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| 1 | Gut microbiota alterations are distinct for primary colorectal cancer and hepatocellular carcinoma显示文摘Colorectal cancer(CRC)and hepatocellular carcinoma(HCC)are the second and third most common causes of death by cancer,respectively.The etiologies of the two cancers are either infectious insult or due to chronic use of alcohol,smoking,diet,obesity and diabetes.Pathological changes in the composition of the gut microbiota that lead to intestinal inflammation are a common factor for both HCC and CRC.However,the gut microbiota of the cancer patient evolves with disease pathogenesis in unique ways that are affected by etiologies and environmental factors.In this review,we examine the changes that occur in the composition of the gut microbiota across the stages of the HCC and CRC.Based on the idea that the gut microbiota are an additional“lifeline”and contribute to the tumor microenvironment,we can observe from previously published literature how the microbiota can cause a shift in the balance from normal→inflammation→diminished inflammation from early to later disease stages.This pattern leads to the hypothesis that tumor survival depends on a less proinflammatory tumor microenvironment.The differences observed in the gut microbiota composition between different disease etiologies as well as between HCC and CRC suggest that the tumor microenvironment is unique for each case. | Wei Jia Cynthia Rajani Hongxi Xu Xiaojiao Zheng | 2021 | Protein & Cell2021，12，5： | 14 |
| 2 | Source of major anions and cations of snowpacks in Hailuogou No.1 glacier, Mt. Gongga and Baishui No.1 glacier, Mt. Yulong显示文摘积雪场样品是从二条冰河的 colleted:在 2006 年 6 月的 Baishui No.1 冰河和 Hailuogou No.1 冰河。海盐离子 tracer。 | LI Zongxing HE Yuanqing PANG Hongxi YANG Xiaomei JIA Wenxiong ZHANG Ningning WANG Xufeng NING Baoying YUAN Lingling SONG Bo | 2008 | Journal of Geographical Sciences2008，18，1： | 13 |
| 3 | Inhibitory effect of human telomerase antisense oligodeoxyribonucleotides on the growth of gastric cancer cell lines in variant tumor pathological subtype显示文摘AIM: To investigate the inhibitory effect of specialized human telomerase antisense oligodeoxyribonucleotides on the growth of well (MKN-28), moderately (SGC-7901)and poorly (MKN-45) differentiated gastric cancer cell lines under specific conditions and its inhibition mechanism,and to observe the correlation between the growth inhibition ratio and the tumor pathologic subtype of gastric cancer cells.METHODS: Telomerase activity in three gastric cancer cell lines of variant tumor pathologic subtype was determined by modified TRAP assay before and after the specialized human telomerase antisense oligodeoxyribonucleotides were dealt with under specific conditions. Effect of antisense oligomer under specific conditions of the growth and viability of gastric cancer cell lines was explored by using trypan blue dye exclusion assay, and cell apoptosis was detected by cell morphology observation, flow cytometry and TUNEL assay.RESULTS: Telomerase activity was detected in well,moderately and poorly differentiated gastric cancer cell lines (the quantification expression of telomerase activity was 43.7TPG, 56.5TPG, 76.7TPG, respectively).Telomerase activity was controlled to 30.2TPG, 36.3TPG and 35.2TPG for MKN-28, SGC-7901 and MKN-45 cell lines respectively after treatment with human telomerase antisense oligomers at the concentration of 5 μmol/L, and was entirely inhibited at 10 μmol/L, against the template region of telomerase RNA component, whereas no inhibition effect was detected in missense oligomers (P<0.05). After treatment with antisense oligomers at different concentrations under specific conditions for 96 h, significant growth inhibition effects were found in MKN-45 and SGC-7901gastric cancer cell lines (the inhibition ratio was 40.89%and 71.28%), but not in MKN-28 cell lines (15.86%). The ratio of inactive SGC-7901 cells increased according to the prolongation of treatment from 