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| 1 | Effects of emitter discharge rates on soil salinity distribution and cotton(Gossypium hirsutum L.) yield under drip irrigation with plastic mulch in an arid region of Northwest China显示文摘A field experiment was carried out to investigate the effects of different emitter discharge rates under drip irrigation on soil salinity distribution and cotton yield in an extreme arid region of Tarim River catchment in Northwest China.Four treatments of emitter discharge rates,i.e.1.8,2.2,2.6 and 3.2 L/h,were designed under drip irrigation with plastic mulch in this paper.The salt distribution in the range of 70-cm horizontal distance and 100-cm vertical distance from the emitter was measured and analyzed during the cotton growing season.The soil salinity is expressed in terms of electrical conductivity(dS/m) of the saturated soil extract(EC e),which was measured using Time Domain Reflector(TDR) 20 times a year,including 5 irrigation events and 4 measured times before/after an irrigation event.All the treatments were repeated 3 times.The groundwater depth was observed by SEBA MDS Dipper 3 automatically at three experimental sites.The results showed that the order of reduction in averaged soil salinity was 2.6 L/h > 2.2 L/h > 1.8 L/h > 3.2 L/h after the completion of irrigation for the 3-year cotton growing season.Therefore,the choice of emitter discharge rate is considerably important in arid silt loam.Usually,the ideal emitter discharge rate is 2.4-3.0 L/h for soil desalinization with plastic mulch,which is advisable mainly because of the favorable salt leaching of silt loam and the climatic conditions in the studied arid area.Maximum cotton yield was achieved at the emitter discharge rate of 2.6 L/h under drip irrigation with plastic mulch in silty soil at the study site.Hence,the emitter discharge rate of 2.6 L/h is recommended for drip irrigation with plastic mulch applied in silty soil in arid regions. | Sulitan DANIERHAN Abudu SHALAMU Hudan TUMAERBAI DongHai GUAN | 2013 | Journal of Arid Land2013，5，1： | 15 |
| 2 | Whether Probiotic Supplementation Benefits Rheumatoid Arthritis Patients: A Systematic Review and Meta-Analysis显示文摘Gut and oral microflora are important factors in the pathogenesis and development of rheumatoid arthritis(RA). Recent studies have shown that probiotic supplements have beneficial consequences on experimental arthritis in rats. However, results from randomized clinical trials on the effects of probiotics have not been consistent. The aim of this study was to systematically review the existing evidence for the effects of probiotic intervention in RA. We included randomized controlled trials(RCTs) of RA patients receiving stable treatment with disease-modifying anti-rheumatic drugs(DMARDs) that:(1) were combined with additional probiotic supplements or(2) were combined with either no additional supplements or only a placebo treatment. Statistical analysis was performed using Review Manager 5.3.3.Six randomized clinical trials were eligible for inclusion in the meta-analysis, with 249 participants in total. The results showed that the probiotic intervention treatment has not yet achieved significant improvement in the American College of Rheumatology 20% improvement criteria(ACR20) score and the disease activity score in 28 joints(DAS28). The laboratory index C-reactive protein(CRP)(mg·L–1) was significantly reduced in the intervention group. The expression of inflammatory cytokines tumor necrosis factor(TNF)-α and interleukine(IL)-1β was also significantly reduced, while IL-10 expression increased in the probiotic intervention groups. This article is the first systematic review and meta-analysis providing a comprehensive assessment of the benefits of treating RA with probiotics. We found that probiotic supplementation may show a limited improvement in RA therapy in existing reports because of a lack of sufficiently high-quality work on the part of clinicians. More multi-centered, large-sample RCTs are needed in order to evaluate the benefits of probiotics in RA treatment. | Hudan Pan Runze Li Ting Li Jun Wang Liang Liu | 2017 | Engineering2017，3，1： | 7 |
