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| 1 | Community-based survey of HCV and HIV coinfection in injection drug abusers in Sichuan Province of China显示文摘AIM: To investigate the prevalence and risk factors of HCV/HIV coinfection in injection drug abusers (IDAs) in Lianshan Yi Autonomous Prefecture of Sichuan province, China. METHODS: From November 8, 2002 to November 29, 2002, a community-based survey was conducted to investigate the demographic characteristics, patterns of shared injectors devices and sexual behaviors in IDAs. Blood samples were also collected to test HCV and HIV infection. A total of 379 subjects were recruited in the study through community outreach and peer recruiting methods. RESULTS: Of the 379 IDAs, the HCV prevalence and HIV prevalence were 71.0% and 11.3%, respectively, and HCV/HIV coinfection was 11.3%. HCV infection was found in 100% and 67.3% of HIV-positive and HIV-negative IDAs, respectively. HIV prevalence was 16.0% in HCV positive IDAs while none of the HCV negative IDAs was positive for HIV. Ethnicity, shared needles or syringes and cotton in the past 3 mo and syphilis infection were associated with HCV/HIV coinfection shown by univariate analysis using chi-square test. Multivariate logistic regression analysis showed that shared needles or syringes in the past 3 mo (Odds ratio=3.121, 95% CI: 1.278-7.617, P<0.05) and syphilis infection (Odds ratio=2.914, 95% CI: 1.327-6.398, P<0.01) were significantly associated with HCV infection. No statistically significant association was found in univariate analysis between sexual behaviors and HCV/HIV coinfection. CONCLUSION: Shared needles and syringes in the past 3 mo and syphilis infection were significantly associated with HCV infection. Further sero-epidemiological prospective cohort studies should be conducted to clarify the impact of syphilis and high risk sexual behaviors on HCV transmission through unprotected sexual intercourse. | Yu-HuaRuan Kun-XueHong Shi-ZhuLiu Yi-XinHe FengZhou Guan-MingQin Kang-LinChen HuiXing Jian-PingChen Yi-MingShao | 2004 | World Journal of Gastroenterology2004，10，11： | 15 |
| 2 | Association of HLA-B Alleles With Human Immunodeficiency Virus Type 1 Infection in the Yi Ethnic Group in Sichuan Province显示文摘Objective To determine the distribution of HLA-B alleles in the Chinese Yi ethnic group and its association with HIV infection. Methods One hundred and six unrelated healthy HIV negative and 73 HIV positive Chinese Yi ethnic individuals were typed by PCR-SSP. Results The frequency of alleles B*07, B*35, and B*46 were increased in HIV-1-positive subjects, whereas the alleles B*55, B*44 and B*78 were absent in the HIV-infected persons studied. The B*46 allele was present in a significantly higher gene frequency among HIV-1-positive individuals (P=0.02, OR=3.32, 95% CI=1.13-9.78) compared with control subjects. Conclusion HLA-B*46 may be associated with its susceptibility to HIV-1 infections. | MING-YANXU KUN-XUEHONG XIAO-LINGDENG JUNLI HONGPENG Yu-HuARUAN GUAN-MINGQIN HUIXING XIAO-HUXU ANDYI-MINGSHAO | 2004 | Biomedical and Environmental Sciences2004，17，2： | 8 |
| 3 | LRP6 downregulation promotes cardiomyocyte proliferation and heart regeneration显示文摘The adult mammalian heart is thought to be a terminally differentiated organ given the postmitotic nature of cardiomyocytes.Consequently,the potential for cardiac repair through cardiomyocyte proliferation is extremely limited.Low-density lipoprotein receptor-related protein 6(LRP6)is a Wnt co-receptor that is required for embryonic heart development.In this study we investigated the role of LRP6 in heart repair through regulation of cardiomyocyte proliferation.Lrp6 deficiency increased cardiomyocyte cell cycle activity in neonatal,juvenile and adult mice.Cardiomyocyte-specific deletion of Lrp6 in the mouse heart induced a robust regenerative response after myocardial infarction(MI),led to reduced MI area and improvement in