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| 1 | Effects of tachyplesin on the morphology and ultrastructure of human gastric carcinoma cell line BGC-823显示文摘AIM To investigate the morphological andultrastructural changes in the human gastriccarcinoma cell line BGC-823 after being treatedwith tachyplesin.METHODS Tachyplesin was isolated from acidextracts of Chinese horseshoe crab(Tachypleustridentatus)hemocytes.BGC-823 cells and thecells treated with 2.0mg/L tachyplesin wereexamined respectively under light microscope,scanning and transmission electron microscope.RESULTS BGC-823 cells had undergone therestorational alteration in morphology andultrastructure after tachyplesin treatment.Thechanges were as follows:the shape of cells wasunanimous,the volume enlarged and cellsturned to be flat and spread,the nucleo-cytoplasmic ratio lessened and nuclear shapebecame rather regular,the number of nucleolusreduced and its volume lessened,heter-chromatin decreased while euchromatinincreased in nucleus.In the cytoplasm,mitochondria grew in number with consistentstructure relatively,Golgi complex turned to betypical and well-developed,rough endoplasmicreticulum increased and polyribosomedecreased.The microvilli at cellular surfacewere rare and the filopodia reduced whilelamellipodia increased at the cell edge.CONCLUSION Tachyplesin could alter themalignant morphological and ultrastructuralcharacteristics of human gastric carcinoma cellseffectively and have a certain inducing differen-tiation effect on human gastric carcinoma cells. | Li QF Ou Yang GL Li CY Hong SG | 2000 | World Journal of Gastroenterology2000，6，5： | 19 |
| 2 | Prospective validation of %p2PSA and the Prostate Health Index, in prostate cancer detection in initial prostate biopsies of Asian men, with total PSA 4-10 ng ml-1显示文摘尽管有它为屏蔽的前列腺癌症的普遍使用,低特性使 PSA 成为非最优的 biomarker,特别在 4-10 ng ml 1 的诊断灰色的地区。假积极与伴随的病态导致不必要的活体检视。这在与在 4.0 和 10 ng ml 1 之间的全部的 PSA 介绍的亚洲人是 % p2PSA 和前列腺健康索引(PHI ) 的第一未来的确认研究。我们学习了在 50 和 75 岁之间的 157 个亚洲人,与每直肠的前列腺考试的正常,经历他们的第一前列腺活体检视,用一个标准化活体检视协议,为 4-10 ng ml 1 的 PSA 层次。(19.1%) 三十被发现在活体检视上有前列腺癌症。有或没有前列腺癌症的病人之间的统计上重要的差别被作出对有利的裁决全部的 PSA, p2PSA, % p2PSA,和 PHI。在为全部的 PSA, % fPSA, % p2PSA,和 PHI 操作典型曲线的接收装置的曲线下面的区域分别地是 0.479, 0.420, 0.695,和 0.794。PHI 最好预言 prostatic 活体检视结果。在 90% 的敏感, PHI 的特性(95% CI ) 是 58.3% ,多于在 17.3% 点使全部的 PSA 的特性增加两倍,潜在地避免 77 (49%) 不必要的活体检视。类似于研究在主要白种人人口,我们有希望地证明了 % p2PSA 和 PHI 极大地超过总数并且释放总计 PSA 比率,在前列腺癌症的察觉起初活体检视。更高的 PHI 层次也对应于增加检测 GS 7 癌症的风险。我们验证了 PHI 的使用与在 4 和 10 ng ml 1 之间的浆液 PSA 在亚洲人关于前列腺活体检视帮助决策。 | Lincoln GL Tan Yung Khan Tan Bee Choo Tai Karen ML Tan Vineet Gauhar Ho Yee Tiong Robert CW Hawkins Thomas P Thamboo Felicia SK Hong Edmund Chiong | 2017 | Asian Journal of Andrology2017，19，3： | 13 |
| 3 | Isolation of a peptide for targeted drug delivery into human head and neck solid tumors显示文摘 | Hong FD Clayman GL | 2000 | Cancer Res2000，60，23： | 1 |
