|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 一蜡样芽胞杆菌食物中毒分离株的表型与基因型显示文摘目的对2003年发生在云南的一起蜡样芽胞杆菌呕吐型食物中毒案例中的分离株YN0303进行表型和基因型分析研究。方法采用16S r DNA序列分析和16S/23S r DNA ITS特征图谱分析结合形态、生理生化和基因型进行菌种鉴定;PCR检测呕吐毒素和肠毒素合成相关基因,高效液相和质谱联用(HPLC-MS)化学定量分析呕吐毒素合成情况,测试部分生理生化特性和生长温度范围,进行了pan C分型和多位点序列分型(multilocus sequence typing,MLST)。结果确认了该菌株确为蜡样芽胞杆菌Bacillus cereus,虽然该食物中毒是典型的呕吐型案例,但是发现该分离株呕吐毒素相关合成基因ces呈阴性,呕吐毒素化学定量分析结果为阴性;其生理生化特性(水杨苷发酵、淀粉水解和溶血特性)与典型呕吐型菌株也不相同。pan C分型并非呕吐型蜡样芽胞杆菌所属的Ⅲ型,而是属于细胞毒性强的IV型,而且其肠毒素基因hbl、nhe和cyt K2也均呈阳性;多位点序列分析显示该菌是一个新型别ST753,是区域性相对独立进化菌株。结论在该呕吐型食物中毒案例中可能有多个蜡样芽胞杆菌参与,该分离株YN0303并非主要致病株—呕吐型菌株,但可能作为细胞毒性强的菌株参与了共感染。 | 周帼萍 Niels Bohse Hendriksen Kai Bester 刘勇 杨祖顺 | 2015 | 中国食品卫生杂志2015，27，1： | 5 |
| 2 | 初级医疗排除肺栓塞:格式塔理论(Gestalt)和威尔斯规则(Wells Rule)的诊断表现对比显示文摘目的威尔斯规则等诊断预测模式可以安全排除疑似肺栓塞。然而,医生的自主可能性评估(格式塔理论)的利用也很常见。评估这两种方法在初级医疗中的诊断表现。方法家庭医生以0—100%的格式塔理论评分对肺栓塞的可能性进行评估,并计算转诊至二级医疗机构进行确诊的疑似肺栓塞患者598例的威尔斯评分。对比两种方法的识别能力(C统计量值)。之后,根据肺栓塞风险类别,将患者分层。对于格式塔理论,低于20%和D-二聚体试验阴性被视为低风险;对于威尔斯规则,4分及以下和D-二聚体试验阴性被视为低风险。对比灵敏度、特异度、有效率(在整个群组中的低风险患者比例)和失败率(被列入低风险的肺栓塞患者)。结果在随访3个月内,73例(12%)患者被确诊为静脉血栓栓塞(基线肺栓塞替代)。格式塔理论与威尔斯规则的C统计量值分别为0.77[95%CI(0.70,0.83)]和0.80[95%CI(0.75,0.86)]。通过格式塔理论识别的152例低风险患者中,有2例患者被遗漏,失败率为1.3%[95%CI(0.2%,4.7%)],有效率为25%[95%CI(22%,29%)];通过威尔斯规则识别的272例低风险患者中,有4例患者被遗漏,失败率为1.5%[95%CI(0.4%,3.7%)],有效率为45%[95%CI(41%,50%)]。结论在初级医疗中,结合D-二聚体试验,格式塔理论分数低于20%和威尔斯规则分数为4分及以下的患者可排除肺栓塞的可能。且威尔斯规则更加有效,可以排除更大比例的疑似患者。 | HENDRIKSEN J M LUCASSEN W A ERKENS P M 本刊编辑部 | 2016 | 中国全科医学2016，19，19： | 4 |
| 3 | In vivo and in vitro production of monoclonal antibodies:Current possibilities and future perspectives,introduction 显示文摘 | GEUS B HENDRIKSEN C F | 1998 | Res Immunol1998，149，： | 2 |
| 4 | Extremely drug-resistant Salmonella enterica serovar Senftenberg infections in patients in Zambia 显示文摘 | Hendriksen RS Joensen KG Lukwesa-Musyani C | 2013 | Journal of Clinical Microbiology2013，51，1： | 1 |
| 5 | Bovine follicle development and its effect on the in vitro competence of oocytes显示文摘 | Hendriksen P J M Vos P L A M Steenweg W N M | 2000 | Theriogenology2000，，： | 1 |
| 6 | Quality of life of children with cerebral palsy: A cross-sectional KIDSCREEN study in the southern part of the Netherlands 显示文摘 | Vies GF Hendriksen RG Hendriksen JG | 2015 | CNS Neurol Disord Drug Targets2015，14，1： | 1 |
| 7 | Bovine follicular development and its effect on the in vitro competence of oocytes 显示文摘 | HENDRIKSEN P J VOS P L STEENWEG W N | 2000 | Theriogenology2000，53，： | 1 |
| 8 | In vivo and in vitro production of monoclonal antibodies: Current possibilities and future perspectives,introduction 显示文摘 | GEUS B HENDRIKSEN C F | 1998 | Res Immunol1998，149，： | 1 |
