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| 1 | Simultaneous occurrence of autoimmune pancreatitis and pancreatic cancer in patients resected for focal pancreatic mass显示文摘AIM To assess the occurrence of autoimmune pancreatitis(AIP) in pancreatic resections performed for focal pancreatic enlargement.METHODS We performed a retrospective analysis of medical records of all patients who underwent pancreatic resection for a focal pancreatic enlargement at our tertiary center from January 2000 to July 2013. The indication for surgery was suspicion of a tumor based on clinical presentation, imaging findings and laboratory evaluations. The diagnosis of AIP was based on histology findings. An experienced pathologist specialized in pancreatic disease reviewed all the cases and confirmed the diagnosis in pancreatic resection specimens suggestive of AIP. The histological diagnosis of AIP was set according to the international consensus diagnostic criteria.RESULTS Two hundred ninety-five pancreatic resections were performed in 201 men and 94 women. AIP was diagnosed in 15 patients(5.1%, 12 men and 3 women) based on histology of the resected specimen. Six of them had AIP type 1, nine were diagnosed with AIP type 2. Pancreatic adenocarcinoma(PC) was also present in six patients with AIP(40%), all six were men. Patients with AIP + PC were significantly older(60.5 vs 49 years of age, P = 0.045), more likely to have been recently diagnosed with diabetes(67% vs 11%, P = 0.09), and had experienced greater weight loss(15.5 kg vs 8.5 kg, P = 0.03) than AIP patients without PC. AIP was not diagnosed in any patients prior to surgery; however, the diagnostic algorithm was not fully completed in every case. CONCLUSION The possible co-occurrence of PC and AIP suggests that preoperative diagnosis of AIP does not rule out simultaneous presence of PC. | Peter Macinga Adela Pulkertova Lukas Bajer Jana Maluskova Martin Oliverius Martin Smejkal Maria Heczkova Julius Spicak Tomas Hucl | 2017 | World Journal of Gastroenterology2017，23，12： | 5 |
| 2 | Epithelial markers of colorectal carcinogenesis in ulcerative colitis and primary sclerosing cholangitis显示文摘AIM:To evaluate the expression of epithelial markers of colorectal carcinogenesis in patients with long-term ulcerative colitis(UC) and primary sclerosing cholangitis(PSC) before and after transplantation.METHODS:Eight patients with UC and PSC prior to liver transplantation(PSC-UC),22 patients with UC after liver transplantation for PSC(OLT),9 patients with active ulcerative colitis without PSC(UCA),7 patients withUC in remission(UCR) and 10 controls(N) underwent colonoscopy with multiple biopsies.Specimens were analysed histologically and semi-quantitatively immunohistochemically for p53,Bcl-2 and cyclooxygenase-2(COX-2) markers.Statistical analysis was performed by Kruskal-Wallis and Fisher's exact tests.RESULTS:PSC-UC had a statistically significantly higher expression of p53 in the nondysplastic mucosa as compared to OLT,UCA,UCR and N(P < 0.05).We also found a statistically significant positive correlation between the incidence of PSC and the expression of p53(P < 0.001).UCA had a higher p53 expression as compared to UCR.OLT had a significantly lower expression of p53 as compared with PSC-UC(P < 0.001).Bcl-2 had a significant higher bcl-2 expression as compared with controls.No difference in COX-2 expression between PSC-UC,UCR and UCA was found.UCA had higher COX-2 expression as compared to UCR.We also found a statistically significant positive correlation between the expression of COX-2 and p53.Patients after liver transplantation for PSC had a statistically significantly lower expression of the p53 compared with PSCUC(P < 0.001).PSC-UC had the