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766篇 您的检索式：作者名="Howell C"

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	题名	作者	年代	出处	被引量
1	Determination of synthetic lethal interactions in KRAS oncogene-dependent cancer cells reveals novel therapeutic targeting strategies显示文摘在地岬基因的 Oncogenic 变化在人的癌症是很普通的,导致有描绘得好的选择优点,而且不太听说得好的危险的房间。我们执行了一幅大规模 loss-of-function 屏幕识别被转变 KRAS 的结肠癌房间,然而并非由缺乏这 oncogene 的衍生物要求的基因。最高得分的基因然后在 KRAS 变异、野类型的癌症房间的一块更大的面板被测试。表示 oncogenic KRAS 的癌症房间被发现高度依赖于抄写因素 GATA2 和 DNA 复制开始管理者 CDC6。与已知的目标用许多药扩大这分析,我们发现有变异的 KRAS 的癌症房间与 topoisomerase 抑制显示出选择嗜好到 proteasome 功能,以及合成致命性。联合指向引起的这些功能改善了相对野类型的房间 KRAS 变异的房间杀死。这些观察建议新奇目标和在地岬变异的癌症为最佳的效果联合存在治疗的新方法,它传统地被看作对治疗高度倔强。	Michael Steckel Miriam Molina-Arcas Britta Weigelt Michaela Marani Patricia H Warne Hanna Kuznetsov Gavin Kelly Becky Saunders Michael Howell Julian Downward David C Hancock	2012	Cell Research2012，22，8：	5
2	Champions of Technological Innovation 显示文摘	Howell J M Higgins C A	1990	Administrative Science Quarterly1990，35，2：	1
3	Epidurdl buttor butorphamol does not reduce side effects from epidural morphine after cesarean birth 显示文摘	GAMBLING D R HOWELL P HUBER C	1994	Anesth Analg1994，78，6：	1
4	Periodic orbits in the restricted four-body problem显示文摘	Howell K C Spencer D B	1986	Acta Astronautica1986，13，8：	1
5	Agrobacterium species opportunistic, avirulent plant symbionts 显示文摘	Harman G E Howell C R Viterbo A Chet I	2004	Nature Reviews2004，2，：	1
6	显示文摘	Bellows DS Howell M Pearson C	2002	J Virol2002，76，5：	1
7	Cotton seeding preemergence damping-off incited by Rhizopus oryzae and Pythium spp and its biological control with Trichoderma spp显示文摘	Howell C R	2002	Phytopatholohy2002，92，：	1
8	Control of Rhizoctonia solani on cotton seedlings with Pseudomonasfluorescens and with an antibiotic produced by the bacterium 显示文摘	HOWELL C R STIPANOVIC R D	1979	Phytopathology1979，69，：	1
9	Foxa2 activity increases plasma high density lipoprotein levels by regulating apolipoprotein M 显示文摘	Wolfrum C Howell J J Ndungo E	2008	J Biol Chem2008，283，16：	1
10	Infectious diseases and the liver显示文摘	Talwani R Gilliam BL Howell C		0，，01：	1
11	Non-linear un- stable response of hanging chains 显示文摘	TRIANTAFYLLOU M S HOWELL C T	1993	Journal of Sound and Vibration1993，162，：	1
12	Empirically based as-sessment of the behavioral/ emotional problems of 2 and 3 year oldchildren显示文摘	Achenbach TM Edelbrock C Howell CT	1987	J Abnorm Child Psychol1987，15，4：	1
13	Child/adolescent behavioral and enmotion alproblems: Implication of cross informant correlations for situational specificity 显示文摘	Achenbach T M Mcconaughy S H Howell C T	1987	Psychological Bulletin1987，，101：	1
14	Application of dynamical systems theory to trajectory design for a libration point mission显示文摘	HOWELL K C BRADEN B T LO M W	1997	Journal of Astronautical Sciences1997，45，：	1
15	Air-to-air heat pumps operating under frosting conditions on the outdoor coil显示文摘	Howell R H	1986	ASHRAE1986，92，82：	1
16	Influence of vascular endothelial growth factor single nucleotide polymorphisms on tumour development in cutaneous malignant melanoma显示文摘	HOWELL W M BATEMAN A C TURNER S J	2002	Hums Immun2002，3，：	1
17	Trichoderma species-opportunistic, avirulent plant symbionts显示文摘	Harman G E Howell C R Viterbo A	2004	Nature Reviews Microbiology2004，2，1：	1
18	Numerical analysis of 2-D nonlinear cable e- quation with application to low tension problems 显示文摘	HOWELL C T	1992	Interna- tional Journal of Offshore and Polar Engineering1992，2，2：	1
19	A new type of heteropolyoxometalates formed from lacunary polyoxotungstate ions and europium or yttrium cations显示文摘	HOWELL R C PEREZ F G JAIN S		0，，：	1
20	The ill-posed problem of a cable in compression 显示文摘	TRIANTAFYLLOU M S HOWELL C W	1993	International Journal of Offshore and Polar Engineering1993，3，：	1

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