| 9 | Neuropsychiatric disorders in males with duchenne muscular dystrophy: Frequency rate of atten- tion-deficit hyperactivity disorder (ADHD), autism spectrum disorder, and obsessive compulsive disorder显示文摘 | Hendriksen JG Vies JS | 2008 | J Child Neurol2008，23，5： | 1 |
| 10 | Comparison of detergent-solubilized membrane and soluble proteins from flow cytometrically sorted X- and Y-chromosome bearing porcine spermatozoa by high resolution 2-D electrophoresis显示文摘 | Hendriksen P J Welch G R Grootegoed J A | | Mol Reprod Dev0，，： | 1 |
| 11 | Combined removal of nitrate and carbon in granular sludge: Substrate competition and activities显示文摘 | H V Hendriksen B K Ahring | 1996 | Antonievan Leeuwenhoek1996，69，1： | 1 |
| 12 | Nasal lymphoid tissue in the rat显示文摘 | B. J. Spit E. G. J. Hendriksen J. P. Bruijntjes C. F. Kuper | 1989 | Cell And Tissue Research1989，，1： | 1 |
| 13 | Integrated removal of nitrate and carbon in an upflow anaerobic sludge blanket(UASB)reactor:operating performance显示文摘 | Hendriksen H V Ahring B K | 1996 | Water Research1996，30，6： | 1 |
| 14 | Evaluating the potential for enzymatic acrylamide mitigation in a range of food products using an asparaginase from aspergillus oryzae显示文摘 | HENDRIKSEN H V KORNBRUST B A STERGAARD P R | 2009 | Jour-nal of Agricultural and Food Chemistry2009，57，： | 1 |
| 15 | Prevalence of an- timicrobial resistance among bacterial pathogens isolated from cattle in different European countries: 2002-2004 显示文摘 | Hendriksen R S Mevius D J Schroeter A | 2008 | Acta Vet Stand2008，，50： | 1 |
| 16 | Workshop on an- imal free detection of pertussis toxin in vaccines-alternatives to the histamine sensitisation test 显示文摘 | Bache C Hoonakker M Hendriksen C et ol | 2012 | Biologicals2012，40，4： | 1 |
| 17 | International spread of multidrug-resistant Salmonella Schwarzengrund in food products显示文摘 | AARESTRUP F M HENDRIKSEN R S LOCKETT J | | 0，，05： | 1 |
| 18 | Extremelydrug-resistant Salmonella enterica serovar Senftenberg infectionsin patients in Zambia显示文摘 | Hendriksen RS Joensen KG Lukwesa-Musyani C | 2013 | J Chn Microbiol2013，51，1： | 1 |
| 19 | Artesunate versus quinine in the treat- ment of severe falciparum malaria in African children (AQUAMAT) : an open - label, randomised trial 显示文摘 | Dondorp AM Fanello CI Hendriksen IC | 2010 | Lancet2010，376，： | 1 |
| 20 | Occurrence and characterization of Salmonella hiduddify from chickens and poultry meat in Nigeria显示文摘 | Raufu I Hendriksen RS Ameh JA | | 0，，04： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员