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| 1 | Effects of resveratrol in experimental and clinical non-alcoholic fatty liver disease显示文摘The prevalence of obesity and related conditions like non-alcoholic fatty liver disease(NAFLD) is increasing worldwide and therapeutic options are limited.Alternative treatment options are therefore intensively sought after.An interesting candidate is the natural polyphenol resveratrol(RSV) that activates adenosinmonophosphate-activated protein kinase(AMPK) and silent information regulation-2 homolog 1(SIRT1).In addition,RSV has known anti-oxidant and anti-inflammatory effects.Here,we review the current evidence for RSVmediated effects on NAFLD and address the different aspects of NAFLD and non-alcoholic steatohepatitis(NASH) pathogenesis with respect to free fatty acid(FFA) flux from adipose tissue,hepatic de novo lipogenesis,inadequate FFA β-oxidation and additional intra- and extrahepatic inflammatory and oxidant hits.We review the in vivo evidence from animal studies and clinical trials.The abundance of animal studies reports a decrease in hepatic triglyceride accumulation,liver weight and a general improvement in histological fatty liver changes,along with a reduction in circulating insulin,glucose and lipid levels.Some studies document AMPK or SIRT1 activation,and modulation of relevant markers of hepatic lipogenesis,inflammation and oxidation status.However,AMPK/SIRT1-independent actions are also likely.Clinical trials are scarce and have primarily been performed with a focus on overweight/obese participants without a focus on NAFLD/NASH and histological liver changes.Future clinical studies with appropriate design are needed to clarify the true impact of RSV treatment in NAFLD/NASH patients. | Sara Heebll Karen Louise Thomsen Steen B Pedersen Hendrik Vilstrup Jacob George Henning Grnbk | 2014 | World Journal of Hepatology2014，6，4： | 11 |
| 2 | Cognition and synaptic plasticity in diabetes mellitus显示文摘 | Willem Hendrik Geert J B | 2000 | Trends Neurosci2000，23，： | 1 |
| 3 | Quality of life evolution after lung cancer surgery: a prospective study in 100 patients 显示文摘 | BALDUYCK B HENDRIKS J LAUWERS P | 2007 | Lung Cancer2007，56，3： | 1 |
| 4 | Increase in tropospheric nitrogen dioxide over China observed from space显示文摘 | Andreas R John P B Hendrik N | 2005 | Nature2005，437，： | 1 |
| 5 | Effects of LAR and PTP-BL phosphatase deficiency on adult mouse retinal cells activated by lens injury显示文摘 | Lorber B Hendriks WJ van der Zee CE | 2005 | Eur J Neurosci2005，21，9： | 1 |
| 6 | Long-term results of surgical resection of lung metastases 显示文摘 | Hendriks JM Romijn S Van Putte B | 2001 | Acta Chir Belg2001，101，： | 1 |
| 7 | Initial validation of two opiate craving questionnaires: the obsessive compulsive drug use scale and the desires for drug questionnaire显示文摘 | Franken IHA Hendriks VM Wim van den B | 2002 | Addict Behav2002，27，5： | 1 |
| 8 | Reflex cardiac activity in ischemia and reperfusion heart rate turbulence in patients undergoing direct percutaneous coronary intervention for myocardial infarction显示文摘 | Hendrik B Uwe KH Julia F | 2003 | Circulation2003，108，： | 1 |
| 9 | A Gravity Model of hnmigration 显示文摘 | Joshua J L Hendrik V B | 2008 | Economics Letters2008，99，1： | 1 |
| 10 | A pilot randomised controlled trial comparing reactive air and active alternating pressure mattresses in the prevention and treatment of pressure ulcers among medical ICU patients显示文摘 | Malbrain M Hendriks B Wijnands P | 2010 | J Tissue Viability2010，19，1： | 1 |
| 11 | Quality of life evolution af- ter lung cancer surgery:A prospective study in 100 patients显示文摘 | Balduyck B Hendriks J Lauwers P | 2007 | Lung Cancer2007，56，3： | 1 |
| 12 | Variable focal length microlenses显示文摘 | Kuiper S Hendriks B H W | 2000 | Optics Communication2000，177，16： | 1 |
| 13 | Variable-focus liquid lens for miniature cameras显示文摘 | Kuiper S Hendriks B H W | 2004 | Applied Physics Letters2004，85，： | 1 |
| 14 | Use of real-time quantitative PCR to compare DNA isolation methods显示文摘 | de Kok J B Hendriks J C van Solinge W W | 1998 | Clin Chem1998，44，10： | 1 |
| 15 | Antral follicle count in the prediction of poor ovarian response and pregnancy after in vitro fertilization:A meta-analysis and comparison with basal follicle-stimulating hormone level显示文摘 | Hendriks DJ Mol B J Bancsi IF | 2005 | Fertility and Sterility2005，83，2： | 1 |
| 16 | Survival and growth of western rock lobster Panulirus cygnus (George) fed formulated diets with and without fresh mussel supplement显示文摘 | JOHNSTON D MELVILLE-SMITH R HENDRIKS B | 2007 | Aquaculture2007，273，： | 1 |
| 17 | A potent antimicrobial protein from onion seeds showing sequence homology to plant lipid transfer proteins显示文摘 | Cammue B P Thevissen K Hendriks M Hendriks M Eggermont K Goderis I J Osbron R W Gerdette F Kader J C | | 0，，： | 1 |
| 18 | Levosimendan in early sepsis:when good ideas give poor results显示文摘 | Daniel D Hendrik B | 2009 | Anesth Analg2009，109，5： | 1 |
| 19 | Effects of Extru- sion Processing on Nutrients in Dry Pet Food显示文摘 | Tran Q D Hendriks W H Van Der Poell A F B | 2008 | Journal of the Sci- ence of Fond and Agriculture2008，88，9： | 1 |
| 20 | Variable-focus liquid lens for miniature cameras 显示文摘 | KUIPER S HENDRIKS B H W | 2004 | Applied Physics Letters2004，85，7： | 1 |
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