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| 1 | 代谢组学及其应用显示文摘对代谢组学的概念、特性、发展历史做了简要介绍 ,综述了当前代谢组学研究中的数据采集、数据分析中采用的技术 ,及代谢组学在疾病诊断、药物毒性研究、植物和微生物等领域的应用 ,并对代谢组学的发展作了展望。 | 杨军 宋硕林 Jose Castro Perez Robert S.Plumb 许国旺 | 2005 | 生物工程学报2005，21，1： | 51 |
| 2 | Bile-acid-induced cell injury and protection显示文摘Several studies have characterized the cellular and molecular mechanisms of hepatocyte injury caused by the retention of hydrophobic bile acids (BAs) in cholestatic diseases. BAs may disrupt cell membranes through their detergent action on lipid components and can promote the generation of reactive oxygen species that, in turn, oxidatively modify lipids, proteins, and nucleic acids, and eventually cause hepatocyte necrosis and apoptosis. Several pathways are involved in triggering hepatocyte apoptosis. Toxic BAs can activate hepatocyte death receptors directly and induce oxidative damage, thereby causing mitochondrial dysfunction, and induce endoplasmic reticulum stress. When these compounds are taken up and accumulate inside biliary cells, they can also cause apoptosis. Regarding extrahepatic tissues, the accumulation of BAs in the systemic circulation may contribute to endothelial injury in the kidney and lungs. In gastrointestinal cells, BAs may behave as cancer promoters through an indirect mechanism involvingoxidative stress and DNA damage, as well as acting as selection agents for apoptosis-resistant cells. The accumulation of BAs may have also deleterious effects on placental and fetal cells. However, other BAs, such as ursodeoxycholic acid, have been shown to modulate BA-induced injury in hepatocytes. The major beneficial effects of treatment with ursodeoxycholic acid are protection against cytotoxicity due to more toxic BAs; the stimulation of hepatobiliary secretion; antioxidant activity, due in part to an enhancement in glutathione levels; and the inhibition of liver cell apoptosis. Other natural BAs or their derivatives, such as cholyl-N- methylglycine or cholylsarcosine, have also aroused pharmacological interest owing to their protective properties. | Maria J Perez Oscar Briz | 2009 | World Journal of Gastroenterology2009，15，14： | 53 |
| 3 | 浙西北天然次生林群落物种多样性研究显示文摘对浙西北地区天然次生林群落植物物种多样性特征进行了研究,测定了群落植物生长型构成以及各层次植物物种的重要值,采用多种测度方法计算了群落各层次植物物种的丰富度指数、均匀度指数和多样性指数。结果表明:(1)浙西北地区天然次生林群落各层次优势种比较明显,乔木树种以青冈为主,灌木树种以柃木和木占优势,草本植物则以箬竹为主;(2)该地区天然次生林群落植物物种比较丰富,乔木树种种数最多,草本植物稀少;就各层次而言,草本层物种数最多,乔木层和灌木层比较接近,各层次的均匀度指数的趋势是灌木层最高,草本层最低,乔木层居中;以多种指标计算各层次物种多样性指数结果均显示,灌木层多样性指数最高,草本层最低,尽管草本层具有最高的丰富度;(3)封育时间长、人为干扰轻的地区具有较高的物种多样性指标以及数量指标,有利于生物多样性的保护。 | 周本智 傅懋毅 李正才 谢锦忠 Manuel Ruiz Perez Brian Belcher 杨校生 吴明 | 2005 | 林业科学研究2005，18，4： | 31 |
| 4 | 委内瑞拉1999年特大泥石流灾害显示文摘受娜尼拉现象的影响 ,1 999-1 2 -1 5~ 1 6委内瑞拉北部阿维拉山区加勒比海沿岸的 8个州连降特大暴雨 ,造成山体大面积滑塌 ,数十条沟谷同时暴发大规模的泥石流。泥石流造成 3万人死亡 ,经济损失高达1 0 0亿美元 ,成为本世纪最严重的泥石流灾害。这次泥石流灾害具有群发性、规模大、低频率和直接入海等特点 ,对这类泥石流进行泥石流成因、活动规律、预测预报、泥石流与异常气候现象关系和直接入海型泥石流运动规律、沉积特征。 | 韦方强 谢洪 Jose L.Lopez David Perez | 2000 | 山地学报2000，18，6： | 31 |
