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| 1 | Flight control for a flexible air-breathing hypersonic vehicle based on quasi-continuous high-order sliding mode显示文摘The focus of this paper is on control design and simulation for the longitudinal model of a flexible air-breathing hypersonic vehicle(FAHV).The model of interest includes flexibility effects and intricate couplings between the engine dynamics and flight dynamics.To overcome the analytical intractability of this model,a nominal control-oriented model is constructed for the purpose of feedback control design in the first place.Secondly,the multi-input multi-output(MIMO) quasi-continuous high-order sliding mode(HOSM) controller is proposed to track step changes in velocity and altitude,which is based on full state feedback.The simulation results are presented to verify the effectiveness of the proposed control strategy. | Jie Wang Qun Zong Bailing Tian Helong Liu | 2013 | Journal of Systems Engineering and Electronics2013，24，2： | 14 |
| 2 | Toripalimab plus chemotherapy as second-line treatment in previously EGFR-TKI treated patients with EGFR-mutant-advanced NSCLC:a multicenter phase-II trial显示文摘This multicenter phase-II trial aimed to investigate the efficacy,safety,and predictive biomarkers of toripalimab plus chemotherapy as second-line treatment in patients with EGFR-mutant-advanced NSCLC.Patients who failed from first-line EGFR-TKIs and did not harbor T790M mutation were enrolled.Toripalimab plus carboplatin and pemetrexed were administrated every three weeks for up to six cycles,followed by the maintenance of toripalimab and pemetrexed.The primary endpoint was objective-response rate(ORR).Integrated biomarker analysis of PD-L1 expression,tumor mutational burden(TMB),CD8+tumor-infiltrating lymphocyte(TIL)density,whole-exome,and transcriptome sequencing on tumor biopsies were also conducted.Forty patients were enrolled with an overall ORR of 50.0%and disease-control rate(DCR)of 87.5%.The median progression free survival(PFS)and overall survival were 7.0 and 23.5 months,respectively.The most common treatment-related adverse effects were leukopenia,neutropenia,anemia,ALT/AST elevation,and nausea.Biomarker analysis showed that none of PD-L1 expression,TMB level,and CD8+TIL density could serve as a predictive biomarker.Integrated analysis of whole-exome and transcriptome sequencing data revealed that patients with DSPP mutation had a decreased M2 macrophage infiltration and associated with longer PFS than those of wild type.Toripalimab plus chemotherapy showed a promising anti-tumor activity with acceptable safety profiles as the second-line setting in patients with EGFR-mutant NSCLC.DSPP mutation might serve as a potential biomarker for this combination.A phase-III trial to compare toripalimab versus placebo in combination with chemotherapy in this setting is ongoing(NCT03924050). | Tao Jiang Pingyang Wang Jie Zhang Yanqiu Zhao Jianying Zhou Yun Fan Yongqian Shu Xiaoqing Liu Helong Zhang Jianxing He Guanghui Gao Xiaoqian Mu Zhang Bao Yanjun Xu Renhua Guo Hong Wang Lin Deng Ningqiang Ma Yalei Zhang Hui Feng Sheng Yao Jiarui Wu Luonan Chen Caicun Zhou Shengxiang Ren | 2021 | Signal Transduction and Targeted Therapy2021，6，11： | 8 |
| 3 | GLOBAL ASYMPTOTIC STABLE ERADICATION FOR THE SIV EPIDEMIC MODEL WITH IMPULSIVE VACCINATION AND INFECTION-AGE显示文摘我们学习脉搏种痘策略的申请根除在潜伏期有传染海角的慢慢地进行的疾病。我们导出根除答案是一个全球引起注意的人的在条件,这个条件取决于脉搏种痘比例 p。我们也获得答案的全球 asymptotic 稳定性的条件。Thecondition 显示出那个足够大的脉搏种痘比例并且相对小内部脉搏时间导致疾病的根除。而且理论学习的结果可能对 HIV 的传染病学有启发性。 | Helong LIU Jingyuan YU Guangtian ZHU | 2006 | Journal of Systems Science & Complexity2006，19，3： | 7 |
| 4 | Potential role of punicalagin against oxidative stress nduced testicular damage显示文摘 | Faiza Rao Hui Tian Wenqing Li Helong Hung Fei Sun | 2016 | Asian Journal of Andrology2016，18，4： | 5 |
