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| 1 | A novel suturing technique for filtering glaucoma surgery:the accordion suture显示文摘AIM:To present a novel scleral flap suturing technique for filtering glaucoma surgery in order to control high postoperative intraocular pressure(IOP).METHODS:Description of ‘the accordion suture' technique for mitomycin C augmented trabeculectomy.In cases of postoperative high IOP,pulling the loop of the suture helps to lift up the scleral flap by an even pressure on both edges.By means of this technique,the scleral flap opens up in an ‘‘accordion'' manner,thus preventing flap obstruction and providing adequate aqueous flow.RESULTS:Our study group consisted of 8 eyes of 8 patients with neovascular glaucoma.Mean age of the subjects was 67.42±8.21 y and female/male ratio was 4/4.Mean preoperative IOP was 37±7.48 mm Hg.Mitomycin C augmented trabeculectomy was carried out on the subjects without any complications.The scleral flap closure is performed with three separate sutures;initially,our accordion suture through the center of the flap,and two releasable sutures on both corners.All the patients received removal of two side releasable sutures concomitant with pulling the accordion suture,without any complications.The average traction time was 3.5±0 wk postoperatively.The mean postoperative IOP was 11.37±2.72 mm Hg.No suture related complications were observed.CONCLUSION:This technique can be the suture of choice for filtering glaucoma surgery in experienced hands by its easy learning curve for precisely indicated patients. | Mehmet Baykara Basak Can Ermerak Huri Sabur Selim Gent | 2017 | International Journal of Ophthalmology(English edition)2017，10，12： | 2 |
| 2 | Development of fluorine-substituted NH_(2)-biphenyl-diarylpyrimidines as highly potent non-nucleoside reverse transcriptase inhibitors:Boosting the safety and metabolic stability显示文摘Our recent studies for nonnucleoside reverse transcriptase inhibitors identified a highly potent compound JK-4b against WT HIV-1(EC_(50)=1.0 nmol/L),but the poor metabolic stability in human liver microsomes(t_(1/2)=14.6 min)and insufficient selectivity(SI=2059)with high cytotoxicity(CC_(50)=2.08μmol/L)remained major issues associated with JK-4b.The present efforts were devoted to the introduction of fluorine into the biphenyl ring of JK-4b,leading to the discovery of a novel series of fluorine-substituted NH_(2)-biphenyl-diarylpyrimidines with noticeable inhibitory activity toward WT HIV-1 strain(EC_(50)=1.8–349 nmol/L).The best compound 5t in this collection(EC_(50)=1.8 nmol/L,CC_(50)=117μmol/L)was 32-fold in selectivity(SI=66,443)compared to JK-4b and showed remarkable potency toward clinically multiple mutant strains,such as L100I,K103N,E138K,and Y181C.The metabolic stability of 5t was also significantly improved(t_(1/2)=74.52 min),approximately 5-fold higher than JK-4b in human liver microsomes(t_(1/2)=14.6 min).Also,5t possessed good stability in both human and monkey plasma.No significant in vitro inhibition effect toward CYP enzyme and hERG was observed.The single-dose acute toxicity test did not induce mice death or obvious pathological damage.These findings pave the way for further development of 5t as a drug candidate. | Xin Jin Shuai Wang Limin Zhao Wenjuan Huang Yinxiang Zhang Christophe Pannecouque Erik De Clercq Ge Meng Huri Piao Fener Chen | 2023 | Acta Pharmaceutica Sinica B2023，13，3： | 1 |