| 5 | Study of the production of Λ_b^0 band ~0 hadrons in pp collisions and first measurement of the Λ_b^0→J/ψpK^- branching fraction显示文摘The product of the A_b^0(B^0) differential production cross-section and the branching fraction of the decay A_b^0→J/ψpK^-(B^0→J/ψK~*(892)~0) is measured as a function of the beauty hadron transverse momentum,p_T,and rapidity,y.The kinematic region of the measurements is p_T <20 GeV/c and 2.0 | O.Kochebina M.Kolpin I.Komarov R.F.Koopman P.Koppenburg M.Kozeiha L.Kravchuk K.Kreplin M.Kreps G.Krocker P.Krokovny F.Kruse W.Krzemien W.Kucewicz M.Kucharczyk V.Kudryavtsev A.K.Kuonen K.Kurek T.Kvaratskheliya D.Lacarrere G.Lafferty A.Lai D.Lambert G.Lanffanchi C.Langenbruch B.Langhans T.Latham C.Lazzeroni R.Le Gac J.van Leerdam J.-P.Lees R.Lefevre A.Leflat J.Lefrancois E.Lemos Cid O.Leroy T.Lesiak B.Leverington Y.Li T.Likhomanenko M.Liles R.Lindner C.Linn F.Lionetto B.Liu X.Liu D.Loh I.Longstaff J.H.Lopes D.Lucchesi M.Lucio Martinez H.Luo A.Lupato E.Luppi O.Lupton A.Lusiani F.Machefert F.Maciuc O.Maev K.Maguire S.Malde A.Malinin G.Manca G.Mancinelli P.Manning A.Mapelli J.Maratas J.F.Marchand U.Marconi C.Marin Benito P.Marino J.Marks G.Martellottil M.Martin M.Martinelli D.Martinez Santos F.Martinez Vidal D.Martins Tostes A.Massafferri R.Matev A.Mathad Z.Mathe C.Matteuzzi A.Mauri B.Maurin A.Mazurov M.McCann J.McCarthy A.McNab R.McNulty B.Meadows F.Meier M.Meissner D.Melnychuk M.Merk E Michielin D.A.Milanes M.-N.Minard D.S.Mitzel J.Molina Rodrigue I.A.Monroy S.Monteil M.Morandin P.Morawski A.Morda M.J.Morello J.Moron A.B.Morris R.Mountain F.Muheim D.Miiller J.Muller K.Muller V.Muller M.Mussini B.Muster P.Naik T.Nakada R.Nandakumar A.Nandi I.Nasteva M.Needham N.Neri S.Neubert N.Neufeld M.Neuner A.D.Nguyen T.D.Nguyen C.Nguyen-Mau V.Niess R.Niet N.Nikitin T.Nikodem D.Ninci A.Novoselov D.P.O'Hanlon A.Oblakowska-Mucha V.Obraztsov S.Ogilvy O.Okhrimenko R.Oldeman C.J.G.Onderwater B.Osorio Rodrigues J.M.Otalora Goicochea A.Otto P.Owen A.Oyanguren A.Palano F.Palombo M.Palutan J.Panman A.Papanestis M.Pappagallo L.L.Pappalardo C.Pappenheimer C.Parkes G.Passaleva G.D.Patel M.Patel C.Patrignani A.Pearce A.Pellegrino G.Penso M.Pepe Altarelli S.Perazzini P.Perret L.Pescatore K.Petridis A.Petrolini M.Petruzzo E.Picatoste Olloqui B.Pietrzyk T:.Pilar D.Pinci A.Pistone A.Piucci S.Playfer M.Plo Casasus T.Poikela F.Polci A.Poluektov I.Polyakov E.Polycarpo A.Popov D.Popov B.Popovici C.Potterat E.Price J.D.Price J.Prisciandaro A.Pritchard C.Prouve V.Pugatch A.Puig Navarro G.Punzi W.Qian R.Quagliani B.Rachwal J.H.Rademacker M.Rama M.S.Rangel I.Raniuk N.Rauschmayr G.Raven F.Redi S.Reichert M.M.Reid A.C.dos Reis S.Ricciardi S.Richards M.Rihl K.Rinnert V.Rives Molina P.Robbe A.B.Rodrigues E.Rodrigues J.A.Rodriguez Lopez P.Rodriguez Perez S.Roiser V.Romanovsky A.Romero Vidalt J.W.R onayne M.Rotondo J.Rouvinet T.Ruf P.Ruiz Valls J.J.Saborido Silva N.Sagidova P.Sail B.Saitta V.Salustino Guimaraes C.Sanchez Mayordomo B.Sanmartin Sedes R.Santacesaria C.Santamarina Rios M.Santimaria E.Santovetti A.Sarti C.Satriano A.Satta D.M.Saunders D.Savrina M.Schiller H.Schindler M.Schlupp M.Schmelling T.Schmelzer B.Schmidt O.Schneider A.Schopper M.Schubiger M.