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| 1 | Exploratory study on microRNA profiles from plasma-derived extracellular vesicles in Alzheimer’s disease and dementia with Lewy bodies显示文摘Background:Because of the increasing life expectancy in our society,aging-related neurodegenerative disorders are one of the main issues in global health.Most of these diseases are characterized by the deposition of misfolded proteins and a progressive cognitive decline.Among these diseases,Alzheimer’s disease(AD)and dementia with Lewy bodies(DLB)are the most common types of degenerative dementia.Although both show specific features,an important neuropathological and clinical overlap between them hampers their correct diagnosis.In this work,we identified molecular biomarkers aiming to improve the misdiagnosis between both diseases.Methods:Plasma extracellular vesicles(EVs)-from DLB,AD and healthy controls-were isolated using size-exclusion chromatography(SEC)and characterized by flow cytometry,Nanoparticle Tracking Analysis(NTA)and cryo-electron microscopy.Next Generation Sequencing(NGS)and related bibliographic search was performed and a selected group of EV-associated microRNAs(miRNAs)was analysed by qPCR.Results:Results uncovered two miRNAs(hsa-miR-451a and hsa-miR-21-5p)significantly down-regulated in AD samples respect to DLB patients,and a set of four miRNAs(hsa-miR-23a-3p,hsa-miR-126-3p,hsa-let-7i-5p,and hsamiR-151a-3p)significantly decreased in AD respect to controls.The two miRNAs showing decreased expression in AD in comparison to DLB provided area under the curve(AUC)values of 0.9 in ROC curve analysis,thus suggesting their possible use as biomarkers to discriminate between both diseases.Target gene analysis of these miRNAs using prediction online tools showed accumulation of phosphorylation enzymes,presence of proteasome-related proteins and genes involved in cell death among others.Conclusion:Our data suggest that plasma-EV associated miRNAs may reflect a differential profile for a given dementia-related disorder which,once validated in larger cohorts of patients,could help to improve the differential diagnosis of DLB versus AD. | Ana Gámez-Valero Jaume Campdelacreu Dolores Vilas Lourdes Ispierto Ramón Reñé RamiroÁlvarez MPilar Armengol Francesc E.Borràs Katrin Beyer | 2019 | Translational Neurodegeneration2019，8，1： | 4 |
| 2 | Efficient metallization of magnetite concentrate by reduction with agave bagasse as a source of reducing agents显示文摘The reduction behavior and metallization degree of magnetite concentrate with agave bagasse were investigated in an inert atmosphere.The effects of temperature,biomass content,and residence time on reduction experiments and metallization degree were investigated by X-ray diffraction and scanning electron microscopy.Compared with other types of biomass,agave bagasse had lower contents of nitrogen,sulfur,and ash.X-ray diffraction analysis showed that the metallization degree improved with increasing temperature and biomass content.Complete metallization was achieved at 1100℃ for 30 min with 65:35 and 50:50 ratios of the magnetite concentrate to the agave bagasse.These results demonstrate that agave bagasse promotes the efficient metallization of magnetite concentrate without the external addition of a reducing agent.Therefore,this biomass is a technical suitable alternative to replace fossil fuels in steelmaking. | Diana Cholico-González NoemíOrtiz Lara Mario Alberto Sánchez Miranda Ricardo Morales Estrella Ramiro Escudero García Carlos ALeón Patiño | 2021 | International Journal of Minerals,Metallurgy and Materials2021，28，4： | 2 |
| 3 | Higher disease activity leads to more structural damage in the spine in ankylosing spondylitis: 12-year longitudinal data from the OASIS cohort显示文摘 | RAMIRO S VAN DER HEIJDE D VAN TUBERGEN A | 2014 | Annals of the Rheumatic Diseases2014，73，8： | 1 |
| 4 | Calprotectin in rheumatoid rthritis :association with disease activity in a cross- sectional and a longitudinal cohort 显示文摘 | Garcia-Arias M Pascual-Salcedo D Ramiro S | 2013 | Mol Diagn Ther2013，17，1： | 1 |
