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| 1 | Circulating autoantibodies to endogenous erythropoietin are associated with chronic hepatitis C virus infection-related anemia显示文摘BACKGROUND: Chronic hepatitis C virus(HCV) infection is associated with autoimmune phenomena and is often complicated by anemia. Circulating autoantibodies to endogenous erythropoietin(anti-EPO) have been detected in patients with chronic viral infections and were correlated to anemia. The present study aimed to determine anti-EPO prevalence in patients with chronic HCV infection and investigate its possible association with anemia.METHODS: Ninety-three consecutive patients(62 males and 31 females) with chronic HCV infection, who had never received antiviral therapy or recombinant EPO, were enrolled in the study. Circulating anti-EPO were detected in the serum by using an ELISA assay. Quantitative determination of serum EPO levels was done by radioimmunoassay. HCV RNA viral load measurement and genotype sequencing were also performed.RESULTS: Circulating anti-EPO were detected in 10.8% of HCV-infected patients and the prevalence of anti-EPO was significantly higher in patients with anemia(19.4% vs 5.3%, P=0.040) compared to that in those without anemia. Compared to anti-EPO negative cases, anti-EPO positive patients had higher frequency of anemia(70.0% vs 34.9%, P=0.030), lower EPO concentrations(median 16.35 vs 30.65 m U/m L, P=0.005), and higher HCV RNA viral load(median 891.5×103 vs 367.5×103 IU/m L, P=0.016). In multivariate regression analysis the presence of anti-EPO remained an independent predictor of anemia(adjusted OR: 14.303, 95% CI: 1.417-36.580, P=0.024). EPO response to anemia was less prominent among anti-EPO positive patients(P=0.001).CONCLUSIONS: Circulating anti-EPO are detected in a significant proportion of treatment-na?ve HCV-infected patients and are independently associated with anemia, suggesting a further implication of autoimmunity in the pathophysiology of HCV-related anemia. | Aristotelis Tsiakalos Theoharis Voumvas Alexandros Psarris Christina K Oikonomou Dimitrios C Ziogas Ioannis Ketikoglou Grigorios Hatzis Nikolaos V Sipsas | 2017 | Hepatobiliary & Pancreatic Diseases International2017，16，3： | 4 |
| 2 | BCL6 repression of EP300 in human diffuse large B cell lymphoma cells provides a basis for rational combinatorial therapy显示文摘 | Cerchietti Leandro C Hatzi Katerina Caldas-Lopes Eloisi Yang Shao Ning Figueroa Maria E Morin Ryan D Hirst Martin Mendez Lourdes Shaknovich Rita Cole Philip A Bhalla Kapil Gascoyne Randy D Marra Marco Chiosis Gabriela Melnick Ari | 2010 | Journal of Clinical Investigation2010，，12： | 1 |
| 3 | Biochemical engineering analysis of critical process factors in the biomass-to-etha- nol technology 显示文摘 | PHILIPPIDIS G P HATZIS C | 1997 | Biotechnology Progress1997，13，3： | 1 |
| 4 | Measurement of Re- sidual Breast Cancer Burden to Predict Survival After Neoadju- vant Chemotherapy显示文摘 | Symmans WF Peintinger F Hatzis C | 2007 | J Clin Oncol2007，25，28： | 1 |
| 5 | Commercialized multigene predictors of clinical outcome for breast cancer显示文摘 | Ross JS Hatzis C Symmans WF | 2008 | Oncologist2008，13，5： | 1 |
| 6 | BCL6-mediated re- pression of p53 is critical for leukemia stem cell survival in chronic myeloid leukemia显示文摘 | Hurtz C Hatzi K Cerchietti L | 2011 | J Exp Med2011，208，11： | 1 |
| 7 | Intrathecal injection of cAMP response element bingding protein(CREB)antisense oligonucleotide attenuates tactile aUodynia caused by partial sciatic nerve ligation显示文摘 | Ma W Hatzis C Eisenach J C | 2003 | Brain Res2003，988，12： | 1 |
| 8 | Commercialized Multigene Predictors of Clinical Outcome for Breast Cancer显示文摘 | ROSS JS HATZIS C SYMMANS WF | 2008 | The Oncolo- gist2008，13，5： | 1 |
| 9 | protein-tan is a bifunctional predictor of endocrine sensitivity and chemotherapy resistance in estrogen receptor-positive breast cancer显示文摘 | Andre F Hatzis C Anderson K | 2007 | Clin Cancer Res2007，13，7： | 1 |
| 10 | Intrathecal injection of cAMP response element binding protein(CREB)antisense oligonucle-otide attenuates tactile allodynia caused by partial sciatic nerve ligation显示文摘 | Ma W Hatzis C Eisenach JC | 2003 | Brain Res2003，988，： | 1 |
| 11 | Microtubule-associated protein-tau is a bifunctional predictor of endocrine sensitivity arid chemotherapy resistance in estrogen receptor positive brest cancer 显示文摘 | Andre F Hatzis C Anderson K | 2007 | clin Cancer Res2007，13，7： | 1 |
| 12 | N-myc oncogene overexpres- sion downregulates IL-6; evidence that IL-6 inhibits angiogenesis and suppresses neurobalstoma tumor growth显示文摘 | Hatzi E Murphy C Zoephel A J | 2002 | Oncogene2002，21，22： | 1 |
| 13 | Smoking status in relation to serum folate and dietary vitamin intake显示文摘 | Vardavas C I Linardakis M K Hatzis C M | 2008 | Toh Indue Dis2008，4，1： | 1 |
| 14 | Intrathecal injection of cAMP re-sponse element binding protein(CREB)antisense oligonucleotide attenuates tactile allodynia caused by partial sciatic nerve ligation显示文摘 | Ma W Hatzis C Eisenach JC | 2003 | Brain Res2003，988，： | 1 |
| 15 | Adaptive Visual Analog Scales(AVAS)-a modifiable software program for the creation, administration, and scoring of visual analog scales显示文摘 | Marsh-Richard D M Hatzis E S Mathias C W | 2009 | Behav Res Methods2009，41，1： | 1 |
| 16 | Ambient partic- ulate matter exhibits direct inhibitory effects on oxidative stress enzymes 显示文摘 | Hatzis C Godleski JJ Gonzalez-Flecha B | 2006 | Environ Sci Technol2006，40，8： | 1 |
| 17 | Mierotubule associated protein-tau is a bifunctional predictor of endocrine sensitivity and chemotherapy resistance in estrogen receptor positive breast cancer显示文摘 | Andre F Hatzis C Anderson K | 2007 | Clin Cancer Res2007，13，7： | 1 |
| 18 | Use of genomic grade index (GGI) to predict pathologic response to preoperative chemotherapy in breast cancer显示文摘 | Symmans WF Hatzis C Liedtke C | 2008 | J Clin Oncol2008，26，： | 1 |
| 19 | Microtubule associated protein-Tau is a bifunetional predictor of endocrine sensitivityand chemotherapy resistance in estrogen receptor positive breast cancer显示文摘 | Andre F Hatzis C Anderson K | 2007 | Clin Cancer Res2007，13，7： | 1 |
| 20 | Measurement of residual breast cancer burden to predict survival after neoadjuvant chemotherapy显示文摘 | Symmans W F Peintinger F Hatzis C | 2007 | J Clin Oncol2007，25，28： | 1 |
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