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| 1 | Metal Sealing Performance of Subsea X-tree Wellhead Connector Sealer显示文摘The metal sealing performance of subsea X-tree wellhead connectors is crucial for the safety and reliability of subsea X-trees. In order to establish the theoretical relation between metal sealing ring's contact stress and its structural parameters and working pressure, a mechanical analysis method for double-cone sealing of high pressure vessels is applied in analyzing the metal sealing ring under the condition of preload and operation. As a result, the formula of the unit sealing load for the metal sealing ring under operation with residual preload is shown in this paper, which ensures that the metal sealing ring has an excellent sealing effect and can prevent the metal sealing ring from yielding. Besides, while analyzing the sealing process of the metal sealing ring, the change rule of contact stress and working pressure is concluded here, putting forward that the structural parameters of the metal sealing ring are the major factors affecting the change rule. Finally, the analytical solution through theoretical analysis is compared with the simulation result through finite element analysis in a force feedback experiment, and both are consistent with each other, which fully verifies for the design and calculation theory on metal sealing ring's contact stress and its structural parameters and working pressure deduced in this paper. The proposed research will be treated as an applicable theory guiding the design of metal seal for subsea X-tree wellhead connectors. | ZHAO Honglin CHEN Rui LUO Xiaolan DUAN Menglan LU Yinghui FU Guowei TIAN Hongping YE Daohui | 2015 | Chinese Journal of Mechanical Engineering2015，28，3： | 9 |
| 2 | SNORD126 promotes HCC and CRC cell growth by activating the PI3K-AKT pathway through FGFR2显示文摘小核仁的 RNA (snoRNA ) 机能障碍与癌症开发被联系了。SNORD126 是在它的主机基因的 introns 5-6 以内被编码的孤儿 C/D 框 snoRNA, cyclin 交往 B1 蛋白质 1 (CCNB1IP1 ) 。SNORD126 触发的联系癌症的分子的机制充分没被理解。这里,我们证明 SNORD126 高度在 hepatocellular 癌(HCC ) 被表示, colorectal 癌症(CRC ) 病人取样。SNORD126 在裸体老鼠增加了 Huh-7 和 SW480 细胞生长和 tumorigenicity。SNORD126 击倒禁止的 HepG2 和 LS174T 房间生长。我们证实 SNORD126 没与 miRNA 活动被处理成小 RNA。而且, SNORD126 没在 HCC 样品与 CCNB1IP1 显示出重要表示关联或调整 CCNB1IP1 表示。我们的基因表示侧面分析显示了基因经常印射到 PI3K-AKT 小径的那 SNORD126-upregulated。SNORD126 overexpression 增加了 phosphorylated AKT, GSK-3,和 p70S6K 的层次并且提高了成纤维细胞生长因素受体 2 (FGFR2 ) 表示。在 SNORD126-overexpressing Huh-7 细胞的 FGFR2 的调停 siRNA 的击倒或调停 AZD4547 的 inactivation 禁止了 AKT phosphorylation 并且压制了细胞生长。这些调查结果在癌症为 SNORD126 显示一个 oncogenic 角色并且作为一个治疗学的目标建议它的潜力。 | Xianlong Fang Dongmei Yang Hongping Luo Shuai Wu Wenjie Dong Jing Xiao Sujing Yuan Aimin Ni Kang-Jian Zhang Xin-Yuan Liu Liang Chu | 2017 | Journal of Molecular Cell Biology2017，9，3： | 5 |
| 3 | Systematic Characterization of Long Non-Coding RNAs and Their Responses to Drought Stress in Dongxiang Wild Rice显示文摘Long non-coding RNAs(lncRNAs) play important roles in response to various biotic and abiotic stresses. So far, systematic identification and characterization of lncRNAs have been reported in a few model plant species and major crops, but their roles in abiotic stress response have not yet been reported in common wild rice(Oryza rufipogon). Dongxiang wild rice(DXWR) possesses a high degree of drought resistance and has been well recognized as a precious genetic resource for drought resistant rice breeding. We presented the reference catalog of 1 655 novel lncRNA transcripts in DXWR using strand-specific RNA sequencing and bioinformatics approaches. Meanwhile, a total of 1092 lncRNAs were determined as differentially expressed lncRNAs under drought stress. Quantitative real-time PCR results exhibited a high concordance with RNA sequencing data, which confirmed that the expression patterns of lncRNAs based on RNA sequencing were highly reliable. Furthermore, 8 711 transcripts were predicted as target genes of