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| 1 | Segmental intrahepatic cholestasis as a technical complication of the transjugular intrahepatic porto-systemic shunt显示文摘BACKGROUND Segmental intrahepatic cholestasis caused by transjugular intrahepatic portosystemic shunt(TIPS)(SIC-T),is a rare complication of this technique and only referred by case reports.Thus,we conducted a systematic,retrospective analysis to provide evidence regarding prevalence and consequences of this TIPS-induced bile duct compression.AIM To assess prevalence and outcome of SIC-T in a large TIPS-cohort.METHODS In this retrospective cohort study,we screened the institutional databases for all consecutive patients that were treated by TIPS-placement or TIPS-revision between January 2005 and August 2013.We analyzed radiologic images for signs of biliary congestion.Cases that were indicative of SIC-T were reviewed by two independent radiologists and additional patient data was collected.Descriptive statistics of patient demographics,indications for TIPS and procedural details were registered.Logistic regression analysis was performed to identify predictors for the development of SIC-T.RESULTS We analyzed 135 cirrhotic patients who underwent TIPS(mean age 55 years,79%male gender).Etiology of cirrhosis was alcohol in most cases and indications for TIPS were mainly refractory ascites and recurrent variceal bleeding.TIPS revision was necessary in 31 patients.We identified 4 cases(2.9%)of SIC-T in direct proximity of the TIPS-stent.Diagnosis was confirmed by CT-scan,MRI or endoscopic retrograde cholangio pancreaticography(ERCP).In two patients TIPS was implanted via the right and in one through the medial hepatic vein.One patient received TIPS-prolongation by multiple revisions.Most patients were asymptomatic but one cholangitic abscess necessitated a transhepatic drain.Logistic regression analysis identified TIPS-placement other than from medial hepatic vein to right portal vein as risk factor(OR 21.0)for SIC-T.CONCLUSION SIC-T ads to(mostly late)complications in the interventional treatment of cirrhotic portal hypertensions and can lead to cholangitic abscesses.Patients,particularly with multiple interventions,should be screened for SIC-T. | Julian Nikolaus Bucher Marcus Hollenbach Steffen Strocka Gereon Gaebelein Michael Moche Thorsten Kaiser Michael Bartels Albrecht Hoffmeister | 2019 | World Journal of Gastroenterology2019，25，43： | 2 |
| 2 | Epidemiology and diagnosis of twin gestation显示文摘 | HOLLENBACH KA HICKOK DE | 1990 | Clin Obstet Gynecol1990，33，1： | 1 |
| 3 | Platelet-derived growth factor (PDGF) autocrine signaling regulates survival and mitogenic pathways in glioblastoma cells: evidence that the novel PDGF-C and PDGF-D ligands may play a role in the development of brain tumors 显示文摘 | Lokker NA Sullivan CM Hollenbach S J | 2002 | Cancer Res2002，62，13： | 1 |
| 4 | Epidemiology and diagnosis of win gestation 显示文摘 | Hollenbach HA Hickok DE | 1990 | Clin Obstet Gynecol1990，33，1： | 1 |
| 5 | Ethyl pyruvate and ethyl lactate down-regulate the production of pro-inflammatory cytokines and modulate expression of immune receptors显示文摘 | Hollenbach M Hintersdorf A Huse K | 2008 | Biochem Pharmacol2008，76，5： | 1 |
| 6 | Laser Interferometer for Measuring High Velocities of any Reflecting Surface 显示文摘 | Hollenbach R E | 1970 | J Appl Phys1970，41，： | 1 |
| 7 | Cadmium leads to stimulated expression of the lipid transfer protein genes in barley: implications for the involvement of lipid transfer proteins in wax assembly显示文摘 | Beate Hollenbach Lukas Schreiber Wolfram Hartung Karl-Josef Dietz | 1997 | Planta1997，，1： | 1 |
| 8 | A specific antidote for reversal of anticoagulation by direct and indirect inhibitors of coagulation factor Xa显示文摘 | Lu G DeGuzman FR Hollenbach SJ | 2013 | Nat Med2013，19，4： | 1 |
| 9 | Shock Wave Studies of PMMA,Fused Silica and Sapphire显示文摘 | Hollenbach R E | 1970 | Journal of Applied Physics1970，41，： | 1 |
| 10 | Biodegradation potential of oily sludge by pure and mixed bacterial cultures显示文摘 | CERQUEIRA V S HOLLENBACH E B MABONI F | 2011 | Bioresource Technology2011，102，11： | 1 |
| 11 | Flow conditioners and ant-caking agents显示文摘 | Peleg M Hollenbach A M | 1984 | Food Technology1984，，3： | 1 |
| 12 | Laser Interferometer for Measuring High Velocities of Any Reflecting Surface显示文摘 | Hollenbach R E | 1972 | Journal of Applied Physics1972，43，11： | 1 |
| 13 | Effect of four anti-caking agents on the bulk characteristics of ground sugar显示文摘 | Hollenbach A M Peleg M Rufner R | 1982 | Journal of Food Science1982，47，： | 1 |
| 14 | Cadmium leads to stimulated expression of the lipid transfer protein genes in barley: implications for the involvement of lipid transfer proteins in wax assembly显示文摘 | Beate Hollenbach Lukas Schreiber Wolfram Hartung Karl-Josef Dietz | 1997 | Planta1997，，1： | 1 |
| 15 | Selenoprotein P in seminal fluid is a novel biomarker of sperm quality显示文摘 | Marten Michaelis Oliver Gralla Thomas Behrends Marcus Scharpf Tobias Endermann Eddy Rijntjes Nicole Pietschmann Birgit Hollenbach Lutz Schomburg | 2013 | Biochemical and Biophysical Research Communications2013，，： | 1 |
| 16 | Daxx and histone deacetylase II associate with chromatin through an interaction with core histones and the chromatin-associated protein Dek显示文摘 | Hollenbach AD McPherson CJ Mientjes EJ | 2002 | Cell Sci2002，115，16： | 1 |
| 17 | Serum selenium and selenoprotein P status in adult Danes 8-year followup显示文摘 | Rasmussen LB Hollenbach B Laurberg P | | 0，，04： | 1 |
| 18 | Analysis of the frequencies of HLA-A,B,and C alleles and haplotypes in the five major ethnic groups of the United States reveals high levels of diversity in these loci and contrasting distribution patterns in these population显示文摘 | Cao K Hollenbach J Shi X | 2001 | Hum Immunol2001，62，9： | 1 |
| 19 | A specific antidotefor reversal of anticoagulation by direct and indirect inhibitorsof coagulation factor Xa显示文摘 | Lu G DeGuzman FR Hollenbach SJ | 2013 | Nat Med’2013，19，4： | 1 |
| 20 | Laser interferometer for measuring high velocities of any reflecting surface显示文摘 | Barker L Hollenbach R | 1972 | J Appl Phys1972，43，： | 1 |
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