| 3 | The effect of posteriordistraction on vertebral growth in immature pigs: an experi- mental simulation of growing rod technique显示文摘 | Yilmaz G Huri G Demirkran G | 2010 | Spine2010，35，7： | 1 |
| 4 | Experiences in laparo-scopic re- moval of upper ureteral stones: muhicenter analysis of cases, based on the turkurolap group 显示文摘 | Huri E Basok EK Uqudu O | 2010 | J Endourol2010，24，8： | 1 |
| 5 | Tubeless percutaneous nephrolithotomy:safe even in supracostal access显示文摘 | Sofikerim M Demirci D Huri E | 2007 | J Endourol2007，21，9： | 1 |
| 6 | Correlation between duration of varicocele and apoptosis in testicular tissue in an experimental model 显示文摘 | Gurdal M Kirecci S Huri E | 2008 | Urology2008，72，4： | 1 |
| 7 | Relationship between the quantity of gingival crevicular fluid and clinical peri- odontalstatus显示文摘 | Ozkavaf A Aras H Huri CB | 2000 | JOral Sci2000，42，4： | 1 |
| 8 | Diabetes and cancer显示文摘 | Chowd hury T A | 2010 | QJ M2010，103，12： | 1 |
| 9 | Glycemic control and antidiabetic drugs in type 2 diabetes mellitus patients with renal eompli- cations显示文摘 | Huri HZ Lim LP Lim SK | 2015 | Drug Des Devel Ther2015，44，9： | 1 |
| 10 | Tubeless percutaneous nephrolithotomy:safe even in supracostal access显示文摘 | Sofikerim M Demirci D Huri E | 2007 | J Endourol2007，21，9： | 1 |
| 11 | Inducible nitric oxide synthase binds,S-nitrosylates, and activates cyclooxygenase-2 显示文摘 | Kim SF Huri DA Snyder SH | 2005 | Sci- ence2005，310，5756： | 1 |
| 12 | Cutaneous burn caused by ra- diofrequency ablation probe during shoulder arthroscopy 显示文摘 | Talati RK Dein E J Huri G | 2015 | Am J Orthop (Belie Mead NJ)2015，44，2： | 1 |
| 13 | Experiences in laparoscopic removal of upper ureteral stones: multi- center analysis of cases, based on the TurkUroLap Group显示文摘 | Huri E Basok E K Ugur | 2010 | J Endourol2010，24，8： | 1 |
| 14 | Dissemination of multiple drug resistance genes by class 1 integrons in Klebsiella pneumoniae isolates from four countries: a comparative study显示文摘 | Piklu P Roy R Chowd hury C | 2011 | Antimicrob Agents Chemother2011，55，7： | 1 |
| 15 | Production of human fat milk analogue containing α-linolenic acid by solvent-free enzymatic interesterification显示文摘 | Huri Ilyasoglu | 2013 | LWT - Food Science and Technology2013，，1： | 1 |
| 16 | Functional outcomes of minimal invasive percntaneous plate osteosynthesis (MIPPO) in humerus shaft fractures : a clinical study 显示文摘 | Huri G Biger OS Ozturk H | 2014 | Acta Orthop Traumatol Turc2014，48，4： | 1 |
| 17 | Prospective randomised study of endovenous radiofrequency obliteration (closure) versus ligation and vein stripping(EVOLVES):two-year follow-up显示文摘 | Hurie F Creton D Eklof B | 2005 | Eur J Vasc Endovasc Surg2005，29，1： | 1 |
| 18 | Use of porcine small intestinal submu- cosa in bladder augmentation in rabbit: long-term histological outcome 显示文摘 | Ayyildiz A Akgul KT Huri E | 2008 | ANZ2008，78，12： | 1 |
| 19 | Comparison of outcome of femo- ral shaft fracture fixation with intramedullary nail in elderly patient and patients younger than 60 years old 显示文摘 | Huri G Biqer OS Ozturk H | 2014 | Arch Bone Jt Surg2014，2，2： | 1 |
| 20 | Potential biomarkers of insulin resistance and atherosclerosis in type 2 diabetes mellitus patients with coronary artery disease 显示文摘 | Syed Ikmal SI Zaman Huri H Vethakkan SR | 2013 | Int J Endocrinol2013，10，69： | 1 |
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