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	题名	作者	年代	出处	被引量
1	Hepatitis B virus-induced oncogenesis显示文摘Hepatocellular carcinoma (HCC) is one of the most com- mon cancers in the world with an annual incidence of more than 500 000 in the year 2000. Its incidence is rising in many countries. Recently, it has been estimated that about 53% of HCC cases in the world are related to hepatitis B virus (HBV). The epidemiological association of HBV with HCC is well established. In recent studies, it was revealed that HBsAg carriers have a 25-37 times increased risk of developing HCC as compared to non-infected people. At present, HBV-associated carcinogenesis can be seen as a multi-factorial process that includes both direct and indirect mechanisms that might act synergistically. The integration of HBV DNA into the host genome occurs at early steps of clonal tumor expansion. The integration has been shown in a number of cases to affect a variety of cancer- related genes and to exert insertional mutagenesis. The permanent liver inflammation, induced by the immune response, resulting in a degeneration and regeneration process confers to the accumulation of critical mutations in the host genome. In addition to this, the regulatory proteins HBx and the PreS2 activators that can be encoded by the integrate exert a tumor promoter-like function resulting in positive selection of cells producing a functional regulatory protein. Gene expression profiling and proteomic techniques may help to characterize the molecular mechanisms driving HBV-associated carcino- genesis, and thus potentially identify new strategies in diagnosis and therapy.	Joachim Lupberger Eberhard Hildt	2007	World Journal of Gastroenterology2007，13，1：	56
2	Identification and characterization of a novel bipartite nuclear localization signal in the hepatitis B virus polymerase显示文摘AIM:To characterize the nuclear import of hepatitis B virus(HBV)polymerase(P)and its relevance for the viral life cycle.METHODS:Sequence analysis was performed to predict functional motives within P.Phosphorylation of P was analyzed by in vitro phosphorylation.Phosphorylation site and nuclear localization signal(NLS)were destroyed by site directed mutagenesis.Functionality of the identified NLS was analyzed by confocal fluorescence microscopy and characterizing the karyopherin binding.Relevance of the structural motives for viral life cycle was studied by infection of primary Tupaia hepatocytes with HBV.RESULTS:We identified by sequence alignment and functional experiments a conserved bipartite NLS containing a casein kinaseⅡ(CKⅡ)phosphorylation site located within the terminal protein domain(TP)of the HBV polymerase.Inhibition of CKⅡimpairs the functionality of this NLS and thereby prevents the nuclear import of the polymerase.Binding of the import factor karyopherin-α2 to the polymerase depends on its CKⅡ-mediated phosphorylation of the bipartite NLS.In HBV-infected primary Tupaia hepatocytes CKⅡinhibition in the early phase(post entry phase)of the infection process prevents the establishment of the infection.CONCLUSION:Based on these data it is suggested that during HBV infection the final import of the genome complex into the nucleus is mediated by a novel bipartite NLS localized in the TP domain of HBV polymerase.	Joachim Lupberger Stephanie Schaedler Alexander Peiran Eberhard Hildt	2013	World Journal of Gastroenterology2013，19，44：	8
3	Reconstitution of gene expression from a regulatory-protein-deficient hepatitis B virus genome by cell-permeable HBx protein显示文摘	Hafner A Brandenburg B Hildt E	2003	EMBO reports2003，4，8：	1
4	The hepatitis B virus large surface protein is a transcriptional factor 显示文摘	Hildt E Saher G Bruss U	1996	Virology1996，225，1：	1
5	HBV life cycle:entry and morphogenesis显示文摘	Schadler S Hildt E		0，，2：	1
6	Conserved transaetivating and pro-apoptotic functions of hepadnaviral X protein in orthoand avihepadnaviruses 显示文摘	Schuster R Hildt E Chang SF	2002	Oncogene2002，21，43：	1
7	The PreS-aetivator MHBs(t) of hepatitis B virus activates c-raf-1/ErK2 signaling in transgenie miee显示文摘	Hildt E Mung B Saher G	2002	EMBO J2002，21，4：	1
8	Novel cell permeable motif derived from the PreS2-domain of hepatitis-B virus surface antigens显示文摘	Oess S Hildt E	2000	Gene Ther2000，7，9：	1
9	Apolipoprotein E interacts with hepatitis C virus nonstructural protein 5A and determines assembly of infectious particles显示文摘	Benga WJA Krieger SE Dimitrova M Zeisel MB Parnot M Lupberger J Hildt E Luo G McLauchlan J Baumert TF Schuster C	2009	Hepatology2009，51，1：	1
10	The PreS2 activator MHBs (t) of hepatitis B virus activates c-raf-1/Erk2 signaling in transgenic mice显示文摘	Hildt E Munz B Saher G	2002	EMBO J2002，21，：	1
11	IFN' expression inhibits HBV-LP storage disease and ground glass hepatoeyte appearance, but exacerbates inflammation and apoptosis in HBV surface protein-aeeumulating transgenic livers显示文摘	Reifenberg K Hildt E Lecher B	2006	Liver Int2006，26，8：	1
12	The preS2 activator MHBs(t)of hepatitis B virus activates c-raf-1/Erk2 signaling in transgenic mice 显示文摘	Hildt E Munz B Saher G	2002	EMBO J2002，21，4：	1
13	Hepatitis B virus-induced oncogenesis显示文摘	Lupberger J Hildt E	2007	World J Gastroenterol2007，13，1：	1
14	Novel cell permeable motif derived fromthe PreS2-domain of hepatitis-B vims surface antigens 显示文摘	Oess S Hildt E	2000	Gene Ther2000，7，9：	1
15	Identification of α-taxilin as an essential factor for the life cycle of Hepatitis B virus显示文摘	Jasmin Hoffmann Caroline Boehm Kiyoshi Himmelsbach Christian Donnerhak Hendrik Roettger Thomas S.Weiss Daniela Ploen Eberhard Hildt	2013	Journal of Hepatology2013，，：	1
16	Duck hepatitis B virus expresses a regulatoryb HBx-like protein from a hidden open reading frame显示文摘	Chang S F Netter H J Hildt E	2001	Virol2001，75，：	1
17	Duck hepatitis B virus expresses a regulatory HBx-like protein from a hidden open reading frame显示文摘	Chang SF Netter HJ Hildt E	2001	J Virol2001，75，：	1
18	The PreS2 activator MHBst of hepatitis B virus activates c-raf-1/Erk2 signaling in transgenic mice显示文摘	Hildt E Munz B Saher G	2002	EMBO J2002，21，4：	1
19	Identification of Grb 2 as a novel binding partner of tumor necrosis factor (TNF) receptor Ⅰ显示文摘	Hildt E Oess S	1999	J Exp Med1999，189，11：	1
20	The hepatitis bvirus large surface protein(LHBs)is a transcriptional activator显示文摘	Hildt E Saher C Bruss V	1996	Viroloy1996，225，：	1

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