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| 1 | Acute pancreatitis associated with peroral double-balloon enteroscopy: A case report显示文摘人有的一个 58 岁的日本人逗留凳子和严重贫血症。既不上面也不更低胃肠(官方补给) 内视镜检查法显示出任何局部性的损害。因此,他的官方补给的流血的来源被怀疑在小肠,并且他用 EN-450T5 每口头的双汽球肠寄生物(DBE ) 经历了(Fujinon 东芝 ES 系统公司,东京,日本) 。没有损害,考虑是官方补给的流血的来源。在过程以后,病人开始经历了腹的疼痛。实验室测试揭示了血淀粉酶过多,腹的计算断层摄影术揭示了胰和仙子胰的发炎。他因此被诊断有尖锐胰腺炎。保守疗法导致了临床并且实验室改善。他没有白酒摄取,胆石疾病或胰腺炎的历史。磁性的回声 cholangiopancreatography 没在 pancreatobiliary 管的系统表明结构的改变和没有石头。当他的腹的疼痛在过程以后开始了,他的尖锐胰腺炎因此被认为与 per 有关是口头的 DBE。这是可能与联系的尖锐胰腺炎的首先报导的案例每口头的 DBE。 | Kuniomi Honda Takahiro Mizutani Kazuhiko Nakamura Naomi Higuchi Kenji Kanayama Yorinobu Sumida Shigetaka Yoshinaga Soichi Itaba Hirotada Akiho Ken Kawabe Yoshiyuki Arita Tetsuhide Ito | 2006 | World Journal of Gastroenterology2006，12，11： | 11 |
| 2 | Development and validation of a simple and multifaceted instrument,GERD-TEST,for the clinical evaluation of gastroesophageal reflux and dyspeptic symptoms显示文摘AIM To evaluate the psychometric properties of a newly developed questionnaire,known as the gastroesophageal reflux and dyspepsia therapeutic efficacy and satisfaction test(GERD-TEST),in patients with GERD.METHODS Japanese patients with predominant GERD symptoms recruited according to the Montreal definition were treated for 4 wk using a standard dose of proton pump inhibitor(PPI). The GERD-TEST and the Medical Outcome Study Short Form-8 Health Survey(SF-8) were administered at baseline and after 4 wk of treatment. The GERD-TEST contains three domains: the severity of GERD and functional dyspepsia(FD) symptoms(5 items),the level of dissatisfaction with daily life(DS)(4 items),and the therapeutic efficacy as assessed by the patients and medication compliance(4 items).RESULTS A total of 290 patients were eligible at baseline; 198 of these patients completed 4 wk of PPI therapy. The internal consistency reliability as evaluated using the Cronbach's α values for the GERD,FD and DS subscales ranged from 0.75 to 0.82. The scores for the GERD,FD and DS items/subscales were significantly correlated with the physical and mental component summary scores of the SF-8. After 4 wk of PPI treatment,the scores for the GERD items/subscales were greatly reduced,ranging in value from 1.51 to 1.87 and with a large effect size(P < 0.0001,Cohen's d; 1.29-1.63). Statistically significant differences in the changes in the scores for the GERD items/subscales were observed between treatment responders and non-responders(P < 0.0001).CONCLUSION The GERD-TEST has a good reliability,a good convergent and concurrent validity,and is responsive to the effects of treatment. The GERD-TEST is a simple,easy to understand,and multifaceted PRO instrument applicable to both clinical trials and the primary care of GERD patients. | Koji Nakada Nobuyuki Matsuhashi Katsuhiko Iwakiri Atsushi Oshio Takashi Joh Kazuhide Higuchi Ken Haruma | 2017 | World Journal of Gastroenterology2017，23，28： | 3 |
| 3 | Effects of oral tacrolimus as a rapid induction therapy in ulcerative colitis显示文摘AIM:To determine the efficacy and safety of rapid induction therapy with oral tacrolimus without a meal in steroid-refractory ulcerative colitis(UC)patients.METHODS:This was a prospective,multicenter,observational study.Between May 2010 and August 2012,49 steroid-refractory UC patients(55 flare-ups)were consecutively enrolled.All patients were treated with oral tacrolimus without a meal at an initial dose of 0.1mg/kg per day.The dose was adjusted to maintain trough whole-blood levels of 10-15 ng/m L for the first 2 wk.Induction of remission at 2 and 4 wk after tacrolimus treatment initiation was evaluated using Lichtiger’s clinical activity index(CAI).RESULTS:The mean CAI was 12.6±3.6 at onset.Within the first 7 d,93.5%of patients maintained high trough levels(10-15 ng/m L).The CAI significantly decreased beginning 2 d after treatment initiation.At 2wk,73.1%of patients experienced clinical responses.After tacrolimus initiation,31.4%and 75.6%of patients achieved