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| 1 | SPSBl-mediated HnRNP A1 alternative splicing and cell ubiquitylation regulates migration in EGF signaling显示文摘细胞外的信号被显示了影响拼接的其他的 pre-mRNA;然而,分子的机制和导致信号的拼接的规定的生物意义仍然保持大部分未知。这里,我们报导那个表皮的生长因素(EGF ) 通过一个著名拼接管理者的 ubiquitylation 导致拼接的变化, hnRNP A1。EGF 发信号 upregulates 一个 E3 ubiquitin (Ub ) ligase 适配器,敏捷的包含域的 SOCS 盒子蛋白质 1 (SPSB1 ) ,它结合离氨酸 29 连接 polyUb 链到 hnRNP A1 上的成员 Elongin B/C-Cullin 建筑群。重要地, hnRNP A1 的 SPSB1 和 ubiquitylation 在驾驶 EGF 的房间移植有一个关键角色。机械学地,和 SR 蛋白质 kinases (SRPK ) 的激活的 hnRNP A1 的导致 EGF 的 ubiquitylation 导致拼接的 Rac1 的 upregulation isoform, Rac1b,支持房间活动性。这些调查结果解开在蛋白质 ubiquitylation 并且在 EGF/EGF 受体发信号的其他的拼接之间的新奇串音,并且在 modulating 房间移植识别新 EGF/SPSB1/hnRNP A1/Rac1 轴,它可以为癌症治疗有重要含意。 | Feng Wang Xing Fu Peng Chen Ping Wu Xiaojuan Fan Na Li Hong Zhu Ting-Ting Jia Hongbin Ji Zefeng Wang Catherine C L Wong Ronggui Hu Jingyi Hui | 2017 | Cell Research2017，27，4： | 5 |
| 2 | Flammability properties and mechanical performance of epoxy modified phe- nolic foams显示文摘 | AUAD M L ZHAO L SHEN Hongbin | 2007 | Journal of Applied Polymer Science2007，104，3： | 1 |
| 3 | Casestudy of the effects of atmospheric aerosols and regional haze onagriculture:an opportunity to enhance crop yields in China throughemission controls显示文摘 | CHAMEIDES W L YU Hongbin LIU Shaochen | 1999 | Proceedings of the National Academy ofSciences of the United States of America1999，96，13： | 1 |
| 4 | Cascaded centralized TSK fuzzy system: universal approximator and high interpretation 显示文摘 | Wang S Chung F L HongBin S | 2005 | Applied Soft Computing2005，5，2： | 1 |
| 5 | Cascaded centralized TSK fuzzy system:universal approximator and high interpretation显示文摘 | Wang Shitong Chung F L Shen Hongbin | 2005 | Applied Soft Computing2005，5，2： | 1 |
| 6 | Flammability properties and mechanical performance of epoxy modified phenolic foams 显示文摘 | Maria L Auad Lihua Zhao Hongbin Shen | 2007 | Journal of Applied Polymer Science2007，104，： | 1 |
| 7 | Anterior cervical dis- cectomy with arthroplasty versus anterior cervical discectomy and fusion for cervical spondylosis 显示文摘 | GaoLing L JianZhong H HongBin L | 2015 | Journal of Clinical Neuro- science2015，22，3： | 1 |
| 8 | Smart 显示文摘 | Fangxing L Wei Q Hongbin S et transmission grid: vision and framework Transactions on SmartGrid 2010 1 (2) : al | 2010 | IEEE2010，，： | 1 |
| 9 | Low Proba-bility of Interception of an Advanced Noise Radar Wave-form with Linear-FM显示文摘 | GOVONI M A HONGBIN L KOSINSKI J A | 2013 | IEEE Transactions on Aerospace and Electronic Systems2013，49，2： | 1 |
| 10 | The impact of human EGFR kinase domain mutations on lung tumorigenesis and in vivo sensitivity to EGFR-targeted therapies 显示文摘 | Hongbin J Danan L Liang C | 2006 | ancer Cell2006，9，6： | 1 |
| 11 | Bank discrimination in transition economies: ideology, information or incentives 显示文摘 | Brandt L Li Hongbin | 2003 | Journal of Comparative Eco- nomics2003，31，3： | 1 |
| 12 | A new derivation of the APES filter显示文摘 | Petre S Hongbin L Jian L | 1999 | IEEE Signal Processing Letters1999，6，8： | 1 |
| 13 | An SMDP-Based Service Model for Inter- domain Resource Allocation in Mobile Cloud Networks显示文摘 | LIANG Hongbin CAI L X HUANG Dijiang | 2012 | IEEE Transactions on Vehicular Technology2012，61，5： | 1 |
| 14 | Effect of ABO blood type on ovarian reserve in Chinese women 显示文摘 | Shengli L Rong L Hongbin C | 2014 | Fertil Steril2014，102，： | 1 |
| 15 | Bank discrimination in transition e- conomies: ideology, information, or incentives? 显示文摘 | Loren B Hongbin L | 2003 | Journal of comparative economics2003，31，3： | 1 |
| 16 | Flammability properties and mechanical performance of epoxy modified phe- nolic foams显示文摘 | Maria L Auad Zhao Lihua Shen Hongbin | 2007 | Journal of Applied Polymer Science2007，104，3： | 1 |
| 17 | Rosiglitazone via upregulation of Akt/eNOS pathways attenuates dysfunction of endothelial progenitor cells,induced by advanced glycation end products显示文摘 | Chun L Yusheng R Hongbin T | | 0，，08： | 1 |
| 18 | 显示文摘 | Maria L Auad Lihua Zhao Hongbin Shen | 2007 | Journal of Applied Polymer Science2007，104，： | 1 |
| 19 | Removal of inflammatory cytokines and endotoxin by veno-venous continuous renal replacement therapy for burned patients with sepsis显示文摘 | Yizhi P Zhiqiang Y Hongbin L | 2005 | Burns2005，31，： | 1 |
| 20 | Graphene oxide : prepa- ration, functionalization, and electrochemical applications 显示文摘 | DA C HONGBIN F JINGHONG L | 2012 | Chemical Reviews2012，112，11： | 1 |
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