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| 1 | Update on the natural history of intracranial atherosclerotic disease: A critical review显示文摘Intracranial atherosclerotic disease (ICAD) contributes to a significant number of ischemic strokes. There is debate in the recent literature concerning the impact of the location of stenosis in ICAD on outcome. Some reports have suggested that disease processes and outcomes vary by vessel location, potentially altering the natural history and indications for intervention. Here we have performed a comprehensive, critical review of the natural history of ICAD by vessel in an attempt to assess the differences in disease specific to each of the vascular territories. Our assessment concludes that only minor differences exist between patients with different vessels affected in vessel-specific ICAD. We have found that middle cerebral artery disease confers a lower mortality than vessel-specific ICAD in other intracranial vessels, asymptomatic disease follows a more benign course than symptomatic disease, andthat plaque progression or the detection of microemboli on transcranial Doppler may predict poor outcome. Given the expanding indications for treatment of ICAD and rapidly developing endovascular techniques to confront this disease, a thorough understanding of the natural history of ICAD aids the interventional neuroradiologist in determining when to treat and how to predict outcome in this patient population. | Ricardo J Komotar Christopher P Kellner Daniel M Raper Dorothea Strozyk Randall T Higashida Philip M Meyers | 2010 | World Journal of Radiology2010，2，5： | 8 |
| 2 | and the PROACT Investigators PROACT:APhase Ⅱ Randomized Trial of Recombinant Pro-urokinase by Direct Arterial Delivery in Acute Middle Cerebral Artery Stroke显示文摘 | del Zoppo G J Higashida R T Furlan A J | 1998 | Stroke1998，29，1： | 1 |
| 3 | Trial design and reporting standards for intra-arterial cerebral thrombolysis for acute ischemic stroke显示文摘 | Higashida RT Fudan A J Roberts H | 2003 | Stroke2003，34，： | 1 |
| 4 | PROACT:a phase Ⅰ randomized trial of recombinant prourokinase by direct arterial delivery in acute middle cerebral artery stroke:PROACT investigators prolyse in aeute cerebral thromboembolism显示文摘 | del Zoppo G J Higashida R T Furlan A J | 1998 | Stroke1998，，： | 1 |
| 5 | Trial design and re- porting standards for intra-arterial cerebral thrombolysis for acute ischemic stroke显示文摘 | Higashida RT Furlan A J Roberts H | 2003 | Stroke2003，34，8： | 1 |
| 6 | Intracranial Angioplasty & Stenting for Cerebral Atherosclerosis:A Position Statement of the American Society of Interventional and Therapeutic Neuroradiology,Society of Interventional Radiology, and the American Society of Neuroradiology 显示文摘 | Higashida RT Meyers PM Connors J J | 2005 | Journal of Vascular &Interventional Radiology ( S1051 -- 0443 )2005，16，10： | 1 |
| 7 | Hypoxia-indueible factor-lalpha contributes to brain edema after stroke by regulating aquaporins and glycerol distribution in brain 显示文摘 | Higashida T Peng C Li J | 2011 | Current Neurovaseular Research2011，8，： | 1 |
| 8 | Hypoxia - inducible factor - lot contributes to brain edema after stroke by regulating aquapor- ins and glycerol distribution in brain 显示文摘 | Higashida T Peng C Li J | 2011 | Curt Neurovasc Res2011，8，1： | 1 |
| 9 | PROACT:A Phase Ⅱ Randomized Trial of Recombinant Pro-Urokinase by Direct Arterial Delivery in Acute Middle Cerebral Artery Stroke显示文摘 | Gregory J del Zoppo Randall T Higashida Anthony J Furlan | 1998 | Stroke1998，29，1： | 1 |
| 10 | Definition and Evaluation of Transient Ischemic Attack: A Scientific Statement for Healthcare Professionals From the American Heart Association/American Stroke Association Stroke Council; Council on Cardiovascular Surgery and Anesthesia; Council on Cardio显示文摘 | J Donald Easton Jeffrey L. Saver Gregory W. Albers Mark J. Alberts Seemant Chaturvedi Edward Feldmann Thomas S. Hatsukami Randall T. Higashida S Claiborne Johnston Chelsea S. Kidwell Helmi L. Lutsep Elaine Miller Ralph L. Sacco | 2009 | Stroke2009，，6： | 1 |
| 11 | Intracranial angioplasty & stenting for cerebral atherosclerosis:a position statement of the American society of interventional and therapeutic neuroradiology,society of interventional radiology,and the American society of neuroradiology显示文摘 | Higashida RT Meyers MP Cormors J J | | 0，，： | 1 |
| 12 | Trial design and reporting standards for intra-arterial cerebral thrombolysis for a- cute isehemic stroke显示文摘 | Higashida R T Furlan A J Roberts H | 2003 | Stroke2003，34，8： | 1 |
| 13 | Intracra-nial angioplasty & stenting for cerebral atherosclerosis:a position statement of the American Society of Interventional and Therapeutic Neuroradiology,Society of Interventional Radiology,and the American Society of Neuroradiology显示文摘 | Higashida R T Meyers P M Connors J J 3rd | 2005 | AJNR Am J Neuroradiol2005，26，9： | 1 |
| 14 | Trial design and reporting standards for intra-arterial cerebral throm- bolysis for acute ischemic stroke 显示文摘 | Higashida RT Furlan A J Roberts H | 2003 | Stroke2003，34，8： | 1 |
| 15 | Trial design and reporting standards for intra-arterial cerebral thrombolysis for acute ischemic stroke显示文摘 | Higashida RT Furlan A J Roberts H | 2003 | Stroke2003，34，8： | 1 |
| 16 | Intra-arterial prouroki nase for acute ischemic stroke:the PROACT Ⅱ study:a randomized controlled trial显示文摘 | Higashida R Wechsler L | 1999 | JAMA1999，282，： | 1 |
| 17 | PROACT: aphase II randomized trial of recombiant Pro-urokinase by direct arterial delivery in acute middle cerebral artery stroke 显示文摘 | del Zopper G J Higashida T R Furlah A J | 1998 | Stroke1998，29，1： | 1 |
| 18 | Treatment of unruptured in- tracranial aneurysms: a nationwide assessment of effec- tiveness显示文摘 | Higashida R T Lahue B J Torbey M T Hopkins L N Leip E Hanley D F | 2007 | AJNR Am J Neuroradiol2007，28，： | 1 |
| 19 | Trial design and reporting standards for intra-arterial cerebral thrombolysis for acute ischemic stroke显示文摘 | HIGASHIDA R T FURLAN A J ROBERTS H | 2003 | Stroke2003，34，8： | 1 |
| 20 | Trial design and reporting standards for intra-arterial cerebral thrombolysis for acute ischemic stroke 显示文摘 | Higashida RT Furlan A J Roberts H | 2003 | Stroke2003，34，： | 1 |
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