-H.Schune R.Schwemmer B.Sciascia A.Sciubba A.Semennikov N.Serra J.Serrano L.Sestini P.Seyfert M.Shapkin I.Shapoval Y.Shcheglov T.Shears L.Shekhtman V.Shevchenko A.Shires B.G.Siddi R.Silva Coutinho L.Silva de Oliveira G.Simi M.Sirendi N.Skidmore T.Skwarnicki E.Smith E.Smith I.T.Smith J.Smith M.Smith H.Snoek M.D.Sokoloff F.J.P.Soler F.Soomro D.Souza B.Souza De Paula B.Spaan P.Spradlin S.Sridharan F.Stagni M.Stahl S.Stahl S.Stefkova O.Steinkamp O.Stenyakin S.Stevenson S.Stoica S.Stone B.Storaci S.Stracka M.Straticiuc U.Straumann L.Sun W.Sutcliffe K.Swientek S.Swientek V.Syropoulos M.Szczekowski P.Szczypka T.Szumlak S.T'Jampens A.Tayduganov T.Tekampe M.T eklishyn G.Teilarini F.Teubert C.Thomas E.Thomas J.van Tilburg V.Tisserand M.Tobin J.Todd S.Tolk L.Tomassetti D.Tonelli S.Topp-Joergensen N.Torr E.Tournefier S.Tourneur K.Trabelsi M.T.Tran M.Tresch A.Trisovic A.Tsaregorodtsev P.Tsopelas N.Tuning A.Ukleja A.Ustyuzhanin U.Uwer C.Vacca V.Vagnonit G.Valentit A.Vallier R.Vazquez Gomez P.Vazquez Regueiro C.Vazquez Sierra S.Vecchi J.J.Velthuis M.Veltri G.Veneziano M.Vesterinen B.Viaud D.Vieira M.Vieites Diaz X.Vitasis-Cardona V.Volkov A.Vollhardt D.Volyanskyy D.Voong A.Vorobyev V.Vorobyev C.Voβ J.A.de Vries R.Waldi C.Wallace R.Wallace J.Walsh S.Wandernoth J.Wang D.R.Ward N.K.Watson D.Websdale A.Weiden M.Whitehead G.Wilkinson M.Wilkinson M.Williams M.P.Williams T.Williams F.F.Wilson J.Wimberley J.Wishahi W.Wislicki M.Witek G.Wormser S.A.Wotton S.Wright K.Wyllie Y.Xie Z.Xu Z.Yang J.Yu X.Yuan O.Yushchenko M.Zangoli M.Zavertyaev L.Zhang Y.Zhang A.Zhelezov A.Zhokhov L.Zhong S.Zucchelli | 2016 | Chinese Physics C2016，40，1： | 23 |
| 6 | Surgical management of necrotizing pancreatitis:An overview显示文摘Necrotizing pancreatitis is an uncommon yet serious complication of acute pancreatitis with mortality rates reported up to 15%that reach 30%in case of infection.Traditionally open surgical debridement was the only tool in our disposal to manage this serious clinical entity.This approach is however associated with poor outcomes.Management has now shifted away from open surgical debridement to a more conservative management and minimally invasive approaches.Contemporary approach to patients with necrotizing pancreatitis and/or infectious pancreatitis is summarized in the 3Ds:Delay,Drain and Debride.Patients can be managed in the intensive care unit and any intervention should be delayed.Percutaneous drainage can be utilized first and early in the course of the disease,followed by endoscopic drainage or video assisted retroperitoneoscopic drainage if necrosectomy is deemed necessary.Open surgery is now less frequently performed and should be reserved for cases refractory to any other approach.The management of necrotizing pancreatitis therefore requires a multidisciplinary dynamic model of approach rather than being a surgical disease. | George Kokosis Alexander Perez Theodore N Pappas | 2014 | World Journal of Gastroenterology2014，20，43： | 16 |
| 7 | A review on synthesis of graphene,h-BN and MoS2 for energy storage applications:Recent progress and perspectives显示文摘The significance of graphene and its two-dimensional(2D)analogous inorganic layered materials especially as hexagonal boron nitride(h-BN)and molybdenum disulphide(MoS2)for“clean energy”applications became apparent over the last few years due to their extraordinary properties.In this review article we study the current progress and selected challenges in the syntheses of graphene,h-BN and MoS2 including energy storage applications as supercapacitors and batteries.Various substrates/catalysts(metals/insulator/semiconducting)have been