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| 1 | Lentiviral-mediated gene transfer into human adipose-derived stem cells:role of NELL1 versus BMP2 in osteogenesis and adipogenesis in vitro显示文摘(NELL1 ) 象 NEL 一样分子 1 是与 craniosynostosis 联系的一个有势力 osteogenic 因素。侵入人体气管粘膜的病菌,大多数通常为基因治疗使用了病毒的向量,有可以限制成骨的几劣势。以前的研究证明了 lentiviruses 能为骨头新生为基因治疗用作理想的向量。在这研究,编码人的 NELL1 和骨头的二 lentiviral 向量(LvNELL1 和 LvBMP2 ) 分别地,形态基因的 protein-2 (BMP2 ) 被构造。在 vitro 的人的脂肪质导出干细胞(hADSCs ) 的增长,成骨,和 adipogenesis 上的 LvNELL1 感染的效果被估计并且与 LvBMP2 的相比。结果显示出感染 LvNELL1 的那 hADSCs 能高效地并且稳定地 overexpress 目标基因。3-(4,5-dimethylthiazol-2-yl )-2,5-diphenyltetrazolium 溴化物试金结果表明了那 LvBMP2,然而并非 LvNELL1,提高了 hADSCs 的增长。对碱的磷酸酶活动和细胞的矿化作用的评价显示 LvNELL1 感染支持了 hADSCs 的 osteogenic 区别,并且效果与 LvBMP2 的是可比较的。实时聚合酶链反应(PCR ) 在 hADSCs 揭示了那 LvNELL1 感染 upregulated OSX 表情然而并非 RUNX2 表示。另外,分析显示出的 adipogenic 标记(类脂化合物微滴, peroxisome 激活 proliferator 受体,和脂蛋白脂肪分解酵素) LvNELL1 能戏剧性地禁止 hADSCs,而是 LvBMP2 的 adipogenic 区别,这没有如此的效果。一起拿,这些调查结果建议在 hADSCs 的调停 lentiviral 的 NELL1 基因转移可以是一条新奇、有希望的途径完成有效、精确的骨头新生。 | Yajing Liu Caiyun Chen Huixia He Dongsheng Wang LingLing E Zhongyu Liu Hongchen Liu | 2012 | Acta Biochimica et Biophysica Sinica2012，44，10： | 10 |
| 2 | Simple model of sludge thickening process in secondary settlers显示文摘在废水处理植物(WWTP ) ,一个第二等的定居者充当 clarifier,污泥 thickener,和污泥存储坦克在期间山峰流动因此在激活的污泥进程的性能起一个重要作用。变厚的污泥在他们的操作期间发生在第二等的 clarifiers 的更低的部分。在这研究,由从激活的污泥的完全的变厚过程检测妨碍的地区,为污泥的一个简单模型变厚的速度, u s =斧子 b (= 0.9925SSVI 3.5, b = 3.541ln (描述在妨碍的地区变厚的激活的污泥的潜力和表演的 SSVI 3.5)+12.973),被开发。然而,因为在压缩地区的污泥显示出有限变厚,在压缩地区变厚的污泥没被学习。这个实验模型用解决从四 WWTP 获得并且从第五 WWTP 用测量数据验证了更好学习污泥变厚的数据的批被开发。探索不同污泥安定和变厚的机制,污泥变厚和污泥安定的曲线被比较。最后,包括温度,激动人心的、起始的深度,和聚合物调节的几个因素能在一个生物学的反应堆导致高度集中的回来污泥和生物资源,这被发现。 | Yuankai ZHANG Hongchen WANG Lu QI Guohua LIU Zhijiang HE Songzhu JIANG | 2016 | Frontiers of Environmental Science & Engineering2016，10，2： | 3 |
| 3 | Development and validation of a questionnaire-based risk scoring system to identify individuals at high risk for gastric cancer in Chinese populations显示文摘Objective:This study aimed to develop and validate a risk scoring system to identify high-risk individuals carrying malignant lesions in stomach for tailored gastric cancer screening.Methods:A gastric cancer risk scoring system(GC-RSS)was developed based on questionnaire-based predictors for gastric cancer derived from systematic literature review.To assess the capability of this system for discrimination,risk scores for 8,214 and 7,235 outpatient subjects accepting endoscopic examination in two endoscopy centers,and 32,630 participants in a community-based cohort in China were calculated to plot receiver operating characteristic curves and generate area under the curve(AUC).To evaluate the performance of GC-RSS,the screening proportion,sensitivity and detection rate ratio compared to universal screening were used under different risk score cutoff values.Results:GC-RSS comprised nine predictors including advanced age,male gender,low body mass index(<18.5 kg/m^(2)),family history of gastric cancer,cigarette smoking,consumption of alcohol,preference for salty food,irregularity of meals and consumption of preserved food.This tool performed well in determining the risk of malignant gastric lesions with AUCs of 0.763,0.706 and 0.696 in three validation sets.When subjects with risk scores≥5 were evaluated with endoscopy,nearly 50%of these endoscopies could be saved with a detection rate of over 1.5 times achieved.When the cutoff