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| 1 | The Phenotypic Characterization of Naturally Occurring Regulatory CD4^+CD25^+T Cells显示文摘免疫系统的动态平衡取决于在对自我抗原的对入侵的病原体和有免疫力的忍耐的有免疫力的反应之间的平衡。中央、外部的忍耐是为 T 房间忍耐的正式就职和维护的重要机制。最近,许多注意对规章的 T 房间(Treg ) 被给予了,它在维持外部有免疫力的忍耐起一个重要作用。到目前为止,关于 Treg 房间的表面标记没有令人满意的进展,因为任何一个都不为 Treg 房间是唯一的。在这评论,我们总结在自然地发生的CD4+CD25+ Treg 房间( nTreg )表示的一些重要分子,包括 forkhead/winged-helix 家庭 transcriptional 抑压者 p3 ( Foxp3 ),肿瘤坏死因素受体( TNFR )家庭, CD28/CTLA4 分子, chemokine 受体,像使用费的受体( TLR ), membranebound TGF-和其它分子例如 neuropilin-1 ,淋巴细胞激活 gene-3 (落后) -3 和 granzyme.This 评论在 nTreg | Huanfa Yi Yu Zhen Lingling Jiang Jialin Zheng Yong Zhao | 2006 | Cellular & Molecular Immunology2006，3，3： | 31 |
| 2 | Low-noise and broadband optical frequency comb generation based on an optoelectronic oscillator 显示文摘 | X1E Xiaopeng SUN Tao PENG Huanfa | 2014 | Optics Letters(S0146-9592)2014，39，4： | 1 |
| 3 | Whole-genome sequence-based association study for immune cells in an eight-breed pig heterogeneous population显示文摘Pigs are an important domestic animal for meat production and animal models for biomedical research such as research on infectious diseases(Meurens et al.,2012).Immune cells,including T cells,B cells,monocytes,and macrophages,are among the major indicators of immune status in health and disease.Revealing the genetic basis of immune cell phenotypes would be helpful for improving the immunity of pigs genetically and reducing the disease occurrence,antibiotic usage. | Qing Zhang Jing Li Yifeng Zhang Huanfa Gong Zhimin Zhou Wenwu Xu Zhongzi Wu Yingchun Sun Tao Jiang Ziqi Ling Shijun Xiao Lusheng Huang Bin Yang | 2022 | Journal of Genetics and Genomics2022，49，11： | 1 |
| 4 | Suppression of antigen-specific CD4+ T cell activation by SRA/CD204 through reducing the immunostimulatory capability of antigen-presenting cell显示文摘 | Huanfa Yi Daming Zuo Xiaofei Yu Fanlei Hu Masoud Manjili Zhengliang Chen John Subjeck Xiang-Yang Wang | 2012 | Journal of Molecular Medicine2012，，4： | 1 |
| 5 | Photoluminescent Lanthanide-Doped Silica Nanotubes:Sol-Gel Transcription from Functional Template显示文摘 | Yan Qiao Huanfa Chen Yiyang Lin | | 0，，： | 1 |
| 6 | Profiling of N6-methyladenosine methylation in porcine longissimus dorsi muscle and unravelling the hub gene ADIPOQ promotes adipogenesis in an m^(6)A-YTHDF1–dependent manner显示文摘Background Intramuscular fat(IMF)content is a critical indicator of pork quality,and abnormal IMF is also relevant to human disease as well as aging.Although N6-methyladenosine(m^(6)A)RNA modification was recently found to regulate adipogenesis in porcine intramuscular fat,however,the underlying molecular mechanisms was still unclear.Results In this work,we collected 20 longissimus dorsi muscle samples with high(average 3.95%)or low IMF content(average 1.22%)from a unique heterogenous swine population for m^(6)A sequencing(m^(6)A-seq).We discovered 70genes show both differential RNA expression and m^(6)A modification from high and low IMF group,including ADIPOQ and SFRP1,two hub genes inferred through gene co-expression analysis.Particularly,we observed ADIPOQ,which contains three m^(6)A modification sites within 3’untranslated and protein coding region,could promote porcine intramuscular preadipocyte differentiation in an m^(6)A-dependent manner.Furthermore,we found the YT521-B homology domain family protein 1(YTHDF1)could target and promote ADIPOQ mRNA translation.Conclusions Our study provided a comprehensive profiling of m^(6)A methylation in porcine longissimus dorsi muscle and characterized the involvement of m^(6)A epigenetic modification in the regulation of ADIPOQ mRNA on IMF deposition through an m^(6)A-YTHDF1-dependent manner. | Huanfa Gong Tao Gong Youhua Liu Yizhen Wang Xinxia Wang | 2023 | Journal of Animal Science and Biotechnology2023，14，3： | 0 |
