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| 1 | Laparoscopic versus open surgery for rectal cancer (COLOR II): short-term outcomes of a randomised, phase 3 trial显示文摘 | Martijn HGM van der Pas Eva Haglind Miguel A Cuesta Alois Fürst Antonio M Lacy Wim CJ Hop Hendrik Jaap Bonjer | 2013 | Lancet Oncology2013，，： | 17 |
| 2 | RANK-ligand and osteoprotegerin as biomarkers in the differentiation between periprosthetic joint infection and aseptic prosthesis loosening显示文摘AIM To assess serum levels of RANK-ligand(RANKL) and osteoprotegerin(OPG) as biomarkers for periprosthetic joint infection(PJI) and compare their accuracy with standard tests.METHODS One hundred and twenty patients presenting with a painful total knee or hip arthroplasty with indication for surgical revision were included in this prospective clinical trial. Based on standard diagnostics(joint aspirate, microbiological, and histological samples) and Musculoskeletal Infection Society consensus classification,patients were categorized into PJI, aseptic loosening,and control groups. Implant loosening was assessed radiographically and intraoperatively. Preoperative serum samples were collected and analyzed for RANKL, OPG, calcium, phosphate, alkaline phosphatase(AP), and the bone-specific subform of AP(b AP). Statistical analysis was carried out, testing for significant differences between the three groups and between stable and loose implants. RESULTS All three groups were identical in regards to age, gender, and joint distribution. No statistically significant differences in the serum concentration of RANKL(P = 0.16) and OPG(P = 0.45) were found between aseptic loosening and PJI, with a trend towards lower RANKL concentrations and higher OPG concentrations in the PJI group. The RANKL/OPG ratio was significant for the comparison between PJI and non-PJI(P = 0.005). A ratio > 60 ruled out PJI in all cases(specificity: 100%, 95%CI: 89, 11% to 100.0%) but only 30% of non-PJI patients crossed this threshold. The positive predictive value remained poor at any cut-off. In the differentiation between stable and loose implants, none of the parameters measured(calcium, phosphate, AP, and b AP) showed a significant difference, and only AP and b AP measurements showed a tendency towards higher values in the loosened group(with P = 0.09 for AP and P = 0.19 for b AP). CONCLUSION Lower RANKL and higher OPG concentrations could be detected in PJI, without statistical significance. | Max J Friedrich Matthias D Wimmer Jan Schmolders Andreas C Strauss Milena M Ploeger Hendrik Kohlhof Dieter C Wirtz Sascha Gravius Thomas M Randau | 2017 | World Journal of Orthopedics2017，8，4： | 4 |
| 3 | Localization and reactivity of an immunodominant domain in the NS3 region of hepatitis C virus 显示文摘 | Hendrik C André V Wilfried M | 1995 | Med Virol1995，45，： | 2 |
| 4 | Histopathological regression grading matches excellently with local and regional spread after neoadjuvant therapy of rectal cancer显示文摘 | Sefer Elezkurtaj Lutz Moser Jan Budczies Alice Josephine Müller Hendrik Bl?ker Heinz Johannes Buhr Manfred Dietel Martin Kruschewski | 2013 | Pathology - Research and Practice2013，，7： | 2 |
| 5 | Electrochemical assembly of ordered macropores in gold 显示文摘 | Wijnhoven J E G J Zevenhuizen S J M Hendriks M A | 2000 | Adv Mater2000，12，12： | 1 |
| 6 | Prognostic factors and patterns of recurrence in esophageal cancer assert arguments for extended two-field transthoracic esophagectomy 显示文摘 | Justin KS Bareld BP Hendrik M | 2010 | J Am Surg2010，16，6： | 1 |
| 7 | Pretreatments to enhance the digestibility of lignocellulosic biomass显示文摘 | Hendriks A T W M Zeeman G | 2009 | Bioresource Technology2009，100，： | 1 |
| 8 | Implementing the concept of reliability for highway capacity analysis显示文摘 | BRILON W GEISTEFELDT J HENDRIK Z M | 2007 | Transportation Research Record2007，2027，： | 1 |
| 9 | Pre- dicting effects of cations on copper toxicity to lettuce (Lactuca sativa) by the biotic ligand model 显示文摘 | Le T T Y Peijnenburg W J G M Hendriks A J | 2012 | Environ- mental Toxicology and Chemistry2012，31，2： | 1 |
| 10 | Starch synthesis in potato tubers is regulated by post-translational redox modification of ADP-glucose pyrophosphorylase: a novel regulatory mechanism linking starch synthesis to the sucrose supply显示文摘 | Tiessen A Hendriks J H Stitt M | 2002 | Plant Cell2002，14，9： | 1 |
| 11 | Preeclampsia is Associ- ated with lower Percentages of Regulatory T Cells in Maternal Blood 显示文摘 | Prins Jelmer R Boelens Hendrik M | 2009 | Hypertension in Pregnancy2009，28，3： | 1 |
| 12 | Pretreatments to enhance the di- gestibility of lignocellulosic biomass显示文摘 | Hendriks A T W M Zeeman G | 2009 | Bioresource Technology2009，100，1： | 1 |
| 13 | Deterioration of dyslexiaafter non-dominant temporal lobectomy for drug-resistant epilepsy显示文摘 | Haeren RH Hendriks MP Vlooswijk M | 2016 | Epileptic Disord2016，18，1： | 1 |
| 14 | Cerebral ischemia after carotid intervention显示文摘 | Flach HZ Ouhlous M Hendriks JM | 2004 | Endovasc Ther2004，11，3： | 1 |
| 15 | ADP glucose pyro- phosphorylase is activated by posttranslation at redox - modifica-tlon in response to light and to sugars in leaves of Arabidopsis and other plant species 显示文摘 | Janneke H M Hendriks Anna K | 2003 | Plant Physiology2003，133，： | 1 |
| 16 | Accumlation of organochlorines and brominated flame retardants in estuarine and marine food chains:Field measurements and model calculations显示文摘 | VELTMAN K HENDRIKS J HUIJBREGTS M LEONARDS P HEUVEL-GREVE M V D VETHAAK D | 2005 | Mar Pollut Bull2005，50，10： | 1 |
| 17 | Common genetic variations in CCK, leptin, and leptin receptor genes are associated with specific human eating patterns 显示文摘 | de Krom M van der Schouw Y T Hendriks J | 2007 | Diabe tes2007，56，1： | 1 |
| 18 | Starch synthesis in potato tubers is regulated by post-transcription-al redox modification of ADP-glucose pyrophosphorylase:a novel regulatory mechanism linking starch synthesis to the sucrose supply显示文摘 | TIESSEN A HENDRIKS J H STITT M | 2002 | Plant Cell2002，14，： | 1 |
| 19 | Starch synthesis in potato tubers is regulated by post-translational redox modification of ADP-glucose pyrophosphorylase: a novel regulatory mecha- nism linking starch synthesis to the sucrose supply 显示文摘 | Tiessen A Hendriks J H M Stitt M | 2002 | Plant Cell2002，14，： | 1 |
| 20 | Cognitive rehabilitation of mem- ory problems in patients with epilepsy显示文摘 | Ponds RW Hendriks M | 2006 | Seizure2006，15，4： | 1 |
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