| 3 | Integrated genomic analysis identifies deregulated JAK/STAT-MYC-biosynthesis axis in aggressive NK-cell leukemia显示文摘好攻击的 NK 房间白血病(ANKL ) 是在从亚洲的人之中是更流行的 NK 房间瘤的一种稀罕形式并且中央并且南美洲。病人们通常在天以内死到月,甚至在收到迅速的治疗学的管理以后。这里,我们由集成整个染色体执行了 ANKL 的第一全面研究, transcriptome 并且定序指向,象功能的试金一样的 cytokine 数组。在 JAK-STAT 小径的变化在 48% 被识别(14/29 ) ANKL 病人,当细胞外的 STAT3 激发器 IL10 被 56 褶层的一般水准提高时(P < 0.0001 ) 在检查的所有病人的血浆。另外的经常变异的基因包括的 TP53 (34%) , TET2 (28%) , CREBBP (21%) 和 MLL2 (21%) 。耐心的 NK 白血病房间在多重新陈代谢的小径显示出 STAT3 phosphorylation, MYC 表示和 transcriptional 活动的突出的激活。机能上地, STAT3 激活和 MYC 表示为 ANKL 房间的增长和幸存是批评的。发信号的 STAT 调整了发信号的 MYC 抄写节目,和两 STAT, MYC 抄写被要求维持核苷酸合成和 glycolysis 的激活。一起, JAK-STAT 小径在 ANKL 为 genomic 改变和 IL10 刺激代表一个主要目标。这最新发现的 JAK/STAT-MYC-biosynthesis 轴可以在对待白血病的这种子类型为新奇治疗学的策略的发展提供机会。 | Liang Huang Dan Liu Na Wang Shaoping Ling Yuting Tang Jun Wu Lingtong Hao Hui Luo Xuelian Hu Lingshuang Sheng Lijun Zhu Di Wang Yi Luo Zhen Shang Min Xiao Xia Mao Kuangguo Zhou Lihua Cao Lili Dong Xinchang Zheng Pinpin Sui Jianlin He Shanlan Mo Jin Yan Qilin Ao Lugui Qiu Hongsheng Zhou Qifa Liu Hongyu Zhang Jianyong Li Jie Jin Li Fu Weili Zhao Jieping Chen Xin Du Guoliang Qing Hudan Liu Xin Liu Gang Huang Ding Ma Jianfeng Zhou Qian-fei Wang | 2018 | Cell Research2018，28，2： | 5 |
| 4 | Targeting oncogenic Myc as a strategy for cancer treatment显示文摘The MYC family oncogene is deregulated in>50%of human cancers,and this deregulation is frequently associated with poor prognosis and unfavorable patient survival.Myc has a central role in almost every aspect of the oncogenic process,orchestrating proliferation,apoptosis,differentiation,and metabolism.Although Myc inhibition would be a powerful approach for the treatment of many types of cancers,direct targeting of Myc has been a challenge for decades owing to its“undruggable”protein structure.Hence,alternatives to Myc blockade have been widely explored to achieve desirable anti-tumor effects,including Myc/Max complex disruption,MYC transcription and/or translation inhibition,and Myc destabilization as well as the synthetic lethality associated with Myc overexpression.In this review,we summarize the latest advances in targeting oncogenic Myc,particularly for cancer therapeutic purposes. | Hui Chen Hudan Liu Guoliang Qing | 2018 | Signal Transduction and Targeted Therapy2018，3，1： | 5 |
| 5 | Ecological service assessment of human-dominated freshwater ecosystem with a case study in Yangzhou Prefecture, China显示文摘Freshwater ecosystems provide a host of services to humanity. These services are now rapidly being lost, not least because of the inability of making the impacts measurable. To overcome this obstacle, assessment frameworks for freshwater ecosystem services are needed. A simple water equivalent framework to assess the ecological services provided by freshwater ecosystems was developed in this study. It translated the occupation of freshwater ecosystem services into biologically freshwater volumes and then compares this consumption to the freshwater throughput, that is, the ecological capacity available in this region. In this way, we use the example of Yangzhou Prefecture, to account the main categories of human occupation of water ecosystem services. The result showed that there is a huge gap between the consumption and the supply of freshwater ecosystem services. This must encourage local government to make land-use and water management decisions both economically rational and environmentally sound. | YEYa-ping WANGRu-song RENJing-ming HUDan YUANShao-jun WANGMin | 2004 | Journal of Environmental Sciences2004，16，5： | 5 |
| 6 | Regulation of cancer cell metabolism:oncogenic MYC in the driver’s seat显示文摘Cancer cells must rewire cellular metabolism to satisfy the demands of unbridled growth and proliferation.As such,most human cancers differ from normal counterpart tissues by a plethora of energetic and metabolic reprogramming.Transcription factors of the MYC family are deregulated in up to 70%of all human cancers through a variety of mechanisms.Oncogenic levels of MYC regulates almost every aspect of cellular metabolism,a recently revisited hallmark of cancer development.Meanwhile,unrestrained growth in response to oncogenic MYC expression creates dependency on MYC-driven metabolic pathways,which in principle provides novel targets for development of effective cancer therapeutics.In the current review,we summarize the significant progress made toward understanding how MYC deregulation fuels metabolic rewiring in malignant transformation. | Yang Dong Rongfu Tu Hudan Liu Guoliang Qing | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 2 |
