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| 1 | Dysfunctional stem and progenitor cells impair fracture healing with age显示文摘Successful fracture healing requires the simultaneous regeneration of both the bone and vasculature;mesenchymal stem cells (MSCs) are directed to replace the bone tissue, while endothelial progenitor cells (EPCs) form the new vasculature that supplies blood to the fracture site. In the elderly, the healing process is slowed, partly due to decreased regenerative function of these stem and progenitor cells. MSCs from older individuals are impaired with regard to cell number, proliferative capacity, ability to migrate, and osteochondrogenic differentiation potential. The proliferation, migration and function of EPCs are also compromised with advanced age. Although the reasons for cellular dysfunction with age are complex and multidimensional, reduced expression of growth factors, accumulation of oxidative damage from reactive oxygen species, and altered signaling of the Sirtuin-1 pathway are contributing factors to aging at the cellular level of both MSCs and EPCs. Because of these geriatric-specific issues, effective treatment for fracture repair may require new therapeutic techniques to restore cellular function. Some suggested directions for potential treatments include cellular therapies, pharmacological agents, treatments targeting age-related molecular mechanisms, and physical therapeutics. Advanced age is the primary risk factor for a fracture, due to the low bone mass and inferior bone quality associated with aging;a better understanding of the dysfunctional behavior of the aging cell will provide a foundation for new treatments to decrease healing time and reduce the development of complications during the extended recovery from fracture healing in the elderly. | Diane R Wagner Sonali Karnik Zachary J Gunderson Jeffery J Nielsen Alanna Fennimore Hunter J Promer Jonathan W Lowery M Terry Loghmani Philip S Low Todd O McKinley Melissa A Kacena Matthias Clauss Jiliang Li | 2019 | World Journal of Stem Cells2019，11，6： | 3 |
| 2 | The Spawning frequency of skipjack tuna, Katsuwonus pelamis, from the South Pacific 显示文摘 | HUNTER J R MACEWICZ B J SIBERT J R | 1986 | Fishery Bulletin1986，84，4： | 1 |
| 3 | The immediate psychological and occupational impact of the 2003 SARS outbreak in a teaching hospital显示文摘 | Maunder R Hunter J Vincent L | 2003 | CMAJ2003，168，10： | 1 |
| 4 | Numerical index of the discriminatory ability of typing systems : an application of Simpson' s index of diversity显示文摘 | Hunter P R Gaston M A | 1988 | Clin Microbiol1988，26，： | 1 |
| 5 | Acute heat stress-induced alterations in blood Acid-based status and skeletal muscle membrane in broiler chickens at two ages: implications for meat quality显示文摘 | Sandercock D A Hunter R R Nute G R | 2001 | Poultry Science2001，80，： | 1 |
| 6 | Optimum preventive maintenance policies 显示文摘 | Barlow R Hunter L | 1960 | European Journal of Operational Research1960，8，： | 1 |
| 7 | Escherichia coli iron superoxide dismutase targeted to the mitochondria of yeast ceils protects the cells against oxidative stress 显示文摘 | Balzan R Bannister W H Hunter G J | 1995 | Proc Natl Acad Sci USA1995，92，： | 1 |
| 8 | Nylon-6 Nano- composites from Alkylammonium-modified Clay: The Role of Alkyl Tails on Exfoliation 显示文摘 | FORNES T D HUNTER D L PAUL D R | 2004 | Macromolecules2004，37，5： | 1 |
| 9 | Stress and anxiety:structural plasticity and epigenetic regulation as a consequence of stress显示文摘 | McEWEN B S EILAND L HUNTER R G | 2012 | Neuropharmacology2012，62，1： | 1 |
| 10 | Adaptation of HIV-1to human leukocyte antigen class I显示文摘 | Kawashima Y Pfafferott K Frater J Matthews P Payne R Addo M Gatanaga H Fujiwara M Hachiya A Koizumi H Kuse N Oka S Duda A Prendergast A Crawford H Leslie A Brumme Z Brumme C Allen T Brander C Kaslow R Tang J Hunter E Allen S Mulenga J Branch S Roach T John M Mallal S Ogwu A Shapiro R Prado J G Fidler S Weber J Pybus O G Klenerman P Ndung'u T Phillips R Heckerman D Harrigan P R Walker B D Takiguchi M Goulder P | 2009 | Nature2009，458，7238： | 1 |
| 11 | Sea-level Rise at Tropical Pacific and Indian Ocean islands 显示文摘 | Church J A White N J Hunter J R | 2006 | Global Planet Change2006，53，： | 1 |
| 12 | Endoscopic surgery for female infertility:a review of current management显示文摘 | Hunter T Hart R | 2009 | Aust N Z J Obstet Gynaecol2009，49，6： | 1 |
| 13 | Profiling early head and neck cancer显示文摘 | HUNTER K D PARKINSON E K HARRISON P R | 2005 | Nat Rev Cancer2005，5，： | 1 |
| 14 | An agonist antibody specific for CD40 induces dendritic cell maturation and promotes autologous anti-tumour T-cell responses in an in vitro mixed autologous tumour cell/lymph node ceU model 显示文摘 | Hunter T B Alsarraj M Gladue R P | 2007 | Scand J Immunol2007，65，5： | 1 |
| 15 | Effect of sodium montmorillonite source on nyton6/clay nanocomposites显示文摘 | Fornes T D Hunter D L Paul D R | 2004 | Polymer2004，45，7： | 1 |
| 16 | Basic types of stratification in small aeolian sand dunes显示文摘 | | 1977 | Sedimentology1977，24，： | 1 |
| 17 | A study of epidermal clear cells with a special referance to their relationship with the cells of Langerhans显示文摘 | Fan J Schoenfeld RJ Hunter R | 1959 | J Invest Dermatol1959，32，： | 1 |
| 18 | 显示文摘 | M Nevier W R Hunter | 1980 | Applied Optics1980，19，12： | 1 |
| 19 | Vitamin E biosynthesis : functional characterization of the monocot homogentisate geranylgeranyl transferase 显示文摘 | Yang W Y Cahoon R E Hunter S C | 2011 | The Plant Journal2011，65，： | 1 |
| 20 | Fecundity of sablefish, Anoplopoma fimbria, from Oregon coastal waters 显示文摘 | MACEWICZ B J HUNTER J R | 1994 | California Cooperative Oceanic Fisheries Investigations Reports1994，35，： | 1 |
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