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| 1 | 不同提取方法山苍子油的化学成分与抗氧化活性分析显示文摘【目的】比较不同提取方法对山苍子油提取效率与抗氧化活性的影响,通过GC-MS分析,研究山苍子油成分构成与抗氧化活性的内在关联,分析山苍子油抗氧化活性的主要物质基础。【方法】采用液液萃取(分别加以超声波与磁化辅助处理)、二氧化碳超临界萃取以及水蒸气蒸馏法提取山苍子油,DPPH法比较不同提取方式对山苍子油抗氧化活力的影响,GC-MS分析山苍子油的主要成分,并以1,4-二溴苯为内标,采用面积归化法解析主要成分的相对含量。【结果】山苍子油具有显著的抗氧化活性。液液萃取法的提取效率与山苍子油抗氧化活性最高,超声波辅助处理油得率最高,为26.3%,磁化辅助处理抗氧化活性最优,达到31.22 mg·mL^-1(IC50),二氧化碳超临界萃取法次之,抗氧化活性为56.95 mg·mL^-1(IC50),水蒸气蒸馏法抗氧化活性最弱,为64.95 mg·mL^-1(IC50);GC-MS分析检测出122种以上的化合物,包括12种脂肪酸,16种萜烯,18种含氧萜烯以及其他微量化合物包括烯烃、醇、酮类与烷烃等。GC-MS分析结果表明:山苍子干果主要成分为饱和脂肪酸(月桂酸等)、不饱和脂肪酸(9,12-十八碳二烯酸、9-十八碳烯酸等)以及α蒎烯、β蒎烯、柠檬烯等萜烯、氧化萜烯类物质。液液萃取法得到的山苍子油脂肪酸含量(53.51%-66.61%)明显高于二氧化碳超临界萃取(17.64%)与水蒸气蒸馏法(8.1%),而二氧化碳超临界萃取与水蒸气蒸馏法得到的萜烯、氧化萜烯类含量分别达到29.37%和17.69%,明显高于液液萃取法(6.49%-9.75%)。【结论】磁化辅助处理有利于抗氧化活性物质的提取,且不饱和脂肪酸的含量最高;超声波辅助处理可以提升油的得率;水蒸气蒸馏法和超临界流体萃取法更有利于萜烯类化合物的获取;联系到水蒸气蒸馏法得到的山苍子油富含萜烯化合物却显示较低的抗氧化活性(64.95 mg·mL^-1),色谱级的柠檬醛抗氧化活性最低(74.33 mg·mL^-1),因此推测脂肪酸成分(特别是不饱和脂肪酸)是山苍子油抗氧化活性的主要物质基础。 | 李芳 Yaru Song Howard Holness Kevin O’Shea | 2015 | 林业科学2015，51，3： | 14 |
| 2 | In vivo theranostics with near-infraredemitting carbon dots—highly efficient photothermal therapy based on passive targeting after intravenous administration显示文摘Carbon dots that exhibit near-infrared fluorescence(NIR CDs)are considered emerging nanomaterials for advanced biomedical applications with low toxicity and superior photostability and targeting compared to currently used photoluminescence agents.Despite progress in the synthesis of NIR CDs,there remains a key obstacle to using them as an in vivo theranostic agent.This work demonstrates that the newly developed sulfur and nitrogen codoped NIR CDs are highly efficient in photothermal therapy(PTT)in mouse models(conversion efficiency of 59%)and can be readily visualized by photoluminescence and photoacoustic imaging.The real theranostic potential of NIR CDs is enhanced by their unique biodistribution and targeting.Contrary to all other nanomaterials that have been tested in biomedicine,they are excreted through the body’s renal filtration system.Moreover,after intravenous injection,NIR CDs are accumulated in tumor tissue via passive targeting,without any active species such as antibodies.Due to their accumulation in tumor tissue without the need for intratumor injection,high photothermal conversion,excellent optical and photoacoustic imaging performance,and renal excretion,the developed CDs are suitable for transfer to clinical biomedical practice. | Xin Bao Ye Yuan Jingqin Chen Bohan Zhang Di Li Ding Zhou Pengtao Jing Guiying Xu Yingli Wang Kateřina Holá Dezhen Shen Changfeng Wu Liang Song Chengbo Liu Radek Zbořil Songnan Qu | 2018 | Light(Science & Applications)2018，7，1： | 13 |
| 3 | 输血相关的急性肺损伤引起的死亡显示文摘美国食品和药品管理局(FDA)生物评估和研究中心(CBER)是一所负责监督由生物制品(包括血液和血液成分)引起严重事件和死亡事件的机构.采血或输血引起的致命性并发症必须向该机构报告.在过去的几年里,该机构每年接到70~80例死亡报告,常见的导致死亡的输血并发症是溶血性输血反应/ABO血型不合、血液产品细菌污染引起的败血症和输血相关的急性肺损伤(TRALI). | Holness L Knippen MA Simmons L 赵凤绵 张燕 董碧晨 | 2005 | 国外医学(输血及血液学分册)2005，28，3： | 3 |
| 4 | Fulminant liver failure following a marathon: Five case reports and review of literature显示文摘BACKGROUND The growing popularity of marathon and half-marathon runs has led to an increased number of patients presenting with exertion-induced heat stroke. Mild hepatic involvement is often observed in these patients;however, fulminant liver failure may occur in approximately 5% of all cases. Liver transplantation is a potentially curative approach for exertion-induced liver failure, although there is a lack of consensus regarding the criteria and optimal timing of this intervention. CASE SUMMARY This paper describes 5 patients (4 men and 1 