| 7 | Deciphering the pharmacological mechanism of Guan-Jie-Kang in treating rat adjuvant-induced arthritis using omics analysis显示文摘Traditional Chinese medicine (TCM) formulas have attracted increasing attention worldwide in the past few years for treating complex disease including rheumatoid arthritis. However, their mechanisms are complex and remain unclear. Guan-Jie-Kang (GJK), a prescription modified from “Wu Tou Decoction,” was found to significantly relieve arthritis symptoms in rats with adjuvant-induced arthritis after 30-day treatment, especially in the 24 g/kg/day group. By analyzing 1749 targets related to 358 compounds in the five herbs of GJK, we identified the possible anti-arthritis pathways of GJK, including the calcium signaling and metabolic pathways. Bone damage levels were assessed by micro-computed tomography, and greater bone protective effect was observed with GJK treatment than with methotrexate. Receptor activator of nuclear factor kB ligand (RANKL)-RANK signaling, which is related to calcium signaling, was significantly regulated by GJK. Moreover, a target metabolomics assay of serum was conducted;17 metabolic biomarkers showed significant correlations with treatment. An integrated pathway analysis revealed that pyruvate metabolism, purine metabolism, and glycolysis metabolism were significantly associated with the effects of GJK in arthritis treatment. Thus, this study establishes a new omics analytical method integrated with bioinformatics analysis for elucidating the multi-pathway mechanisms of TCM. | Hudan Pan Yanfang Zheng Zhongqiu Liu Zhongwen Yuan Rutong Ren Hua Zhou Ying Xie Liang Liu | 2019 | Frontiers of Medicine2019，13，5： | 1 |
| 8 | Hsp90 regulates processing of NF-κB2 p100 involving protection of NF-κB-inducing kinase (NIK) from autophagy-mediated degradation显示文摘NF-κB-inducing kinase (NIK) is required for NF-κB activation based on the processing of NF-κB2 p100. Here wereport a novel mechanism of NIK regulation involving the chaperone 90 kDa heat shock protein (Hsp90) and autophagy.Functional inhibition of Hsp90 by the anti-tumor agent geldanamycin (GA) efficiently disrupts its interaction with NIK,resulting in NIK degradation and subsequent blockage of p100 processing. Surprisingly, GA-induced NIK degradationis mediated by autophagy, but largely independent of the ubiquitin-proteasome system. Hsp90 seems to be specificallyinvolved in the folding/stabilization of NIK protein, because GA inhibition does not affect NIK mRNA transcription andtranslation. Furthermore, Hsp90 is not required for NIK-mediated recruitment of the a subunit of IκB kinase to p100, akey step in induction of p100 processing. These findings define an alternative mechanism for Hsp90 client degradationand identify a novel function of autophagy in NF-κB regulation. These findings also suggest a new therapeutic strategyfor diseases associated with p100 processing. | Guoliang QingPengrong YanZhaoxia Qu Hudan LiuGutian Xiao, Department of Cell Biology and Neuroscience, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA | 2007 | Cell Research2007，17，6： | 1 |
| 9 | Epidemiology and eti-ology of childhood pneumonia显示文摘 | Hudan I Boschi-Pinto C Biloglav Z | 2008 | Bull World Health Organ2008，86，5： | 1 |
| 10 | Directed and elliptic flow in 197 Au + 197 Au at intermediate energies显示文摘 | J. ?ukasik G. Auger M.L. Begemann-Blaich N. Bellaize R. Bittiger F. Bocage B. Borderie R. Bougault B. Bouriquet J.L. Charvet A. Chbihi R. Dayras D. Durand J.D. Frankland E. Galichet D. Gourio D. Guinet S. Hudan P. Lautesse F. Lavaud A. Le Fèvre R. Legrain | 2005 | Physics Letters B2005，，3： | 1 |
| 11 | Antibiotic resistance and plasmid profile of Escherichia coli isolated from ducks in Penang,Malaysia显示文摘 | Adzitey F AliGRR HudaN et aI | 2013 | Inter- national Food Research Journal2013，20，3： | 1 |
| 12 | Quantitative analysis of imazamox herbicide in environmental water samples by capillary electrophoresis electrospray ionization mass spectrometry显示文摘 | Hudan Safarpour Reza Asiaie Stanley Katz | 2004 | Journal of Chromatography A2004，，1036： | 1 |
