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| 1 | Progression of diethylnitrosamine-induced hepatic carcinogenesis in carnitine-depleted rats显示文摘AIM:To investigate whether carnitine deficiency is a risk factor during the development of diethylnitrosamine (DENA)-induced hepatic carcinogenesis. METHODS:A total of 60 male Wistar albino rats were divided into six groups with 10 animals in each group.Rats in group 1(control group)received a single intraperitoneal(i.p.)injection of normal saline. Animals in group 2(carnitine-supplemented group) were given L-carnitine(200 mg/kg per day)in drinking water for 8 wk.Animals in group 3(carnitine-depleted group)were given D-carnitine(200 mg/kg per day)and mildronate(200 mg/kg per day)in drinking water for 8 wk.Rats in group 4(DENA group)were injected with a single dose of DENA(200 mg/kg,i.p.)and 2 wk later received a single dose of carbon tetrachloride(2 mL/kg) by gavage as 1:1 dilution in corn oil.Animals in group 5(DENA-carnitine depleted group)received the same treatment as group 3 and group 4.Rats in group 6 (DENA-carnitine supplemented group)received the same treatment as group 2 and group 4.RESULTS:Administration of DENA resulted in a significant increase in alanine transaminase(ALT), gamma-glutamyl transferase(G-GT),alkaline phosphatase(ALP),total bilirubin,thiobarbituric acid reactive substances(TBARS)and total nitrate/ nitrite(NOx)and a significant decrease in reduced glutathione(GSH),glutathione peroxidase(GSHPx), catalase(CAT)and total carnitine content in liver tissues.In the carnitine-depleted rat model,DENA induced a dramatic increase in serum ALT,G-GT,ALP and total bilirubin,as well as a progressive reduction in total carnitine content in liver tissues.Interestingly, L-carnitine supplementation resulted in a complete reversal of the increase in liver enzymes,TBARS and NOx,and a decrease in total carnitine,GSH,GSHPx, and CAT induced by DENA,compared with the control values.Histopathological examination of liver tissues confirmed the biochemical data,where L-carnitine prevented DENA-induced hepatic carcinogenesis while D-carnitine-mildronate aggravated DENA-induced hepatic damage. CONCLUSION:Data from this study suggest for the first time that:(1)carnitine deficiency is a risk factor and should be viewed as a mechanism in DENA- induced hepatic carcinogenesis;(2)oxidative stress plays an important role but is not the only cause of DENA-induced hepatic carcinogenesis;and(3) long-term L-carnitine supplementation prevents the development of DENA-induced liver cancer. | Salim S Al-Rejaie Abdulaziz M Aleisa Abdulaziz A Al-Yahya Saleh A Bakheet Abdulmalik Alsheikh Amal G Fatani Othman A Al-Shabanah Mohamed M Sayed-Ahmed | 2009 | World Journal of Gastroenterology2009，15，11： | 4 |
| 2 | Metallothionein Induction Reduces Caspase-3 Activity and Tnfα Levels with Preservation of Cognitive Function and Intact Hippocampal Neurons in Carmustine-Treated Rats显示文摘 | Gouda K. Helal Abdulaziz M. Aleisa Omayma K. Helal Salim S. Al-Rejaie Abdulaziz A. Al-Yahya Abdulhakeem A. Al-Majed Othman A. Al-Shabanah | 2009 | Oxidative Medicine and Cellular Longevity2009，，1： | 1 |
| 3 | Plasticity of synaptic transmission in autonomic ganglia 显示文摘 | Alkadhi KA Alzoubi KH Aleisa AM | 2005 | Prog Neurobiol2005，75，2： | 1 |
| 4 | The protection role of heat shock protein 70 (HSP-70) in the testes of cadmium-exposed rats显示文摘 | Selim ME Rashedel HA Aleisa NA | 2012 | Bioinformation2012，8，1： | 1 |