used to obtain graphene,h-BN and MoS2 using different kinds of precursors.The most widespread methods for synthesis of graphene,h-BN and MoS2 layers are chemical vapor deposition(CVD),plasma-enhanced CVD,hydro/solvothermal methods,liquid phase exfoliation,physical methods etc.Current research has shown that graphene,h-BN and MoS2 layered materials modified with metal oxide can have an insightful influence on the performance of energy storage devices as supercapacitors and batteries.This review article also contains the discussion on the opportunities and perspectives of these materials(graphene,h-BN and MoS2)in the energy storage fields.We expect that this witen review article including recent research on energy storage will help in generating new insights for further development and practical applications of graphene,h-BN and MoS2 layers based materials. | Rajesh Kumar Sumanta Sahoo Ednan Joanni Rajesh Kumar Singh Ram Manohar Yadav Rajiv Kumar Verma Dinesh Pratap Singh Wai Kian Tan Angel Perez del Pino Stanislav A.Moshkalev Atsunori Matsuda | 2019 | Nano Research2019，12，11： | 12 |
| 8 | 不同栽培环境下有机与常规蔬菜土壤的细菌群落多样性差异显示文摘土壤细菌群落在蔬菜栽培中发挥着重要作用。基于DNA和RNA水平,利用PCR-DGGE技术研究了不同栽培环境下有机与常规蔬菜土壤细菌群落多样性差异,以及土壤理化性质与细菌群落多样性的关系。结果表明:不同栽培方式下土壤细菌多样性存在明显差异,土壤微生物的优势种群和数量受有机、常规栽培和季节影响,有机栽培较之常规栽培能够显著增加土壤细菌群落多样性;聚类分析表明,16S rDNA细菌群落多样性与季节相关,而16S rRNA细菌群落多样性与栽培方式相关;差异条带测序显示,大多细菌与不可培养细菌种属有较高同源性,其余9种推测属于假单胞菌属;CCA分析说明pH是影响土壤细菌群落多样性的主要因素,有机栽培土壤中微生物生物量C、N以及有机质含量显著高于常规栽培土壤。综上,有机栽培能够丰富活性细菌群落多样性,具有土壤优化效应。 | 叶俊 Pablo Gonzalez Perez 王小丽 黄丹枫 | 2012 | 农业环境科学学报2012，31，4： | 10 |
| 9 | The relevance of serum albumin among elderly patients with acute decompensated heart failure显示文摘Objective To assess the prognostic utility of serum albumin among elderly patients admitted for acute decompensated heart failure(ADHF)in terms of all-cause mortality and also to identify the predictors of hypoalbuminemia.Methods Retrospective cohort study of 119 elderly patients admitted for ADHF.Elderly patients were defined as patients over the age of 65 years.The patients were followed up for approximately 11 years.Patients with advanced renal failure,liver disease not due to HF,cancer and other causes of low life expectancy were excluded.Hypoalbuminemia was defined as serum albumin≤2.9 g/dL.Results The study was made up of 65 females and 54 males with age ranging from 65 to 96 years.Of the 119 elderly patients with ADHF,there were 26 deaths.A significantly higher proportion of patients in the mortality group had an admission serum albumin level of≤2.9 g/dL than those surviving(P=0.011).After Cox’s logistic regression,low albumin(P=0.016),elevated direct bilirubin(P=0.03),age greater than 85(P=0.008),lack of use of beta blockers(P=0.0001)and left ventricular ejection fraction less than 35%(P=0.005)increased the risk of death.Elevated serum creatinine(P=0.0357)was the only predictor of hypoalbuminemia following multiple linear regression.Conclusions Hypoalbuminemia may be an unrecognized marker of death in elderly patients with ADHF. | Tuoyo O Mene-Afejuku Ela-Anamaria Moisa Adedoyin Akinlonu Carissa Dumancas Shushan Veranyan Jose A Perez Peggy Salazar Shobhana Chaudhari Gerald Pekler Savi Mushiyev Ferdinand Visco | 2019 | Journal of Geriatric Cardiology2019，16，7： | 10 |
