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| 1 | Chronic pancreatitis:A diagnostic dilemma显示文摘Typical clinical symptoms of chronic pancreatitis are vague and non-specific and therefore diagnostic tests are required, none of which provide absolute diagnostic certainly, especially in the early stages of disease. Recently-published guidelines bring much needed structure to the diagnostic work-up of patients with suspected chronic pancreatitis. In addition, novel diagnostic modalities bring promise for the future. The assessment and diagnosis of pancreatic exocrine insufficiency remains challenging and this review contests the accepted perspective that steatorrhea only occurs with > 90% destruction of the gland. | Sinead N Duggan Hazel M NíChonchubhair Oladapo Lawal Donal B O’Connor Kevin C Conlon | 2016 | World Journal of Gastroenterology2016，22，7： | 4 |
| 2 | BRAF inhibitor treatment of melanoma causing colonic polyps:An alternative hypothesis显示文摘Colonic polyps may arise from BRAF inhibitor treatment of melanoma, possibly due paradoxical activation of the mitogen-activated protein(MAP)-kinase pathway. In an alternative evidence based scenario, tubular colonic adenomas with APC gene mutations have also been identified in the context of BRAF inhibitor treatment, in the absence of mutations of MAPK genes. A minority of colorectal cancers develop by an alternative 'serrated polyp pathway'. This article postulates a novel hypothesis, that the established phenotypic and molecular characteristics of serrated colonic polyps/CRC offer an intriguing insight into the pathobiology of BRAF inhibitor induced colonic polyps. Serrated polyps are characterized by a Cp G island methylation phenotype, MLH1 silencing and cellular senescence. They also have BRAF mutations. The contention is that BRAF inhibitor induced polyps mimic the afore-described histology and molecular features of serrated polyps with the exception that instead of the presence of BRAF mutations they induce C-RAF homodimers and B-RAF: C-RAF heterodimers. | Fergal C Kelleher Grainne Callaghan Catriona Gallagher Hazel O'Sullivan | 2017 | World Journal of Gastroenterology2017，23，17： | 2 |
| 3 | Coral bleaching in philippine reefs: coincident evidences with mesoscale thermal anomalies显示文摘 | Hazel O Arceo Miledel C Quibilan Porfirio M Alno | 2001 | Bullenin of marine science2001，69，2： | 1 |
| 4 | Immunohis tochemincal detection of inducible nitric oxide synthase, nitroty rosine and manganese superoxide dismutase following hyperglycemic focal cerebral ischemia显示文摘 | STE-MARIE L HAZELL AS BEMEUR C | 2001 | Brain Res2001，918，： | 1 |
| 5 | Intergenerational transmission and continuity of stress and depression: depressed women and their offspring in 20 years of follow-up 显示文摘 | Hammen C Hazel NA Brennan PA | 2012 | Psychol Med2012，42，5： | 1 |
| 6 | Molecular mechanisms of temperature compensafion in poikilothermos 显示文摘 | Hazel J R Prosser C L | 1974 | Physiol Rev1974，54，： | 1 |
| 7 | Molecular mechanisms of tem- perature compensation in poikilotherms 显示文摘 | HAZEL J R PROSSER C L | 1974 | Physiological Reviews1974，54，： | 1 |
| 8 | Energy metabolismin astrocytes and neurons treated with manganese:relation among cell-specific energy failure,glucosemetabolism,and intercellular trafficking usingmultinuclear NMR-spectroscopic analysis显示文摘 | Zwingmann C Leibfritz D Hazell AS | 2003 | Cereb BloodFlow Metab2003，23，： | 1 |
| 9 | Adipose-Derived Stem Cells: Characterization and Current Application in Orthopaedic Tissue Repair 显示文摘 | Hazel T Edward N Joshua C | 2009 | Exper Biol Med2009，234，1： | 1 |
| 10 | The usefulness of Vistech and FACT contrast sensitivity charts for cataract and refractive surgery outcomes research 显示文摘 | Pesudovs K Hazel C A Doran R M L | 2004 | Scientific Re- port2004，88，1： | 1 |
| 11 | High temperature seques- tration of COz using lithium zirconates显示文摘 | Alina I Hazel S William C | 2009 | Chem Eng J2009，146，： | 1 |
| 12 | A portable,multiprocess,track-based robot for in situ work on hydropower equipment显示文摘 | Hazel B CtéJ Laroche Y | 2012 | Journal of Field Robotics2012，29，1： | 1 |
| 13 | Reduced expression of astrocytic glycine transporter (Glyt-1) in acute liver failure 显示文摘 | Zwingmann C Desjardins P Hazell A Chatauret N Michalak A Butterworth RF | 2002 | Metab Brain Dis2002，17，4： | 1 |
| 14 | New Multiple Herbicide Crop Resistance and Formulation Technology to Augment the Utility of Glyphosate显示文摘 | GREEN J M HAZEL C B FORNY D R | 2008 | Pest Manage Sci2008，64，： | 1 |
| 15 | Review: biosynthesis and function of yeast vacuolar proteases 显示文摘 | Van Den Hazel H B Kielland-Brandt M C WintherJ R | 2006 | Yeast2006，12，： | 1 |
| 16 | Immuno-histochemical detection of inducible nitric oxide syn-thase, nitrotyrosine and manganese superoxide dismutase following hyperglycemic focal cerebral ischemia显示文摘 | Ste-Marie L Hazell AS Bemeur C | 2001 | BrainRes2001，918，12： | 1 |
| 17 | Coral bleaching in Philippine reefs: Coinci-dent evidences with mesoseale thermal anomalies显示文摘 | Hazel O A Miledel C Q Porfirio M A | 2001 | Bullenin of Marine Seienee2001，69，2： | 1 |
| 18 | Immunohistochemical detection of inducible nitric oxide synthase,nitrotyrosine and maganese superoxide dismutase following hyperglycemic focal cerebral显示文摘 | Hazell AS Bemeur C | 2001 | Brain RES2001，918，12： | 1 |
| 19 | New Multiple-herbicide Crop Resistance and Formulation Technology to Augment the Utility of Glyphosate显示文摘 | GREEN J M HAZEL C B FORNEY D R | 2008 | Pest Manag Sci2008，64，： | 1 |
| 20 | Immunohistochemical detection of inducible nitric oxide synthase,nitrotyrosine and manganese superoxide dismutase following hyperglycemic focal cerebral ischemia显示文摘 | Hazell AS Bemeur C | 2001 | Brain Res2001，918，12： | 1 |
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