| 5 | Safety and immunogenicity of a SARS-CoV-2 inactivated vaccine in patients with chronic hepatitis B virus infection显示文摘Coronavirus disease 2019(COVID-19),caused by SARS-CoV-2 infection,has become a major global public health threat.Although significant advances have been made in developing and applying different vaccines in clinical trials[1,2],data are limited on the safety and efficacy of the inactivated vaccine in patients with chronic liver disease[3].Recent studies have preliminarily described the safety and immunogenicity of SARS-CoV-2 vaccines in patients with nonalcoholic fatty liver disease and in liver transplant recipients[4,5]. | Tiandan Xiang Boyun Liang Hua Wang Xufeng Quan Shengsong He Helong Zhou Yongwen He Dongliang Yang Baoju Wang Xin Zheng | 2021 | Cellular & Molecular Immunology2021，18，12： | 5 |
| 6 | Equivalent efficacy study of QL1101 and bevacizumab on untreated advanced non-squamous non-small cell lung cancer patients: a phase 3 randomized, double-blind clinical trial显示文摘Objective:This phase 3 study aimed to test equivalence in efficacy and safety for QL1101,a bevacizumab analogue in Chinese patients with untreated locally advanced non-squamous non-small cell lung cancer(NSCLC).Methods:Eligible patients were randomly assigned 1:1 to receive carboplatin and paclitaxel in combination with either QL1101 or bevacizumab,15 mg/kg every 3-week for 6 cycles.This was followed by maintenance treatment with single agent QL1101 every 3-week.The primary end-point was objective response rate(ORR),with secondary end-points being progression-free survival(PFS),overall survival(OS),disease control rate(DCR),and adverse events(AEs).Results:Of 675 patients,535 eligible patients were randomized to the QL1101 group(n=269)and bevacizumab group(n=266).ORRs were 52.8%and 56.8%,respectively,for the QL1101 and bevacizumab groups,with an ORR hazard ratio 0.93(95%confidence interval:0.8-0131.1).The PFS,OS,DCR,and AEs were comparable between the 2 groups,which remained the same after stratification according to epidermal growth factor receptor mutation or smoking history.Conclusions:QL1101 showed similar efficacy and safety profiles as compared to bevacizumab among Chinese patients with untreated locally advanced non-squamous NSCLC. | Tianqing Chu Jun Lu Minghong Bi Helong Zhang Wu Zhuang Yan Yu Jianhua Shi Zhendong Chen Xiaochun Zhang Qisen Guo Quan Liu Huijuan Wu Jian Fang Yi Hu Xiuwen Wang Cuicui Han Kai Li Baohui Han | 2021 | Cancer Biology & Medicine2021，18，3： | 4 |
| 7 | 吉林省和龙县兴城遗址发掘简报显示文摘The Xingcheng site is llcated at northeast Helong county,Jilin province,it’s on the north bank of HailanJiang river. The site consists of two kinds of remains which belong to the Neolithic Age and Bronze Age. The latter is more importont.The pottery includes jar,jug, basin and bowl, ete. Most of the stone tools are polished (the chopped ones are seldom seen ),such as hoe, shovel, axe,celt, saddlequern,roller spear,arrow head,and net-sinking etc.The remains similar to Xingcheng distribute densely in Hailanjing river and Tumenjiang river bank known so far,The age of these remains falls between 3800 and 3300 BP. we name this sort of Bronze Age remains──Xingcheng Culture. | (office for the preservation of cultural relics,Helong county) | 1998 | 北方文物1998，，1： | 3 |
| 8 | Spatial and Temporal Evolution Characteristics of PM2.5 in China from 1998 to 2016显示文摘The rapid development of China’s economy and urbanization has given rise to noticeable environmental problems,among which the change of air quality has received extensive attention.The panel data of PM2.5(particles with an aerodynamic diameter of 2.5μm or less)in 343 prefecture-level cities in China from 1998 to 2016 were statistically analyzed to reveal the characteristics of the temporal evolution and spatial variation of China’s air quality in the past two decades.The results show that:1)the overall deterioration trend of air quality is obvious throughout the country.The variation trend of PM2.5 was divided into three phases:rapid-growth phase(1998–2007),lag phase(2006–2011)and mildly-incremental phase(2012–2016),with their average growth rates of 7.19%,-3.59%and 0.52%,respectively.2)The spatial difference of PM2.5 values in China increased significantly with time.Since 2003,the high-value area in the east has expanded rapidly,and polarization became much more pronounced.The change rate of PM2.5 is high in the east and west and low in the middle.The change rates of most areas in the west exceed more than 80%,and in the east lie somewhere between 40%and 60%.In the midlands,the change rate is not large and some regions even show a negative growth.3)The change rate of PM2.5 is also high in areas with higher values.However,in regions where the change rate of PM2.5 is high,the value of PM2.5 is not always high.The high change rate is mainly attributable to the low base value of PM2.5 and the cities concerned belong to sensitive areas.4)According to the PM2.5 warning index,the number of strong,medium,weak and non-warning areas in China is 45,85,159 and 54,respectively. | LI Hua TONG Helong WU Xianhua LU Xiaoli MENG Shuhan | 2020 | Chinese Geographical Science2020，30，6： | 2 |
