiaoming Wei Tom H.Cheung Cora S.W.Lai Nikki P.Lee Kevin K.Tsia Kenneth K.Y.Wong Thomas Huser | 2020 | Light(Science & Applications)2020，9，1： | 5 |
| 4 | Baculovirus- based vaccination vectors allow for efficient induction of immune responses against Plasmodium falcipa- rum circumsporozoite protein显示文摘 | STRAUSS R HUSER A NI S | 2007 | Mol Ther2007，15，： | 1 |
| 5 | Combined immunosuppressive and antibiotic therapy improves bacterial clearance and survival of polymicrobial septic peritonitis 显示文摘 | Assfalg V Huser N Reim D | 2008 | Shock2008，33，2： | 1 |
| 6 | Spatially non-uniform Ca signals induced by the reduction of transverse tubules in citrate loaded guinea-pig ventricular myocytes in culture显示文摘 | Huser J Pott L | 1996 | J Physiol1996，497，3： | 1 |
| 7 | Absolute equation of state measurements of iron using laser driven shocks显示文摘 | Benuzzi-Mounaix A Koenig M Huser G | | 0，，06： | 1 |
| 8 | Electrocatalytic oxidation of 1,2-propanediol-Ⅲa kinetic analysis of its oxidation on platinum in acid medium显示文摘 | Leger J M Lamy C | 1988 | Electrochemical Acta1988，33，10： | 1 |
| 9 | Infection with Chlamydophila pneumaniae as a cause of female infertility of tubal origin显示文摘 | Pospisil L Canderle J Huser M | 2004 | Ceska Gynekol2004，69，5： | 1 |
| 10 | Intracellular Ca2+ release contributes to automaticity in cat atrial pacemaker cells显示文摘 | Huser J Blatter LA Lipsius SL | 2000 | J Physiol2000，5242，： | 1 |
| 11 | Lean Production 显示文摘 | Warnecke H J Huser M | 1995 | International Journal of Production Economics1995，41，1： | 1 |
| 12 | Effects of Orthodontic Bands on Microbiologic and Clinical Parameters显示文摘 | Huser MC Baehni PC Lang R | 1990 | Am J Orthod Dentofacial Orthop1990，97，3： | 1 |
| 13 | Effets of orthodontic bands on mi- crobiologic and clinical parameters 显示文摘 | Huser MC Baehni PC Lang R | 1990 | Am J Orthod1990，97，3： | 1 |
| 14 | MIP-1alpha,MIP-1beta,RANTES,and ATAC/lymphotactin function together with IFN-gamma as type 1 cytokines显示文摘 | Dorner BG Scheffold A Rolph MS Huser MB Kaufmann SH Radbruch A Flesch IE Kroczek RA | 2002 | Proc Natl Acad Sci USA2002，99，9： | 1 |
| 15 | Baculovirus vectors: novel mammalian cell gene - delivery vehicles and their applications 显示文摘 | Huser A Hafmann C | 2003 | Am J Pharmacogenomics2003，3，1： | 1 |
| 16 | Imaging the permeability pore transition in single mitochondria显示文摘 | HUSER J RESHENMACHER C E BLATTER L A | 1998 | Biophys J1998，，74： | 1 |
| 17 | Baculovirus-based vaccination vectors allow for efficient induction of immune responses against plasmodium falciparum circumsporozoite protein 显示文摘 | Strauss R Huser A Ni S | 2007 | Mol Ther2007，15，1： | 1 |
| 18 | Implementations of the HL7 context aware knowledge retrieval (“infobutton”) standard: challenges, strengths, limitations, and uptake 显示文摘 | DEL FIOL G HUSER V STRASBERG H R | 2012 | Journal of Biomedical Informatics2012，45，4： | 1 |
| 19 | MEK kinase activity is not necessary for Raf-1 function显示文摘 | Huser M Luckett J Chiloeches A | 2001 | EMBO J2001，20，8： | 1 |
| 20 | MIP-1 alpha,MIP-1 beta,RANTES,and ATAC/Iymphotaction function together with IFN gamma as type I cytokines显示文摘 | Scheffold A Rolph MS Huser MB | 2002 | Proc Nati Acad Sci USA2002，99，9： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员