| 13 | Inter-femtocell interference coordination in 3D in-building scenario显示文摘With rapid development of femtocell,dense deployment of femtocells in buildings will become an important study scenario.In this scenario,there exists severe inter-femtocell interference in the same building,which is revealed by our simulations in the 3-dimention(3D) scenario.If this type of interference is not well controlled,services to indoor users are bound to be deteriorated,especially for the femtocell edge users.Motivated by this problem,femto users' received interference model is constructed based on the scenario of 3D femtocell deployment.Then,a graph theory based in-building inter-femtocell coordination scheme is proposed,which includes three phases:establishment of femtocell interference graph,femtocell clustering and frequency resources allocation based on the proposed cluster influence circle.Finally,the simulation results confirm that the proposed scheme improves the femtocell average throughput by 22.4% and 26.2% in comparison with frequency universal reuse scheme and frequency hopping scheme respectively,and ensures the channel demodulation reliability of cell edge femto users. | HUDan LIHong-jia XUXiao-dong TAOXiao-feng | 2012 | The Journal of China Universities of Posts and Telecommunications2012，19，2： | 0 |
| 14 | MYC in T-cell acute lymphoblastic leukemia: functional implications and targeted strategies显示文摘T-cell acute lymphoblastic leukemia(T-ALL)is an aggressive hematological cancer that frequently occurs in children and adolescents,which results from the transformation of immature T-cell progenitors.Aberrant cell growth and proliferation of T-ALL lymphoblasts are sustained by activation of strong oncogenic drivers.Mounting evidence highlights the critical role of the NOTCH1-MYC highway toward the initiation and progression of T-ALL.MYC has been emphasized as a primary NOTCH1 transcriptional target impinging in leukemia-initiating cell activity particularly responsible for disease onset and relapse.These findings lay a foundation of T-ALL as an ideal disease model for studying MYC-mediated cancer.The biology of MYC deregulation in T-ALL supports innovative strategies for therapeutic targeting of MYC.To summarize the relevant literature and data in recent years,we here provide a comprehensive overview of the functional importance of MYC in T-ALL development,and the molecular mechanisms underlying MYC deregulation in T-ALL.Finally,we illustrate the innovative MYC-targeted approaches that have been evaluated in pre-clinical models and shown significant efficacy.Given the complexity of T-ALL molecular pathogenesis,we propose that a combination of anti-MYC strategies with conventional chemotherapies or other targeted/immunotherapies may provide the most durable response,especially for those patients with relapsed and refractory T-ALL. | Qilong Li Sa Pan Ting Xie Hudan Liu | 2021 | Blood Science2021，3，3： | 0 |
| 15 | Polo样激酶1通过PLK1-Myc反馈激活信号环路稳定癌蛋白Myc并促进肿瘤细胞生长存活显示文摘癌基因MYCN(编码N-Myc)在癌症中出现扩增突变预示不良预后和复发耐药。众多细胞水平和模式动物研究表明,干预癌蛋白N-Myc的表达或活性能够显著甚至完全抑制肿瘤发生和发展。 | Daibiao Xiao Ming Yue Hexiu Su Ping Ren Jue Jiang Feng Li Yufeng Hu Haining Du Hudan Liu 卿国良 | 2017 | 科学新闻2017，19，4： | 0 |
| 16 | Cloning and Bioinformation Analysis of Carbonic Anhydrase Gene FsCA1 of Tibet Wild Buckwheat显示文摘A carbonic anhydrase( CA) transcript was obtained from the Contig library according to the published sequencing information of the buckwheat transcripts. The full length of the CA gene was amplified by reverse transcription PCR( RT-PCR). The bioinformatics analysis showed that the full length of Fs CA1 gene was 1233 bp and open reading frame was 978 bp,and encoding 325 amino acids. The molecular weight was 35. 11 ku and the isoelectric point was 7. 59; there were 9 α helices,6 β folds,many randon coil and extension chain,containing one signal peptide and one transmembrane region,having a 2 amino acid conserved domains with typical beta-type carbonic anhydrase. Subcellular localization showed that the protein is most likely to appear in the chloroplast. The three-dimensional structure model of Fs CA1 was built by homologous modeling method,indicating that the homo-octamer of buckwheat CA and pea CA could match well,so it can be inferred that buckwheat CA is also homo-octamer. Real-time quantitative PCR was used to detect the expression of Fs CA1 in different organs of buckwheat.The results showed that Fs CA1 had the highest expression level in leaves,then in the stems,and the lowest in roots. | Weihai HOU Jianlin WANG Danba Hudan | 2017 | Asian Agricultural Research2017，9，11： | 0 |
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