woman) who were referred to the department where this study was performed with the diagnosis of exertioninduced acute liver failure. Three patients underwent liver transplantation, 1 recovered spontaneously, and 1 patient died on day 11 following the exertion. CONCLUSION Exertion-induced heat stroke may present as fulminant liver failure. These patients may recover with conservative treatment, may require liver transplantation, or may die. No definitive criteria are available to determine patient suitability for a conservative vs surgical approach. | Wojciech Figiel Marcin Morawski Michal Grat Oskar Kornasiewicz Grzegorz Niewiński Joanna Raszeja-Wyszomirska Maciej Krasnodebski Arkadiusz Kowalczyk Waclaw Holówko Waldemar Patkowski Krzysztof Zieniewicz | 2019 | World Journal of Clinical Cases2019，7，12： | 2 |
| 5 | Moraxella catarrhalis: from emerging to established pathogen 显示文摘 | Verduin CM Hol C Fleer A | 2002 | Clin Microbiol Rev2002，15，1： | 1 |
| 6 | Cognitive behavioral group treatment for adolescent social phobia: a preliminary study 显示文摘 | Albano AM Marten PA Hol TCS | 1995 | Nerv and Ment Dis1995，183，： | 1 |
| 7 | Purification and characterization of neutral trehalase from the ABYS1 mutant显示文摘 | APP H HOL ZER H | 1989 | J Biol Chem1989，264，17： | 1 |
| 8 | Treatment of inferior turbinate pathololgy: a review and critical evaluation of the different techniques显示文摘 | Hol MKS Hiuzing EH | 2000 | Rhinology2000，38，： | 1 |
| 9 | Improved infarction rates in fibroids after the introduction of contrast-enhanced ultrasound during uterine artery embolization显示文摘 | Dorenberg E J Hol PK Jakobsen J | 2012 | Acta Radiol2012，53，1： | 1 |
| 10 | A biomechanical comparison of three lower extremity tendons for ligamentous reconstruction about the knee显示文摘 | Pearsal AW Hol is JM Russel GV Jr | | 0，，： | 1 |
| 11 | A simple hydro- dynamic model for the liquid circulation velocity in a full- scale two- and three-phase internal airlift reactor operating in the gas recirculation regime 显示文摘 | Heijnen J J Hols J Van Der Lans R | 1997 | Chem Eng Sci1997，52，15： | 1 |
| 12 | Competition between adsorption- induced swelling and elastic compression of coal at CO2 pressures up to 100 MPa显示文摘 | HOL S SPIERS C J | 2012 | Journal of the Mechanics and Physics of Solids2012，60，11： | 1 |
| 13 | Role of nuclear receptors in the modulation of insulin secretion in lipid-induced insulin resistance 显示文摘 | SUGDEN M C HOLNESS M J | 2008 | Biochem Soc Trans2008，36，5： | 1 |
| 14 | GFAP in health and disease 显示文摘 | Middeldorp J Hol EM | 2011 | Prog Neurobiol2011，93，3： | 1 |
| 15 | Regulation of branched-chain amino acid biosyntheses by α-acetolactate decarboxylase in Streptococ- cus thermophilus显示文摘 | MONNET C NARDI M HOLS P | 2003 | Appli Microbiol2003，36，6： | 1 |
| 16 | Interaction between endometrial epithelial cells and blood leucocytes promotes cytokine release and epithelial barrier function in response to Chlamydia trachomatis lipopolysaccharide stimulation显示文摘 | Sze HoL He Q Chen J | | 0，，09： | 1 |
| 17 | GFAP in health and disease显示文摘 | Middeldorp J Hol EM | 2011 | Prog Neu- robiol2011，93，3： | 1 |
| 18 | GFAP in health and disease显示文摘 | Middeldorp J Hol EM | 2011 | Prog Neurobiol2011，93，3： | 1 |
| 19 | Rhizosphere fungal communities are influenced by Senecio jacobaea pyrrolizidine alkaloid content and composition显示文摘 | Kowalchuk G A Hol W H G Van Veen J A | 2006 | Soil Biology & Biochemistry2006，38，9： | 1 |
| 20 | Definition of HPV 16 DNA levels in low and high grade cervical lesion by a simple PCR显示文摘 | Hol TG Jenkins D Hills M | 1993 | Arch Virol1993，128，： | 1 |
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