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| 1 | Vitamin D deficiency and hepatitis viruses-associated liver diseases:a literature review显示文摘The secosteroid hormone vitamin D has, in addition to its effects in bone metabolism also functions in the modulation of immune responses against infectious agents and in inhibiting tumorigenesis. Thus, deficiency of vitamin D is associated with several malignancies, but also with a plethora of infectious diseases. Among other communicable diseases, vitamin D deficiency is involved in the pathogenesis of chronic liver diseases caused by hepatitis B and C viruses(HBV, HCV) and high prevalence of vitamin D deficiency with serum levels below 20 mg/mL in patients with HBV and HCV infection are found worldwide. Several studies have assessed the effects of vitamin D supplementation on the sustained virological response(SVR) to interferon(IFN) plus ribavirin(RBV) therapy in HBV and HCV infection. In these studies, inconsistent results were reported. This review addresses general aspects of vitamin D deficiency and, in particular, the significance of vitamin D hypovitaminosis in the outcome of HBVand HCV-related chronic liver diseases. Furthermore,current literature was reviewed in order to understand the effects of vitamin D supplementation in combination with IFN-based therapy on the virological response in HBV and HCV infected patients. | Nghiem Xuan Hoan Hoang Van Tong Le Huu Song Christian G Meyer Thirumalaisamy P Velavan | 2018 | World Journal of Gastroenterology2018，24，4： | 9 |
| 2 | Genetic variants of interferon regulatory factor 5 associated with chronic hepatitis B infection显示文摘AIM To investigate possible effects of IRF5 polymorphisms in the 3' UTR region of the IFR5 locus on susceptibilityto hepatitis B virus(HBV) infection and progression of liver diseases among clinically classified Vietnamese patients.METHODS Four IFR5 SNPs(rs13242262 A/T, rs77416878 C/T, rs10488630 A/G, and rs2280714 T/C) were genotyped in clinically classified HBV patients [chronic hepatitis B(CHB). n = 99; liver cirrhosis(LC), n = 131; hepatocellular carcinoma(HCC), n = 149] and in 242 healthy controls by direct sequencing and Taq Man realtime PCR assays. RESULTS Comparing patients and controls, no significant association was observed for the four IFR5 variants. However, the alleles rs13242262 T and rs10488630 G contributed to an increased risk of liver cirrhosis(LC vs CHB: OR = 1.5, 95%CI: 1.1-2.3, adjusted P = 0.04; LC vs CHB: OR = 1.7, 95%CI: 1.1-2.6, adjusted P = 0.019). Haplotype IRF5*TCGT constructed from 4 SNPs was observed frequently in LC compared to CHB patients(OR = 2.1, 95%CI: 1.2-3.3, adjusted P = 0.008). Haplotype IRF5*TCAT occurred rather among CHB patients than in the other HBV patient groups(LC vs CHB: OR = 0.4, 95%CI: 0.2-0.8, adjusted P = 0.03; HCC vs CHB: OR = 0.3, 95%CI: 0.15-0.7, adjusted P = 0.003). The IRF5*TCAT haplotype was also associated with increased levels of ALT, AST and bilirubin. CONCLUSION Our study shows that IFR5 variants may contribute as a host factor in determining the pathogenesis in chronic HBV infections. | Bui Tien Sy Nghiem Xuan Hoan Hoang Van Tong Christian G Meyer Nguyen Linh Toan Le Huu Song Claus-Thomas Bock Thirumalaisamy P Velavan | 2018 | World Journal of Gastroenterology2018，24，2： | 9 |