48 to 96 h. Missense oligomers could not lead to the same effect (P<0.05).Apoptosis of SGC-7901 and MKN-45 cells was detected not only by morphology and TUNEL assay but also by flow cytometry. The apoptotic rate reached 33.56% for SGC-7901 cells and 44.75% for MKN-45 cells.CONCLUSION: The viability and proliferation of gastric cancer cells can be inhibited by antisense telomerase oligomers. The growth inhibition of gastric cancer cells is correlated with concentration, time and sequence specialty of antisense oligomers. The inhibition mechanism of antisense human telomerase oligomers depends not only on the sequence specialty but also on the biological characteristics of gastric cancer cell lines. | JingYe Yun-LinWu ShuZhang ZiChen Li-XiaGuo Ruo-YuZhou HongXie | 2005 | World Journal of Gastroenterology2005，11，15： | 9 |
| 4 | Optimal Energy-Efficient Transmission for Hybrid Spectrum Sharing in Cooperative Cognitive Radio Networks显示文摘In order to improve the energy efficiency(EE)in cognitive radio(CR),this paper investigates the joint design of cooperative spectrum sensing time and the power control optimization problem for the secondary user systems to achieve the maximum energy efficiency in a cognitive network based on hybrid spectrum sharing,meanwhile considering the maximum transmit power,user quality of service(QoS)requirements,interference limitations,and primary user protection.The optimization of energy efficient sensing time and power allocation is formulated as a non-convex optimization problem.The Dinkelbach’s method is adopted to solve this problem and to transform the non-convex optimization problem in fractional form into an equivalent optimization problem in the form of subtraction.Then,an iterative power allocation algorithm is proposed to solve the optimization problem.The simulation results show the effectiveness of the proposed algorithms for energy-efficient resource allocation in the cognitive network. | Linna Hu Rui Shi Minghe Mao Zhiyu Chen Hongxi Zhou Weiliang Li | 2019 | China Communications2019，16，6： | 9 |
| 5 | Synoptic-scale variation of δ^(18)O in summer monsoon rainfall at Lijiang, China显示文摘Based on the daily δ^(18)O data in June―September 2003 at Lijiang and the daily mean NCEP/ NCAR reanalysis data, synoptic-scale variation of δ^(18)O in summer monsoon rainfall was investigated. The 'precipitation amount effect' is obvious for the daily δ^(18)O variation, whereas the 'temperature effect' is insignificant. Alternate occurrences of active phase and break phase of the southwest monsoon probably influence the synoptic-scale δ^(18)O variation prominently. Moreover, the isotopic composition in precipitation during the late monsoon months is presumably influenced significantly by recycling of monsoon precipitation. Both the above factors disturb the 'amount effect' of isotopic variation in the monsoon region. This study also indicates that the synoptic-scale rainfall δ^(18)O variation at Lijiang in summer is domi-nated by the Indian monsoon depression (low pressure) system at large scale. These results are important for further studying the 'amount effect' and reconstructing paleoclimate in the monsoon region. | PANG Hongxi HE Yuanqing LU Aigang ZHAO Jingdong NING Baoying YUAN Lingling SONG Bo | 2006 | Chinese Science Bulletin2006，51，23： | 9 |
| 6 | Effect of Landform on Seasonal Temperature Structures across China in the Past 52 Years显示文摘The data of 160 national meteorological observatory stations including the long-term monthly temperature data in China were analyzed to study the seasonal variation of the spatial temperature structures across China in the past half century. It is found that temperature structures differ between seasons: a latitude temperature pattern in winter and a landform temperature pattern in summer, which indicate that the effect of landform on temperature structure is much stronger in summer than that in winter and the effect of latitudinal temperature is much stronger in winter than that in summer. The mechanisms of the seasonal difference in temperature structures are also discussed in this paper. | LU Aigang PANG Deqian GE Jianping HE Yuanqing PANG Hongxi YUAN Lingling | 2006 | Journal of Mountain Science2006，3，2： | 7 |