left ventricular systolic function.In vivo genetic lineage tracing revealed that the newly formed cardiomyocytes in Lrp6-deficient mouse hearts after MI were mainly derived from resident cardiomyocytes.Furthermore,we found that the pro-proliferative effect of Lrp6 deficiency was mediated by the ING5/P21 signaling pathway.Gene therapy using the adeno-associated virus(AAV)9 miRNAi-Lrp6 construct promoted the repair of heart injury in mice.Lrp6 deficiency also induced the proliferation of human induced pluripotent stem cell-derived cardiomyocytes(iPSC-CMs).Our study identifies LRP6 as a critical regulator of cardiomyocyte proliferation,which may lead to the development of a novel molecular strategy to promote myocardial regeneration and repair. | Yahan Wu Liping Zhou Hongyu Liu Ran Duan Huixing Zhou Fulei Zhang Xiaoyu He Dongbo Lu Ke Xiong Maolin Xiong Jinzhu Zhuang Yi Liu Li Li Dandan Liang Yi-Han Chen | 2021 | Cell Research2021，31，4： | 5 |
| 4 | Development and clinical application of a new testicular prosthesis显示文摘用有椭圆的形状的 silastic 做的阴囊的修复术的一种新类型被我们的队开发模仿一个正常睾丸并且为在中国获专利提交了。修复术在不同尺寸被生产模仿病人的正常睾丸。调查阴囊的修复术的效果和安全,收到阴囊的修复术培植的 20 个病人为这研究被招募。在 6 个月以后的后续没在病人揭示复杂并发症。所有病人回答了那他们对他们的身体图象和 implants 的位置满意, 19 个病人对尺寸满意, 16 个病人对重量满意。这些结果证明在这研究使用的阴囊的修复术能遇见病人的期望。经历 orchiectomy 的病人应该被提供选择收到阴囊的修复术培植。尺寸和重量可得到修复术植入应该进一步被探讨改进耐心的满足。 | Ye Ning Zhikang Cai Huixing Chen Ping Ping Peng Li Zhong Wang Zheng Li | 2011 | Asian Journal of Andrology2011，13，6： | 4 |
| 5 | Damage detection based on the propagation of longitudinal guided wave in a bimetal composite pipe显示文摘This paper investigates the damage detection based on the propagation of guided wave in bimetal composite pipes,which can identify damage locations in both axial and circumferential directions.The feasibility of the method is showed by numerical simulations using FEM code ANSYS. Mode analysis is used to evaluate the guided wave mode and its structure,which can provide the basis of the mode selection in measurements scheme.The guided wave propagation in a damaged pipe is computed by transient analysis.16 ... | Huixing Yun~(1,a) and Weiwei Zhang~2 1.College of Engineering Shanxi Agricultural University,Taigu 030801,China 2.College of Science & Engineering,Jinan University,Guangzhou,China | 2011 | Theoretical & Applied Mechanics Letters2011，1，2： | 4 |
| 6 | 3D printing of tissue engineering scaffolds:a focus on vascular regeneration显示文摘Tissue engineering is an emerging means for resolving the problems of tissue repair and organ replacement in regenerative medicine.Insufficient supply of nutrients and oxygen to cells in large-scale tissues has led to the demand to prepare blood vessels.Scaffold-based tissue engineering approaches are effective methods to form new blood vessel tissues.The demand for blood vessels prompts systematic research on fabrication strategies of vascular scaffolds for tissue engineering.Recent advances in 3D printing have facilitated fabrication of vascular scaffolds,contributing to broad prospects for tissue vascularization.This review presents state of the art on modeling methods,print materials and preparation processes for fabrication of vascular scaffolds,and discusses the advantages and application fields of each method.Specially,significance and importance of scaffold-based tissue engineering for vascular regeneration are emphasized.Print materials and preparation processes are discussed in detail.And a focus is placed on preparation processes based on 3D printing technologies and traditional manufacturing technologies including casting,electrospinning,and Lego-like construction.And related studies are exemplified.Transformation of vascular scaffolds to clinical application is discussed.Also,four trends of 3D printing of tissue engineering vascular scaffolds are presented,including machine learning,near-infrared photopolymerization,4D printing,and combination of self-assembly and 3D printing-based methods. | Pengju Wang Yazhou Sun Xiaoquan Shi Huixing Shen Haohao Ning Haitao Liu | 2021 | Bio-Design and Manufacturing2021，4，2： | 3 |
