|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 慢性肾脏病中的炎症和动脉硬化:慢性肾功能不全队列研究中的发现显示文摘慢性肾脏病(chronic kidney disease,CKD)和动脉硬化程度与心血管病发病率和死亡率增加相关。目前认为炎症在动脉硬化发展中发挥作用,而CKD被认为是一种促炎症反应的状态。CKD患者的动脉僵硬度增加,横断面数据提示CKD中增多的炎症标志物与较高动脉僵硬度值相关。 | Peyster E Chen J Feldman HI Go AS Gupta J Mitra N Pan Q Porter A Rahman M Raj D Reilly M Wing MR Yang W Townsend RR 陈云 叶鹏 | 2017 | 中华高血压杂志2017，25，11： | 12 |
| 2 | RTOG 0211:a phase 1/2 study of radiation therapy with concurrent gefitinib for newly diagnosed glioblastoma patients显示文摘PURPOSE: To determine the safety and efficacy of gefitinib,an epidermal growth factor receptor(EGFR) tyrosine kinase inhibitor,in combination with radiation for newly diagnosed glioblastoma(GBM) patients.METHODS AND MATERIALS: Between March 21,2002,and May 3,2004,Radiation Therapy Oncology Group(RTOG) 0211 enrolled 31 and 147GBM patients in the phase 1 and 2 arms,respectively.Treatment consisted of daily oral gefinitnib started at the time of conventional cranial radiation therapy(RT) and continued post RT for 18 months or until progression.Tissue microarrays from 68 cases were analyzed for EGFR expression.RESULTS: The maximum tolerated dose(MTD) of gefitinib was determined to be 500 mg in patients on non-enzyme-inducing anticonvulsant drugs(non-EIAEDs).All patients in the phase 2 component were treated at a gefitinib dose of 500 mg;patients receiving EIADSs could be escalated to 750 mg.The most common side effects of gefitinib in combination with radiation were dermatologic and gastrointestinal.Median survival was 11.5 months for patients treated per protocol.There was no overall survival benefit for patients treated with gefitinib + RT when compared with a historical cohort of patients treated with RT alone,matched by RTOG recursive partitioning analysis(RPA) class distribution.Younger age was significantly associated with better outcome.Per protocol stratification,EGFR expression was not found to be of prognostic value for gefitinib + RT-treated patients.CONCLUSIONS: The addition of gefitinib to RT is well tolerated.Median survival of RTOG 0211 patients treated with RT with concurrent and adjuvant gefitinib was similar to that in a historical control cohort treated with radiation alone. | Chakravarti A Wang M Robins HI Lautenschlaeger T Curran WJ Brachman DG Schultz CJ Choucair A Dolled-Filhart M Christiansen J Gustavson M Molinaro A Mischel P Dicker AP Bredel M Mehta M | 2013 | 中国神经肿瘤杂志2013，11，1： | 8 |
| 3 | Comparison of psychologic and cognitive functions after general or regional anesthesia 显示文摘 | Ghoneim M M Hi nrichs JV O'Hara MW | 1988 | Anesthesiology1988，69，4： | 1 |
| 4 | Electromyographic compari- sons of the pelvic Floor in Women with Dysesthetic Vulvodynia and A- symptomatic Women显示文摘 | Glazer HI Jantos M Hartmann EH | 1998 | J Reprod Med1998，43，1： | 1 |
| 5 | Cyclosporin in atopic dermatitis: time to relapse and effect of intermittent therapy 显示文摘 | Granlund HI Erkko P Sinisalo M | 1995 | BrJ Dermatol1995，132，1： | 1 |
| 6 | Failure analysis of a gas turbine compressor显示文摘 | FARR HI G H TIREHDAST M KHALIL ABAD E M | 2011 | Engineering Fail-ure Analysis2011，18，1： | 1 |
| 7 | A novel electrochemically active and Fe(III)-reducing bacterium phylogenetically related to Clostridium butyricum isolated from a microbial fuel cell 显示文摘 | Park HS Kim BH Kim HS Kim HJ Kim GT Kim M Chang IS Park YK Chang HI | 2001 | Anaerobe2001，7，6： | 1 |
| 8 | Binaural redundancy an d int er-aural time difference cues f or patients wearing a cochlear implant and a hearing aid in opposite ears显示文摘 | Ching TYC van Wanrooy E Hi ll M | 2005 | Int J Audiol2005，44，： | 1 |
| 9 | Overexpression of Cyclin D 1 is associated with metastatic prostate cancer to bone显示文摘 | Drobnjak M Osman I Scher HI | 2000 | Clin Cancer Res2000，6，： | 1 |
| 10 | Pregnancy-associated plasma protein A and proform eosinophilic major basic protein in the detection of different types of coronary artery disease 显示文摘 | Hajek P Macek hi Hladfkova M | 2008 | Physiol Res2008，57，1： | 1 |
| 11 | Dosimetric consideration for cathter-based and gamma emitters in the therapy of neointimal hyperplasia in human coronary arteries显示文摘 | Amols HI Zaider M Weinberger J | 1996 | Int J Radiat Oncol Biol Phys1996，36，： | 1 |
| 12 | Environmental tobacco smoke and deaths from coronary heart disease in Canada 显示文摘 | deGroh M Morrison HI | 2002 | Chonic Dis Can2002，23，1： | 1 |
| 13 | Single cell oil pro- duction by Goldoni DG using agro-industrial wastes 显示文摘 | Gouda M K Omar S Hi Aouad L M | 2008 | World J Microbial Biotech2008，，24： | 1 |
| 14 | Thymus andautoimm unity: production of CD4 + CD25 + naturally anerfgic and suppressive Tcells a sakey function Ofthethym us inmain taining immunologic self-tolerance 显示文摘 | Itoh M takahaS hi T S akaguch i | 1999 | J Immunol1999，162，9： | 1 |
| 15 | Enhanced detection of Theilcr' s virus RNA copy equivalents in the mouse central nervous system by real-time RT-PCR 显示文摘 | Trottier M Schlitt BP l ipton HI | 2002 | Journal of Virological Methods2002，103，： | 1 |
| 16 | Particulate contamination of lyophilized amphotericin B preparation during reconstitution process显示文摘 | Sendo T Hi rakawa M Makino K | 2001 | Journal of Clinical Pharmacy and Therapeutics2001，，2： | 1 |
| 17 | Essential role of Smad3 in infarct healing and in the pathogenesis of cardiac remodeling显示文摘 | Bujak M Ren G Kweon HI | 2007 | Circulation2007，116，： | 1 |
| 18 | Long-term stability ofamino acids and acylcarnitines in dried blood spots显示文摘 | Strnadova KA Holub M hi AM | 2007 | ClinC7^m2007，53，： | 1 |
| 19 | Supplementation with selenium restores age - related decline in immune cell function显示文摘 | Roy M Kiremidjian SL Wishe HI | 1995 | Proc Sor Exp Biol Med1995，209，： | 1 |
| 20 | CT and MRI findingsof ameloblstoma in two cases显示文摘 | Cihangiroglu M Akfirat M Yilirim HI | 2002 | Neuraradiology2002，44，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员