was set at 8,only about 10%of subjects with the highest risk would be offered endoscopy,and detection rates for gastric cancer could be increased 2-4 fold compared to universal screening.Conclusions:An effective questionnaire-based GC-RSS was developed and validated.This tool may play an important role in establishing a tailored screening strategy for gastric cancer in China. | Ren Zhou Hongchen Zheng Mengfei Liu Zhen Liu Chuanhai Guo Hongrui Tian Fangfang Liu Ying Liu Yaqi Pan Huanyu Chen Zhe Hu Hong Cai Zhonghu He Yang Ke | 2021 | Chinese Journal of Cancer Research2021，33，6： | 3 |
| 4 | Applications of hollow nanomaterials in environmental remediation and monitoring: A review显示文摘因为他们的高化学、热的稳定性,高特定的表面区域,高孔,低密度,和好 biocompatibility,空 nanomaterials 吸引了重要注意。这些最先进的 nanomaterials 被显示了高效地吸附重金属,和不稳定的危险物质, photodegrade 坚持的器官的污染物质,和另外的混合物,并且使细菌失去活性。如此的性质为环境补习启用了这些材料的使用,例如在水 / 废水处理,土壤补习,空气纯化,并且物质监视等等。没有空结构,空 nanomaterials 由于他们的高活跃的表面区域比那些显示出更高的 photocatalytic 活动,减少了散开抵抗,并且改进了可接近性。并且,做的方法能在可见的光下面进一步改进空 nanomaterials 的 photocatalytic 表演。而且,因为他们的尺寸和形态学帮助决定他们的精确性质,这些材料的合成机制和方法是重要的。这篇文章考察环境应用和这些材料的潜在的风险,除了他们的综合体。最后,进这些材料的发展的眼界被提供。 | Yuankai ZHANG Zhijiang HE Hongchen WANG Lu QI Guohua LIU Xiaojun ZHANG | 2015 | Frontiers of Environmental Science & Engineering2015，9，5： | 2 |
| 5 | The AIDER system and its clinical applications显示文摘Spinal cord injury(SCI)significantly affects thousands of individuals every year.SCI is due to various pathogenic factors such as trauma,inflammation,and tumors.SCI caused spinal neurological dysfunction below the injury plane,e.g.,it affects motor,sensory nerve,sphincter,and vegetative nerve function.A robotic exoskeleton system is an emerging rehabilitation therapy for SCI worldwide.For patients with SCI,correction of gait and improvement of the function of the lower limbs during walking are particularly important. | Yilin WANG Hong CHENG Jing QIU Anren ZHANG Hongchen HE | 2021 | Science China(Information Sciences)2021，64，8： | 2 |
| 6 | Size controlled prepa ration of Cu2O Octahedron nanocrystals and studies on their optical absorption 显示文摘 | He Ping Shen Xinghai Gao Hongchen | 2005 | Journal of Colloid and Interface Science2005，284，： | 1 |
| 7 | Synthesis and kinetic shape and size evolution of magnetite nanoparticles显示文摘 | ZHANG Ling HE Rong GU Hongchen | 2006 | Materials Research Bulletin2006，41，： | 1 |
| 8 | Pt supported on Zn modified silicalite-1 zeolite as a catalyst for n-hexane aromatization显示文摘Platinum(Pt)supported on Zinc(Zn)modified silicalite-1(S-1)zeolite(denoted as Pt-Zn/S-1)was prepared by using a wetness-impregnation method and applied in the n-hexane aromatization reaction for the first time.Both Lewis and Bronsted acid sites were detected in Pt-Zn/S-1 catalyst by means of FT-IR adsorption of NH3 experiment,which were identified as mostly weak and medium ones.Besides,Pt and Zn species showed strong interaction,as revealed by the TPR(Temperature-programmed reduction)and XPS(X-ray photoelectron spectroscopy)experiments.Pt-Zn/S-1 catalyst exhibited excellent aromatization function rather than isomerization and cracking side reactions in the conversion of n-hexane.Pulse experimental study showed that 75.6%of n-hexane conversion and 76.8%of benzene selectivity were obtained over Pt0.1-Zn60/S-l catalyst at 550℃ and under atmospheric pressure.By spectroscopy tests and pulse experimental results,it was concluded that the n-hexane aromatization over Pt-Zn/S-1 catalyst follows a metal-acid bifunctional mechanism.Furthermore,with the assistance of Zn,the electron-deficient Pt species in Pt-Zn/S-1 showed good sulfur tolerance performance. | Guodong Liu Jiaxu Liu Ning He Shishan Sheng Guiru Wang Hongchen Guo | 2019 | Journal of Energy Chemistry2019，28，7： | 1 |