same inflammatory endoscopic activity as OLT and UCR when evaluated with the Mayo score.CONCLUSION:Our study shows that the nondysplatic mucosa of UC patients with PSC is characterised by a higher expression of the tumour suppressor gene p53,suggesting a higher susceptibility of cancer.This p53 overexpression correlates with the presence of PSC whilst it is not present in patients with UC after liver transplantation for PSC. | Pavel Wohl Tomas Hucl Pavel Drastich David Kamenar Julius Spicak Eva Honsova Eva Sticova Alena Lodererova Jan Matous Martin Hill Petr Wohl Milos Kucera | 2013 | World Journal of Gastroenterology2013，19，14： | 2 |
| 3 | Physicochemical and structural characteristics of flours and starches from waxy and nowaxy wheats显示文摘 | Abdel - Aal E - S Hucl P Chibbar R N | 2002 | Cereal Chemistry2002，79，3： | 1 |
| 4 | A rapid method for quantifying total pigment s in blue aleurone and purple pericarp wheats显示文摘 | Abdel-Aal E S M Hucl P A | 1999 | Cereal Chemistry1999，76，： | 1 |
| 5 | Physicochemi-cal and structural characteristics of flours and starches from waxy andnonwaxy wheats显示文摘 | ABDEL-AAL E S M HUCL P CHIBBAR R N | 2002 | Cereal Chemistry2002，79，3： | 1 |
| 6 | Repeatability of a simplified method for determining sprou- ting resistance in wheat 显示文摘 | Hucl P | 1994 | Plant Var Seeds1994，7，： | 1 |
| 7 | Validation of molecular markers for pre-harvest sprouting resistance in bread wheat R 显示文摘 | SINGH R HUCL P BAGA M | 2012 | Cereal Research Communications2012，40，2： | 1 |
| 8 | Transgene inheritance and silencing in hexaploid spring wheat显示文摘 | Demeke T Hucl P Bga M | 1999 | Theoretical and Applied Genetics1999，99，6： | 1 |
| 9 | Separation and characterization of A-and B-type starch granules in wheat endosperm显示文摘 | Peng M S Gao M Abdel-Aal E S M Hucl P Chibbar R N | | 0，，： | 1 |
| 10 | A rapid method for quantifying total anthocyaains in blue aleurone and purple pericarp wheats显示文摘 | ABDEL-AAL E S M HUCL P | 1999 | Cereal Chemistry1999，76，3： | 1 |
| 11 | Starch-branching enzymes preferentially associated with A-type starch granules in wheat endosperm显示文摘 | Peng M S Gao M Baga M Hucl P Chibbar R N | | 0，，： | 1 |
| 12 | Identifying allelic loss and homozygous deletions in pancreatic cancer without matched normals using highdensity singlenucleotide polymorphism arrays显示文摘 | Calhoun ES Hucl T Gallmeier E | 2006 | Cancer Res2006，66，16： | 1 |
| 13 | Genotype variation for competitive ability in spring wheat显示文摘 | Huel D G Hucl P | 1996 | Plant Breeding1996，115，5： | 1 |
| 14 | DNA Repair: Exploiting the Fanconi Anemia Pathway As a Potential Therapeutic Target显示文摘 | Hucl T Gallmeier E | 2011 | Physiological Research2011，，3： | 1 |
| 15 | Separation and Characterization of A-and B-type Starch Granules in Wheat Endosperm显示文摘 | PENG M GAO M HUCL P | 1999 | Cereal Chemistry1999，76，330： | 1 |
| 16 | Evaluation of Canadian and other wheat for waxy proteins显示文摘 | Demeke T Hucl P Nair R B | 1997 | Cereal Chemistry1997，74，4： | 1 |
| 17 | The genetics of rachis fragility and glume tenacity in semi-wheat显示文摘 | Cao W G Scoles G J Hucl P | 1997 | Euphytica1997，94，： | 1 |
| 18 | Genetic analysis of imidazolinone resistance in mutation-derived lines of common wheat显示文摘 | Pozniak C J Hucl P J | 2004 | Crop Sci2004，44，1： | 1 |
| 19 | Targeted deletion of MKK4 in cancer cells: a detrimental phenotype manifests as decreased experimental metastasis and suggests a counterweight to the evolution of tumor-suppressor loss 显示文摘 | Cunningham SC Gallmeier E Hucl T | 2006 | Cancer Res2006，66，11： | 1 |
| 20 | DNA repair:exploiting the Fanconi anemia pathway as a potential therapeutic target显示文摘 | Hucl T Gallmeier E | 2011 | Physiol Res2011，60，3： | 1 |
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