| 7 | ActivityNET:Neural networks to predict public transport trip purposes from individual smart card data and POIs显示文摘Predicting trip purpose from comprehensive and continuous smart card data is beneficial for transport and city planners in investigating travel behaviors and urban mobility.Here,we propose a framework,ActivityNET,using Machine Learning(ML)algorithms to predict passengers’trip purpose from Smart Card(SC)data and Points-of-Interest(POIs)data.The feasibility of the framework is demonstrated in two phases.Phase I focuses on extracting activities from individuals’daily travel patterns from smart card data and combining them with POIs using the proposed“activity-POIs consolidation algorithm”.Phase II feeds the extracted features into an Artificial Neural Network(ANN)with multiple scenarios and predicts trip purpose under primary activities(home and work)and secondary activities(entertainment,eating,shopping,child drop-offs/pick-ups and part-time work)with high accuracy.As a case study,the proposed ActivityNET framework is applied in Greater London and illustrates a robust competence to predict trip purpose.The promising outcomes demonstrate that the cost-effective framework offers high predictive accuracy and valuable insights into transport planning. | Nilufer Sari Aslam Mohamed R.Ibrahim Tao Cheng Huanfa Chen Yang Zhang | 2021 | Geo-Spatial Information Science2021，24，4： | 0 |
| 8 | Mapping short tandem repeats for liver gene expression traits helps prioritize potential causal variants for complex traits in pigs显示文摘Background:Short tandem repeats(STRs)were recently found to have significant impacts on gene expression and diseases in humans,but their roles on gene expression and complex traits in pigs remain unexplored.This study investigates the effects of STRs on gene expression in liver tissues based on the whole-genome sequences and RNA-Seq data of a discovery cohort of 260 F6 individuals and a validation population of 296 F7 individuals from a heterogeneous population generated from crosses among eight pig breeds.Results:We identified 5203 and 5868 significantly expression STRs(eSTRs,FDR<1%)in the F6 and F7 populations,respectively,most of which could be reciprocally validated(π1=0.92).The eSTRs explained 27.5%of the cisheritability of gene expression traits on average.We further identified 235 and 298 fine-mapped STRs through the Bayesian fine-mapping approach in the F6 and F7 pigs,respectively,which were significantly enriched in intron,ATAC peak,compartment A and H3K4me3 regions.We identified 20 fine-mapped STRs located in 100 kb windows upstream and downstream of published complex trait-associated SNPs,which colocalized with epigenetic markers such as H3K27ac and ATAC peaks.These included eSTR of the CLPB,PGLS,PSMD6 and DHDH genes,which are linked with genome-wide association study(GWAS)SNPs for blood-related traits,leg conformation,growth-related traits,and meat quality traits,respectively.Conclusions:This study provides insights into the effects of STRs on gene expression traits.The identified eSTRs are valuable resources for prioritizing causal STRs for complex traits in pigs. | Zhongzi Wu Huanfa Gong Zhimin Zhou Tao Jiang Ziqi Lin Jing Li Shijun Xiao Bin Yang Lusheng Huang | 2022 | Journal of Animal Science and Biotechnology2022，13，3： | 0 |
| 9 | 高定之姿显示文摘从1858年第一家高级定制沙龙在巴黎开门迎客,到21世纪高定体系源源不断地吸纳新鲜血液,一百多年间,无论面对高潮还是低谷,也无论标准和门槛如何变化,高级定制所追求的核心无可匹敌的精湛手工技艺--始终不曾改变。 | 徐善来 ALEX HUANFA CHENG(摄影) | 2022 | 服饰与美容2022，，11： | 0 |
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