| 7 | Effect of SrO Content on Structure,Thermal Properties and Chemical Stability of Bi2O3-B2O3-ZnO-SrO Low-melting Glass for Si-Al Alloy Package显示文摘The 40Bi2O3-30B2O3-(30-x)ZnO-xSrO (x=0-15mol%,BBZSr) glass system was prepared by the conventional melt quenching method.The effect of SrO addition on structure,thermal properties,chemical stability and sealing performance of BBZSr glass were investigated thoroughly.The experimental results show that the total proportions of [BO3] group and [BO4] group decrease and the vibrations of [BiO3] group and [BiO6] group become weaker with the increase of SrO addition content,suggesting the glass network structure is strengthened owing to the SrO addition.Hence,both the thermal and chemical stability were significantly improved as the SrO content was increased.When the SrO content increased from 0 to 15mol%,the glass transition temperature and softening temperature slightly increased from 380 to 388 ℃ and from 392.7 to 402.2 ℃,respectively,meanwhile the coefficient of thermal expansion also increased from 10.49×10^-6 to 11.16×10^-6/℃ (30-300 ℃).The BBZSr glass with 15mol% SrO exhibited excellent comprehensive properties with low glass transition temperature(384.9 ℃),low softening temperature(400.3 ℃),high coefficient of thermal expansion (11.14×10^-6 ℃,30-300 ℃),good thermal and chemical stability.Besides,the glass had the good wetting behavior and sealing performance for Al-50%Si alloy. | WU Zhilun ZHANG Ming ZHANG Chunyan MENG Fancheng LIN Huixing | 2020 | Journal of Wuhan University of Technology(Materials Science)2020，35，2： | 2 |
| 8 | Effect of frozen storage on thermal stability of sarcoplasmic protein and myofibrillar protein from common carp ( C yprinus carpio ) muscle显示文摘 | Hang Wang Yongkang Luo Huixing Shen | 2013 | Int J Food Sci Technol2013，，9： | 2 |
| 9 | Experimental Investigation of Cutting Nitrogen Oxides Emission from Cement Kilns using Coal Preheating Method显示文摘The large consumption of coal in cement industry leads to a significant nitrogen oxide(NO_(x))emission,which has caused severe atmospheric pollution due to the existing low-efficiency denitration technologies.In this research,a fuel pretreatment method on the concept of coal preheating was proposed to reduce NO_(x)emission from cement kilns.A special bench-scale experiment was designed to verify the feasibility of the proposed method.Experimental results showed that the proposed method could achieve high combustion efficiency,steady operation and low NO_(x)emission.The maximum reduction efficiency of primary NO in kiln gas reached 91.4%while the lowest NO_(x)emission was 145 mg/m^(3)(@10%O_2)during the experiment.The effects of key parameters on NO_(x)emission and primary NO_(x)reduction efficiency were comprehensively investigated.It was found that primary and secondary air ratios determined the oxygen content in the flue gas and the reaction temperature,which multiply affected the fuel-NO_(x)formation and activity of reductants.Increasing the length of the reducing zone could not only enhance the primary NO_(x)reduction efficiency,but also lower the combustion efficiency.In addition,cement raw material could greatly accelerate the formation of fuel-NO_(x)while its catalytic action on NO_(x)reduction was limited. | WU Huixing CAI Jun REN Qiangqiang CAO Xiaoyang LYU Qinggang | 2021 | Journal of Thermal Science2021，30，4： | 2 |
