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| 1 | Axial strain enhances osteotomy repair with a concomitant increase in connexin43 expression显示文摘The mechanical environment is known to influence fracture healing. We speculated that connexin43(Cx43) gap junctions, which impact skeletal homeostasis, fracture healing and the osteogenic response to mechanical load,may play a role in mediating the response of the healing bone to mechanical strain. Here, we used an established rat fracture model, which uses a 2 mm osteotomy gap stabilized by an external fixator, to examine the impact of various cyclical axial loading protocols(2%, 10%, and 30% strain) on osteotomy healing. We examined the presence of Cx43 in the osteotomy-healing environment and assessed how mechanical strain modulates Cx43 expression patterns in the callus. We demonstrated that increased cyclical axial strain results in increased radiographic and histologic bone formation. In addition, we show by immunohistochemistry that Cx43 is abundantly expressed in the healing callus, with the expression most robust in samples exposed to increased cyclical axial strain. These data are consistent with the concept that an increase in Cx43 expression by mechanical load may be part of the mechanisms by which mechanical forces enhances fracture healing. | Rishi R Gupta Hyunchul Kim Yu-Kwan Chan Carla Hebert Leah Gitajn David J Yoo Robert V O’Toole Adam H Hsieh Joseph P Stains | 2015 | Bone Research2015，3，2： | 2 |
| 2 | Scanning mutagenesis of interleukin - 8 identifies a cluster of residues required for receptor binding显示文摘 | Hebert C A Vitangcol R V Baker J B | 1991 | J Biol Chem1991，266，18： | 1 |
| 3 | Use of stable tracer studies to evaluate pesticide photolysis at elevated temper atures显示文摘 | Hebert V R Hoonhout C Miller G C | 2000 | Journal of Agricultural and Food Chemistry2000，48，19： | 1 |
| 4 | An inexpensive automation friendly protocol for recovering high quality DNA 显示文摘 | Ivanova N V Dewaard J R Hebert P D N | 2006 | Mol Eeol Notes2006，6，： | 1 |
| 5 | Autonomous driving in urban environments: Boss and the urban challenge 显示文摘 | URMSON C ANHALT J BAGNELL D BAKER C BITTNER R CLARK M N DOLAN J DUGGINS D GALATALI T GEYER C GITTLEMAN M HARBAUGH S HEBERT M HOWARD T M KOLSKI S KELLY A LIKHACHEV M MCNAUGHTON M MILLER N PETERSON K PILNICK B RAJKUMAR R RYBSKI P SALESKY B SEO Y W SINGH S SNIDER J STENTZ A WHITTAKER W WOLKOWICKI Z Z1GLAR J BAE H BROWN T DEMITRISH D LITKOUHI B NICKOLAOU J SADEKAR V ZHANG Wen-de STRUBLE J TAYLOR M DARMS M FERGUSON D | 2008 | Journal of Field Robotics2008，25，8： | 1 |
| 6 | A simple technique for purification of tobacco mosaic virus in large quantities显示文摘 | Gooding G V J R Hebert T T | 1967 | Phytopathology1967，57，11： | 1 |
| 7 | Evaluation of pheromone release from commercial mating disruption dispensers显示文摘 | Tomaszewska E Hebert V R Brunner J F | 2005 | J Agric Food Chem2005，53，： | 1 |
| 8 | Gas-phase photolysis of phorate, a phosphorothioate insecticide 显示文摘 | HEBERT V R GEDDES J D MENDOSA J | 1998 | Chemosphere1998，36，9： | 1 |
| 9 | Depth dependence of direct and indirect photolysis on soil surfaces显示文摘 | HEBERT V R Miller G C | 1990 | J Agric Food Chem1990，，38： | 1 |
| 10 | Role of COX-2 in the bioactivation of methylenediauiline and in its proliferative effects in vascular smooth muscle cells显示文摘 | HEBERT V Y JONES B C MIFFLIN R C | 2011 | Cardiovasc Toxieol2011，11，4： | 1 |
| 11 | What questions do family caregivers want to discuss with health care providers in order to prepare for the deathof a loved one? An ethnographic study of caregivers of patients at end of life 显示文摘 | Hebert RS Schulz R Copeland V | 2008 | J Palliat Med2008，11，3： | 1 |
| 12 | Determina- tion of acephate in human urine 显示文摘 | LEPAGE J T HEBERT V R TOMASZEWSKA E M | 2005 | Journal of AOAC Interna- tional2005，88，6： | 1 |
| 13 | Depth dependence of direct and indirect photolysis on soil surfaces显示文摘 | Hebert V R Miller G C 1990 | 1990 | J Agric Food Chem1990，38，： | 1 |
| 14 | Photolysis of octachlorodibenzo-p-dioxin on soils: production of 2,3,7,8-TCDD显示文摘 | Miller G C Hebert V R Miille M J | 1989 | Chemosphere1989，18，： | 1 |
| 15 | A DNA ' bar- code blitz' : rapid digitization and sequencing of a natural history collection 显示文摘 | Hebert P D de Waard J R Zakharov E V | 2013 | PLoS ONE2013，8，68： | 1 |
| 16 | Depth dependence of direct and indirect photolysis on soil surfaces显示文摘 | Hebert V R Miller G C | 1990 | J Agric Food Chem1990，38，： | 1 |
| 17 | Depth dependence of direct and indirect photolysis on soil surfaces 显示文摘 | Miller G C | 1990 | J Agric Food Chem1990，38，： | 1 |
| 18 | A simple teehnique for purification of tobacco mosaic virus in large quantities显示文摘 | GOODING G V J R HEBERT T T | 1967 | Phytopathology1967，57，11： | 1 |
| 19 | An inexpen- si-e, automation- friendly protocol for reco-ering high - quality DNA 显示文摘 | I-ano-a N V Dewaard J R Hebert P D N | 2006 | Mol Ecol Notes2006，6，4： | 1 |
| 20 | Changes in photosynthesis, ribulose bisphosphate earboxylase,proteolytic activity,and uhrastructure of soybean leaves during senescence显示文摘 | WITTENBACH V A ACKERSON R C GIAQUINTA R T HEBERT R R | 1980 | Crop Science Society of America1980，20，： | 1 |
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