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| 1 | Overview of acidic deep eutectic solvents on synthesis,properties and applications显示文摘This review divides the acidic deep eutectic solvents(ADES) into Br?nsted and Lewis DES according to their diversity of acidic character.The hydrogen bond donors and halide salts for formulating an ADES are classified, the synthesis methods are described, and the physicochemical properties including freezing point, acidity, density, viscosity and conductivity are presented. Furthermore, the applications of Br?nsted acidic deep eutectic solvents(BADES) and Lewis acidic deep eutectic solvents(LADES) are overviewed, respectively, covering the fields in dissolution, extraction, organic reaction and metal electrodeposition. It is expected that the ADES has great potential to replace the pollutional mineral acid, expensive and unstable solid acid, and costly ionic liquid in many acid-employed chemical processes, thus meeting the demands of green chemistry. | Hao Qin Xutao Hu Jingwen Wang Hongye Cheng Lifang Chen Zhiwen Qi | 2020 | Green Energy & Environment2020，5，1： | 17 |
| 2 | Dosage effect of multiple genes accounts for multisystem disorder of myotonic dystrophy type 1显示文摘Multisystem manifestations in myotonic dystrophy type 1(DM1)may be due to dosage reduction in multiple genes induced by aberrant expansion of CTG repeats in DMPK,including DMPK,its neighboring genes(SIX5 or DMWD)and downstream MBNLh However,direct evidence is lacking.Here,we develop a new strategy to generate mice carrying multigene heterozygous mutations to mimic dosage reduction in one step by injection of haploid embryonic stem cells with mutant Dmpk,Six5 and Mbnll into oocytes.The triple heterozygous mutant mice exhibit adult-onset DM1 phenotypes.With the additional mutation in Dmwd,the quadruple heterozygous mutant mice recapitulate many major manifestations in congenital DM1.Moreover,muscle stem cells in both models display reduced sternness,providing a unique model for screening small molecules for treatment of DM1.Our results suggest that the complex symptoms of DM1 result from the reduced dosage of multiple genes. | Qi Yin Hongye Wang Na Li Yifu Ding Zhenfei Xie Lifang Jin Yan Li Qiong Wang Xinyi Liu Liuqing Xu Qing Li Yongjian Ma Yanbo Cheng Kai Wang Cuiqing Zhong Qian Yu Wei Tang Wanjin Chen Wenjun Yang Fan Zhang Chen Ding Lan Bao Bin Zhou Ping Hu Jinsong Li | 2020 | Cell Research2020，30，2： | 7 |
| 3 | Computer-aided ionic liquid design for alkane/cycloalkane extractive distillation process显示文摘A computer-aided ionic liquid design(CAILD) study is presented for the frequently encountered alkane/cycloalkane separations in petrochemical industry. Exhaustive experimental data are first collected to extend the UNIFAC-IL model for this system, where the proximity effect in alkanes and cycloalkanes is considered specifically by defining distinct groups. The thermodynamic performances of a large number of ILs for 4 different alkane/cycloalkane systems are then compared to select a representative example of such separations. By applying n-heptane/methylcyclohexane extractive distillation as a case study, the CAILD task is cast as a mixed-integer nonlinear programming(MINLP) problem based on the obtained task-specific UNIFAC-IL model and two semi-empirical models for IL physical properties. The top 5 IL candidates determined by solving the MINLP problem are subsequently introduced into Aspen Plus for process simulation and economic analysis, which finally identify 1-hexadecyl-methylpiperidinium tricyanomethane([C_(16)MPip][C(CN)_3]) as the best entrainer for this separation. | Zhen Song Xinxin Li He Chao Fan Mo Teng Zhou Hongye Cheng Lifang Chen Zhiwen Qi | 2019 | Green Energy & Environment2019，4，2： | 6 |
| 4 | Investigation of frost heave prevention using permeable subgrade structure显示文摘This paper set up a series of comprehensive targets based on the concept of 'anti-freeze filler', which include reasonable water retention rate, frost heave characteristics, and compaction characteristics of filling material. Then, a type of permeable graded gravel is proposed, suitable for high-speed railway subgrade. A series of in-door water retention, permeability, and frost heave tests were performed under different graded conditions. Water retention, permeability, and frost heave characteristic of different graded filling materials can be determined, in order to define the gradation range of permeable graded gravel. Relying on the frost-heave monitoring record of high speed railway in Northeast China, a series of experimental studies were performed, which included on-site filler production, compaction test, and the anti-frost effect test, in order to improve the production and compaction techniques of permeable graded gravel. From the research of this paper, the use of permeable graded gravel subgrade as the anti-frost structure for the high-speed railway subgrade in cold areas is feasible. | DeGou Cai JianPing Yao HongYe Yan QianLi Zhang AiJun Cheng Jie Liu | 2015 | Research in Cold and Arid Regions2015，7，5： | 3 |