| 9 | Microstructure, mechanical properties and tribological behavior of tribofilm generated from natural serpentine mineral powders as lubricant additive显示文摘 | Helong Yu Yi Xu Peijing Shi Hongmei Wang Min Wei Keke Zhao Binshi Xu | 2013 | Wear (-)2013，，1： | 2 |
| 10 | GLOBAL STABILITY OF AN AGE-STRUCTURED SIR EPIDEMIC MODEL WITH PULSE VACCINATION STRATEGY显示文摘这份报纸讨论脉搏种痘策略的申请阻止并且控制传染疾病,它被组织年龄的先生描述在易受影响、恢复的个人到按年代先后的年龄在哪个被组织建模的一些,当感染的个人到感染年龄被组织时(持续时间自从感染) 。依赖没有疾病的平衡被决定的时间,为哪个明确的表情存在。分析结果证明那在那里存在一种全球性稳定的没有感染的状况如果冲动的时期 T 和比例 p 满足 R 0 (p, T )< 1。最佳的问题被讨论:有在给定的 R 0 的最小的费用的脉搏种痘策略(p, T )< 1。 | Helong LIU Jingyuan YU Guangtian ZHU | 2012 | Journal of Systems Science & Complexity2012，25，3： | 2 |
| 11 | Hilbert-Huang trans- form for analysis of heart rate variability in cardiac health 显示文摘 | Li Helong Kwong Sam Yang Lihua | 2011 | IEEE/ACM Transactions on Computational Biology and Bioin- formatics2011，8，6： | 1 |
| 12 | Effect of human‐controlled hydrological regime on the source, transport, and flux of particulate organic carbon from the lower Huanghe (Yellow River)显示文摘 | Bangqi Hu Jun Li Naishuang Bi Houjie Wang Helong Wei Jingtao Zhao Luhua Xie Liang Zou Ruyong Cui Song Li Ming Liu Guogang Li | 2015 | Earth Surf. Process. Landforms2015，，8： | 1 |
| 13 | Improved fluid search optimization-based real-time weed mapping显示文摘In the field of agriculture,variable-rate herbicide spraying(VRHS)technology has been used to solve the low efficiency of pesticides and crop chemical residues.The key of VRHS is the quick and precise identification of weeds from field images,which forms a weed map.Fluid search optimization(FSO)was able to simplify the threshold optimization process to create a weed map,which simulated the fluid flowing from high pressure to low pressure,but it is time consuming and often converges prematurely.So,an explosion mechanism and a twophase optimization were introduced to improve the FSO-based segmentation algorithm.Experiments of segmentation weeds from a corn field at seedling growth stage showed that the IFSO algorithm obtained the best accuracy of 93.3%and the least running time of 0.019 s,compared with the standard PSO,GA,and FSO algorithms. | Chengcheng Chen Shengsheng Wang Xianchang Wang Helong Yu Ruyi Dong | 2020 | Information Processing in Agriculture2020，7，3： | 1 |
| 14 | The study of the intermittency test filtering character of Hilbert-Huang transform 显示文摘 | LI Helong YANG Lihua HUANG Daren | 2005 | Mathematics and Computers in Simulation2005，70，： | 1 |
| 15 | Structural damage de- tection using the combination method of EMD and wavelet analy- sis显示文摘 | Helong Li Xiaoyan Deng Hongliang Dai | 2007 | Mechanical Systems and Signal Processing2007，，21： | 1 |
| 16 | Tribologieal properties and lubricating mechanisms of Cu nanoparticles in lubricant显示文摘 | YU Helong XU Yi SHI Peijing | 2008 | Transactions of Nonferrous Metals Society of China2008，18，： | 1 |
| 17 | Structural Damage Detection Using the Combination Method of EMD and Wavelet Analysis 显示文摘 | Li Helong Deng Xiaoyan Dai Hongliang | 2007 | Mechanical Systems and Signal Processing2007，21，： | 1 |
| 18 | COPO显示文摘 | Liu Bing analysis of the causes of 65 cases of patients with acute disturbance of consciousness of Tan Helong | 2012 | Journal of Liaoning Medical University2012，33，3： | 1 |
| 19 | Tribological properties and lubricating mechanisms of Cu nanoparticles in lubricant显示文摘 | Yu Helong | 2008 | Trans Nonferrous Metals Soc China2008，，3： | 1 |
| 20 | Effects of sediment pretreat- ment on the performance of sediment microbial fuel cells 显示文摘 | TIANSHUN S HELONG J | 2011 | Bioresource Technology2011，102，10： | 1 |
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