clinical remission at 2 and 4 wk,respectively.Treatment was well tolerated.CONCLUSION:Rapid induction therapy with oral tacrolimus shortened the time to achievement of appropriate trough levels and demonstrated a high remission rate 28 d after treatment initiation.Rapid induction therapy with oral tacrolimus appears to be a useful therapy for the treatment of refractory UC. | Ken Kawakami Takuya Inoue Mitsuyuki Murano Ken Narabayashi Sadaharu Nouda Kumi Ishida Yosuke Abe Koji Nogami Nobuyuki Hida Hirokazu Yamagami Kenji Watanabe Eiji Umegaki Shiro Nakamura Tetsuo Arakawa Kazuhide Higuchi | 2015 | World Journal of Gastroenterology2015，21，6： | 3 |
| 4 | Rebamipide, a gastro-protective and anti-inflammatory drug, promotes gastric ulcer healing following eradication therapy for Helicobacter pylori in a Japanese population: a randomized, double-blind, placebo-controlled trial显示文摘 | Akira Terano Tetsuo Arakawa Toshiro Sugiyama Hidekazu Suzuki Takashi Joh Toshikazu Yoshikawa Kazuhide Higuchi Ken Haruma Kazunari Murakami Kenzo Kobayashi | 2007 | Journal of Gastroenterology2007，，8： | 1 |
| 5 | An Extendible Multidimensional Array System for MOLAP显示文摘 | Tatsuo Tsuji Akihiro Hara Ken Higuchi | 2006 | SAC2006，，： | 1 |
| 6 | Development and Flight Test of Metallined CFRP Cryogenic Tank for Reusable Rocket 显示文摘 | Higuchi Ken Takeuchi Shinsuke Sato Eiichi | 2005 | Acta Astronautica2005，57，： | 1 |
| 7 | A patient with undifferentiated carcinoma of gallbladder presenting with hemobilia显示文摘 | Hiroyuki Kubota Masanobu Kageoka Hirohiko Iwasaki Ken Sugimoto Ryota Higuchi Satoshi Honda Fumitoshi Watanabe Kenji Koda Hiroyuki Hanai Eizo Kaneko | 2000 | Journal of Gastroenterology2000，，1： | 1 |
| 8 | An Implementation Scheme of Multidimensional Arrays For MOLAP显示文摘 | Tatsuo Tsuji Akihiro Hara Teruhisa Hoehin Ken Higuchi | 2007 | Computer Socitey2007，，： | 1 |
| 9 | Rebamipide, a gastro-protective and anti-inflammatory drug, promotes gastric ulcer healing following eradication therapy for Helicobacter pylori in a Japanese population: a randomized, double-blind, placebo-controlled trial显示文摘 | Akira Terano Tetsuo Arakawa Toshiro Sugiyama Hidekazu Suzuki Takashi Joh Toshikazu Yoshikawa Kazuhide Higuchi Ken Haruma Kazunari Murakami Kenzo Kobayashi | 2007 | Journal of Gastroenterology2007，，8： | 1 |
| 10 | Increased proliferation of middle to distal colonic cells during colorectalcarcinogenesis in experimental murine ulcerative colitis显示文摘 | Takuya Inoue Mitsuyuki Murano Takanori Kuramoto Kumi Ishida Ken Kawakami Yosuke Abe Eijiro Morita Naoko Murano Ken Toshina Takashi Nishikawa Kentaro Maemura Chikao Shimamoto Ichiro Hirata Ken-Ichi Katsu Kazuhide Higuchi | 2007 | Oncology Reports2007，，6： | 1 |
| 11 | ATP-binding cassette transporter G4 is highly expressed in microglia in Alzheimer’s brain显示文摘 | Yoshinari Uehara Tatsuo Yamada Yasuhiko Baba Shin-ichiro Miura Satomi Abe Ken Kitajima Masa-aki Higuchi Takahiro Iwamoto Keijiro Saku | 2008 | Brain Research2008，，： | 1 |
| 12 | Comparative study of conventional colonoscopy and pan-colonic narrow-band imaging system in the detection of neoplastic colonic polyps: a randomized, controlled trial显示文摘 | Takuya Inoue Mitsuyuki Murano Naoko Murano Takanori Kuramoto Ken Kawakami Yosuke Abe Eijiro Morita Ken Toshina Hideo Hoshiro Yutaro Egashira Eiji Umegaki Kazuhide Higuchi | 2008 | Journal of Gastroenterology2008，，1： | 1 |
| 13 | Clinical effects of adalimumab treatment with concomitant azathioprine in Japanese Crohn's disease patients显示文摘AIM:To assess adalimumab's efficacy with concomitant azathioprine (AZA) for induction and maintenance of clinical remission in Japanese Crohn's disease (CD) patients. METHODS:This retrospective, observational, singlecenter study enrolled 28 consecutive CD patients treated with adalimumab (ADA). Mean age and mean disease duration were 38.1 ± 11.8 years and 11.8 ± 10.1 years, respectively. The baseline mean Crohn's disease activity index (CDAI) and C-reactive protein were 177.8 ± 82.0 and 0.70 ± 0.83 