the differentially expressed lncRNAs. Functional annotation analysis based on Gene Ontology and Kyoto Encyclopedia of Genes and Genomes databases showed that the target genes were significantly enriched in cellular and metabolic processes, cell part, binding and plant hormone signal transduction, as well as many other terms related to abiotic stress resistance. These results expanded our understanding of lncRNA biology and provided candidate regulators for genetic improvement of drought resistance in rice cultivars. | QI Weidong CHEN Hongping YANG Zuozhen HU Biaolin LUO Xiangdong AI Bing LUO Yuan HUANG Yu XIE Jiankun ZHANG Fantao | 2020 | Rice science2020，27，1： | 3 |
| 4 | Identification and Characterization of Drought Stress-Responsive Novel microRNAs in Dongxiang Wild Rice显示文摘MicroRNAs(miRNAs) are non-coding small RNAs, which play important regulatory roles in response to biotic and abiotic stresses. Dongxiang wild rice(Oryza rufipogon, DXWR) can survive in extreme drought environment, but its molecular mechanism of drought resistance is still largely unknown. To further explore miRNA regulatory mechanisms involved in drought resistance, we identified 138 novel miRNAs in DXWR using small RNA sequencing and bioinformatics approaches, and found that the expression levels of 67 novel miRNAs were significantly affected by drought stress. In total, 200 candidate target genes were predicted and annotated for the drought stress-responsive novel miRNAs. Gene Ontology(GO) analysis and Kyoto Encyclopedia of Genes and Genomes(KEGG) pathways suggested that most of the target genes were related to metabolism. Stem-loop quantitative real-time PCR(qRT-PCR) results exhibited high concordance with sequencing data, which confirmed that miRNA expression patterns based on small RNA sequencing in the present study were reliable. Meanwhile, qRT-PCR validated the inverse expression patterns between several miRNAs and their target genes. These results will enhance our understanding of miRNA regulatory mechanisms in response to drought stress in DXWR, and can serve as an important reference for the protection and utilization of this valuable genetic resource. | ZHANG Fantao LUO Yuan ZHANG Meng ZHOU Yi CHEN Hongping HU Biaolin XIE Jiankun | 2018 | Rice science2018，25，4： | 3 |
| 5 | Surgical treatment of hepato-pancreato-biliary disease in China:the Tongji experience显示文摘Hepato-pancreato-biliary(HPB) tumors are common in China. However, these tumors are often diagnosed at intermediate/advanced stages because of the lack of a systemic surveillance program in China. This situation creates many technical challenges for surgeons and increases the incidence of postoperative complications. Therefore, Dr. Xiao-Ping Chen has made many important technical improvements, such as Chen's hepatic portal occlusion method, the anterior approach for liver resection of large HCC tumors, the modified technique of Belghiti's liver-hanging maneuver, inserting biliary-enteric anastomosis technique, and invaginated pancreaticojujunostomy with transpancreatic U-sutures. These techniques are simple, practical, and easy to learn. Owing to these advantages, complicated surgical procedures can be simplified, and the curative effects are greatly improved. These improved techniques have been widely applied in China and will benefit many additional patients. In this review, we introduce our experience of surgically treating intermediate/advanced hepatocellular carcinoma(HCC), hilar cholangiocarcinoma(HC), and pancreatic carcinoma, mainly focusing on technical innovations established by Dr. Chen in HPB surgery. | binhao zhang wei dong hongping luo xuanru zhu lin chen changhai li wei zhang shuai xiang wanguang zhang zhiyong huang xiao-ping chen | 2016 | Science China(Life Sciences)2016，59，10： | 2 |