| 7 | Preliminary results of the close-off depth and the stable isotopic records along a 109.91 m ice core from Dome A, Antarctica显示文摘A 109.91 m ice core was recovered from Dome A (or Dome Argus), the highest ice feature in Antarctica, during the 2004/05 austral summer by the 21st Chinese National Antarctic Research Expedition (CHINARE-21). Both methane profile along the core and firn densification model calculation suggest that the close-off depth is at about 102.0 m with an ice age about 4200 a. Stable isotopes (δ18O and δD) of the chips samples produced during each run of ice core drilling at Dome A, together with those of the other cores recovered from the eastern inland Antarctica, suggest a relative stable climate with a temperature fluctuation amplitude about ±0.6℃ at the eastern inland Antarctica during the late Holocene. The average d-excess (or d =δ D-8δ 18O) of 17.1‰ along the Dome A core is probably the highest among the Antarctic inland ice cores, which may be resulted from the kinetic fractionation during the snow formation under an oversaturation condition. Moreover, the increasing trend of d-excess during the late Holocene reflects mainly the migration of the water source area for precipitation at Dome A towards low latitudes. This paper presents the first results of a shallow ice core recovered from the unexplored highest area of the Antarctic ice sheet, providing a background for the proposing deep ice core drilling at Dome A. | HOU ShuGui LI YuanSheng XIAO CunDe PANG HongXi XU JianZhong | 2009 | Science China Earth Sciences2009，52，10： | 5 |
| 8 | Climatology of stable isotopes in Antarctic snow and ice:Current status and prospects显示文摘Stable isotopic composition in Antarctic snow and ice is commonly regarded as one of invaluable palaeoclimate proxies and plays a critically important role in reconstructing past climate change.In this paper we summarized the spatial distribution and the controlling factors of δD,δ18O,d-excess and 17O-excess in Antarctic snow and ice,and discussed their reliability and applicability as palaeoclimate proxies.Recent progress in the stable isotopic records from Antarctic deep ice cores was reviewed,and perspectives on bridging the current understanding gaps were suggested. | HOU ShuGui WANG YeTang PANG HongXi | 2013 | Chinese Science Bulletin2013，58，10： | 4 |
| 9 | CONSTRUCTIONS OF THREE-TRANSMIT-ANTENNA SPACE-TIME CODES显示文摘在这篇论文,我们为时空编码有合理参数的 three-transmit-antenna 给设计方法。一些例子被给证明与我们的方法构造的一些单一的时空代码比以前最著名的好。 | Hongxi TONG .Fei YU | 2007 | Journal of Systems Science & Complexity2007，20，3： | 3 |
| 10 | Origin of summer monsoon rainfall identified by δ^(18)O inprecipitation显示文摘A negative correlation between δ 18O in mon-soon precipitation and f, the ratio of precipitable water in monsoon region to that in water source area, is hypothesized. Using the Rayleigh model, a new method for identifying ori-gin of summer monsoon rainfall is developed based on the hypothesis. In order to validate the method, the isotopic data at New Delhi, a typical station in the southwest monsoon region, and Hong Kong, a typical station in the southeast monsoon region, were collected and analyzed for case studies. The case studies indicate that the water source areas of the monsoon rainfall at the two stations identified by the method are accordant with the general atmosphere circulation pat-terns. The method developed in this paper is significantly important for tracing the origin of summer monsoon pre-cipitation. | PANG Hongxi HE Yuanqing ZHANG Zhonglin LU Aigang GU Juan ZHAO Jingdong | 2005 | Chinese Science Bulletin2005，50，23： | 3 |