| 5 | Flavonoid, morin inhibits oxidative stress, inflammation and en- hances neurotrophic support in the brain of streptozotocin -induced diabetic rats 显示文摘 | Ola MS Aleisa AM A1-Rejaie SS | 2014 | Neurol Sei2014，35，7： | 1 |
| 6 | Team formation in concur- rent engineering using group technology (gt) concepts显示文摘 | Aleisa Esra | 2011 | Concurrent Engineering Research and Applications2011，，3： | 1 |
| 7 | Levothyroxin restores hypothyroidism-induced impairment of hippocampus-dependent learning and memory: behavioral,electrephysiological,and molecular studies 显示文摘 | Alzoubi KH Gerges NZ Aleisa AM | 2009 | Hippocampus2009，19，： | 1 |
| 8 | Chronic caffeine treatment prevents stress-induced LTP impairment:the critical role of phosphorylated Ca MKII and BDNF显示文摘 | Alzoubi KH Srivareerat M Aleisa AM | 2013 | J Mol Neurosci2013，49，1： | 1 |
| 9 | Levothyroxinrestores hypothyroidism-induced impairment of hippocampus-dependent learning and memory : Behavioral, electrophysio-logical, and molecular studies 显示文摘 | Alzoubi KH Gerges NZ Aleisa AM et ai | 2009 | Hippocampus2009，19，1： | 1 |
| 10 | Molecular cytogenet- ic evaluation of the mechanism of micronuelei formation in- duced by camptothecin, topoteean, and irinoteean显示文摘 | Attia SM Aleisa AM Bakheet SA etal | 2009 | Environ Mol Mutagen2009，50，2： | 1 |
| 11 | Metallothionein induc- tion reduces caspase-3 activity and TNFalpha levels with preser- vation of cognitive function and intact hippocampal neurons in carmustine treated rats显示文摘 | Helal GK Aleisa AM Helm OK | 2009 | Oxid Med Cell Longev2009，2，1： | 1 |
| 12 | Psychosocial stress- induced hypertension results from in vivo expression of long-term potentiation in ratsympathetic ganglia 显示文摘 | Alkadhi KA Alzoubi KH Aleisa AM | 2005 | Neurobiol Dis2005，20，3： | 1 |
| 13 | Levothyroxin restores hypothyroidism-induced impairment of hippocampus-dependent learning and memory:Behavioral,electrophysiological,and molecular studies显示文摘 | Alzoubi K H Gerges N Z Aleisa A M | 2009 | Hippocampus2009，19，1： | 1 |
| 14 | Chronic psychosocial stress-induced impairment of hippocampal LTP: possible role of BDNF 显示文摘 | ALEISA A M ALZOUBI K H GERGES N Z | 2006 | Neurobiol Dis2006，22，3： | 1 |
| 15 | Post-learning REM sleep deprivation impairs long-term memory:Reversal by acute nicotine treatment 显示文摘 | Aleisa A M Alzoubi K H Alkadhi K A | 2011 | Neurosci Lett2011，499，1： | 1 |
| 16 | Chronic nicotine restores normal Aβ levels and prevents short-term memory and E-LTP impairment in Aβ rat model of Alzheimer’s disease显示文摘 | Marisa Srivareerat Trinh T. Tran Samina Salim Abdulaziz M. Aleisa Karim A. Alkadhi | 2009 | Neurobiology of Aging2009，，： | 1 |
| 17 | Levothyroxin restoreshypothyroidism-induced impairment of hippocampus-dependent learn-ing and memory:Behavioral,electrophysiological,and molecularstudies显示文摘 | Alzoubi K H Gerges N Z Aleisa A M | 2009 | Hippocampus2009，19，1： | 1 |
| 18 | Psychosocial stress-induced hypertension results from in vivo expression of long-term potentiation in rat sympathetic ganglia显示文摘 | Alkadhi KA Alzoubi KH Aleisa AM | 2005 | Neurobiol Dis2005，20，3： | 1 |
| 19 | Molecular studies on the protective effect of nicotine in adult-onset hypothyroidism-induced impairment of long-term potentiation 显示文摘 | Alzoubi KH Aleisa AM Alkadhi KA | 2006 | Hippocampus2006，16，： | 1 |
| 20 | Dynamic relationships among GCC stock markets and NYMEX oil futures显示文摘 | HAMMOUDEH S ALEISA E | 2004 | Contemporary Economic Policy2004，22，2： | 1 |
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