| 10 | Subclinical high altitude pulmonary edema: A clinical observation of 12 cases in Yushu显示文摘During the Yushu Earthquake on April 14,2010,a high incidence of acute high altitude illness was observed in the mountain rescuers,and 0.73 % of these patients suffered from high altitude pulmonary edema,of which 12 patients developed subclinical pulmonary edema and concomitantly contracted acute mountain sickness. Symptoms and signs were atypically high heart rate with high respiratory rate,striking cyanosis,and significantly low oxygen saturation,whereas no moist rates were heard on auscultation,and Chest X-ray showed peripheral with a patchy distribution of mottled infiltrations in one or both lung fields. We believe that subclinical high altitude pulmonary edema is an earliest stage of pulmonary edema at high altitude. The possible pathogenesis and the diagnosis were discussed. | Li Shuzhi Zheng Bihai Wu Tianyi Chen Huixing Zhang Ming | 2013 | Engineering Sciences2013，11，2： | 2 |
| 11 | Clinical evaluation of Technetium-99m sestamibi myocardial perfusion SPECT in diabetes with suspected coronary artery diseases显示文摘Objective:To study the clinical value of Technetium-99m sestamibi myocardial perfusion single photon emission computed tomography(SPECT) in diabetes with suspected coronary artery diseases.Methods:Seventy-eight diabetic patients complicated with cardiac symptoms or electrocardiogram(ECG) abnormalities and suspected coronary heart disease hospitalized in the department of endocrinology from January,2008 to December,2008 were investigated.Technetium-99m sestamibi myocardial perfusion SPECT was performed in all patients.Exercise stress test was done in 35 cases(group A).Adenosine stress test was done in 43 cases(group B).Results:The positive rates in the two groups were 54.29%(19/35) and 53.48%(23/43),respectively.There was no statistic difference between the 2 groups(P>0.05).The abnormality rates in male and female groups were 63.04% and 28.13%,respectively(P<0.01).Eighty-six segments of perfusion abnormality were detected in 38 positive patients.Four segments of fixed defect were found in 4 cases.Conclusion:As non-invasive method,myocardial perfusion SPECT can play an important role in the treatment of diabetes with suspected coronary artery disease. | Deng Huixing Ma Aiqun Yang Aimin Cheng Hu Ran Hongde | 2010 | Journal of Medical Colleges of PLA(China)2010，25，4： | 2 |
| 12 | Effect of Different Thawing Methods and Multiple Freeze-Thaw Cycles on the Quality of Common Carp (Cyprinus carpio)显示文摘 | Hang Wang Yongkang Luo Ce Shi Huixing Shen | 2015 | Journal of Aquatic Food Product Technology2015，，2： | 2 |
| 13 | microRNA-133b downregulation and inhibition of cell proliferation, migrationand invasion by targeting matrix metallopeptidase?9 in renal cell carcinoma显示文摘 | Deyao Wu Huixing Pan Yunfeng Zhou Jian Zhou Yuanfeng Fan Ping Qu | 2014 | Molecular Medicine Reports2014，，6： | 2 |
| 14 | Diabetic cardiomyopathy: con- cept, heart function,and pathogenesis显示文摘 | Codinach Huix P Freixa Pamias R | 2002 | An Med Interna2002，19，6： | 1 |
| 15 | Diabetic cardiomyopathy: concept, heart function, and pathogenesis 显示文摘 | Codinach Huix P Freixa Pamias R | 2002 | An Med Interna2002，19，6： | 1 |
| 16 | Electrical properties of polymer modified by metal ion implantation显示文摘 | Wu Yuguang Zhang Tonghe Zhang Huixing | 2000 | Nuclear Instrument and Methods in Physics Research2000，169，： | 1 |
| 17 | Self - expand-able metal stents for relieving malignant colorectal obstruction: short -term safety and efficacy within 30 days of stent procedure in 447 patients显示文摘 | Meisner S Gonzdlez - Huix F Vandervoort JG | 2011 | Gastrointest Endosc2011，74，4： | 1 |
| 18 | A modified, filtered, pulsed, cathodic vacuum arc implantation and deposition facility with the filtered duct working as second anode 显示文摘 | Wang Guangfu Zhang Huixing Zhang Xiaoji | 2000 | Surface and Coating Technology2000，，： | 1 |
| 19 | Enteral versus parenteral nutrition as adjunct therapy in acute ulcerative colitis 显示文摘 | Gonzalez- Huix F Ferndndez-Banares F Esteve-Comas M | 1993 | Am J Gastroenterol1993，88，2： | 1 |
| 20 | Gel properties of surimi from silver carp ( Hypophthalmichthys molitrix ) as affected by heat treatment and soy protein isolate显示文摘 | Yongkang Luo Huixing Shen Daodong Pan Guanhao Bu | 2007 | Food Hydrocolloids2007，，8： | 1 |
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