| 11 | Impact of Global Warming on Water Resource in Arid Area of Northwest China显示文摘As the unprecedented global warming is under way, the glacier retreat is getting more and more serious. In the inland arid area of Northwest China, due to very scarce precipitation, where there is water, there are oases. And the glacier melt water amounts to 22 % of the total direct supply of the inland river water and is of crucial importance to the survival and development of the oases. In this paper, using both the observed data and the previous research achievements of the glaciers in the inland valley of Northwest China where the oasis depending on the glacier is the only location suitable for human living, the authors describe the glacier retreat trend over the past half century, focusing on discussing the possible impact of the glacier retreat on the melt water runoff that is almost the only water resource efficient to nourish the oases. The authors find that even with increasing amount of water from the glacier with global warming, the water shortage is getting more and more serious and the environment is under a degrading way due to the accelerating economical development. The water shortage is bound to be more serious if the glacier retreat keeps on, especially after the glacier melt water is over its top for the degradedglacier scale. So suggestions are stressed in the end that a new water-saving pattern should be adopted in the area for a sustainable development due to the warming-up induced continuous glacier retreat. | LU Aigang DING Yongjian PANG Hongxi YUAN Lingling HE Yuanqing | 2005 | Journal of Mountain Science2005，2，4： | 3 |
| 12 | Toxicity of copper,lead,and cadmium on the motility of two marine microalgae Isochrysis galbana and Tetraselmis chui显示文摘Computer assisted movement tracking was used to characterize the motility of two marine microalgae,Isochrysis galbana and Tetraselmis chui,and to investigate the toxicity of Cu,Pb,and Cd on motile percentage,curvilinear velocity,average path velocity,straight line velocity,linearity,straightness,and wobble.Except for motile percentage,all other motility parameters differed significantly between I.galbana and T.chui.Based on relative motile percentage data,the median effective concentration (EC 50) of Cu on the motility of I.galbana and T.chui was 31.4 and 1.3 μmol/L,respectively,while for Pb it was 37.8 and 10.9 μmol/L and for Cd it was 121.6 and 37.8 μmol/L,respectively.Compared to I.galbana,T.chui was more sensitive to all tested metals.The toxic effect of the heavy metals on motility exhibited the following decreasing order for both species:Cu > Pb > Cd.Our results indicate that I.galbana and T.chui motility is sensitive to heavy metals and can be used as an indicator for toxicology bioassays. | Guangxu Liu Xueliang Chai Yanqing Shao Lihua Hu Qilang Xie Hongxi Wu | 2011 | Journal of Environmental Sciences2011，23，2： | 2 |
| 13 | Integration of high-performance spin-orbit torque MRAM devices by 200-mm-wafer manufacturing platform显示文摘We demonstrate in-plane field-free-switching spin-orbit torque(SOT)magnetic tunnel junction(MTJ)devices that are capable of low switching current density,fast speed,high reliability,and,most importantly,manufactured uniformly by the 200-mm-wafer platform.The performance of the devices is systematically studied,including their magnetic properties,switch-ing behaviors,endurance and data retention.The successful integration of SOT devices within the 200-mm-wafer manufactur-ing platform provides a feasible way to industrialize SOT MRAMs.It is expected to obtain excellent performance of the devices by further optimizing the MTJ film stacks and the corresponding fabrication processes in the future. | Hongchao Zhang Xiangyue Ma Chuanpeng Jiang Jialiang Yin Shuqin Lyu Shiyang Lu Xiantao Shang Bowen Man Cong Zhang Dandan Li Shuhui Li Wenjing Chen Hongxi Liu Gefei Wang Kaihua Cao Zhaohao Wang Weisheng Zhao | 2022 | Journal of Semiconductors2022，43，10： | 2 |
