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| 1 | TALEN-based generation of a cynomolgus monkey disease model for human microcephaly显示文摘基因在非人类的首领编辑可以为在人探索病原学和遗传上基于的神经病学的混乱的治疗学的策略导致珍贵模型。然而,仔细在人模仿病理学、行为的赤字的神经病学的混乱的一个猴子模型成功地还没被产生了。Microcephalin 1 (MCPH1 ) 在人的大脑,和智力迟钝伴随的 MCPH1 变化原因头小畸型的进化被含有。这里,我们产生了用抄写带 biallelic MCPH1 变化的一只 cynomolgus 猴子(Macaca fascicularis ) 像使活跃之物的受动器核酸酶。猴子概括了大多数在病人观察的重要临床的特征,包括在头圆周,早熟的染色体冷凝作用(PCC ) ,语料库 callosum 的发育不全和上面的手足 spasticity 的显著减小。而且,在变异的真皮的成纤维细胞的 MCPH1 的 overexpression 救了 PCC 症候群。这个猴子模型可以帮助我们阐明在人的头小畸型并且更好的致病的 MCPH1 的角色在首领大脑尺寸的进化理解这蛋白质的功能。 | Qiong Ke Weiqiang Li Xingqiang Lai Hong Chen Lihua Huang Zhuang Kang Kai Li Jie Ren Xiaofeng Lin Haiqing Zheng Weijun Huang Yunhan Ma Dongdong Xu Zheng Chen Xinming Song Xinyi Lin Min Zhuang Tao Wang Fengfeng Zhuang Jianzhong Xi Frank Fuxiang Mao Huimin Xia Bruce T Lahn Qi Zhou Shihua Yang Andy Peng Xiang | 2016 | Cell Research2016，26，9： | 13 |
| 2 | A study of the shelf- life of cold- stored longan fruit显示文摘 | Chen S J Hong Q Z | 2001 | Acta Hort2001，558，： | 1 |
| 3 | Correlation between Indian Ocean summer monsoon and North Atlantic climate during the Holocene 显示文摘 | Hong Y T Hong B Lin Q H | 2003 | Earth and Planetary Science Letters2003，211，： | 1 |
| 4 | Acute respiratory symp- toms in adults in general practice显示文摘 | Hong C Y Lin R T 'Fan E S | 2004 | Faro Pract2004，21，3： | 1 |
| 5 | Resveratrol induces FasL-related apoptosis through Cdc42 aclivation of ASK1/JNK- dependent signaling pathway in human leukemia HL-60 cells 显示文摘 | SU J L LIN M T HONG C C | 2005 | Carcinogenesis2005，26，1： | 1 |
| 6 | Inverse phase oscillations between the East Asian and Indian Ocean summer monsoons during the last 12 000 years and paleo-E1 Nino 显示文摘 | Hong Y T Hong B Lin Q H | 2005 | Earth and Planetary Science Letters2005，231，： | 1 |
| 7 | Hypoxia inducescy steine-rich 61,vascular endothelial growth factor,and interleukin-8expressions in human nasal polyp fibroblasts:An implication of neutrophils in the pathogenesis of nasal polyposis显示文摘 | SHUN C T LIN S K HONG C Y | 2011 | Am J Rhinol Allergy2011，25，： | 1 |
| 8 | Mining association rules with multiple minimum supports using maximum constraints显示文摘 | LEE Y C HONG T P LIN W Y | 2005 | International Journal of Approximate Reasoning2005，40，7： | 1 |
| 9 | Mining fuzzy association rules with multiple minimum supports using maximum constraints 显示文摘 | Lee Y C Hong T P Lin W Y | 2004 | Lecture Notes in Computer Science2004，3214，： | 1 |
| 10 | Geochemical variation of soil-gas composition forfault trace and earthquake precursory studies along the Hsin- cheng fault in NW Taiwan 显示文摘 | Walia V Yang T F Hong W L Lin S J Fu C C Wen K L Chen C H | 2009 | Applied Radiation and Iso- topes2009，67，： | 1 |
| 11 | Linguistic data mining with fuzzy FP-trees显示文摘 | Lin C W Hong T P Lu W H | 2010 | Expert Systems with Applications2010，37，： | 1 |
| 12 | Quantitative analysis and computation of two-dimensional bubble columns 显示文摘 | Lin T J Reese J Hong T | 1996 | AIChE J1996，42，： | 1 |
| 13 | Electronic structures of Ga2O3(Gd2O3) gate dielectric on n-Ge(001) as grown and after CF4 plasma treatment:A synchrotron-radiation photoemission study显示文摘 | Pi T W Lee W C Huang M L Chu L K Lin T D Chiang T H Wang Y C Wu Y D Hong M Kwo J | | 0，，： | 1 |
| 14 | InGaAs and Ge MOSFETs with high-k dielectrics显示文摘 | Lee C W Chang P Lin T D Chu L K Chiu H C Kwo J Hong M | | 0，，： | 1 |
| 15 | Application of sal- esman-like recommendation system in 3G mobile phone on-line shopping decision support显示文摘 | LIN C T HONG W C CHEN Y F | 2010 | Expert Systems with Applica- tions2010，37，12： | 1 |
| 16 | Correlation between Indian Ocean summer monsoon and North Atlantic climate during the Holocene显示文摘 | Hong Y T Hong B Lin Q H | 2003 | Earth and Planetary Science Letters2003，211，： | 1 |
| 17 | A study of the shelf-life of cold-stored longan fruit 显示文摘 | LIN H T CHEN S J HONG Q Z | 2001 | Acta Horticulturae2001，558，： | 1 |
| 18 | Anti-phase oscillation of Asian monsoons during the Younger Dryas period: Evi- dence from peat eellulose 13C of Hani, Northeast China 显示文摘 | Hong B Hong Y T Lin Q H | 2010 | Palaeogeography Palaeoelimatology Palaeoeeology2010，297，： | 1 |
| 19 | Mining association rules with multiple minimum supports using maximum constraints显示文摘 | Lee Y C Hong T P Lin Wen-yang | 2005 | International Journal of Approximate Reasoning2005，40，： | 1 |
| 20 | Enveloping porphyrins for efficient dye-sensitized solar cells显示文摘 | Wang C L Lan C M Hong S H Wang Y F Pan T Y Chang C W Kuo H H Kuo M Y Diau E W G Lin C Y | | 0，，05： | 1 |
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