| 10 | Mechanical thrombectomy in patients with M1 occlusion and NIHSS score≤5:a single-centre experience显示文摘Background:The recent success of several mechanical thrombectomy trials has resulted in a significant change in management for patients presenting with stroke.However,it is still unclear how to manage patients that present with stroke and low National Institutes of Health Stroke Scale(NIHSS)≤5.We sought to review our experience of mechanical thrombectomy in patients with low NIHSS and confirmed M1 occlusion.Methods:We retrospectively analysed our prospectively maintained database of all patients undergoing mechanical thrombectomy between January 2008 and August 2016.We identified 41 patients with confirmed M1 occlusion and low NIHSS(≤5)on admission to our hospital.We collected demographic,radiological,procedural and outcome data.Results:The mean age of patients was 72±14,with 20 male patients.Associated medical conditions were common with hypertension seen in∼80%.Just over 50%presented with NIHSS 4 or 5.The average ASPECTS score on admission was 8.8(range 6–10),and the average clot length 10 mm.Angiographically Thrombolysis in Cerebral Infarction(TICI)≥2b was obtained in 87.8%of patients.7 patients had haemorrhage on follow-up,2 of which were symptomatic.Of 40 patients with 90-day follow-up,75%had modified Rankin Scale(mRS)score 0–2.There were 3 deaths at 90 days.Conclusions:Mechanical thrombectomy in patients with low NIHSS and proximal large vessel occlusion is technically possible and carries a high degree of success with good safety profile.Patients with low NIHSS and confirmed occlusion should be considered for mechanical thrombectomy. | P Bhogal P Bucke O Ganslandt H Bazner H Henkes M Aguilar Perez | 2016 | Stroke & Vascular Neurology2016，1，4： | 9 |
| 11 | 四价人乳头瘤病毒疫苗的效力和效果:10年真实世界研究的系统综述显示文摘预防性人乳头瘤病毒(HPV)疫苗接种计划是全球性的重要公共卫生措施。本文分析了四价HPV疫苗对HPV感染和相关疾病的全球影响。系统检索PubMed和Embase数据库2007年1月至2016年2月发表的四价HPV疫苗对感染、肛门生殖器疣、宫颈癌或癌前病变的效力或效果的观察性研究的报道。十年来,真实世界环境中HPV疫苗效果越来越明显,尤其在疫苗接种率较高国家中那些在HPV暴露发生之前接种的女孩。据报道,疫苗可使HPV6、11、16、18感染最多减少约90%,生殖器疣减少约90%,低度宫颈细胞学异常减少约45%,经组织学证实的高度宫颈异常减少约85%。但HPV疫苗接种计划的公共卫生潜力尚未完全实现,HPV相关疾病仍具有较高的发病率和死亡率,因此仍需要提高HPV疫苗接种计划的人群覆盖率。 | Suzanne M.Garland Susanne K.Kjaer Nubia Muoz Stan L.Block Darron R.Brown Mark J.DiNubile Brianna R.Lindsay Barbara J.Kuter Gonzalo Perez Geraldine Dominiak-Felden Alfred J.Saah Rosybel Drury Rituparna Das Christine Velicer 王华庆 | 2018 | 中国病毒病杂志2018，8，4： | 9 |
| 12 | 有机和常规生产模式下菜田土壤酶活性差异研究显示文摘通过对露地及温室环境下有机和常规蔬菜栽培土壤采样,测定分析了5种参与土壤碳氮循环的酶活性,及其与土壤相关理化性质之间的关系。结果显示:温室及露地土壤EC值在有机生产中相应低于常规生产12%和16%;有机生产土壤微生物碳氮含量显著高于常规生产;不同生产模式下土壤酶活性差异显著,有机生产土壤中的蛋白酶、脲酶、脱氢酶、β-葡糖苷酶活性高于常规生产,而硝酸还原酶活性较常规生产低;有机与常规栽培对蛋白酶活性影响极显著(P=0.006 8),对脲酶活性影响程度达显著水平(P=0.012 4)。除脱氢酶以外,不同栽培模式环境对土壤中另外4种酶活性均有显著影响,温室栽培环境中的蛋白酶、脲酶和硝酸还原酶活性高于露地。除硝酸还原酶外,其他4种酶活性与可溶性全氮、微生物碳、微生物氮相关系数达到显著水平。分析表明,土壤酶活性受到栽培方式以及环境的影响,并且有机生产能够提高参与土壤碳氮循环的酶活性。土壤蛋白酶、脲酶、脱氢酶和β-葡糖苷酶活性能够作为表征土壤碳氮循环以及微生物活性的指标。 | 叶俊 王小丽 Gonzalez Perez Pablo 刘晓嵩 黄丹枫 | 2012 | 中国生态农业学报2012，20，3： | 8 |