| 4 | Complete repair of tetralogy of Fallot in infancy显示文摘 | Jeoung RL Jun SK Hong GL | 2004 | Interact Cardiovasc Thorac Surg2004，3，5： | 1 |
| 5 | Clinical measures of auditory function: the cochlea and beyond 显示文摘 | Baiduc RR Poling GL Hong 0 | 2013 | Dis Mon2013，59，4： | 1 |
| 6 | Understanding and preventing noise-induced hearing loss显示文摘 | Hong O Kerr MJ Poling GL | | 0，，04： | 1 |
| 7 | Complications induced by decompressive craniectonifes after traumatic brain injury显示文摘 | Yang X J Hong GL Su SB | | 0，，： | 1 |
| 8 | Wheat pentosans (Ⅱ) :Estimating kernel hardness and pentosans in water extracts by near - infrared reflectance 显示文摘 | B H Hong GL Rub enthaler R E Allen | 1989 | Cereal Chemistry1989，66，5： | 1 |
| 9 | Genetic variations inMOVlOand CACNB2 are associated with hypertension ina Chinese Han population显示文摘 | Hong GL Chen XZ Liu Y | 2013 | Genet Mol Res2013，12，4： | 1 |
| 10 | The incidence of bladder cancer in the black foot disease Area in Taiwan显示文摘 | Guo HR Hong GL | 1993 | British Journal of Urology1993，71，： | 1 |
| 11 | Understanding and preventing noise-induced hearing loss显示文摘 | HONG O KERR MJ POLING GL | 2013 | Dis Mon2013，59，4： | 1 |
| 12 | Bcl-2 family- mediated apoptotic effects of 3,3'-diindolylmethane (DIM) in human breast cancer cells 显示文摘 | Hong C Firestone GL Bjeldanes LF | 2002 | Biochem Pharmacol2002，63，6： | 1 |
| 13 | Complications induced by decompressive craniectomies after traumatic brain injury显示文摘 | Yang XJ Hong GL Su SB | | 0，，02： | 1 |
| 14 | Cytochrome P450 1A2 (CYP1A2) activity and risk factors for breast cancer:a cross-sectional study显示文摘 | Hong CC Tang BK Hammond GL | 2004 | Breast Cancer Res2004，6，： | 1 |
| 15 | The reversal of paraquat- induced mitochondria-mediated apoptosis by cycloartenyl ferulate, the important role of Nrf2 pathway 显示文摘 | Hong GL Liu JM Zhao GJ | 2013 | Exp Cell Res2013，319，18： | 1 |
| 16 | Bc1-2 family- mediated apoptotic effects of 3, 3 - diindolylmethane (DIM) in human breast cancer cells 显示文摘 | Hong C Firestone GL Bjeldanes LF | 2002 | Biochem Pharmacol2002，63，6： | 1 |
| 17 | Exogenous pathogen and plant 15-1ipoxygenase initiate endogenous lipoxin A4 biosyn- thesis显示文摘 | Bannenberg GL Aliberti J Hong S et el | 2004 | J Exp Med2004，199，4： | 1 |
| 18 | Isolation of a peptide for targeted drug delivery into human head and neck solid tumors 显示文摘 | Hong FD Clayman GL | 2000 | Cancer Research2000，60，： | 1 |
| 19 | The reversal of paraquat-induced mitochondria-mediated apoptosis by cycloartenyl ferulate, the important role of Nrf2 pathway显示文摘 | Hong GL Liu JM Zhao GJ | 2013 | Exp Cell Res2013，319，18： | 1 |
| 20 | Complications induced by decompresive craniectomy after traumatic brain injury显示文摘 | Hong GL Su SB | 2003 | Chin J Traumatol2003，6，： | 1 |
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