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| 1 | RANK-ligand and osteoprotegerin as biomarkers in the differentiation between periprosthetic joint infection and aseptic prosthesis loosening显示文摘AIM To assess serum levels of RANK-ligand(RANKL) and osteoprotegerin(OPG) as biomarkers for periprosthetic joint infection(PJI) and compare their accuracy with standard tests.METHODS One hundred and twenty patients presenting with a painful total knee or hip arthroplasty with indication for surgical revision were included in this prospective clinical trial. Based on standard diagnostics(joint aspirate, microbiological, and histological samples) and Musculoskeletal Infection Society consensus classification,patients were categorized into PJI, aseptic loosening,and control groups. Implant loosening was assessed radiographically and intraoperatively. Preoperative serum samples were collected and analyzed for RANKL, OPG, calcium, phosphate, alkaline phosphatase(AP), and the bone-specific subform of AP(b AP). Statistical analysis was carried out, testing for significant differences between the three groups and between stable and loose implants. RESULTS All three groups were identical in regards to age, gender, and joint distribution. No statistically significant differences in the serum concentration of RANKL(P = 0.16) and OPG(P = 0.45) were found between aseptic loosening and PJI, with a trend towards lower RANKL concentrations and higher OPG concentrations in the PJI group. The RANKL/OPG ratio was significant for the comparison between PJI and non-PJI(P = 0.005). A ratio > 60 ruled out PJI in all cases(specificity: 100%, 95%CI: 89, 11% to 100.0%) but only 30% of non-PJI patients crossed this threshold. The positive predictive value remained poor at any cut-off. In the differentiation between stable and loose implants, none of the parameters measured(calcium, phosphate, AP, and b AP) showed a significant difference, and only AP and b AP measurements showed a tendency towards higher values in the loosened group(with P = 0.09 for AP and P = 0.19 for b AP). CONCLUSION Lower RANKL and higher OPG concentrations could be detected in PJI, without statistical significance. | Max J Friedrich Matthias D Wimmer Jan Schmolders Andreas C Strauss Milena M Ploeger Hendrik Kohlhof Dieter C Wirtz Sascha Gravius Thomas M Randau | 2017 | World Journal of Orthopedics2017，8，4： | 4 |
| 2 | A new Early Cretaceous dinosaur track assemblage and the first definite non-avian theropod swim trackway from China显示文摘The trackway of a swimming theropod (ichnogenus Characichnos) is reported from the Lower Cretaceous Feitianshan Formation of Sichuan, China. These swim tracks help confirm that non-avian theropods were capable of forging moderately deep bodies of water. The trackway occurs on the same surface as a typical walking trackway of a sauropod (ichnogenus Brontopodus). Both occurrences are the first reported from the Cretaceous of Sichuan, and the swim tracks are the first well-preserved example of a Characichnos trackway from China. Additionally, a theropod walking trackway and several ornithopod walking trackways (similar to the ichnogenus Caririchnium) occur in the same horizon. The ornithopod trackways show a parallel orientation, suggesting gregarious behavior of the trackmakers, which may have been iguanodontiforms and/or hadrosauriforms. The co-occurrence of theropod swim tracks and theropod walking tracks suggests a fluctuation of water depth within a distinct time span. | XING LiDa LOCKLEY Martin G ZHANG JianPing MILNER Andrew R C KLEIN Hendrik LI DaQing PERSONS IV W Scott EBI JieFang | 2013 | Chinese Science Bulletin2013，58，19： | 3 |
| 3 | Localization and reactivity of an immunodominant domain in the NS3 region of hepatitis C virus 显示文摘 | Hendrik C André V Wilfried M | 1995 | Med Virol1995，45，： | 2 |
| 4 | Using line segments as struetruing elements for sampling-invariant mesurements 显示文摘 | HENDRIKS C L VLIET L J | 2005 | IEEE Transaction on Pattern Analysis and Machine Intellingnce2005，27，11： | 1 |
| 5 | Liquid chromatographic method for the quantitative determina- tion of Nepsilon-carboxymethyllysine in human plasma proteins 显示文摘 | Van de Merbel N C Mentink C J Hendriks G | 2004 | Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences2004，808，2： | 1 |
| 6 | RnaPrediet-an evolutionary algorithm for RNA secondary structure prediction显示文摘 | WIESE K C DESCHENES A A HENDRIKS A G | 2008 | IEEE/ACM Transactions on Computational Biology and Bioinformatics2008，5，1： | 1 |
| 7 | DFT-domainbased single-microphone noise reduction for speech en-hancement :A survey of the state of the art 显示文摘 | Hendriks R C Gerkmann T Jensen J | 2013 | Syn-thesis Lectures on Speech and Audio Processing2013，9，1： | 1 |
| 8 | Top management team functional diversity and firm performance:the moderating role of CEO characteristics显示文摘 | Buyl T Boone C Hendriks W Matthyssens P | 2010 | Journal of Management Studies2010，48，1： | 1 |
| 9 | Linear stability of thermocapillary flow in partially confined half-zones显示文摘 | SUGURU SHIRATORI HENDRIK C KUHLMANN TAKETOSHI HIBIYA | 2007 | Physics of Fluids2007，19，： | 1 |
| 10 | The βA4 amyloid precursor protein gene and Alzheimer's disease显示文摘 | Hendriks L Van Broeckhoven C | 1996 | Eur J Biochem1996，237，： | 1 |
| 11 | Pereutaneous epidymal aspiration : a diagnostic tool for the prediction of complete spermato- genesis 显示文摘 | Ramos L Wetzels A M Hendriks J C | 2004 | Reprod Biomed Online2004，8，6： | 1 |
| 12 | Unbiased MMSEbased noise power estimation with low complexity and low tracking delay显示文摘 | Gerkmann T Hendriks R C | 2012 | IEEE Transactions on Audio Speech and Language Processing2012，20，4： | 1 |
| 13 | Dynamis CO2 quality recommendations显示文摘 | Visser E D Hendriks C Barrio M | 2008 | International Journal o{ Green- house Gas Control2008，2，4： | 1 |
| 14 | Quality of life after laparoscopic and abdominal hysterectomy: a randomized controlled trial显示文摘 | Nieboer T E Hendriks J C Bongers M Y | 2012 | Obstet Gynecol2012，119，1： | 1 |
| 15 | Personality factors and breast cancer development: A prospective longitudinal study显示文摘 | Bleiker E M van der Ploeg H M Hendriks J H C L | 1996 | Journal of National Cancer Institute1996，88，： | 1 |
| 16 | Advances of modeling water flow in variably saturated soils with SWAP显示文摘 | van Dam J C Groenendijk P Hendriks R F A | 2008 | Vadose Zone Journal2008，7，2： | 1 |
| 17 | RnaPredict --an evolutionary algorithm for RNA secondary structure prediction显示文摘 | Wiese K C Deschenes A A Hendriks A G | 2008 | Computational Biology and Bioinformaties2008，5，1： | 1 |
| 18 | Use of real-time quantitative PCR to compare DNA isolation methods显示文摘 | de Kok J B Hendriks J C van Solinge W W | 1998 | Clin Chem1998，44，10： | 1 |
| 19 | A potent antimicrobial protein from onion seeds showing sequence homology to plant lipid transfer proteins显示文摘 | Cammue B P Thevissen K Hendriks M Hendriks M Eggermont K Goderis I J Osbron R W Gerdette F Kader J C | | 0，，： | 1 |
| 20 | Aerobic granulation in a sequencing batch reactor显示文摘 | Beun J J Hendriks A van Loosdrecht M C M | 1999 | Water Research1999，33，10： | 1 |
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