| 13 | Neuroprotective action of Ginkgo biloba on the enteric nervous system of diabetic rats显示文摘AIM: To investigate the effect of Ginkgo biloba extract on the enteric neurons in the small intestine of diabetic rats. METHODS: Fifteen Wistar rats were divided into three groups: control group (C), diabetic group (D) and diabetic-treated (DT) daily with EGb 761 extract (50 mg/kg body weight) for 120 d. The enteric neurons were identified by the myosin-V immunohistochemical technique. The neuronal density and the cell body area were also analyzed. RESULTS: There was a significant decrease in the neuronal population (myenteric plexus P = 0.0351; submucous plexus P = 0.0217) in both plexuses of the jejunum in group D when compared to group C. With regard to the ileum, there was a significant decrease (P = 0.0117) only in the myenteric plexus. The DT group showed preservation of the neuronal population in the jejunum submucous plexus and in the myenteric plexus in the ileum. The cell body area in group D increased significantly (P = 0.0001) in the myenteric plexus of both segments studied as well as in the ileum submucosal plexus, when compared to C. The treatment reduced (P = 0.0001) the cell body area of the submucosal neurons of both segments and the jejunum myenteric neurons. CONCLUSION: The purified Ginkgo biloba extract has a neuroprotective effect on the jejunum submucous plexus and the myenteric plexus of the ileum of diabetic rats. | Glasiella Gonzalez Perez da Silva Jacqueline Nelisis Zanoni Nilza Cristina Buttow | 2011 | World Journal of Gastroenterology2011，17，7： | 8 |
| 14 | 幕阜山森林群落结构与物种多样性研究显示文摘幕阜山地处中亚热带一北亚热带过渡地带,物种资源丰富。通过对其典型样地的调查,分别采用Shannon-Wiener指数、Simpson指数和Pielou均匀度指数作为测度指标,研究了幕阜山地区森林群落结构及其物种多样性特征。结果表明,该地区主要有21个森林群落类型。其中常绿阔叶林中,物种丰富度指数与多样性指数在群落梯度上的总体趋势均为灌木层相对高于乔木层,乔木层相对高于草本层;在落叶阔叶林中,其丰富度指数的趋势为灌木层〉草本层和乔木层,而在草本层与乔木层间是波动的,多样性指数的趋势为灌木层〉草本层〉乔木层;在针叶林中,物种丰富度、多样性指数表现的总趋势基本一致,即灌木层的丰富度相对较高,其次为草本层,乔木层的相对较小。在其他群落类型中,多样性指数、均匀度指数在乔木层、灌木层和草本层则表现出多样化的趋势;另外,从总体上看,各种指数在海拔梯度上并未表现出明显的规律性。 | 王刚 周本智 李正才 傅懋毅 杨校生 Manuel Ruiz Perez 黄展鹏 毛喜荣 | 2010 | 生态科学2010，29，4： | 8 |
| 15 | 迷走神经与肺部疾病(英文)显示文摘迷走神经支配人体的内脏器官,其传出纤维激活后可释放乙酰胆碱调节器官功能,而传入纤维能感知器官中机械和化学信号,并将其传入中枢,这种双向交流使得神经中枢能够反馈性调节器官功能。在呼吸系统中,迷走神经调节气道张力、血流供应、黏液分泌及呼吸型式。近来发现,迷走神经与免疫系统产生交互作用,在肺部疾病的发病机制中发挥重要作用,如哮喘、慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)、急性呼吸窘迫综合征(acute respirtory distress sydrome,ARDS)、肺纤维化和肺癌。在疾病状态下,多种细胞释放的细胞因子、化学因子和其他介质激活迷走神经,将免疫信息传到中枢,从而改变病程。激活迷走神经还可以释放神经肽调节免疫细胞的活动,并通过胆碱能抗炎通路控制肺部炎症,因此了解迷走神经在神经免疫反应中的作用对于肺部疾病的临床治疗有着重要意义。 | 宋娜娜 刘俊 Bogdan Moldoveanu Juan Guardiola Rafael Perez 於峻 | 2012 | 复旦学报(医学版)2012，39，2： | 8 |
| 16 | Effect of music on patients undergoing outpatient colonoscopy显示文摘AIM: To evaluate the effect of relaxing music during colonoscopy under low-dose conscious sedation, on patient satisfaction, scope insertion time and procedure duration, medication doses, and the perceived adequacy of sedation and scope insertion difficulty on the part of the endoscopist. METHODS: One hundred and sixty-seven consecutive adult outpatients presenting for routine colonoscopy under low-dose conscious sedation were randomized to undergo their procedures either with music played during the procedure or no music played. RESULTS: There were no statistical differences between the two groups in terms of meperidine dose, midazolam dose, time to reach the cecum, total procedure time, endoscopist assessment of scope insertion difficulty, endoscopist assessment of adequacy of sedation, or the pain experience of the patients during their