| 6 | Statistical damage detection method for frame structures using a confidence interval显示文摘A novel damage detection method is applied to a 3-story frame structure,to obtain statistical quantification control criterion of the existence,location and identification of damage.The mean,standard deviation,and exponentially weighted moving average(EWMA) are applied to detect damage information according to statistical process control(SPC) theory.It is concluded that the detection is insignificant with the mean and EWMA because the structural response is not independent and is not a normal distribution.On the other hand,the damage information is detected well with the standard deviation because the influence of the data distribution is not pronounced with this parameter.A suitable moderate confidence level is explored for more significant damage location and quantification detection,and the impact of noise is investigated to illustrate the robustness of the method. | Li Weiming,Zhu Hongping~(++),Luo Hanbin~(++) and Xia Yong~(++) School of Civil Engineering and Mechanics,Huazhong University of Science and Technology,Wuhan 430074,China ~+PhD Candidate ++ Professor | 2010 | Earthquake Engineering and Engineering Vibration2010，9，1： | 2 |
| 7 | Numerical analysis of asphalt pavements under moving wheel loads 显示文摘 | Luo Hui Zhu Hongping Hao Xingzhou | 2006 | Journal of China Univeristy of Geosciences2006，17，4： | 1 |
| 8 | Numerical analysis of asphalt pavements under mo-ving wheel loads 显示文摘 | Luo Hui Zhu Hongping Hao Xingzhou | 2006 | Journal of China Univeristy of Geoscienees2006，17，4： | 1 |
| 9 | Preoperative total cholesterol predicts postoperative outcomes after partial hepatectomy in patients with chronic hepatitis B- or C-related hepatocellular carcinoma显示文摘 | Qi Wang W.Y. Lau Bixiang Zhang Zhiwei Zhang Zhiyong Huang Hongping Luo Xiaoping Chen | 2013 | Surgery2013，，： | 1 |
| 10 | Numerical analysis of asphalt pavements under moving wheel loads 显示文摘 | Luo Hui Zhu Hongping Hao Xingzhou | 2006 | Journal of China Univeristy of Geosciences2006，17，4： | 1 |
| 11 | The immunomodulatory effect of bone marrow stromal cells (BMSCs) on interleukin (IL)-23/IL-17-mediated ischemic stroke in mice显示文摘 | Shuainan Ma Di Zhong Hongping Chen Yi Zheng Yanyan Sun Jian Luo Hulun Li Guozhong Li Yanhong Yin | 2013 | Journal of Neuroimmunology . 2013 (1-2)2013，，1： | 1 |
| 12 | Biogas residue biochar integrated with phosphate from its ash for the effective recovery of nutrients from piggery biogas slurry显示文摘Magnesium ammonium phosphate(MAP)precipitation generally requires an external phosphorus source to increase the recovery of NH_(4)^(+)-N from biogas slurry.However,P-rich piggery biogas residue has been ignored as a phosphorus source.In this study,biogas residue was carbonized into biogas residue biochar(BRC),followed by acid leaching to synthesize functionalized BRC and release PO_(4)^(3−)-P from its ash as the phosphorus source.The effects of different acids on the leaching efficiency and morphological changes of P in BRC were investigated,and NH_(4)^(+)-N and PO_(4)^(3−)-P in the biogas slurry were recovered with functionalized BRC and MAP precipitation.The results showed that oxalic acid-hydrochloric acid mixed acid could leach more than 96%of P in BRC,while weakening the inhibitory effect of Ca^(2+)on MAP precipitation.The BRC was mainly composed of inorganic P,and most nonapatite IP and apatite P(Ca_(3)(PO_(4))2)were leached during acid leaching,with the latter more easily leached.Under optimal recovery conditions,the method had a significant recovery effect on NH_(4)^(+)-N(96.4%)and PO_(4)^(3−)-P(99.3%)in biogas slurry.The recovery of NH_(4)^(+)-N and PO_(4)^(3−)-P by functionalized BRC was mainly through chemical precipitation(forming NH_(4)MgPO_(4)·H_(2)O precipitate)while bonding with-OH,C=O and C-H functional groups.The final recovery product was also a BRC-based slow-release N-P fertilizer rich in struvite.This study solved the disposal problems of P-rich biogas residue and N-rich biogas slurry while providing an innovative technology for the resource utilization of faecal sewage at pig farms. | Zifeng Luo Hongping Wen Haotian Zhang Yunliang Li Xueyi Mai Yulong Zhang Jinjin Wang Yongtao Li Zhen Zhang | 2022 | Biochar2022，4，1： | 1 |