| 5 | Effect of water on extractive desulfurization of fuel oils using ionic liquids: A COSMO-RS and experimental study显示文摘When evaluating ionic liquids(ILs) for extractive desulfurization(EDS) of fuel oils, the inevitable presence of water in the system may have a significant and in many cases strongly negative effect. However, few studies have considered this particular issue and a promoted water effect on EDS is scarcely reported. In this work,COSMO-RS was firstly employed to calculate the capacity and selectivity for EDS of various IL/H_2 O mixtures,which cover different IL characters and a wide water concentration range. Experiments were then conducted with a representative IL [C_4MIM][H_2PO_4], whose stable and even promoted extraction performance with a small amount of water was suggested by COSMO-RS. Through analyses of the desulfurization ratio, the crosssolubility and the water content in the desulfurized fuel, the promoted effect of water within a certain range(b 10 wt%) was experimentally demonstrated. Moreover, such effect of water was explained combining the viscosity, the solvent–solute interactions and the COSMO-RS based analysis. | Zhen Song Dian Yu Qian Zeng Jingjing Zhang Hongye Cheng Lifang Chen Zhiwen Qi | 2017 | Chinese Journal of Chemical Engineering2017，25，2： | 3 |
| 6 | Development of a bifurcation analysis approach based on gPROMS platform显示文摘A bifurcation analysis approach is developed based on the process simulator gPROMS platform, which can automatically trace a solution path, detect and pass the bifurcation points and check the stability of solutions. The arclength continuation algorithm is incorporated as a process entity in gPROMS to overcome the limit of turning points and get multiple solutions with respect to a user-defined parameter. The bifurcation points are detected through a bifurcation test function τ which is written in C ++ routine as a foreign object connected with gPROMS through Foreign Process Interface. The stability analysis is realized by evaluating eigenvalues of the Jacobian matrix of each steady state solution. Two reference cases of an adiabatic CSTR and a homogenous azeotropic distillation from literature are studied, which successfully validate the reliability of the proposed approach. Besides the multiple steady states and Hopf bifurcation points, a more complex homoclinic bifurcation behavior is found for the distillation case compared to literature. | Xueqing Kang Hongye Cheng Liwei Tong Lifang Chen Zhiwen Qi | 2016 | Chinese Journal of Chemical Engineering2016，24，12： | 1 |
| 7 | Dynamic landscape mapping of humoral immunity to SARS-CoY-2 identifies non-structural protein antibodies associated with the survival of critical COVID-19 patients显示文摘A comprehensive analysis of the humoral immune response to the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is essential in understanding COVID-19 pathogenesis and developing antibody-based diagnostics and therapy.In this work,we performed a longitudinal analysis of antibody responses to SARS-CoV-2 proteins in 104 serum samples from 49 critical COVID-19 patients using a peptide-based SARS-CoV-2 proteome microarray.Our data show that the binding epitopes of IgM and IgG antibodies differ across SARS-CoV-2 proteins and even within the same protein. | Linlin Cheng Xiaomei Zhang Yu Chen Dan Wang Dong Zhang Songxin Yan Hongye Wang Meng Xiao Te Liang Haolong Li Meng Xu Xin Hou jiayu Dai Xian Wu Mingyuan Li Minya Lu Dong Wu Ran Tian Jing Zhao Yan Zhang Wei Cao Jinglan Wang Xiaowei Yan Xiang Zhou Zhengyin Liu Yingchun Xu Fuchu He Yongzhe Li Xiaobo Yu Shuyang Zhang | 2021 | Signal Transduction and Targeted Therapy2021，6，9： | 1 |
| 8 | Application of an amphipathic molecule at the NiO_(x)/perovskite interface for improving the efficiency and long-term stability of the inverted perovskite solar cells显示文摘The presence of defects and detrimental reactions at NiO_(x)/perovskite interface extremely limit the efficiency performance and long-term stability of the perovskite solar cells(PSCs) based on NiO_(x).Herein,an amphipathic molecule Triton X100(Triton) is modified on the NiO_(x)surface.The hydrophilic chain of Triton as a Lewis base additive can coordinate with the Ni3+on the NiO_(x)surface which can passivate the interfacial defects and hinder the detrimental reactions at the NiO_(x)/perovskite interface.Additionally,the hydrophobic chain of Triton protrudes from the NiO_(x)surface to prevent moisture from penetrating into the NiO_(x)/perovskite interface.Consequently,the