mg/dL, respectively. Twelve of these patients also received a concomitant stable dose of AZA. ADA was subcutaneously administered:160 mg at week 0, 80 mg at week 2, followed by 40 mg every other week. Clinical response and remission rates were assessed via CDAI and C-reactive protein for 24 wk. RESULTS:The mean CDAI at weeks 2, 4, 8, and 24 was 124.4, 120.2, 123.6, and 135.1, respectively. The CDAI was significantly decreased at weeks 2 and 4 with ADA and was significantly suppressed at 24 wk with ADA/AZA. Overall clinical remission rates at weeks 4 and 24 were 66.7% and 63.2%, respectively. Although no statistically significant difference in C-reactive protein was demonstrated, ADA with AZA resulted in a greater statistically significant improvement in CDAI at 24 wk, compared to ADA alone. CONCLUSION:Scheduled ADA with concomitant AZA may be more effective for clinical remission achievement at 24 wk in Japanese Crohn's disease patients. | Kumi Ishida Takuya Inoue Kaori Fujiwara Taisuke Sakanaka Ken Narabayashi Sadaharu Nouda Toshihiko Okada Kazuki Kakimoto Takanori Kuramoto Ken Kawakami Yosuke Abe Toshihisa Takeuchi Mitsuyuki Murano Satoshi Tokioka Eiji Umegaki Kazuhide Higuchi | 2013 | World Journal of Gastroenterology2013，19，17： | 0 |
| 14 | Comparison of fecal calprotectin levels and endoscopic scores for predicting relapse in patients with ulcerative colitis in remission显示文摘BACKGROUND Although the usefulness of endoscopic scores,such as the Mayo Endoscopic Subscore(MES),Ulcerative Colitis Endoscopic Index of Severity(UCEIS),and Ulcerative Colitis Colonoscopic Index of Severity(UCCIS),and biomarkers such as fecal calprotectin(FC)for predicting relapse in ulcerative colitis(UC)has been reported,few studies have included endoscopic scores for evaluating the entire colon.AIM To compare the usefulness of FC value and MES,UCEIS,and UCCIS for predicting relapse in patients with UC in clinical remission.METHODS In total,75 patients with UC in clinical and endoscopic remission who visited our institution between February 2019 and March 2022 were enrolled.The diagnosis of UC was confirmed based on the clinical presentation,endoscopic findings,and histology,according to the current established criteria for UC.Fecal samples were collected the day before or after the colonoscopy for measurement of FC.Endoscopic evaluations were performed using MES,UCEIS,and UCCIS.The primary outcome measure of this study was the assessment of the association between relapse within 12 mo and MES,UCEIS,UCCIS,and FC.The secondary outcome was the comparison between endoscopic scores and biomarkers in en-rolled patients with UC with mucosal healing.RESULTSFC and UCCIS showed a significant correlation with UCEIS (r = 0.537, P < 0.001 and r = 0.957, P < 0.001, respectively).Receiver-operating characteristic analysis for predicting MES 0 showed that the area under the curve ofUCCIS was significantly higher than that of FC (P < 0.01). During the 1-year observation period, 18 (24%) patientsexperienced a relapse, and both the FC and UCCIS of the relapse group were significantly higher than that of theremission group. The cut-off values for predicting relapse were set at FC = 323 mg/kg and UCCIS = 10.2. The areaunder the curve of the receiver-operating characteristic analysis for predicting relapse did not show a significantdifference between FC and UCCIS. The accuracy of the endoscopic scores and biomarkers in predicting relapse was86.7% for UCCIS, 85.3% for UCEIS, 76.0% for FC, and 73.3% for MES.CONCLUSIONThe three endoscopic scores and FC may predict UC relapse during clinical remission. Among these scores, UCEISmay be the most useful in terms of ease of evaluation and accuracy. | Natsuki Ishida Tatsuhiro Ito Kenichi Takahashi Yusuke Asai Takahiro Miyazu Tomohiro Higuchi Satoshi Tamura Shinya Tani Mihoko Yamade Moriya Iwaizumi Yasushi Hamaya Satoshi Osawa Ken Sugimoto | 2023 | World Journal of Gastroenterology2023，29，47： | 0 |
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