procedure. The music group did report significantly better overall procedure satisfaction as compared to the non music group on two of our three different scales. CONCLUSION: While music does not result in shortened procedure times, lower doses of sedative medications or perceived patient pain, the patients who have music playing during their procedures report modestly greater satisfaction with their procedures. | Matthew L Bechtold Rodney A Perez Srinivas R Puli John B Marshall | 2006 | World Journal of Gastroenterology2006，12，45： | 8 |
| 17 | Functions of NKG2D in CD8^(+) T cells: an opportunity for immunotherapy显示文摘Natural killer group 2 member D(NKG2D)is a type II transmembrane receptor.NKG2D is present on NK cells in both mice and humans,whereas it is constitutively expressed on CD8+T cells in humans but only expressed upon T-cell activation in mice.NKG2D is a promiscuous receptor that recognizes stress-induced surface ligands.In NK cells,NKG2D signaling is sufficient to unleash the killing response;in CD8+T cells,this requires concurrent activation of the T-cell receptor(TCR).In this case,the function of NKG2D is to authenticate the recognition of a stressed target and enhance TCR signaling.CD28 has been established as an archetype provider of costimulation during T-cell priming.It has become apparent,however,that signals from other costimulatory receptors,such as NKG2D,are required for optimal T-cell function outside the priming phase.This review will focus on the similarities and differences between NKG2D and CD28;less well-described characteristics of NKG2D,such as the potential role of NKG2D in CD8+T-cell memory formation,cancer immunity and autoimmunity;and the opportunities for targeting NKG2D in immunotherapy. | Kushal Prajapati Cynthia Perez Lourdes Beatriz Plaza Rojas Brianna Burke Jose A Guevara-Patino | 2018 | Cellular & Molecular Immunology2018，15，5： | 7 |
| 18 | Application of artificial intelligence in the diagnosis and treatment of hepatocellular carcinoma: A review显示文摘Although artificial intelligence(AI)was initially developed many years ago,it has experienced spectacular advances over the last 10 years for application in the field of medicine,and is now used for diagnostic,therapeutic and prognostic purposes in almost all fields.Its application in the area of hepatology is especially relevant for the study of hepatocellular carcinoma(HCC),as this is a very common tumor,with particular radiological characteristics that allow its diagnosis without the need for a histological study.However,the interpretation and analysis of the resulting images is not always easy,in addition to which the images vary during the course of the disease,and prognosis and treatment response can be conditioned by multiple factors.The vast amount of data available lend themselves to study and analysis by AI in its various branches,such as deeplearning(DL)and machine learning(ML),which play a fundamental role in decision-making as well as overcoming the constraints involved in human evaluation.ML is a form of AI based on automated learning from a set of previously provided data and training in algorithms to organize and recognize patterns.DL is a more extensive form of learning that attempts to simulate the working of