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| 1 | Determination of synthetic lethal interactions in KRAS oncogene-dependent cancer cells reveals novel therapeutic targeting strategies显示文摘在地岬基因的 Oncogenic 变化在人的癌症是很普通的,导致有描绘得好的选择优点,而且不太听说得好的危险的房间。我们执行了一幅大规模 loss-of-function 屏幕识别被转变 KRAS 的结肠癌房间,然而并非由缺乏这 oncogene 的衍生物要求的基因。最高得分的基因然后在 KRAS 变异、野类型的癌症房间的一块更大的面板被测试。表示 oncogenic KRAS 的癌症房间被发现高度依赖于抄写因素 GATA2 和 DNA 复制开始管理者 CDC6。与已知的目标用许多药扩大这分析,我们发现有变异的 KRAS 的癌症房间与 topoisomerase 抑制显示出选择嗜好到 proteasome 功能,以及合成致命性。联合指向引起的这些功能改善了相对野类型的房间 KRAS 变异的房间杀死。这些观察建议新奇目标和在地岬变异的癌症为最佳的效果联合存在治疗的新方法,它传统地被看作对治疗高度倔强。 | Michael Steckel Miriam Molina-Arcas Britta Weigelt Michaela Marani Patricia H Warne Hanna Kuznetsov Gavin Kelly Becky Saunders Michael Howell Julian Downward David C Hancock | 2012 | Cell Research2012，22，8： | 5 |
| 2 | Thrombolysis of stroke mimics via telestroke显示文摘Background The rate of intravenous tissue plasminogen activator(IVtPA)administered to stroke mimics(SM)occurs in 24%-44%of telestroke series.Methods We reviewed 270 suspected acute ischaemic stroke(AIS)patients who were evaluated by telestroke and received IVtPA from 1 July 2016 to 30 September 2017 at our academic comprehensive stroke centre.Results Among 270 AIS patients who received IVtPA via telestroke,64(23.7%)were diagnosed with SM.Compared with patients who had a stroke,the SM group was younger(mean age 56.4 vs 68.2,p<0.0001),more likely to be female(60.9%vs 45.6%,p=0.0324)and had longer door-to needle times(85.3 vs 69.9,p=0.0008).The most common SM diagnoses were migraine 26(40.6%),conversion disorder 12(18.8%),encephalopathy 7(10.9%)and unmasking(9.4%).Among the SM,migraine and conversion disorder were younger compared with the other subgroups(p<0.001).Functional exam elements were noted more frequently in conversion disorder(66.7%)and migraine(34.6%),but rare in other diagnoses(p=0.006).Among the SM,23(35.9%)had a history of a prior similar episodes,and 15(23.4%)had a history of more than 5 spells.Conclusions In our telestroke programme,23.7%of those administered thrombolysis had a final diagnosis of SM. | Vivien H Lee Ravyn Howell Randheer Yadav Sharon Heaton Karen L Wiles Sushil Lakhani | 2022 | Stroke & Vascular Neurology2022，7，3： | 2 |
| 3 | Symptom burden and performance status in a population-based cohort ofambulatory cancer patients显示文摘 | Barbera L Seow H Howell D | 2010 | Cancer2010，8，5： | 1 |
| 4 | Child/adolescent behavioral and enmotion alproblems: Implication of cross informant correlations for situational specificity 显示文摘 | Achenbach T M Mcconaughy S H Howell C T | 1987 | Psychological Bulletin1987，，101： | 1 |
| 5 | Ferric uptake regulator (Fur) mutants of Pseudomonas aeruginosa demonstrate defective siderophore-mediated iron uptake, altered aerobic growth, and decreased superoxide dismutase and catalase activities显示文摘 | Hassett D J Sokol P A Howell M L Ma J F Schweizer H T | 1996 | Journal of Bacteriology1996，178，14： | 1 |
| 6 | Air-to-air heat pumps operating under frosting conditions on the outdoor coil显示文摘 | Howell R H | 1986 | ASHRAE1986，92，82： | 1 |
| 7 | Genetic determinants of volatile-thiol release by Saccharomyces cerevisiae during wine fermentation 显示文摘 | Kate S Howell Mathias Klein Jan H Swiegers | 2005 | Appl Environ Microbiol2005，71，9： | 1 |
| 8 | Growth and mineral absorption by striped bass Monroe saratilis fed a plant feedstuff based diet supplemented with phytase 显示文摘 | Papatryphon E Howell R A Soares J H | 1999 | World Aquac Soc1999，30，： | 1 |
| 9 | Glucose-insulin-potassiumreduces the incidence of low cardiac output episodes after aorticvalve replacement for aortic stenosis in patients with left ventricularhypertrophy:results from the Hypertrophy,Insulin,Glucose,andElectrolytes(HINGE)trial显示文摘 | Howell NJ Ashrafian H Drury NE | 2011 | Circulation2011，123，2： | 1 |
| 10 | The synthe- sis of some new compounds related to apoeynin and apocynol显示文摘 | Howells H P Little B H Andersen H P | 1930 | J Am Chem Soc1930，52，10： | 1 |
| 11 | Energy use and heat recovery in water-loop heat pump, vaiable - air- volume, and reheat HVAC systems: part1 显示文摘 | J H Zaidi R H Howell | 1993 | ASHRAE Trans1993，，： | 1 |
| 12 | Students' perceptions of prosthodontics in a PBL hybrid curriculum 显示文摘 | Sukotjo C Thammasitboon K Howell H | 2008 | J Prosthodont2008，17，6： | 1 |
| 13 | Multi-laboratory validation of a standard method for quantifying proanthocyanidins in cranberry powders显示文摘 | Prior R L Fan E Ji H P Howell A Nio C Payne M J Reed J | 2010 | Journal of the Science of Food and Agriculture2010，90，9： | 1 |
| 14 | A study of amber and copal samples using FT-Ramanspeetroscopy显示文摘 | Rachel H Brody Howell G M Edwards | 2001 | Spectrochimica Acta Part A2001，，57： | 1 |
| 15 | An adaptive mesh projection method for viscous incompressible flow显示文摘 | Howell L H Bell J B | | 0，，04： | 1 |
| 16 | The nature of acicular in HSLA steelweld显示文摘 | Ricks H A Howell P R | 1982 | Journal of Materials Science1982，17，3： | 1 |
| 17 | Microscale abrasion-corrosion be- haviour of WC-Co hardmetals and HVOF sprayed coatings 显示文摘 | Shipway P H Howell L | 2005 | Wear2005，258，14： | 1 |
| 18 | Spatial and temporal variation of polyehlorinated biphenyls in the Houston Ship Channel 显示文摘 | Lakshmanan D Howell N L Rifai H S | 2010 | Chemosphere2010，80，： | 1 |
| 19 | Diagnostic utility of GLUT-1 expression in the cytologic evaluation of serous fluids显示文摘 | Afify A Zhou H Howell L | | 0，，06： | 1 |
| 20 | Cytokinins and shoot development显示文摘 | Howell S H Lall S Che P | 2003 | Trends in Plant Science2003，8，9： | 1 |
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