| 5 | Transcatheter aortic valve implantation in very elderly patients: immediate results and medium term follow-up显示文摘ObjectiveTo 评估立即的 transcatheter 在有严重、征兆的大动脉的狭窄的很老的病人的大动脉的阀门培植(TAVI ) 结果和中期的后续(作为).MethodsThis multicenter,观察、未来的学习在三所医院里被执行。我们包括了连续很老(>85 年) 病人与作为严重由 TAVI 对待。主要端点是在包括的二 years.ResultsThe 研究从任何原因评估死亡率有一个平均数的 160 个连续病人 87 ± 变老;2.1 年(从 85 ~ 94 年的范围) 和 18.8%± 的吝啬的逻辑 EuroSCORE;11.2% 与 57 (35.6%) 病人得分 ≥20% 。程序的成功率是 97.5% ,与 25 (15.6%) 与主要流血经历尖锐复杂并发症的病人(最经常) 。全球死亡率在住院期间是 8.8%(n = 14 ) 并且 30 天的死亡率是 10%(n = 16 ) 。中部在时期上面列在后面是 252.24 ±232.17 天。在后续时期期间, 28 (17.5%) 病人们死了(他们中的 17 个由于心脏的原因) 。估计的二年全面、心脏的幸存率使用 Kaplan-Meier 方法分别地是 71% 和 86.4% 。比例的危险回归给看了的考克斯可变 EuroSCORE ≥20 是与全面 mortality.ConclusionsTAVI 联系的唯一的变量在很老的病人的一张选择人口安全、有效。我们的调查结果支持在病人的这个复杂的组的这个新过程的采纳。 | Isaac Pascual Antonio J Mu oz-García Diego López-Otero Pablo Avanzas Manuel F Jimenez-Navarro Belén Cid-Alvarez Raquel del Valle Juan H Alonso-Briales Raimundo Ocaranza-Sanchez José M Hemández Ramiro Trillo-Nouche César Morís | 2015 | Journal of Geriatric Cardiology2015，12，4： | 1 |
| 6 | Evolution of radiographic damage in ankylosing spon- dylitis: a 12 year prospective follow-up of the OASIS study显示文摘 | RAMIRO S STOLWIJK C VAN TUBERGEN A | 2013 | Annals of the Rheumatic Diseases2013，，： | 1 |
| 7 | Catprotectin in rheumatoid arthritis : association with disease activity in a cross-sectional and a longitudinal cohort显示文摘 | Garcia-Arias M Pascual-Salcedo D Ramiro S | 2013 | Mol Diagn Ther2013，17，1： | 1 |
| 8 | Efficacy of conventional synthetic disease-modifying antirheumatic drugs, glucocorticoids and tofacitinib: a systematic literature review informing the 2013 update of the EULAR recommendations for management of rheumatoid arthritis显示文摘 | Ganjoux-Viala C Nam J Ramiro S | 2014 | Ann Rheum Dis2014，73，3： | 1 |
| 9 | Efficacy of conventional synthetic disease-modifying antirheumatic drugs,glucocorticoids and tofacitinib:a systematic literature review informing the 2013 update of the EULAR recommendations for management of rheumatoid arthritis显示文摘 | Gaujoux-Viala C Nam J Ramiro S | 2014 | Ann Rheum Dis2014，73，3： | 1 |
| 10 | Evolution of radiographic damage in ankylosing spondylitis: a 12 year prospective follow-up of the OASIS study 显示文摘 | Ramiro S Stolwijk C van Tubergen A | 2015 | Ann Rheum Dis2015，74，1： | 1 |
| 11 | Development of new syndesmophytes and bridges in ankylosing spondylitis and their predictors : a longitudinal study显示文摘 | van Tubergen A Ramiro S van der Heijde D | 2012 | Ann Rheum Dis2012，71，4： | 1 |
| 12 | Uveal melanoma expresses NK-1 receptors and cyclos- porin A induces apoptosis in human melanoma cell lines over- expressing the NK-1 receptor显示文摘 | Gonzcilez Ortega A Stlnchez Vaderrdbanos E Ramiro Fuentes S | 2014 | Peptides2014，55，： | 1 |
| 13 | Direct injection of vascular endothelial growth factor into the ovary of mice promotes follicular development显示文摘 | Ramiro Quintana Laura Kopcow Carlos Sueldo Guillermo Marconi Nidia Gomez Rueda Rosa Inés Bara?ao | 2004 | Fertility and Sterility2004，，： | 1 |
| 14 | Ependymal reaction afterexperimental spinal cord injury 显示文摘 | Vaquero J Ramiro MJ Oya S | 1981 | Acta Neurochir ( Wien )1981，55，34： | 1 |
| 15 | Higher disease activity leads to more structural damage in the spine in ankylosing spondylitis:12-year longitudinal data from the OASIS cohort显示文摘 | Ramiro S van der Heijde D van Tubergen A | 2014 | Ann Rheum Dis2014，73，8： | 1 |
| 16 | Efficacy of biological disease -modifying antirheumatic drugs: a systematic literature review informing the 2013 update of the EULAR recommendations for the management of rheumatoid arthritis显示文摘 | Nam JL Ramiro S Gaujoux Viala C | 2014 | Ann Rheum Dis2014，73，： | 1 |
| 17 | Efficacy of conventional synthetic disease-modifying antirheumatic drugs,glucocorticoids and tofacitinib:a systematic literature review informing the 2013update of the EULAR recommendations for management of rheumatoid arthritis显示文摘 | Gaujoux-Viala C Nam J Ramiro S | 2014 | Ann Rheum Dis2014，73，3： | 1 |
| 18 | Control of hypertension with medication: a comparative analysis of national surveys in 20 countries 显示文摘 | Nayu I David S Ramiro G | 2014 | Bull World Health Organ2014，92，1： | 1 |
| 19 | Posttraumatic cerebral hemispheric swelling显示文摘 | Ramiro D Rosario S Francisco C | 1988 | J Neurosurg1988，68，： | 1 |
| 20 | Efficacy of biological dis- ease- modifying antirheumatic drugs : a systematic literature review in- forming the 2013 update of the EULAR recommendations for the manage- ment of rheumatoid arthritis显示文摘 | Nam JL Ramiro S Gaujoux -Viala C | 2014 | Ann Rheum Dis2014，73，3： | 1 |
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