the human brain,using a lot more data and more complex algorithms.This review specifies the type of AI used by the various authors.However,welldesigned prospective studies are needed in order to avoid as far as possible any bias that may later affect the interpretability of the images and thereby limit the acceptance and application of these models in clinical practice.In addition,professionals now need to understand the true usefulness of these techniques,as well as their associated strengths and limitations. | Miguel Jimenez Perez Rocio Gonzalez Grande | 2020 | World Journal of Gastroenterology2020，26，37： | 7 |
| 19 | Is autoimmune hepatitis a frequent finding among HCV patients with intense interface hepatitis?显示文摘AIM:To evaluate the overlap of autoimmune hepatitis in hepatitis C virus(HCV)-infected patients with intense interface hepatitis.METHODS:Among 1759 patients with hepatitis C submitted to liver biopsy,92(5.2%) presented intense interface hepatitis.These patients were evaluated regarding the presence of antinuclear antibody(ANA),anti-smooth muscle antibody(SMA) and anti-liver/kidney microsomal antibody(LKM-1),levels of γ-globulin and histological findings related to autoimmune hepatitis(plasma cell infiltrate and presence of rosettes).RESULTS:Among patients with hepatitis C and intense interface hepatitis there was a low prevalence of autoantibodies(ANA=12%,SMA=5%,LKM-1=0%) and the median γ-globulin level was within the normal range.Typical histological findings of autoimmune disease were observed in only two cases(2%).After applying the score for diagnosis of autoimmune hepatitis,only one patient was classified with a definitive diagnosis of autoimmune hepatitis.Since overlap with autoimmune hepatitis was not the explanation for the intense necroinflammatory activity in patients with chronic hepatitis C we sought to identify the variables associated with this finding.The presence of intense interface hepatitis was associated with more advanced age,both at the time of infection and at the time of the biopsy,and higher prevalence of blood transfusion and alcohol abuse.CONCLUSION:Although possible,overlap with autoimmune hepatitis is a very rare association in HCV-infected patients with intense interface hepatitis,an unusual presentation which seems to be related to other host variables. | Rosilene G Badiani Vitória Becker Renata M Perez Carla AL Matos Lara B Lemos Valéria P Lanzoni Luis Eduardo C Andrade Alessandra Dellavance Antonio Eduardo B Silva Maria Lucia G Ferraz | 2010 | World Journal of Gastroenterology2010，16，29： | 7 |
| 20 | 胸腰段脊柱骨折定量影像学显示文摘描述影响胸腰段脊柱不同类型骨折,以及指导脊柱骨折治疗的不同分类及关键影响因素。目前脊柱骨折分类以Denis三柱模型为基石,包括压缩性骨折、爆裂性骨折、屈曲牵张骨折和骨折伴脱位。骨折分类系统包括胸腰椎损伤分类和严重程度评分(Thoracolumbar Injury Classification and Severity Score,TLICS)系统和AO脊柱胸腰椎损伤分类和严重程度评分(AOSpine-TLICS)。正确分类需要定量成像方法,采用多个测量指标来评定其属于不同TLICS或AOSpine-TLICS类型。如果TLICS评分>4或者AOSpine-TLICS评分>5,则患者需要手术治疗。本文重点描述X线片、CT及MRI影像表现和测量参数,包括爆裂性骨折患者中椎体楔形变成角和压缩性骨折椎体高度丢失百分比、椎弓根间距和腰椎管狭窄程度以及一些严重骨折(如屈曲牵张骨折、骨折伴脱位)患者的椎体位移和棘突间距增加。通过图解和影像案例展现这些影像学特征和相关参数。 | Fernando Ruiz Santiago Pablo Tomas Munoz Elena Moya Sanchez Marta Revelles Paniza Alberto Martinez Martinez Antonio Luis Perez Abela | 2017 | 临床与病理杂志2017，37，4： | 7 |
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