| 13 | Three new indole alkaloids from the leaves of Alstonia scholaris 显示文摘 | Zhou Hua He Hongping Luo Xiaodong | 2005 | Helv Chim Ac- ta2005，88，9： | 1 |
| 14 | Bedding-parallel fractures in ultradeep tight sandstone reservoirs in Jurassic and Cretaceous of Yongjin Oil Field,Junggar Basin,China显示文摘Bedding-parallel fractures are fractures that are parallel to rock bedding structure planes and have been widely accepted as a key factor for oil and gas production in tight sandstone and shale reservoirs.However,the formation mechanisms of these parallel-bedding fractures are still under debate.In this study,bedding-parallel fractures in Yongjin Oil Field were analyzed using methods including core and microscopic observations,element geochemistry,and carbon and oxygen isotope analysis.Their origin and relations to reservoir quality,faults,and rock mechanical properties were examined.The discovery of bedding-parallel fractures in both the Upper Jurassic and Lower Cretaceous formations indicates that the BPFs are generated later than the early Cretaceous.The filling state of bedding-parallel fractures that with no bitumen and carbonate cement indicate that they formed after oil charging and carbonate cementation.The tensile fracture characteristics in core and thin section observa-tions,and the fact that overburden stress exceeds the pore pressure indicate that the bedding-parallel fractures were neither generated from tectonic compression nor over-pressure.The most likely generation mechanism is stress relief during core drilling under high in situ stress conditions.High in situ stress and low tensile strength lead to thinner fracture spacing.The existence of high bedding-parallel fracture density is an indicator of good reservoir quality and result in high oil/gas production. | Hongping LIU Changmin ZHANG Li ZHANG Yang LUO | 2022 | Frontiers of Earth Science2022，16，4： | 0 |
| 15 | Engineering Dual Oxygen Simultaneously Modified Boron Nitride for Boosting Adsorptive Desulfurization of Fuel显示文摘Oxygen atoms usually co-exist in the lattice of hexagonal boron nitride(h-BN). The understanding of interactions between the oxygen atoms and the adsorbate, however, is still ambiguous on improving adsorptive desulfurization performance. Herein, simultaneously oxygen atom-scale interior substitution and edge hydroxylation in BN structure were constructed via a polymer-based synthetic strategy.Experimental results indicated that the dual oxygen modified BN(BN–2O) exhibited an impressively increased adsorptive capacity about 12% higher than that of the edge hydroxylated BN(BN–OH) fabricated via a traditional method. The dibenzothiophene(DBT) was investigated to undergo multimolecular layer type coverage on the BN–2O uneven surface via π–π interaction, which was enhanced by the increased oxygen doping at the edges of BN–2O. The density functional theory calculations also unveiled that the oxygen atoms confined in BN interior structure could polarize the adsorbate, thereby resulting in a dipole interaction between the adsorbate and BN–2O. This effect endowed BN–2O with the ability to selectively adsorb DBT from the aromatic-rich fuel, thereafter leading to an impressive prospect for the adsorptive desulfurization performance of the fuel. The adsorptive result was in good accordance with Freundlich and pseudo-second-order adsorption kinetics model results. Therefore, the designing of a polymer-based strategy could be also extended to other heteroatom doping systems to enhance adsorptive performance. | Jing Luo Yanchen Wei Yanhong Chao Chao Wang Hongping Li Jun Xiong Mingqing Hua Huaming Li Wenshuai Zhu | 2022 | Engineering2022，8，7： | 0 |
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