| 3 | The neurosurvival factor huma- nin inhibits beta-cell apoptosis via signal transducer and activator of transcription 3 activation and delays and ameliorates diabetes in nono- bese diabetic mice 显示文摘 | Hoang P T Park P Cobb L J | 2010 | Metabolism2010，59，3： | 1 |
| 4 | An analysis of factors affecting software reliability 显示文摘 | Zhang X M Hoang P | 2000 | The Journal of Systems and Saftzvare2000，50，1： | 1 |
| 5 | Purification/deodorization of indoor air and gaseous effluents by TiO2 photocatalysis显示文摘 | Pichat P Disdier J Hoang V C | 2000 | Catalysis Today2000，63，2： | 1 |
| 6 | Cryptococcus neoformans infections at Vancouver Hospital and Health Sciences Centre (1997-2002): epidemiology, microbiology and histopathology 显示文摘 | Hoang LM Maguire JA Doyle P | 2004 | Med Microbiol2004，53，9： | 1 |
| 7 | Behaviour of Bolted Flange Joints in Tubular Structures Under Monotonic,Repeat- ed and Fatigue Loadings I: Experimental tests显示文摘 | Hoang V L Jaspart J P Demonceau J F | 2013 | Journal of Constructional Steel Research2013，85，6： | 1 |
| 8 | Laminar separation flow over a prolate spheroid 显示文摘 | Costis C E Hoang N T Telionis D P | 1989 | Journal of Aircraft1989，26，9： | 1 |
| 9 | HER-2/neu gene amplification compared with HER-2/neu protein overexpression and interobserver reproducibility in invasive breast carcinoma显示文摘 | Hoang M P Sahin A A Ordonez N G | 2000 | Am J Clin Pathol2000，113，6： | 1 |
| 10 | Congenital idiopathic hypogonadotropic hypogonadism:evidence of defects in the hypothalamus,pituitary,and testes显示文摘 | Sykiotis G P Hoang X H Avbelj M | | 0，，6： | 1 |
| 11 | Abnormalities of the ocular surface in patients with AIDS显示文摘 | Burtin T Guepratte N Bourges JL Garcher C Le Hoang P Bau- douln C | 1998 | J Fr Ophtalmol1998，21，9： | 1 |
| 12 | Alagille syndrome in a Vietnamese cohort: mutation analysis and assessment of facial features显示文摘 | Lin HC Le Hoang P Hutchinson A | 2012 | Am J Med Genet A2012，158，5： | 1 |
| 13 | Minimization of Torque Ripple in Brushless DC Motor Drives显示文摘 | Hoang L H Robert P Rene F | 1986 | IEEE Transactions on Industry Application1986，22，4： | 1 |
| 14 | Design of multiple tuned mass damp- ers by using a numerical optimizer显示文摘 | Hoang N Warnitchai P | 2005 | Earthquake Engineer- ing and Structural Dynamics2005，，34： | 1 |
| 15 | Induction of cell cycle arrest and apoptosis in human prostate carcinoma cell by a recombinant adenovirus expressing显示文摘 | KATNER A L HOANG Q B GOOTAM P | 2002 | Prostate2002，53，1： | 1 |
| 16 | Measuring and decomposing sustainable efficiency in agricultural production: a cumulative exergy balance approach 显示文摘 | Hoang V N Rao D S P | 2010 | Ecological economics2010，，69： | 1 |
| 17 | CFD model of the airflow, heat and mass transfer in cool stores显示文摘 | Nahor H B Hoang M L Verboven P | 2005 | International Jour- nal of Refrigeration2005，28，3： | 1 |
| 18 | Design of multiple tuned mass dampers by using a numerical optimizer显示文摘 | Hoang N Warnitchai P | 2005 | Earthquake Engineering & Structural Dynamics2005，34，2： | 1 |
| 19 | Wide-angle beam refocusing using negative refraction in non-uniform photonic crystal waveguides 显示文摘 | R Zengerle P Hoang | 2005 | Opt Express2005，13，15： | 1 |
| 20 | Estimation of radiation exposure for brain perfusion CT: standard protocol compared with deviations in protocol 显示文摘 | HOANG J K WANG C FRUSH D P | 2013 | AJR Am J Roent- genol2013，201，5： | 1 |
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