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| 1 | Prevention and management of hepatitis B virus reactivation in patients with hematological malignancies treated with anticancer therapy显示文摘Hepatitis due to hepatitis B virus(HBV) reactivation can be severe and potentially fatal, but is preventable. HBV reactivation is most commonly reported in patients receiving cancer chemotherapy, especially rituximabcontaining therapy for hematological malignancies and those receiving stem cell transplantation. All patients with hematological malignancies receiving anticancer therapy should be screened for active or resolved HBV infection by blood tests for hepatitis B surface antigen(HBs Ag) and antibody to hepatitis B core antigen(antiHBc). Patients found to be positive for HBs Ag should be given prophylactic antiviral therapy to prevent HBV reactivation. For patients with resolved HBV infection, no standard strategy has yet been established to prevent HBV reactivation. There are usually two options. One is pre-emptive therapy guided by serial HBV DNA monitoring, whereby antiviral therapy is given as soon as HBV DNA becomes detectable. However, there is little evidence regarding the optimal interval and period of monitoring. An alternative approach is prophylactic antiviral therapy, especially for patients receiving highrisk therapy such as rituximab, newer generation of anti-CD20 monoclonal antibody, obinutuzumab or hematopoietic stem cell transplantation. This strategy may effectively prevent HBV reactivation and avoid the inconvenience of repeated HBV DNA monitoring. Entecavir or tenofovir are preferred over lamivudine as prophylactic therapy. Although there is no well-defined guideline on the optimal duration of prophylactic therapy, there is growing evidence to recommend continuing prophylactic antiviral therapy for at least 12 mo after cessation of chemotherapy, and even longer for those who receive rituximab or who had high serum HBV DNA levels before the start of immunosuppressive therapy. Many novel agents have recently become available for the treatment of hematological malignancies, and these agents may be associated with HBV reactivation. Although there is currently limited evidence to guide the optimal preventive measures, we recommend antiviral prophylaxis in HBs Ag-positive patients receiving novel treatments, especially the Bruton tyrosine kinase inhibitors and the phosphatidylinositol 3-kinase inhibitors, which are B-cell receptor signaling modulators and reduce proliferation of malignant B-cells. Further studies are needed to clarify the risk of HBV reactivation with these agents and the best prophylactic strategy in the era of targeted therapy for hematological malignancies. | Man Fai Law Rita Ho Carmen KM Cheung Lydia HP Tam Karen Ma Kent CY So Bonaventure Ip Jacqueline So Jennifer Lai Joyce Ng Tommy HC Tam | 2016 | World Journal of Gastroenterology2016，22，28： | 10 |
| 2 | Diffraction resonance with strong optical - field enhancement from gain - assisted hybrid plasmonic structure显示文摘 | Zhang HX Lu HF Ho HP | 2010 | Appl Phys Lett2010，100，16： | 1 |
| 3 | Real-time posturereconstruction for Microsoft Kinect 显示文摘 | Shum HP Ho E S Jiang Y | 2013 | Cybernetics IEEETransactions on2013，43，5： | 1 |
| 4 | Problems and timing in the removal of silicone oil显示文摘 | KAMPIK A HOING C HEIDENKUMMER HP | 1992 | Retina1992，12，3： | 1 |
| 5 | The factors associated with aself-perceived hearing handicap in elderly people with hearing impairment-results from a community-based study显示文摘 | Chang HP Ho CY Chou P | 2009 | Ear and Hearing2009，30，： | 1 |
| 6 | Increased production of hydrogen peroxide and expression of CD11b/CD18 on alveolar macrophages in patients with active pulmonary tuberculosis显示文摘 | Kuo HP Ho TC Wang CH | 1996 | Tuber Lung Dis1996，77，： | 1 |
| 7 | Exercise training with negative pressure ventilation improves exercise capacity in patients with severe restrictive lung disease: a prospective controlledstudy显示文摘 | Ho SC Lin HC Kuo HP | 2013 | RespirRes2013，14，1： | 1 |
| 8 | Effectiveness of the Sonicare sonic toothbrush on reduction of plaque,gingivitis,probing pocket depth and subgingival bacteria in adolescent orthodontic patients显示文摘 | Ho HP Niederman R | | 0，，1： | 1 |
| 9 | The serotonin reuptake inhibitor fluoxetine reduces sex steroid-related aggression in female rats: an animal model of premenstrual irritability?显示文摘 | Ho HP Olsson M Westberg L | 2001 | Neuropsychopharmacol2001，24，5： | 1 |
| 10 | Postnatal endotoxin exposure results in increased insulin sensitivity and altered activity of neu-roendocrine axes in adult female rats显示文摘 | Nilsson C Jennische E Ho HP | 2002 | Eur J Endocrinol2002，146，： | 1 |
| 11 | Problems and timing inthe removal of silicone oil显示文摘 | Kampik A Hoing G Heidenkummer HP | 1992 | Retina1992，12，3： | 1 |
| 12 | Radiofrequency ablation for metachronous hepatic metastases from gas- tric cancer显示文摘 | Kim HO Hwang SI Hong HP | 2009 | Surg Laparosc Endosc Percutan Tech2009，19，3： | 1 |
| 13 | The serotonin reuptake inhibitor fluoxetine reduces sex steroid-related aggression in female rats:an animal model of premenstrual irritability显示文摘 | Ho HP Olsson M Westberg L | 2001 | Neuropsychopharmacology2001，24，5： | 1 |
| 14 | Association between estrus cycle-related aggression and tidal volume variability in female Wistar rats显示文摘 | Ho HP Olsson M Annerbrink K | 2004 | Psychoneuroendocrinology2004，29，8： | 1 |
| 15 | The factors associated with aself -perceived hearing handicap in elderly people with hear-ing impairment- results from a community- based study显示文摘 | Chang HP Ho CY Chou P | 2009 | Ear and Hearing2009，30，： | 1 |
| 16 | Epidermal growth factor expression in middle ear cholesteatoma显示文摘 | Chi HP Ho KY Chai CY | 2004 | Kaohsiung J Med Sci2004，20，： | 1 |
| 17 | Diagnosis of progressive compression of the aortic true lumen with intraoperative transesophageal echocardiography during repair of dissection of dissection of thoracic aortic case report 显示文摘 | Hong CL Ho AC Liu HP | 2001 | Acta Anaesthesiol Sin2001，39，4： | 1 |
| 18 | Problems and timing in the removal of silicone oil显示文摘 | Kampik A Hoing C Heidenkummer HP | 1992 | Retina1992，12，3： | 1 |
| 19 | High-throughput screening for multi-class veterinary drug residues in animal muscle using liquid chromatography/tandem mass spectrometry with on-line solid-phase extraction 显示文摘 | Tang HP Ho C Lai S S | 2006 | Rapid Commun Mass Speetrom2006，20，： | 1 |
| 20 | High-throughput screening for multi-class veterinary drug residues in animal muscle using liquid chromatography/tandem mass spectrometry with on-line solid-phase extraction显示文摘 | Tang HP Ho C Lai SS | 2006 | Rapid Commun Mass Spectrom2006，20，17： | 1 |
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