| 14 | Comparisons of stable isotopic fractionation in winter and summer at Baishui Glacier No.1,Mt.Yulong,China显示文摘Based on the data of δ18O in surface snow, snow pits, meltwater and the glacier-fed river water at Baishui Glacier No.1, Mt. Yulong, the isotopic fractionation behaviors in the typical monsoonal temperate glacier system in winter and summer were compared. The results indicate that the isotopic fractionation degree in summer is greater than that in winter, suggesting that the snow/ice melting is more intense in summer. Moreover, whenever it is in winter or summer, from surface snow to meltwater, and to glacier-fed river water, the gradient of δ18O with altitude gradually increases. This shows that the degree of isotopic fractionation gradually strengthens when surface snow is being converted into meltwater and finally into glacial river water, which suggests that the influence of post-depositional processes on δ18O gradient in the monsoonal temperate glacier region differs spatially. | PANG Hongxi HE Yuanqing LU Aigang ZHAO Jingdong NING Baoying YUAN Lingling SONG Bo ZHANG Ningning | 2006 | Journal of Geographical Sciences2006，16，3： | 2 |
| 15 | Nontoxic engineered virus nanofibers as an efficient agent for the prevention and detection of fungal infection显示文摘Candida albicans (C。albicans ) 感染让高死亡在 immunocompromised 病人评价。由于当前的诊断系统的无效和对 candidiasis 的准许的疫苗的缺席, C 的预防。albicans 感染仍然是挑战。C。albicans 感染能被藏匿反的 aspartyl 朊酶评估并且阻止 2 抗体(anti-Sap2 IgG ) 和 Hsp90 抗体(anti-Hsp90 IgG ) 。在这研究,为诊断和 C 的预防的改进探索一个新代理人。albicans 感染,设计 fd 抗菌素,被认为对人安全的病毒 nanofiber,与二被设计并且准备能导致并且捕获 anti-Sap2 IgG 和 anti-Hsp90 IgG 的 epitopes。双显示的噬菌体作为一根新奇俘获探针被采用开发一个新连接酶的 immunosorbent 试金( ELISA )方法,它显著地 recombinant 蛋白质 Sap2 在被用作涂层抗原捕获特定的抗体( rSap2-ELISA )的 ELISA 和 recombinant 蛋白质 Hsp90 在被用作涂层抗原捕获特定的抗体( rHsp90-ELISA )的 ELISA 与那些相比改进了察觉率。另外, nanofibers 充当了一支潜在的疫苗使老鼠,以及 recombinant 蛋白质免疫,更高效地调停了体液、细胞的有免疫力的回答, C 的减少的层次。albicans 殖民,并且在 C 增加了幸存率。感染 albicans 的老鼠。因此,双显示的 nanofiber 被显示了是为保护对的一个强大的 bifunctional 代理人的噬菌体和临床的感染的敏感察觉,它有潜力广泛地在生命科学,临床的药,和环境科学被过去常。 | Yicun Wang Hongxi Shi Shuai Dong Yan Li Meng Wang Yanyan Huai Xintong Zhang Xi Chen Chuanbin Mao Xiang Gao Li Wang | 2018 | Nano Research2018，11，4： | 2 |
| 16 | Metabolite profiling of plasma and urine from rats with TNBS‐induced acute colitis using UPLC‐ESI‐QTOF‐MS‐based metabonomics – a pilot study显示文摘 | Xiaojun Zhang Franky F. K. Choi Yan Zhou Feung P. Leung Shun Tan Shuhai Lin Hongxi Xu Wei Jia Joseph J. Y. Sung Zongwei Cai Zhaoxiang Bian | 2012 | FEBS Journal2012，，： | 2 |
| 17 | A construction of fully diverse unitary space-time codes显示文摘Fully diverse unitary space-time codes are useful in multiantenna communications, especially in multiantenna differential modulation. Recently, two constructions of parametric fully diverse unitary space-time codes for three antennas system have been introduced. We propose a new construction method based on the constructions. In the present paper, fully diverse codes for systems of odd prime number antennas are obtained from this construction. Space-time codes from present construction are found to have better error performance than many best known ones. | YU Fei TONG HongXi | 2009 | Science China Mathematics2009，52，10： | 2 |
| 18 | Changes of the hydrological cycle in two typical Chinese monsoonal temperate glacier basins,: A response to global warming?显示文摘学习反应到在瓷器适度的冰河区域水文学系统温暖是必要的以便提供为持续开发要求的信息。结果显示温暖的气候影响了水文学周期。当到融化的冰河区域题目增加了,脱离季节变得更长,到年度河分泌物的 meltwater 的贡献增加了。在更高的举起冰河的脱离的更早的发作导致了在一年更早发生的最小的分泌物的时期。季节的流量变化被雪和冰河统治融化,并且 meltwater 的增加在丽江盆和 Hailuogou 盆导致了年度水周期的变化。在冰川的区域的下游的区域的流量的增加振幅比降水的强壮得多,源于从在二盆的冰河区域的 meltwater 的突出的增加。在 glacierized 盆的继续的观察应该被承担以便监视变化,以揭示在气候,冰河,水文学和水供应之间的关系,并且在维持持续地区性的开发帮助。 | PANG Hongxi LI Zongxing Wilfred H. THEAKSTONE | 2012 | Journal of Geographical Sciences2012，22，5： | 1 |
| 19 | The origin of summer monsoon rainfall at New Delhi by deuteri excess显示文摘 | Pang Hongxi He Yuanqing Zhang Zhonglin | 2004 | Hydrology andEarth System Science2004，8，1： | 1 |
| 20 | Isolation and characterization of an anti - HSV polysaccharide from Prunella vulgaris显示文摘 | XU Hongxi Lee S H Lee S F | 1999 | Antiviral-Res1999，44，1： | 1 |
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