| 9 | Effects of Pulsed Electromagnetic Fields on Bone Mass and Wnt/β-Catenin Signaling Pathway in Ovariectomized Rats显示文摘 | Jun Zhou Hongchen He Lin Yang Shiju Chen Hua Guo Lu Xia Huifang Liu Yuxi Qin Chuan Liu Xiaofei Wei Yujing Zhou Chengqi He | 2012 | Archives of Medical Research2012，，4： | 1 |
| 10 | Surface defect and lattice engineering of Bi_(5)O_(7)Br ultrathin nanosheets for efficient photocatalysis显示文摘The effective separation and migration of photogenerated charge carriers in bulk and on the surface of photocatalysts will significantly promote photocatalytic efficiency.However,the synchronous regulation of photocharges on both counts is challenging.Herein,the simultaneous separation of bulk and surface photocharges is conducted to enhance photocatalytic activity by coupling the surface defects and lattice engineering of bismuth oxybromide.The depth-modulated Bi_(5)O_(7)Br ultrathin nanosheets with an abundance of bismuth in the crystal structure increased the internal electric field,which propelled the separation and migration of photocharges from bulk to the surface.Creation of oxygen vacancies(OVs)on the nanosheet surface forms local electric fields,which can stimulate the migration of charges to active sites on the catalyst surface.Therefore,the OV-assembled Bi_(5)O_(7)Br nanosheets demonstrated enhanced photocatalytic degradation efficiency under simulated solar-light illumination.This study proved the possibility of charge governing via electric field modulation based on an integrated strategy. | Yunjing Wang Hongchen He Yunjiang Wang Meili Xie Feng Jing Xianhong Yin Feilong Hu Yan Mi | 2023 | Nano Research2023，16，1： | 1 |
| 11 | Microwave Drying of Scots Pine Lumber:Structure Changes,Its Effect on Liquid Permeability显示文摘Microwave(MW)drying method was adopted to enhance the liquid permeability of Scots pine lumber.Structure changes were characterized by stereoscope microscope,scanned electron microscope(SEM)and transmission electron microscope(TEM)examination.Pore parameters before and after MW treatment were detected by mercury intrusion porosimetry(MIP)method,and the effect of structure changes on liquid permeability were analyzed.As stereoscope microscope,SEM and TEM examination results showed,macro and micro checks mainly developed at intercellcular of tracheids,intercellular of ray parenchyma and tracheid,while these checks extend main along the radial-longitudinal plane.Pit border destruction,aspirated pits’orus translocation and micro-checks in tracheid cell wall were also observed.MIP test shown that pore volume and pore area increased as macro and micro checks generated to form new cavities.Microstructure changes would increase the quantity of pores or enlarge the pore diameter.Liquid flow pathways increased as macro and micro checks generated,aspirated pits reopened to form new pathways;liquid flow efficiency improved as porosity,pore volume and pore diameter increased which facilitated the liquid flow. | Sheng He Weiqi Leng Yuhe Chen Hongchen Li Jingpeng Li Zaixing Wu Zizhang Xiao | 2023 | Journal of Renewable Materials2023，11，1： | 0 |
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