NiO_(x)/Triton-based devices(MAPbI3as absorbing layer) show superior moisture and thermal stability,retaining 88.4% and 64.3% of the initial power conversion efficiency after storage in air(40%-50% relative humidity(RH)) at 25 ℃ for 1070 h and in N2at 85℃ for 800 h,respectively.Moreover,the efficiency increases from 17.59% to 19.89% because of the passivation defect and enhanced hole-extraction capability.Besides,the NiO_(x)/Triton-based PSCs with Cs_(0.05)(MA_(0.15)FA_(0.85))_(0.95)Pb(I_(0.85)Br_(0.15))3perovskite as the light-absorbing layer also exhibits better moisture and thermal stability compared to the control devices,indicating the viability of our strategies.Of particular note,a champion PCE of 22.35% and 20.46% was achieved for small-area(0.1 cm^(2)) and large-area(1.2 cm^(2)) NiO_(x)/Triton-based devices,respectively. | Guibin Shen Hongye Dong Fan Yang Xin Ren Ng Xin Li Fen Lin Cheng Mu | 2023 | Journal of Energy Chemistry2023，，3： | 0 |
| 9 | Investigation of insulation layer dynamic characteristics for high-speed railway显示文摘Dynamic performance of insulation is one of the key parameters during the insulation application for high-speed railway subgrade. This paper conducted laboratory and field tests for the materials and dynamic load, especially for thermal performance, elastic deformation, and accumulated deformation of insulation materials. Experiment results show that mechanical properties of insulation layer structure are stable, which satisfies the requirements of the high speed railway. | HongYe Yan GuoTang Zhao DeGou Cai QianLi Zhang JianPing Yao AiJun Cheng | 2015 | Research in Cold and Arid Regions2015，7，4： | 0 |
| 10 | Proteome-wide epitope mapping identifies a resource of antibodies for SARS-CoV-2 detection and neutralization显示文摘Dear Editor,Since December 2019,the coronavirus disease 2019(COVID-19)caused by the severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)has become a worldwide pandemic.1 Significant efforts have been made to generate antibodies to help study COVID-19 pathogenesis,perform diagnostic testing,and develop treatment to neutralize SARS-CoV-2 activity.However,the specific sequence of amino acids recognized and bound by an antibody,the'epitope'is unknown for most antibodies.In this study,we developed a high-throughput epitope mapping platform using a peptide-based SARS-CoV-2 proteome microarray.2 to detect the binding epitopes of 57 commercial antibodies to ORFlab,nudeocapsid(N);spike(S),envelop(E),membrane(M),ORF3a,ORF6,ORF7a,and ORF8 proteins(Supplementary Table S1). | Te Liang Mengli Cheng Fei Teng Hongye Wang Yongqiang Deng Jiahui Zhang Chengfeng Qin Shubin Guo Hui Zhao Xiaobo Yu | 2021 | Signal Transduction and Targeted Therapy2021，6，5： | 0 |
| 11 | Reactive extraction for synthesizing long chain ester butyl hexanoate intensified by deep eutectic solvent显示文摘Butyl hexanoate(BuHE)is an important long-chain ester that is widely used in the food,beverage and cosmetic industries.In this work,reactive extraction concept was proposed to intensify the BuHE formation in a biphasic system,in which deep eutectic solvent(DES)comprising 2-methylimidazole(2-MIm)and p-toluenesulfonic acid(PTSA)was used as dual solvent-catalyst.First,the effect of 2-MIm to PTSA molar ratio on esterification was investigated to determine the optimum DES of[2-MIm:2PTSA],which was characterized by FT-IR and TGA.Then,the liquid–liquid equilibrium(LLE)and esterification experiments were carried out to confirm the extraction and catalytic effect of[2-MIm:2PTSA],respectively.Afterwards,the pseudo-homogeneous kinetic model was employed to describe the esterification kinetics.Finally,the intensification mechanism of reactive extraction for BuHE formation was proposed according to the experiments and interaction effect analysis. | Yishan Zhou Hao Qin Hongye Cheng Lifang Chen Bingjian Zhang Zhiwen Qi | 2021 | Chinese Journal of Chemical Engineering2021，34，8： | 0 |
| 12 | Efficient Knoevenagel condensation catalyzed by imidazole-based halogenfree deep eutectic solvent at room temperature显示文摘For the first time,we employed the halogen-free deep eutectic solvent(DES)into the Knoevenagel condensation between aromatic aldehydes and active methylene compounds at room temperature.The DESs[3Im:PTSA]and[4Im:PTSA]were prepared by imidazole(Im)and p-tol-uenesulfonic acid(PTSA),which were experimentally screened from a series of organic acids with imidazole.a,b-Unsaturated carbonyl compounds were obtained in good to excellent yields under solvent-free conditions with fast reaction rate.These two DESs can be reused for multiple times with no loss of catalytic activity. | Hao Qin Yishan Zhou Qian Zeng Hongye Cheng Lifang Chen Bingjian Zhang Zhiwen Qi | 2020 | Green Energy & Environment2020，5，2： | 0 |
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